Disaccharides (e.g., Maltose, Sucrose, Lactose, Formaldehyde Lactose, Etc.) Patents (Class 536/123.13)
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Publication number: 20120157676Abstract: A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.Type: ApplicationFiled: March 24, 2010Publication date: June 21, 2012Applicant: Tate & Lyle Technology Ltd.Inventors: John Kerr, Robert Jansen, Anthony Baiada, Duane Leinhos, James Edwin Wiley
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Patent number: 8202987Abstract: A new sucrose is obtained through the present invention. The new sucrose has a lower solubility and a lower melting point. Thus, the new sucrose has a higher stability. The new sucrose obtained through the present invention can be used as an added functionality excipient of drug in pharmaceutical industry. And the new sucrose can also be used in sugar and food industries.Type: GrantFiled: January 23, 2008Date of Patent: June 19, 2012Assignee: National Central UniversityInventors: Tu Lee, Yu-Sheng Lin
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Publication number: 20120135955Abstract: Disclosed is an external preparation containing nonsteroidal anti-inflammatory drugs (NSAIDs), which is suppressed in cytotoxicity induced by the NSAIDs. Also disclosed is a method for producing the external preparation. The present invention is based on the finding that skin disorders induced by nonsteroidal anti-inflammatory drugs (NSAIDs) can be suppressed when the NSAIDs form intermolecular compounds together with trehalose, which is an example of disaccharides. A disaccharide other than trehalose may be used therefor.Type: ApplicationFiled: July 21, 2010Publication date: May 31, 2012Applicants: The University of Tokyo, Next21 K.K.Inventors: Yuichi Tei, Nobuo Sasaki, Shigeki Suzuki
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Patent number: 8188268Abstract: An object of the present invention is to provide a crystalline saccharide having novel physical properties, a preparation and uses thereof. The present invention solves the above objects by providing a porous crystalline saccharide having a number of pores, a process for producing the same, comprising the step of keeping hydrous crystalline saccharide at an ambient temperature or higher in an organic solvent for the dehydration, and the use thereof.Type: GrantFiled: December 25, 2006Date of Patent: May 29, 2012Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
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Publication number: 20120114602Abstract: The present invention relates to a process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules of varying nature, comprising small molecules and macro-molecules. In particular, the present invention relates to the conjugation of hyaluronic acid (HA) and its derivatives with polypeptides and proteins with a biological action, such as, for example, interferons, erythropoietins, growth factors, insulin, cytokines, antibodies and hormones. An object of the present invention also relates to isolatable intermediates obtained by the partial or total reaction of GAG with protected amino aldehydes in the conjugation process mentioned above.Type: ApplicationFiled: June 4, 2010Publication date: May 10, 2012Applicant: FIDIA FARMACEUTICI S.p.A.Inventors: Matteo D'Este, Davide Renier, Gianfranco Pasut, Antonio Rosato
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Patent number: 8173173Abstract: The invention relates to a process for the preparation of anhydrous lactose agglomerates, said process comprising (i) subjecting essentially anhydrous lactose primary particles comprising at least 60 wt % crystalline-lactose in a granulator to a wet granulation step at a temperature in the range of 30-100° C. using a binder solution, wherein the granulation mass is subjected to drying for at least part of the granulation step, and (ii) after-drying the granulation mass. The anhydrous lactose agglomerates thus produced comprise at least 50 wt %-lactose crystallites and have a total water content in the range of 0-1.0 wt %, which is required according to the standards laid down by the Pharmacopoeia for anhydrous lactose excipients. These agglomerates combine have excellent compactibility and flowability properties and are particularly useful as excipient in moisture-sensitive applications.Type: GrantFiled: December 21, 2005Date of Patent: May 8, 2012Assignee: Campina Nederland Holding B.V.Inventors: Klaas Daniël Kussendrager, Bouwe Walsma
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Patent number: 8168778Abstract: An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-?-maltosyl- and/or 6-?-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.Type: GrantFiled: March 14, 2006Date of Patent: May 1, 2012Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Tomoyuki Nishimoto, Katsuhiko Hino, Takanori Okura, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
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Patent number: 8168779Abstract: Objects of the present invention are to provide a novel anhydrous crystalline ?-maltose, its preparation and uses. The present invention attains the above objects by providing an anhydrous crystalline ?-maltose with a melting point of 154 to 159° C.; a process for producing the same, comprising a step of keeping hydrous crystalline ?-maltose in an organic solvent at an ambient temperature or higher for the dehydration; and uses of the same.Type: GrantFiled: July 5, 2007Date of Patent: May 1, 2012Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
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Patent number: 8153610Abstract: The present invention relates to compounds of the following general formula: (I) wherein R1 and R2 are fatty acyl groups, a process to extract them from Mycobacterium tuberculosis, and their use in the treatment or the prophylaxis of tuberculosis.Type: GrantFiled: April 9, 2004Date of Patent: April 10, 2012Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), University Hospital of Basel, University of ErlangenInventors: Germain Puzo, Martine Gilleron, Steffen Stenger, Gennaro De Libero
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Publication number: 20120070386Abstract: The present invention relates to a trehalulose-containing composition, its preparation and use.Type: ApplicationFiled: April 15, 2010Publication date: March 22, 2012Inventors: Wolfgang Wach, Thomas Rose, Michael Klingeberg, Siegfried Peters, Tillmann Dörr, Stephan Theis, Jorg Kowalczyk, Stephan Hausmanns
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Patent number: 8138162Abstract: The invention relates to extracts, in particular non-nutrient phytochemicals, form sugar cane or sugar beet waste products, such as molasses, sugar mud and bagasse, which have Glycemic Index (GI) lowering properties and their use as sweeteners and in foods containing sugar.Type: GrantFiled: June 3, 2005Date of Patent: March 20, 2012Assignee: Horizon Science Pty Ltd.Inventors: David Kannar, Barry James Kitchen
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Publication number: 20120064536Abstract: The present invention relates to a exsiccated or lyophilized composition comprising: a nucleic acid polymerization enzyme and cellobiose, in which the enzyme is stable for a period of time, even at a temperature of up to 55° C. The composition of the invention can also comprise further reagents, such as salts, primers specific for a template DNA present in a sample, probes, etc., and possibly other stabilizing compounds. The invention relates to a method for preparing a exsiccated or lyophilized composition comprising a nucleic acid polymerization enzyme and cellobiose, possibly in containers, in which the enzyme is lyophilized and ready for use in molecular biology applications upon addition of the sample.Type: ApplicationFiled: May 19, 2010Publication date: March 15, 2012Applicant: Sentinel CH S.p.A.Inventors: Ugo De Luca, Luigi Roveda, Maurizio Gramegna
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Publication number: 20120035356Abstract: Compositions which inhibit corrosion and alter the physical properties of concrete (admixtures) are prepared from salt mixtures of hydroxycarboxylic acids, carboxylic acids, and nitric acid. The salt mixtures are prepared by neutralizing acid product mixtures from the oxidation of polyols using nitric acid and oxygen as the oxidizing agents. Nitric acid is removed from the hydroxycarboxylic acids by evaporation and diffusion dialysis.Type: ApplicationFiled: October 20, 2011Publication date: February 9, 2012Inventors: Donald E. Kiely, Kirk R. Hash, Kylie Kramer-Presta, Tyler Smith
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Patent number: 8110380Abstract: A starch-based biodegradable material composition includes: an enzyme-hydrolyzed starch; and a biodegradable polyester selected from at least one of an aliphatic polyester of polybutylene succinate and an aliphatic-aromatic copolyester. The enzyme-hydrolyzed starch is prepared by hydrolyzing a native starch using a starch-hydrolyzing enzyme. The starch-hydrolyzing enzyme has an activity unit ranging from 15000 to 40000.Type: GrantFiled: April 29, 2008Date of Patent: February 7, 2012Assignee: Grace Biotech CorporationInventors: C. Will Chen, Ching-Huang Wang, Chin-Wei Chen, Yun-Ping Wang
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Patent number: 8101746Abstract: Granular sucralose-containing particles are produced by the methods of the invention, which involve coating sucralose from solution to form granules with this coated sucralose on an outer region thereof. The granules may incorporate agglomerated sucralose particles, with the solution-coated sucralose adding mass and generally resulting in a granule having a relatively smoothed and rounded. The granules have good flow properties, are low dusting, and resist caking. Methods of making the granules involve spraying an aqueous sucralose solution onto a fluidized bed of sucralose particles, followed by drying to form the granules.Type: GrantFiled: March 20, 2006Date of Patent: January 24, 2012Assignee: Tate & Lyle Technology LimitedInventors: Warren L. Nehmer, Roy O. Elmore, William R. Skelding, Alexandria L. Bailey
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Publication number: 20120015841Abstract: The invention relates to novel cells and cell lines, and methods for making and using them.Type: ApplicationFiled: February 1, 2010Publication date: January 19, 2012Applicant: CHROMOCELL CORPORATIONInventors: Kambiz Shekdar, Dennis Sawchuk, Purvi Manoj Shah
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Publication number: 20120003477Abstract: Particles of a polysaccharide derivative, having at least one substituent with conjugated unsaturated bonds and exhibiting an index of refraction in excess of 1.50 and a method for the production thereof. In the method, the raw-material is suspended in an organic solvent to form a suspension, which is contacted with an organic reactant comprising a residue with conjugated unsaturated bonds; the raw-material and the organic reactant are reacted to form a derivative exhibiting ester or ether bond between the raw-material and the residue with conjugated unsaturated bonds; the polysaccharide derivative is dissolved in a solvent to form a solution; and the solution is contacted with a non-solvent to precipitate particles of the polysaccharide derivative invention provides lightweight, optically improved organic pigments and fillers based on renewable resources and which are recyclable by combustion or composting.Type: ApplicationFiled: December 30, 2009Publication date: January 5, 2012Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Hannu Mikkonen, Kaisa Putkisto, Soili Peltonen, Sari Hyvärinen, Kimmo Koivunen
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Publication number: 20110306574Abstract: The present invention relates to blood group A/B/H determinant on Type 1 Core glycosphingolipids chains as recognition point for the FedF protein of F18-fimbriated Enterotoxigenic and verotoxinogenic Escherichia coli and the use of compounds comprising such determinants for the treatment of F18? E. coli infections in pigs and in screening methods.Type: ApplicationFiled: September 30, 2009Publication date: December 15, 2011Applicant: GHENT UNIVERSITYInventors: Annelies Coddens, Eric Cox, Susann Eva Teneberg
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Publication number: 20110301083Abstract: Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.Type: ApplicationFiled: January 27, 2010Publication date: December 8, 2011Inventors: Todd C. Zion, Thomas M. Lancaster
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Patent number: 8067393Abstract: It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein interaction easily and at a low cost using the same without labeling, and a method for simply recovering a protein from a sugar-protein interactant. A maltose-immobilized gold nanoparticle was obtained by binding a ligand complex, in which maltose and a linker compound had been bound to each other, to a gold nanoparticle. By adding this maltose-immobilized gold nanoparticle to a dilution series of concanavalin A, a sugar-protein interactant of maltose and ConA was formed, and red-purple color derived from a colloidal solution of maltose-immobilized gold nanoparticle disappeared. That is, sugar-protein interaction could be confirmed by visual observation without labeling.Type: GrantFiled: May 26, 2006Date of Patent: November 29, 2011Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Tomoaki Nishimura, Yuko Kishimoto, Hiromi Nakagawa
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Patent number: 8048997Abstract: The present invention relates to a process for spray drying uronic acid oligosaccharides and to a powder compositions thus obtained. Typically the powder composition comprises between 25 and 100 wt.% uronic acid oligosaccharide with a DP between 2 and 50 based on total weight of uronic acid, with and an average particle size between 20 ?m and 100 ?m.Type: GrantFiled: April 21, 2006Date of Patent: November 1, 2011Assignee: N.V. NutriciaInventors: Martin Van Eert, Bernd Stahl, Antonie Van Baalen
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Publication number: 20110258742Abstract: Disclosed herein are novel variant bacterial cold shock proteins and recombinant DNA for expressing such proteins to produce transgenic plants with enhanced stress tolerance and/or enhanced yield.Type: ApplicationFiled: August 14, 2009Publication date: October 20, 2011Applicant: MONSANTO TECHNOLOGY LLCInventors: Christopher P. Bonin, Paolo Castiglioni, Robert L. D'Ordine, Jacqueline E. Heard, Robert M. McCarroll, Sara Salvador, Michael J. Storek
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Patent number: 8039615Abstract: The invention provides a process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2? and 2,3? (di-D-fructofuranose-1,2?,2,3?-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to 8, and more preferably 6 to 8. In accordance with the invention, DFA III can be produced industrially without lowering the crystal yield even when the crystallization thereof is done in a recycling system; additionally by adjusting the total fructose content in mother solutions for (crude) crystallization to 5% or less per a solid content basis and adjusting the fructose content to 1% or less, DFA III can more effectively be produced.Type: GrantFiled: December 28, 2004Date of Patent: October 18, 2011Assignee: Nippon Beet Sugar Manufacturing Co., Ltd.Inventors: Taizo Nagura, Katsuya Honjyo, Hiroto Kikuchi, Norimitsu Takagi, Tsutomu Aritsuka
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Publication number: 20110245488Abstract: The present invention relates to a process for the synthesis of L-fucosyl di- or oligosaccharides and their novel 2,3,4-tri-O-benzyl-fucosyl synthetic intermediates derivatives of easy crystallization. In particular the present invention relates to a process applicable to industrial scale for the synthesis of 2?O-fucosyl lactose.Type: ApplicationFiled: December 18, 2009Publication date: October 6, 2011Applicant: INALCO S.P.A.Inventors: Liana Salsini, Marco Manoni, Giovanni Cipolletti
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Publication number: 20110245487Abstract: The invention relates to a multiprofile chromatographic sequential SMB process of separating and recovering betaine and sucrose from concentrated raw juice or thick juice. In the process of the invention, the betaine subprofile and the residual subprofile of successive separation profiles are overlapping. A sucrose fraction and a betaine fraction containing also residual components are recovered. Betaine is further separated from the betaine fraction for example by chromatographic processes.Type: ApplicationFiled: March 29, 2011Publication date: October 6, 2011Applicant: DANISCO A/SInventors: Jyrki AIRAKSINEN, Hannu PAANANEN, Jari LEWANDOWSKI, Kari LAIHO
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Patent number: 8017767Abstract: The present invention provides an improved form of crystalline sucralose.Type: GrantFiled: September 18, 2006Date of Patent: September 13, 2011Assignee: Tate & Lyle Public Limited CompanyInventors: Fiesal El Kabbani, Amal Brohmi, Christian Heiss, Juan Navia, Steven J. Catani
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Patent number: 8008275Abstract: A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate selective proliferation of mammalian natural killer (NK) cells and ??T cells. These compounds are useful as pharmaceuticals, particularly as immunostimulants, e.g., in the treatment of cancer and viral infections.Type: GrantFiled: October 2, 2008Date of Patent: August 30, 2011Inventor: Gradimir Misevic
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Publication number: 20110201801Abstract: Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.Type: ApplicationFiled: May 29, 2009Publication date: August 18, 2011Applicant: MOMENTA PHARAMACEUTICALS, INC.Inventors: Sucharita Roy, Takashi Kei Kishimoto, Ganesh Venkataraman
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Patent number: 7989601Abstract: Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).Type: GrantFiled: April 20, 2010Date of Patent: August 2, 2011Assignee: GlycoMimetics, Inc.Inventors: John L. Magnani, John T. Patton, Jr., Arun K. Sarkar, Sergei A. Svarovsky, Beat Ernst
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Publication number: 20110130553Abstract: Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3?-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.Type: ApplicationFiled: May 18, 2009Publication date: June 2, 2011Inventor: Ulf Nilsson
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Publication number: 20110110893Abstract: The present invention provides a therapeutic agent for anaerobic diseases such as solid tumor, comprising in combination a pharmaceutical composition for the treatment of an anaerobic disease containing the transformed anaerobic microorganism as an active component and a pharmaceutical composition containing as an active component an anaerobic microorganism colonization and growth enhancer for enhancing the specific colonization and proliferation of the anaerobic microorganism at an anaerobic disease site. Furthermore, the present invention provides to an anaerobic microorganism colonization and growth enhancer for enhancing colonization and growth of the transformed anaerobic microorganism at a disease site that is in an anaerobic environment.Type: ApplicationFiled: April 17, 2009Publication date: May 12, 2011Applicant: ANAEROPHARMA SCIENCE, INC.Inventors: Takayuki Sasaki, Hitomi Shimizu, Yuko Shimatani-Shibata, Hiromi Yonekura
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Publication number: 20110097470Abstract: The invention provides an improved antioxidant for food, animal feed, cosmetics and pharmaceuticals, as well as compositions that contain this antioxidant as preferably the only additive having an anitoxidative effect.Type: ApplicationFiled: April 8, 2009Publication date: April 28, 2011Inventors: Joerg Kowalczyk, Stephan Hausmanns, Tillmann Doerr
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Publication number: 20110097765Abstract: Described herein are compositions and methods for enhanced fermentation of molasses using transglucosidase.Type: ApplicationFiled: April 30, 2009Publication date: April 28, 2011Inventors: Gang Duan, Zhenhua Ruan, Jayarama K. Shetty, Hongxian Xu
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Patent number: 7927627Abstract: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.Type: GrantFiled: May 23, 2007Date of Patent: April 19, 2011Assignees: Elan Pharma International, Ltd., Fournier Laboratories Ireland, Ltd.Inventors: Tuula Ryde, Evan E. Gustow, Stephen B. Ruddy, Rajeev Jain, Rakesh Patel, Michael John Wilkins
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Publication number: 20110077392Abstract: A method of crystallization is provided. The method includes providing a solution comprising a solute dissolved in a first solvent. The method includes providing a dispersion comprising a plurality of nanoparticles in a second solvent. The first solvent and the second solvent are mutually miscible. The method includes combining the solution and the dispersion to form a mixture. The nanoparticles remain dispersed in the mixture and the solute remains dissolved in the mixture at or below a saturation concentration. The method includes cooling the mixture such that the solute exceeds the saturation concentration forming crystals in the presence of the dispersed nanoparticles. The method includes separating the crystals from the mixture, wherein the nanoparticles remain dispersed in the mixture.Type: ApplicationFiled: June 26, 2009Publication date: March 31, 2011Inventors: Jimmie R. Baran, JR., William J. Hunt
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Publication number: 20110034685Abstract: The present invention relates to improved methods of purification of sugars and in particular to a method of preparing lactose. A low purity lactose source such as whey is subjected to a first demineralization step involving either ion-exchange or the addition of divalent metal cations, followed by a second demineralization step where alcohol is added. The invention also relates to lactose produced by this method and products comprising lactose produced by this method.Type: ApplicationFiled: July 12, 2010Publication date: February 10, 2011Inventors: Estelle V. Lifran, Robert W. Sleigh, Robert L. Johnson, Robert J. Steele, James A. Hourigan, Sean M. Dalziel
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Patent number: 7879805Abstract: A stabilized pharmaceutical composition in the form of a lyophilized product to be later reconstituted to generate an aqueous drug product is described herein. The therapeutically active ingredient in the form of a peptide of sequence TDLQERGDNDISPFSGDGQPFKD is stabilized with a buffer, carbohydrate stabilizer, a nonionic bulking agent and a surfactant to facilitate reconstitution. The preferred preparation contains a peptide of the sequence TDLQERGDNDISPFSGDGQPFKD, histidine buffer, mannitol or glycine, sucrose and/or Polysorbate 20. This combination of excipients has demonstrated exceptional stability as a lyophilized product when stored at the elevated temperature of 40° C. for at least 6 months and for at least 3 Months at 50° C. The lyophilized mixture thus formed is reconstituted to a high peptide concentration without apparent loss of stability of the peptide.Type: GrantFiled: May 29, 2008Date of Patent: February 1, 2011Assignee: Acologix, Inc.Inventors: Dennis Chen, Russell Wayne Blacher, Byeong Chang
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Patent number: 7875707Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: GrantFiled: April 24, 2003Date of Patent: January 25, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
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Publication number: 20100330671Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.Type: ApplicationFiled: August 20, 2010Publication date: December 30, 2010Applicants: Postech Foundation, Postech Academy-Industry FoundationInventors: Sung-Kee CHUNG, Kaustabh Kumar Maiti, Woo Sirl Lee, Ock-Youm Jeon, Seok-Ho Lee
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Publication number: 20100317845Abstract: A sucrose of a conformational polymorph and its manufacturing method are disclosed. The sucrose is a Form II sucrose having a melting point of 140-180° C., and furfuryl alcohol is added into a saturated sucrose solution by a reverse solution method, such that the saturated solution is recrystallized to form a new sucrose. The sucrose of this conformational polymorph has a melting point lower than the melting point of a general Form I sucrose, and the solubility of the Form II sucrose is different from the solubility of the Form I sucrose. Thus the Form II sucrose can be used as an excipient of medicines, sacrificial fiber blood vessel network structure for cell cultivations, or the manufacture of an optical interference wavy device. Since the hydrogen bonds in the molecular structure of the Form II sucrose and the Form I sucrose are different, the mechanoluminescence of the sucrose is affected.Type: ApplicationFiled: September 21, 2009Publication date: December 16, 2010Applicant: NATIONAL CENTRAL UNIVERSITYInventors: Tu Lee, Gen-Da Chen
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Publication number: 20100317846Abstract: A process for the production of polysaccharide (20) from disaccharide (10) and saccharide (21), wherein R1 to R10 are each independently the same or different protecting groups; R is an optionally substituted aryl group or an optionally substituted saturated or unsaturated alkyl group; X is selected from the group consisting of hydrogen, alkyl and amino; Y is selected from the group consisting of a protecting group and one or more saccharide residues; and n is a positive integer; and further wherein said process comprises removal of the R7 protecting group and reaction of the deprotected C4-oxygen atom of compound (21) with the C1-carbon atom of the 1-ido moiety of compound (10).Type: ApplicationFiled: February 4, 2009Publication date: December 16, 2010Applicant: THE UNIVERSITY OF MANCHESTERInventors: Steen Uldall Hansen, Gordon Jayson, John Gardiner, Marek Barath
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Publication number: 20100297159Abstract: Modified Thomsen-Friedenreich disaccharide (TFD) immunogen, preparation procedure, compositions containing it, uses, and treatment methods. More specifically, the present invention refers to a immunogen obtained by modifying TFD, and comprising the general formula D-TFD-Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Gal?3GalNAc?; Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier. In a preferred embodiment, the modified invention immunogen comprises the general formula Bzl?TFD-Lys5-KLHs, wherein Bzl is benzyl, TFD is disaccharide Gal?3GalNAc?; Lys5 is penta-lysine, and KLHs is succinilated Keyhole limpets hemocyanin.Type: ApplicationFiled: November 19, 2008Publication date: November 25, 2010Applicants: CONSEJO NACIONAL DE INVESTIGACIONES CIETIFICAS Y TECNICAS (CONICET), UNIVERSIDAD NACIONAL DE CORDOBA, INIS BIOTEC LLCInventors: Fernando José Irazoqui, Víctor Germán Sendra, Gustavo Alejandro Nores
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Publication number: 20100298260Abstract: Preparations of polysaccharides lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.Type: ApplicationFiled: November 3, 2008Publication date: November 25, 2010Applicant: MOMENTA PHARMACEUTICALS, INC.Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
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Publication number: 20100292462Abstract: The present invention discloses a process for synthesizing sucralose, which comprises reacting sucrose with acetic anhydride in the solvent of a N-amide compound in the presence of an organic complex alkali metal salt catalyst to produce sucrose-6-acetate, and then chlorinating and deacetylating the sucrose-6-acetate to give sucralose. The present invention also discloses a process for purifying sucralose, which comprises purifying crude sucralose with one or more organic solvents to obtain purified sucralose.Type: ApplicationFiled: December 19, 2008Publication date: November 18, 2010Applicants: ZHEJIANG HANGZHOU XINFU PHARMACEUTICAL CO., LTD., SHANGHAI TONGCHEN BIOTECH CO., LTD.Inventors: Xinmin Chen, Yanbing Bai, Jianxin Peng
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Patent number: 7820628Abstract: The present invention discloses that an intratumoral injection of: i) glycolipids with ?-gal epitope; ii) gene vectors comprising an ?1,3galactosyltransferase gene; or iii) a mixture of ?1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose results in tumor regression and/or destruction. Binding of the natural anti-Gal antibody to de novo expressed tumoral ?-gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumor cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumor specific T cells thereby converting the treated tumor lesions into in situ autologous tumor vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumor resection.Type: GrantFiled: February 16, 2006Date of Patent: October 26, 2010Assignee: University of Massachusetts Medical SchoolInventor: Uri Galili
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Publication number: 20100261894Abstract: The invention relates to a method for enzyme cleavage of polysaccharides comprising a first sequence [?4)-?-D-GlcpA-(1?4)-?-L-Rhap3 sulphate-(1?]n and a second sequence [?4)-?-L-IdopA-(1?4)-?-L-Rhap3 sulphate-(1?]m, the first and second sequences respectively comprising two monosaccharide units connected by an osidic bond, wherein said method is such that: said polysaccharide sequences are provided; a microorganism capable of producing an enzyme substance of the lyase class is provided; and said enzyme substance is brought into contact with said polysaccharide sequences in such a way as to bring about cleavage of the osidic bond according to a ?-elimination reaction. The invention is characterised in that a microorganism belonging to the bacteria of the Ochrobactrum genus is chosen for producing said enzyme substance.Type: ApplicationFiled: June 23, 2008Publication date: October 14, 2010Inventors: Redouan El Boutachfaiti, Patrice Pheulpin, Bernard Courtois, Josiane Courtois-Sambourg
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Publication number: 20100249057Abstract: The object of the present invention is to provide a novel trehalose compound having a high affinity for an adenosine A3 receptor. The trehalose compound of the present invention is represented by General Formula (1): wherein X and X? represent a hydrogen atom, and the like; Y and Y? independently represent an oxygen atom, and the like; R1 and R2 independently represent a C1-C6 alkyl group; and R3 and R4 independently represent a C3-C6 alkyl group. The trehalose compound of the present invention has a remarkably high affinity for an adenosine A3 receptor.Type: ApplicationFiled: March 22, 2007Publication date: September 30, 2010Applicant: OTSUKA CHEMICAL CO., LTD.Inventors: Mugio Nishizawa, Hiroshi Imagawa, Hirofumi Yamamoto
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Publication number: 20100239584Abstract: The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.Type: ApplicationFiled: May 16, 2008Publication date: September 23, 2010Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS DESCARTESInventors: Laurence Mulard, Julien Boutet, Catherine Guerreiro, Farida Nato, Philippe Sansonetti, Armelle Phalipon
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Patent number: 7799765Abstract: The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in water, etc., are improved; and their preparation and uses. The present invention solves the above object by providing an associate of trehalose or maltitol and a metal ion compound or bittern component, and their preparation and uses.Type: GrantFiled: August 8, 2002Date of Patent: September 21, 2010Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20100233761Abstract: A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately contacting the pH adjusted solution with at least one non-polar solvent, partitioning to obtain an non-polar solvent solution and a polar biomass solution, and recovering cell and cell derived products from the non-polar solvent solution and polar biomass solution. Products recovered from the above method. A method of operating a renewable and sustainable plant for growing and processing algae.Type: ApplicationFiled: March 10, 2010Publication date: September 16, 2010Inventors: Thomas J. Czartoski, Robert Perkins, Jorge L. Villanueva, Glenn Richards