Containing Chemically Combined Protein Or Biologically Active Polypeptide Patents (Class 525/54.1)
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Publication number: 20120263759Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.Type: ApplicationFiled: September 2, 2011Publication date: October 18, 2012Applicant: Abbott Cardiovascular Systems Inc.Inventors: Syed F.A. Hossainy, Yiwen Tang, Lothar W. Kleiner
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Publication number: 20120258068Abstract: Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.Type: ApplicationFiled: December 16, 2010Publication date: October 11, 2012Applicant: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Shachaf Yonatan
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Publication number: 20120258049Abstract: Nanoconjugates that include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold are provided. Methods of targeting a diseased cell or a diseased tissue in a subject by administering the nanoconjugate are described. Methods of synthesizing the nanoconjugate are also provided.Type: ApplicationFiled: April 6, 2012Publication date: October 11, 2012Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Keith L. Black, Julia Ljubimova, Alexander Ljubimov, Eggehard Holler
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Patent number: 8283438Abstract: A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided. The methods may be used to make functional polymers and other molecules. The method of making a functionalized polymer using a thiol-ene reaction comprises: providing a functionalized thioester having the following formula: wherein R is a functional group and COR? is a protecting group; cleaving the functionalized thioester, forming a functional thiol and an acyl group; providing a polymer having a pendant vinyl group; and reacting the polymer with the functional thiol whereby a functionalized polymer is formed, wherein the functional thiol is not isolated prior to reacting with the polymer.Type: GrantFiled: December 6, 2010Date of Patent: October 9, 2012Assignee: California Institute of TechnologyInventors: Ralph L. David, Julia A. Kornfield
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Patent number: 8283414Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.Type: GrantFiled: November 23, 2005Date of Patent: October 9, 2012Assignee: The Johns Hopkins UniversityInventors: Michael Yu, Jennifer H. Elisseeff, Hyeseung Janice Lee, Xiao Mo, Allen Yi-Lan Wang
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Publication number: 20120251586Abstract: Methods for protecting biomaterials comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated damage to the biomaterial. Also provided are kits for practicing these methods and the protected biomaterials.Type: ApplicationFiled: April 9, 2010Publication date: October 4, 2012Applicant: The Children's Hospital of PhiladelphiaInventors: Stanley J. Stachelek, Dennis Discher, Robert J. Levy, Richard Tsai
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Publication number: 20120245289Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.Type: ApplicationFiled: March 27, 2012Publication date: September 27, 2012Applicant: NEKTAR THERAPEUTICSInventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
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Publication number: 20120245288Abstract: Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.Type: ApplicationFiled: March 16, 2012Publication date: September 27, 2012Applicant: NANOMIMETICS, INC.Inventors: Jan J. LEWANDOWSKI, Yubiao LIU
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Patent number: 8273833Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through ether linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.Type: GrantFiled: December 8, 2010Date of Patent: September 25, 2012Assignee: Nektar TherapeuticsInventors: Michael David Bentley, Xuan Zhao, Xiaoming Shen, William Dudley Battle, III
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Publication number: 20120231519Abstract: Methods for constructing tyrosine-derived biotinylated polymers. Biotinylated polymers and polymer scaffolds constructed with the biotinylated polymers are also disclosed.Type: ApplicationFiled: January 17, 2012Publication date: September 13, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Jared S. Bushman, Jenny E. Raynor, Joachim B. Kohn
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Patent number: 8263127Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.Type: GrantFiled: December 8, 2009Date of Patent: September 11, 2012Assignee: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
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Publication number: 20120225101Abstract: Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.Type: ApplicationFiled: March 2, 2012Publication date: September 6, 2012Inventors: Weiyuan J. KAO, Yao Fu
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Publication number: 20120220721Abstract: The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X?—X2??(III) X1 and X2 each representing a peptide fragment, and X? representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2??(I) and a polypeptide of formula: H—X?—X2.??(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.Type: ApplicationFiled: October 28, 2010Publication date: August 30, 2012Applicants: Institut Pasteur de Lille, Centre National de la Recherche Scientifique (CNRS)Inventors: Oleg Melnyk, Reda Mhidia, Julien Dheur, Nathalie Ollivier
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Publication number: 20120220720Abstract: Synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, are disclosed. The synthetic cell culture surfaces have a functionalized peptide, a peptide that has been functionalized to contain a polymerization moiety, and optionally a spacer, grafted to a hydrophilic polymeric base material. Methods of making the surfaces and methods of using the surfaces are also disclosed.Type: ApplicationFiled: July 29, 2010Publication date: August 30, 2012Inventors: Dana Craig Bookbinder, Arthur Winston Martin, Jodelle Karen Nelson, Shawn Michael O'Malley, Yue Zhou
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Patent number: 8252571Abstract: Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material.Type: GrantFiled: May 1, 2009Date of Patent: August 28, 2012Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, Regents of the University of MinnesotaInventors: Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Xiaodong Tong, Minjuan Zhang
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Patent number: 8252846Abstract: The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.Type: GrantFiled: March 12, 2008Date of Patent: August 28, 2012Assignees: Emory University, Georgia Tech Research Corporation, University of RochesterInventors: Niren Murthy, Bali Pulendran, Robert H. Pierce, Michael John Heffernan, Jihua Hao, Marcin Kwissa, Michael Davis, Stephen C. Yang
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Publication number: 20120211423Abstract: A draw solute for forward osmosis may include a copolymer including a first structural unit where a temperature-sensitive side chain is graft polymerized, and a second structural unit including a hydrophilic functional group. The temperature-sensitive side chain may include a structural unit for a side chain including a temperature-sensitive moiety.Type: ApplicationFiled: February 16, 2012Publication date: August 23, 2012Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jae-Eun Kim, Bo-Kyung Jung, Jung-Im Han, Hyo Kang, Hyo-Rang Kang, Sung-Soo Han
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Patent number: 8242179Abstract: The invention provides a system and method for treating an orthopedic condition using a hydrogel-forming composition, which forms a hydrogel in situ at a target location and at least bio-mechanically treats the condition. The invention also provides a hydrogel forming composition designed to form a hydrogel with desirable biocompatible and biomechanical properties. In some aspects the hydrogel is formed in a water-permeable casing, which is delivered to an orthopedic joint in a minimally invasive manner. In particular, the system and method can be used for intervertebral disc replacement or repair.Type: GrantFiled: June 22, 2007Date of Patent: August 14, 2012Assignee: Surmodics, Inc.Inventor: Stephen J. Chudzik
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Patent number: 8241738Abstract: Hydroxyl polymer-containing compositions, especially hydroxyl polymer-containing compositions that can be processed into polymeric structures, especially polymeric structures in the form of fibers are provided.Type: GrantFiled: February 13, 2012Date of Patent: August 14, 2012Assignee: The Procter & Gamble CompanyInventors: Paul Arlan Forshey, Gregory Charles Gordon, Larry Neil Mackey, Mark Ryan Richards
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Publication number: 20120202397Abstract: The present invention, in some embodiments thereof, relates to material science in general, and, more particularly, to sequence variants of Stable Protein 1 (SP1), to uses thereof, for binding of carbon nanotubes, production of composite polymers and polymer materials, such as fabrics, based on SP1-polypeptide-carbon nanotube-complexes, and the use thereof for enhancing conductivity in tire.Type: ApplicationFiled: August 26, 2010Publication date: August 9, 2012Applicant: Fulcrum S.P. Materials Ltd.Inventors: Amnon Wolf, Nimrod Litvak, Elena Grimberg, Galit Cohen, Arnon Heyman, Izhar Medalsy, Danny Porath, Oded Shoseyov, Asa Eitan
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Publication number: 20120202948Abstract: The present disclosure provides substantially monodisperse random coil polypeptides, vectors encoding the polypeptides, conjugates containing the polypeptides, methods for their preparation, and their uses in nucleic acid separations, DNA sequencing, and other applications requiring high monodispersity.Type: ApplicationFiled: December 15, 2011Publication date: August 9, 2012Inventors: JENNIFER SUE LIN, Annelise E. Barron, Jennifer Coyne Albrecht, Xiaoxiao Wang
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Publication number: 20120201858Abstract: The present invention concerns compositions of matter, pharmaceutical compositions and method to produce multiple arm peptides-substrate (MAP-S) as composites having molecules covalently bonded thereto which exhibit enhanced cell adhesion, attachment, proliferation and the like in vivo. The composites MAP-S described herein as compositions and implants improve and accelerate the healing process and tissue implant integration for vascular and soft tissue, joint, bone and combinations thereof.Type: ApplicationFiled: August 12, 2011Publication date: August 9, 2012Inventors: Cheng Li, Mir Imran
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Publication number: 20120202263Abstract: The invention concerns macromers, having a molecular weight of at least 2 kDa, comprising at least one unit of the formula P-(protein-P)n, wherein: P is selected from polyethylene glycol (PEG), alginate, polyurethane, and polyvinyl alcohol; protein comprises at least one bis-cysteine matrix metalloproteinase (MMP)-sensitive peptide; and n is an integer from 2 to 500. Other aspects of the invention concern hydrogels utilizing cross-linked macromers and methods of producing such macromers and hydrogels.Type: ApplicationFiled: February 3, 2012Publication date: August 9, 2012Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Brandon L. Blakely, Jordan Miller, Christopher S. Chen
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Publication number: 20120195847Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.Type: ApplicationFiled: September 17, 2009Publication date: August 2, 2012Applicant: Nektar TherapeuticsInventors: Yujun Wang, Ping Zhang, Mary J. Bossard, Steven O. Roczniak
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Publication number: 20120190097Abstract: The present invention is directed to compositions comprising a polymer backbone with protective chain and anionic groups, and a cationic therapeutic agent. The present invention is directed to compositions for treating infections, inflammatory diseases, excess growth, and damaged cells and organs.Type: ApplicationFiled: September 8, 2010Publication date: July 26, 2012Inventors: Gerardo M. Castillo, Elijah M. Bolotin, Akiko Nashimoto-Ashfield
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Patent number: 8217123Abstract: Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.Type: GrantFiled: November 10, 2010Date of Patent: July 10, 2012Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Samuel P. McManus
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Publication number: 20120171763Abstract: A method for dissociating avidin or streptavidin efficiently from a biotin derivative, thereby making it possible to isolate a target material efficiently under a mild condition in a short period, and a dissociation agent for use thereof, are provided. The method for dissociating avidin or streptavidin from a biotin derivative, includes mixing a combination of avidin or streptavidin with desthiobiotin with a water-soluble polymer to which biotin or a derivative thereof is bound.Type: ApplicationFiled: September 16, 2010Publication date: July 5, 2012Applicant: JSR CORPORATIONInventor: Satoshi Katayose
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Publication number: 20120164100Abstract: The present disclosure provides temperature sensitive hydrogels and block copolymers, processes for the production thereof, and therapeutic and research compositions employing these copolymers.Type: ApplicationFiled: November 2, 2011Publication date: June 28, 2012Inventors: Ren-Ke Li, Faquan Zeng
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Publication number: 20120164098Abstract: The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.Type: ApplicationFiled: March 8, 2012Publication date: June 28, 2012Applicant: ALLERGAN, INC.Inventors: Jacqueline A. Schroeder, Gregory S. Dapper, Kenneth C. Olson
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Publication number: 20120164749Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.Type: ApplicationFiled: August 19, 2008Publication date: June 28, 2012Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Caterina Longo, Virginia Espina, Alexis Patanarut
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Patent number: 8206744Abstract: The invention concerns novel materials based on biodegradable branched polyaminoacids particularly useful for transporting active principle(s). The invention also concerns novel pharmaceutical, cosmetic, dietetic or phytosanitary compositions based on polyaminoacids. The invention aims at providing a novel polymeric material, capable of being used for transporting active principle(s) and enabling all the required relevant specifications to be optimally satisfied: biocompatibility, biodegradability, easy ability to be combined with a large number of active principles or to solubilize same, and to release the active principles in vivo. This is achieved by the present invention which firstly concerns branched polyaminoacids comprising aspartic acid units and or glutamic acid units, and which bear hydrophobic groups including 8 to 30 carbon atoms.Type: GrantFiled: July 19, 2005Date of Patent: June 26, 2012Assignee: Flamel TechnologiesInventors: Rémi Soula, Gauthier Pouliquen, You-Ping Chan
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Patent number: 8207263Abstract: The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond.Type: GrantFiled: November 13, 2007Date of Patent: June 26, 2012Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paris 7—Denis DiderotInventors: Jean-Luc Popot, Delphine Charvolin, Fabrice Giusti
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Patent number: 8207262Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.Type: GrantFiled: September 15, 2008Date of Patent: June 26, 2012Assignee: The Cleveland Clinic FoundationInventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukamachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
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Publication number: 20120149120Abstract: There is provided a chimeric protein of capsid protein of Hepatitis B virus (HBV) and B domain of Staphylococcal protein A (SPAB); a method for fabricating the same; the substrate and nanosensor immobilized with HBV-derived chimeric protein; and the use of the above nanosensor.Type: ApplicationFiled: September 2, 2011Publication date: June 14, 2012Applicant: Korea University Research and Business FoundationInventors: Jee Won Lee, Young Keun Kim, Moon Kyu Cho, Jin Seung Park, Eun Jung Lee
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Publication number: 20120149843Abstract: The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.Type: ApplicationFiled: February 1, 2012Publication date: June 14, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Miao-Ping Chien, Nathan C. Gianneschi
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Patent number: 8198364Abstract: There are provided poly(vinyl alcohol) polymers and copolymers containing vinyl alcohol or vinyl acetate and derivatives thereof such as poly(ethylene glycol)-grafted poly(vinyl alcohol) polymers or polyether-grafted poly(vinyl alcohol) polymers. These polymers can contain various functional groups. Such polymers can be use as polymer matrix or solid support for various chemical substrates such as organic substrates and reagents. Cross-linked poly(vinyl alcohol) polymers and copolymers are also provided. Methods for preparing such polymers as well as several of their uses are also included.Type: GrantFiled: June 14, 2007Date of Patent: June 12, 2012Assignee: Valorisation-Recherche, Limited PartnershipInventors: Julian Xiao-Xia Zhu, Pardin Christophe, Juntao Luo, William A. Lubell, Tarek Kassem
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Patent number: 8197802Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.Type: GrantFiled: December 28, 2010Date of Patent: June 12, 2012Assignee: AngioDevice International GmbHInventors: Woonza M. Rhee, Frank A. DeLustro, Richard A. Berg
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Patent number: 8198363Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.Type: GrantFiled: December 2, 2008Date of Patent: June 12, 2012Assignee: Tenaxis Medical, Inc.Inventors: Ronald Dieck, Ian J. Handley, Neil Winterbottom, Joanna Wong
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Publication number: 20120142861Abstract: A method is provided for solubilising a membrane protein. The method is applied to cellular material comprising the membrane protein and an associated membrane lipid. A copolymer of styrene and maleic acid, wherein the styrene:maleic acid ratio is between 1:2 and 10:1, is mixed with the cellular material to cause the copolymer, lipid and protein to form soluble macromolecular assemblies.Type: ApplicationFiled: July 8, 2010Publication date: June 7, 2012Inventors: Timothy Dafforn, Michael Overduin, Timothy Knowles
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Patent number: 8192760Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: GrantFiled: December 4, 2006Date of Patent: June 5, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Publication number: 20120129766Abstract: The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.Type: ApplicationFiled: November 15, 2011Publication date: May 24, 2012Applicants: IRM LLC, NOVARTIS AGInventors: Brian R. BOETTCHER, Shari L. CAPLAN, Douglas S. DANIELS, Bernhard H. GEIERSTANGER, Norio HAMAMATSU, Stuart LICHT, Andreas LOEW, Stephen Craig WELDON
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Publication number: 20120129270Abstract: Disclosed is a vesicular system comprising a surface with a vesicle immobilized thereon. The immobilized vesicle has a circumferential membrane of an amphiphilic polymer. The vesicle is coupled to a surface by means of a molecule with a non-polar moiety. The non-polar moiety comprises a main chain of 3 to about 30 carbon atoms and 0 to about 12 heteroatoms selected from Si, O, S, and Se. The molecule with the non-polar moiety is coupled to the surface via a covalent or non-covalent bond. A portion of the non-polar moiety is integrated in the circumferential membrane.Type: ApplicationFiled: April 20, 2010Publication date: May 24, 2012Inventors: Madhavan Nallani, Eva-Kathrin Sinner, Madanagopal Kunnavakkam
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Publication number: 20120121531Abstract: The present invention concerns a biocomposite useful in artificial tissue replacement, methods for its production, and methods of use. The biocomposite can be implanted into humans or animals as an artificial tissue for treatment of a tissue defect. The biocomposite can be formed or manipulated into a desired shape for implantation.Type: ApplicationFiled: January 10, 2012Publication date: May 17, 2012Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: EDWARD TUROS, Thomas J. Koob, Kerriann Robyn Greenhalgh
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Publication number: 20120121517Abstract: The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T-2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.Type: ApplicationFiled: June 30, 2011Publication date: May 17, 2012Inventors: Soo-Chang SONG, Jang Il KIM
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Publication number: 20120121537Abstract: Compositions and methods for reducing hepatitis C virus (HCV) replication are provided. Also provided are compositions and methods of treating an HCV infection; methods of reducing the incidence of complications associated with HCV and cirrhosis of the liver; and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from HCV infection.Type: ApplicationFiled: January 11, 2010Publication date: May 17, 2012Inventors: Chaomin Sun, James Harrison Doudna Cate
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Patent number: 8178617Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.Type: GrantFiled: July 11, 2008Date of Patent: May 15, 2012Assignees: Allvivo Vascular, Inc., The State of Oregon Acting by and through the State Board of Higher Ed. on Behalf of Oregon State Univ.Inventors: Jennifer A. Neff, Joseph McGuire, Pranav R. Joshi
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Publication number: 20120115962Abstract: The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles.Type: ApplicationFiled: October 11, 2011Publication date: May 10, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Ki-Bum Lee, Birju Shah, Prasad Subramaniam, Cheoljin Kim
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Patent number: 8173115Abstract: A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the surface receptors of the cell and ii) a preselected shape, where a surface distribution of the surface moieties on the particles and the shape of the particles are effective for the pre-selected cell internalization mode.Type: GrantFiled: July 29, 2008Date of Patent: May 8, 2012Assignee: The Board of Regents of The University of Texas SystemInventors: Paolo Decuzzi, Mauro Ferrari
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Patent number: 8173597Abstract: The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.Type: GrantFiled: November 7, 2008Date of Patent: May 8, 2012Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Hans-Peter Schwarz, Peter Turecek
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Publication number: 20120108748Abstract: The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.Type: ApplicationFiled: June 29, 2010Publication date: May 3, 2012Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Muriel Caussil-Amblard, Jean Martinez, Julien Tailhades