Containing Chemically Combined Protein Or Biologically Active Polypeptide Patents (Class 525/54.1)
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Publication number: 20130072598Abstract: A thermoplastic biobased material-containing composition comprising chemically-modified feathers and/or dried distillers grains and a process for forming the thermoplastic biobased material-containing composition. More specifically, the thermoplastic biobased material-containing composition comprises one or more of the following chemically-modified biobased materials: (a) acylated biobased material having a % Acyl Content that is at least 3% and a % Weight Gain that is at least 1%, and; (b) etherified biobased material having a % Weight Gain that is at least 2%; and (c) graft polymerized biobased material having a % Monomer Conversion that is at least 40%, a % Grafting Efficiency that is at least 30%, and a % Grafting that is at least 10%.Type: ApplicationFiled: March 19, 2012Publication date: March 21, 2013Applicant: Board of Regents of the University of NebraskaInventors: Yiqi Yang, Narendra Reddy, Chunyan Hu, Jin Enqi
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Publication number: 20130071862Abstract: The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particularly visceral leishmaniasis in animals such as humans and dogs.Type: ApplicationFiled: July 27, 2012Publication date: March 21, 2013Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTEInventors: Ajay Bhatia, Steven G. Reed
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Publication number: 20130053514Abstract: The invention provides a method comprising the steps of providing a poly(ethylene glycol) having one terminal hydroxyl group; reacting the terminal hydroxyl group of the poly(ethylene glycol) with di(1-benzotriazolyl)carbonate to form a 1-benzotriazolylcarbonate ester of the poly(ethylene glycol); reacting the 1-benzotriazolylcarbonate ester of the poly(ethylene glycol) with an amino acid to form an amino acid derivative; and reacting the amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.Type: ApplicationFiled: October 30, 2012Publication date: February 28, 2013Applicant: Nektar TherapeuticsInventor: Nektar Therapeutics
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Publication number: 20130052664Abstract: Provided are a method and kit for isolating a target cell by using particles comprising polymers having positive charge and negative charge and at least one antibody bound to polymers. The target cell in the biological sample may be efficiently isolated and detected by using a method and kit according to an exemplary embodiment.Type: ApplicationFiled: March 7, 2011Publication date: February 28, 2013Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jong-myeon Park, Jeong-gun Lee
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Publication number: 20130052134Abstract: This invention belongs to the nanotechnology field, and discloses a nano drug delivery system with polyethyleneglycol-poly(lactic-co-glycolic acid)-poly-L-lysine (PEG-PLGA-PLL) polymer as the skeleton. The carrier can have the function of passive targeting through control of the carrier particle size. The polymer skeleton is modified through introducing side chains and specific targeting groups, so as to adjust and improve the carrier performance, and enable the carrier to have the function of active targeting. Such carrier material also has the functions of transporting active substances, tumor treatment and diagnosis, ultrasonic contrast, reversing or reducing drug resistance and so on.Type: ApplicationFiled: December 28, 2010Publication date: February 28, 2013Applicant: Shanghai Cancer InstituteInventors: Yourong Duan, Peifeng Liu, Ying Sun, Ming Shen, Mingjie Zhu, Yanming Sun, Qi Wang, Zelai He, Liubin Qin, Hui Yu, Xiaoyu Li, Xuelian Qi, Xiaoyan Chen, Qiufen Sun, Bingwu Wang
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Publication number: 20130052155Abstract: The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.Type: ApplicationFiled: November 9, 2010Publication date: February 28, 2013Inventors: Michele Marcolongo, Edward Vresilovic, Benjamin Jackson, Sumona Sarkar, Caroline Schauer
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Patent number: 8383380Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.Type: GrantFiled: October 6, 2011Date of Patent: February 26, 2013Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Xiaoming Shen, Michael D. Bentley, Zhihao Fang, Tony L. Sander
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Publication number: 20130045522Abstract: The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.Type: ApplicationFiled: December 20, 2010Publication date: February 21, 2013Applicant: OligasisInventors: Stephen A. Charles, D. Victor Perlroth, Lane A. Clizbe, Didier G. Benoit, Wayne To
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Publication number: 20130045489Abstract: Neural nanoprobes are described, as well as methods for their use, including for use as a tagging system for neuronal pathway identification. The neural nanoprobes comprise metallic nanoparticles that are conjugated to both (i) a cationic polymer such as polyethylenimine and (ii) an antibody to a vesicular transporter protein. These methods allow retrograde characterization of glutamatergic neurons in a tissue slice preparation. Since the nanoparticles used are non-lipid-soluble and are specifically conjugated to enter and escape the synaptic vesicular machinery, these nanoparticles allow probing of a neuron's somatic origin, via the synapse, by diffusional means.Type: ApplicationFiled: February 10, 2012Publication date: February 21, 2013Applicant: COLLEGE OF WILLIAM AND MARYInventors: Karl Mendoza, John D. Griffin
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Publication number: 20130046056Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.Type: ApplicationFiled: June 6, 2012Publication date: February 21, 2013Applicant: EMD Millipore CorporationInventors: Shari Spector, Robert Smith, Joe Orlando, Nanying Bian
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Patent number: 8377717Abstract: This invention provides molecularly imprinted polymers (MIPs) for the detection of analytes, methods for forming the MIPs and detecting the analyte using the MIPs. The MIP comprises templated sites which are formed using a mimic of the analyte such that a reporter compound can be selectively attached at the templated sites, thus providing a site selectively tagged and templated MIP.Type: GrantFiled: March 22, 2010Date of Patent: February 19, 2013Assignee: The Research Foundation of State University of New YorkInventor: Frank V. Bright
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Patent number: 8378022Abstract: A biocompatible, biodegradable, macromolecular water-absorbent hybrid material (WAHM), having a three-dimensional configuration with intermolecular covalent bonds and containing free functional groups, said polymer being formed by polymer-polymer intercoupling reaction between a natural water-soluble polymer A or its derivatives having a molecular weight between 20,000 and 300,000 Da, and a synthetic polymer B in an adequate ratio wherein the natural polymer A is selected from amphoteric reactants, partially denatured or chemically modified natural polymer, that dissociates in water to form both anions and cations, and which can undergo polymer-polymer intercoupling reactions, and wherein synthetic polymer B s a linear or branched reactive synthetic copolymer having a molecular weight of 50,000-500,000 Da derived from a vinyl monomer and an ethylenically unsaturated monomer, having a backbone with polymeric subunits covalently bonded to the polymer backbone, the subunits comprising ones with non-reactive andType: GrantFiled: March 6, 2009Date of Patent: February 19, 2013Assignee: Exotech Bio Solutions Ltd.Inventors: Mircea Dan Bucevschi, Monica Colt, Mendy Axlerad
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Publication number: 20130039878Abstract: The present invention relates to a method for manufacturing a triple cross-linked collagen, which comprises the following steps: providing a soluble collagen sample; mixing the collagen sample with a first cross-linking agent to form a one cross-linked collagen; mixing the first cross-linked collagen with a second cross-linking agent to form a second cross-linked collagen; and mixing the second cross-linked collagen with a third cross-linking agent to form a triple cross-linked collagen, wherein each of the first cross-linking agent, the second cross-linking agent, and the third cross-linking agent is selected from the group consisting of an aldehyde cross-linking agent, an imine cross-linking agent, and an epoxide cross-linking agent. In addition, the first cross-linking agent is different form the second cross-linking agent, and the third cross-linking agent is different form the first cross-linking agent and the second cross-linking agent.Type: ApplicationFiled: April 10, 2012Publication date: February 14, 2013Applicant: SunMax Biotechnology Co., Ltd.Inventors: Yu-Te LIN, Chien-Hsin Lin, Hsiang-Yin Lu, Feng-Huei Lin
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Publication number: 20130039880Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: August 10, 2012Publication date: February 14, 2013Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Patent number: 8362144Abstract: N-hydroxysuccinimide acrylate ester monomers are described which provide N-hydroxysuccinimide derivatized monomers for the formation of polymeric cell culture surfaces suitable for culture of difficult to culture cells including undifferentiated embryonic stem cells. Methods of making the monomers and are also described.Type: GrantFiled: May 19, 2010Date of Patent: January 29, 2013Assignee: Corning IncorporatedInventors: Arthur W. Martin, Shawn M. O'Malley, Simon K. Shannon
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Publication number: 20130023026Abstract: The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond.Type: ApplicationFiled: May 24, 2012Publication date: January 24, 2013Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jean-Luc Popot, Delphine Charvolin, Fabrice Giusti
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Publication number: 20130023444Abstract: Provided herein are novel reagents and their use in color-producing detection systems for performing diagnostic tests and analytical assays.Type: ApplicationFiled: May 23, 2012Publication date: January 24, 2013Applicant: Diagnostic Innovations, LLCInventor: Victor Kovalenko
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Patent number: 8357779Abstract: The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.Type: GrantFiled: November 28, 2011Date of Patent: January 22, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann
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Publication number: 20130017166Abstract: The present invention provides polymer conjugates and methods of use thereof.Type: ApplicationFiled: April 7, 2011Publication date: January 17, 2013Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Alexander V. Kabanov, Jing Tong
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Publication number: 20130011931Abstract: A solid support comprising a polymer that includes a group having at least two hydroxyls or a zwitterionic group and a method of using the same.Type: ApplicationFiled: July 3, 2012Publication date: January 10, 2013Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Chang-eun YOO, Ga-hee KIM, Hyun-ju KANG
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Publication number: 20130011363Abstract: Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: UNIVERSITY OF WASHINGTONInventors: Shaoyi Jiang, Shengfu Chen, Zheng Zhang, Gang Cheng, Hong Xue, Louisa R. Carr
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Patent number: 8349349Abstract: Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses.Type: GrantFiled: May 27, 2010Date of Patent: January 8, 2013Assignee: Covidien LPInventors: Timothy Sargeant, Joshua Stopek, Ahmad Robert Hadba
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Patent number: 8349621Abstract: A ligand molecule-immobilized polymer has a structure represented by the following general formula (1). In the general formula (1), R1 represents a ligand molecule-containing group, R2 represents a hydrophobic group, R3 represents a spacer site, R4 represents a hydrophilic group, R5 represents a group having charge, a to d specify a composition ratio and each represent an integer of 1 or more, and n and m specify chain lengths and represent integers satisfying the relationships of 1?n(a+b+c+d)?10,000 and 1?m?350.Type: GrantFiled: November 24, 2008Date of Patent: January 8, 2013Assignee: Canon Kabushiki KaishaInventor: Kousuke Mukumoto
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Publication number: 20130005048Abstract: The present invention provides a test device for indicating the presence, concentration and effectiveness of chemical and biological agents. The test device interacts with the target agent producing a detectable signal indicating the presence, concentration and effectiveness of the agent.Type: ApplicationFiled: June 29, 2011Publication date: January 3, 2013Inventors: Monika Felten, Juli Patricia Hood
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Publication number: 20130004490Abstract: The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing such compositions. The invention further provides a diabody capable of binding specifically to ICAM-1 and transthyretin. The invention also provides a method of use of such composition in the manufacture of a medicament for treating an amyloid-? related neurodegenerative disease, comprising administering to a subject a composition comprising transthyretin coupled to an ICAM-1 targeting agent in an amount effective to treat the neurodegenerative disease, wherein the composition is administered to the subject outside of the blood-brain barrier.Type: ApplicationFiled: December 14, 2010Publication date: January 3, 2013Applicants: UNIVERSITY OF MARYLAND, COLLGE PARK, of Health and Human ServicesInventors: Juan Jose Marugan, Wei Zheng, Silvia Muro-Galindo
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Publication number: 20130005016Abstract: The invention relates to an amphiphilic polymer comprising at least 75% of amphiphilic monomers of formula (I), the average molar mass of the polymer being between 800 and 100 000, and also water-soluble complexes between the polymer according to the invention and a hydrophobic or amphiphilic compound, in particular a membrane protein, a concentrated aqueous solution of one or more such complex(es), a product comprising one or more such complex(es) attached to a substrate by means of the polymer according to the invention, and various uses of these products.Type: ApplicationFiled: November 16, 2010Publication date: January 3, 2013Applicant: Centre National de la Recherche Scientifique (CNRSInventors: Bernard Pucci, Jean-Luc Popot, Sharma Kshatrapati Shivaji, Fabrice Giusti, Paola Bazzacco, Gregory Durand
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Publication number: 20130004455Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.Type: ApplicationFiled: June 30, 2011Publication date: January 3, 2013Applicant: Korea Institute of Science and TechnologyInventors: Soo-Chang SONG, Thrimoorthy Potta, Mi-Ran Park
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Publication number: 20120329708Abstract: Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.Type: ApplicationFiled: June 12, 2012Publication date: December 27, 2012Applicant: Indiana University Research and Technology CorporationInventors: Richard D. DiMARCHI, David L. SMILEY
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Publication number: 20120328556Abstract: A comb-like surfactant polymer for changing the surface properties of biomaterials is described. The surfactant polymer comprises a polymeric backbone of repeating monomeric units having functional groups for chemically attaching to side chains, a plurality of hydrophobic side chains attached to the backbone via the functional groups and a plurality of hydrophilic side chains chemically attached via functional groups to the polymeric backbone. The hydrophilic side chains providing anti-thrombogenic properties to the surfactant. An antimicrobial agent selectively attached to some hydrophilic side chains thereby providing additional antimicrobial properties to the surfactant. The surfactant polymer may be applied to the surface of medical devices to reduce the surfaces thrombogenicity and decrease the number of microorganisms on the surface.Type: ApplicationFiled: June 27, 2012Publication date: December 27, 2012Applicant: Greatbatch Ltd.Inventors: Jan J. Lewandowski, Yubiao Liu
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Publication number: 20120329127Abstract: The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.Type: ApplicationFiled: May 25, 2012Publication date: December 27, 2012Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.Inventors: Juergen Siekmann, Alfred Weber, Hanspeter Rottensteiner, Peter Turecek
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Publication number: 20120328706Abstract: The present invention provides biodegradable polymer particle delivery compositions based on polymers, such as polyester amide (PEA) and polyester urethane (PEUR) polymers, that contain amino acids in the polymer. The polymer particle delivery compositions can be formulated as a liquid dispersion of polymer particles with the bioactive agents dispersed in the particle or conjugated attached to polymer molecules or particle surfaces. The bioactive agents can include drugs, polypeptides, DNA and cells for cell-based therapies using particles sized for local, mucosal or circulatory delivery. Methods of treating a disease by administering to a subject the polymer particle delivery composition, which incorporates a bioactive agent suitable for treatment of the disease, or its symptoms, are also included.Type: ApplicationFiled: May 22, 2012Publication date: December 27, 2012Applicant: MEDIVAS, LLCInventors: William G. TURNELL, Hong LI, Zaza D. GOMURASHVILI, Ramaz KATSARAVA
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Publication number: 20120328555Abstract: The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.Type: ApplicationFiled: December 10, 2010Publication date: December 27, 2012Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Rameshwar Patil, Eggehard Holler, Keith L. Black, Julia Y. Ljubimova
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Publication number: 20120328557Abstract: Described herein is a cell tissue gel cross-linked with a cross-linking agent, and a quenching agent bound to a reactive group of the cross-linking agent.Type: ApplicationFiled: June 23, 2011Publication date: December 27, 2012Applicants: Excel Med, LLC, National Cheng Kung UniversityInventor: Lynn L.H. Huang
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Publication number: 20120329707Abstract: Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.Type: ApplicationFiled: June 12, 2012Publication date: December 27, 2012Applicant: Indiana University Research and Technology CorporationInventors: Richard D. DiMARCHI, David L. SMILEY, Bin YANG
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Patent number: 8338532Abstract: The invention further relates to multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore.Type: GrantFiled: March 1, 2011Date of Patent: December 25, 2012Assignee: The Regents of the University of CaliforniaInventors: Guillermo C. Bazan, Bin Liu
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Publication number: 20120318701Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.Type: ApplicationFiled: August 21, 2012Publication date: December 20, 2012Applicant: Nektar TherapeuticsInventors: Sean M. Culbertson, Samuel P. McManus
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Publication number: 20120321583Abstract: A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ?5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.Type: ApplicationFiled: June 11, 2012Publication date: December 20, 2012Applicant: Mersana Therapeutics, Inc.Inventors: Aleksandr Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Charles E. Hammond, Cheri A. Stevenson, Natalya D. Bodyak, Patrick R. Conlon, Dmitry R. Gumerov
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Publication number: 20120315265Abstract: Disclosed herein are a hydrogel-forming polymer and a process of making the same. Also disclosed are a sustained-release pharmaceutical composition that contains a therapeutic agent and the aforesaid hydrogel-forming polymer, and a method for treating or preventing an ophthalmic disorder, which includes intraocularly administering into an eye of a mammal in need of such treatment a sustained-release pharmaceutical composition that contains an ophthalmic drug and the aforesaid hydrogel-forming polymer.Type: ApplicationFiled: January 20, 2012Publication date: December 13, 2012Applicant: CHANG GUNG UNIVERSITYInventors: Jui-Yang Lai, Ai-Ching Hsieh, Pei-Lin Lu
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Publication number: 20120315239Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.Type: ApplicationFiled: May 3, 2012Publication date: December 13, 2012Applicant: University of Washington through its Center for CommercializationInventors: Shaoyi Jiang, Andrew Keefe, Hong Xue
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Patent number: 8329876Abstract: The invention provides reagents and methods for conjugating a polymer specifically to the ?-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the ?-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.Type: GrantFiled: October 26, 2011Date of Patent: December 11, 2012Assignee: Nektar TherapeuticsInventors: Michael J. Roberts, Zhihao Fang
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Publication number: 20120301518Abstract: Disclosed herein are biocompatible and biodegradable polymers comprising one or more ECM-mimetic peptides and one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof. Further disclosed herein are methods for making and using the disclosed biocompatible polymers.Type: ApplicationFiled: August 3, 2012Publication date: November 29, 2012Inventor: Asima Pattanaik
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Patent number: 8313771Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.Type: GrantFiled: May 23, 2008Date of Patent: November 20, 2012Assignee: Korea Institute of Science and TechnologyInventors: Soo-Chang Song, Thrimoorthy Potta, Sun-Mi Lee
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Publication number: 20120282671Abstract: A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m-, the average value of m is an integer of 2-250; I is an integer of 1 or more. The method for producing the multi-arm polyethylene glycol having different kinds of reactive groups, the multi-arm polyethylene glycol active derivatives comprising linking groups X attached to PEG and terminal reactive groups F attached to X, the gels formed by the multi-arm polyethylene glycol active derivatives, the drug conjugates formed by the multi-arm polyethylene glycol active derivatives and drug molecules, and the uses thereof in preparing drugs are also disclosed.Type: ApplicationFiled: December 23, 2010Publication date: November 8, 2012Applicant: JENKEM TECHNOLOGY CO. LTD., TIANJIN BRANCHInventors: Xuan Zhao, Meina Lin
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Publication number: 20120282211Abstract: We provide methods and compositions for the treatment of dysregulation of blood vessel growth by regulation of neovascularization. Embodiments accomplish this by restricting the diffusion and transport of therapeutic agents through conjugating them to polymers or polymer constructs while retaining the binding affinities and functions of the therapeutic agents.Type: ApplicationFiled: November 24, 2010Publication date: November 8, 2012Applicant: CARNEGIE MELLON UNIVERSITYInventors: Newell R. Washburn, Liang Tso Sun
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Publication number: 20120282632Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.Type: ApplicationFiled: November 9, 2010Publication date: November 8, 2012Applicant: Clemson UniversityInventors: Daniel T. Chiu, Changfeng Wu, Jason McNeill, Jiangbo Yu
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Publication number: 20120277376Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, JR., Xue-min Cheng, Thommey P. Thomas, Baohua Mark Huang
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Publication number: 20120276159Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Applicant: Selecta Biosciences, Inc.Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
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Patent number: 8299172Abstract: A method for producing biodegradable plastic from natural materials containing polysaccharides by treating the polysaccharide-containing materials with a basic aqueous solution, subsequently treating the mixture with a modifying material that converts pendant hydroxyl groups at any carbon atom of the anhydroglucose units of the saccharide to create polysaccharide carboxylate, and then reacting the product with proteins to produce a biodegradable copolymer with electrostatic chemical bonds between protein and polysaccharide carboxylate molecules. The process provides relatively inexpensive methods for preparing biodegradable plastics that are useful for manufacturing various articles.Type: GrantFiled: January 14, 2008Date of Patent: October 30, 2012Assignee: Saginaw Valley State UniversityInventors: Christopher H. Schilling, David S. Karpovich, Piotr Tomasik
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Publication number: 20120271000Abstract: Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.Type: ApplicationFiled: June 21, 2012Publication date: October 25, 2012Applicant: Nektar TherapeuticsInventors: Antoni Kozlowski, John Handley, Anthony G. Schaefer, Brian Bray, Ryan Odom, Tony L. Sander
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Patent number: 8293190Abstract: A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.Type: GrantFiled: November 29, 2011Date of Patent: October 23, 2012Assignees: Sumitomo Bakelite Company, Ltd., Somalogic, Inc.Inventors: Mitsutaka Matsumoto, Sumio Shibahara, Takayuki Matsumoto, Kanehisa Yokoyama, Sohei Funaoka, Daisuke Masuda, Michael Patrick Coleman, Dominic Zichi