Nitrogen Bonded Directly To Phenothiazine Ring System Patents (Class 544/37)
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Patent number: 6743817Abstract: Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are also disclosed.Type: GrantFiled: September 6, 2001Date of Patent: June 1, 2004Assignee: Neurogen CorporationInventors: George Maynard, LingHong Xie, Stanislaw Rachwal
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Publication number: 20040019042Abstract: Compounds of formula (I) 1Type: ApplicationFiled: July 26, 2002Publication date: January 29, 2004Inventors: Chih-Hung Lee, Meiqun Jiang, Richard Perner, Arthur Gomtsyan, Erol Bayburt, Guo Zhu Zheng
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Publication number: 20030229073Abstract: The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical bond; Y=O, (CH2)m, S, SO, SO2, NH, NR8; Z=NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.Type: ApplicationFiled: July 5, 2002Publication date: December 11, 2003Inventors: Richard John Booth, Vara Prasad Venkata Nagendra Josyula, Annette Lynn Meyer, Bruce Allan Steinbaugh
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Patent number: 6594066Abstract: An electrochromic device comprising at least one substantially transparent substrate having an electrically conductive material associated therewith, and an electrochromic medium which comprises a solvent, a cathodic material, and an anodic electrochromic material represented by the formula: wherein R1-R10 are the same or different and at least three of R1-R10 are the same or different and comprise a straight or branched alkyl, aryl, alkaryl, or aralkyl group containing approximately 1 to approximately 40 carbon atom(s), and/or a silyl or siloxyl group containing approximately 1 to approximately 40 silicon atom(s), wherein the carbon or silicon atom(s) may be a linking group to, or part of, one or more functional groups comprising nitrites; nitro constituents; sulfoxides; sulfonates; phosphonium constituents; phosphonates; phosphonites; ammonium constituents; viologens, including bipyridinyl constituents; carbonyls, including carbonates, carbamates; ketones; esters; and amides; ethers, incluType: GrantFiled: April 22, 2002Date of Patent: July 15, 2003Assignee: Gentex CorporationInventors: Jeffrey R. Lomprey, Thomas F. Guarr
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Patent number: 6544986Abstract: This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C═O or CH2; and R7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl and (C1-C12)alkyl (C6-C14)aryl; or R7 and R8 when taken together form a (C2-C7)alkylene group; or —NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.Type: GrantFiled: October 9, 2001Date of Patent: April 8, 2003Assignee: Dalhousie UniversityInventors: Sultan Darvesh, David Magee, Zdenek Valenta, Earl Martin
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Patent number: 6372904Abstract: A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N′-dimethyl-&rgr;-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.Type: GrantFiled: January 11, 2001Date of Patent: April 16, 2002Assignee: Zila, Inc.Inventor: Douglas D. Burkett
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Patent number: 6210536Abstract: This invention is directed to certain N,N′-dinitroso phenylenediamines useful as polymerization inhibitors for acrylic acids and esters thereof. Also disclosed are compositions containing such compounds, and methods for inhibiting polymerization using such compounds and compositions.Type: GrantFiled: September 2, 1993Date of Patent: April 3, 2001Assignee: Uniroyal Chemical Company, Inc.Inventors: Anthony Vincent Grossi, Paul Edwin Stott
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Patent number: 6194573Abstract: A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N′-dimethyl-&rgr;-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.Type: GrantFiled: July 6, 1998Date of Patent: February 27, 2001Assignee: Zila, Inc.Inventor: Douglas D. Burkett
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Patent number: 6159966Abstract: A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are the same or different; R.sup.1 and R.sup.2 together represent along with carbon atoms to which they are attached an aromatic cyclic structure containing 5-6 ring atoms which may optionally be substituted; X represents a heteroatom selected from oxygen or sulfur; R.sup.7 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl group or forms a bond together with R.sup.8 ; R.sup.8 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl or R.sup.8 forms a bond together with R.sup.Type: GrantFiled: August 14, 1998Date of Patent: December 12, 2000Assignees: Reddy-Cheminor Inc., Dr. Reddy's Research FoundationInventors: Braj Bhushan Lohray, Vidya Bhushan Lohray, Ashok Chennaveerappa Bajji, Shivaramayya Kalchar, Sekar Reddy Alla, Rajagopalan Ramanujam, Reeba Kannimel Vikramadithyan
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Patent number: 6153399Abstract: A reagent, kit and method for the quantative determination of ascorbic acid in a sample uses ascorbate oxidase which catalyzes the reaction of reduced ascorbic acid to oxidized ascorbic acid and hydrogen peroxide. Ascorbic acid in the sample is reacted with oxygen in the presence of the ascorbate oxidase, chromogen and peroxidase. Absorbance is determined and compared with a known calibration curve.Type: GrantFiled: September 18, 1998Date of Patent: November 28, 2000Assignee: Kyowa Medex Co., Ltd.Inventors: Kinya Fujishiro, Katsuyuki Taga, Norihito Aoyama, Akira Miike
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Patent number: 6140325Abstract: Thienopyrimidine derivatives are disclosed. Also disclosed are methods for the production and use of these compounds.Type: GrantFiled: September 30, 1996Date of Patent: October 31, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuichi Furuya, Nobuo Choh, Tetsuya Ohtaki, Toshifumi Watanabe
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Patent number: 5883256Abstract: A process for removing aromatic heterocyclic compounds from a product-containing solution, in particular a protein solution, by bringing the solution into contact with a support material. The process is preferably carried out following a virus inactivation with acridine or acridine derivatives and makes it possible to remove these virus-inactivating agents from the solution without there being any significant product losses or changes in the biological activity of the solution.Type: GrantFiled: November 26, 1996Date of Patent: March 16, 1999Assignee: Behringwerke AktiengesellschaftInventors: Eckhard Schuler, Karl-Heinz Wenz
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Patent number: 5840980Abstract: A diamine compound of the following formula (1): ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group or a lower alkoxy group, each of A.sub.1, A.sub.2 and A.sub.3 which are independent of one another, is a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a group of the following formula (2): ##STR2## wherein R.sub.1 is as defined above, and X is a substituted or unsubstituted arylene group or a substituted or unsubstituted heterocyclic bivalent group.Type: GrantFiled: July 24, 1997Date of Patent: November 24, 1998Assignee: Hodogaya Chemical Co., Ltd.Inventors: Mitsutoshi Anzai, Atsushi Takesue, Takanobu Watanabe, Chieko Inayoshi
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Patent number: 5830902Abstract: A quinuclidine derivative represented by the following general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, which has strong squalene synthase inhibiting activity and is useful as a cholesterol lowering agent without causing side effects. ##STR1## (Symbols in the formula represent the following meanings; R.sub.1 : a hydrogen atom, a halogen atom or a lower alkyl group,R.sub.2 : a hydrogen atom, a hydroxyl group or a lower alkoxy group,. . : a single bond or a double bond, with the proviso thatR.sub.2 does not exist when . . . is a double bond,X and Y: the same or different from each other and each represents a bond, an oxygen atom (--O--), a carbonyl group (--CO--), a group represented by the formula --S(O).sub.p -- or a group represented by the formula --NR.sub.3 --,p: 0, 1 or 2,R.sub.3 : a hydrogen atom or a lower alkyl group which may have a substituent,A: a saturated or unsaturated lower alkylene group, a group of the formula --(CH.sub.2).sub.m Z(CH.sub.Type: GrantFiled: August 21, 1997Date of Patent: November 3, 1998Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masahiko Isaka, Tsukasa Ishihara, Koyo Matsuda, Hirotoshi Kakuta, Hiroshi Moritani
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Patent number: 5631371Abstract: The present invention involves a method for the preparation of substituted 3-(phenylimino)-3 H-phenothiazines or phenoxazines which method involves reacting phenothiazine or phenoxazine with an aromatic amine in the presence of periodic acid as coupling agent.Type: GrantFiled: November 22, 1995Date of Patent: May 20, 1997Assignee: Bayer CorporationInventor: Michael L. Bloczynski
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Patent number: 5372801Abstract: A biological stain composition contains toluidine blue O and a pharmaceutically acceptable oxidizing agent to convert any leuco toluidine blue O to the chromo form. A dry composition for preparing the stain includes the toluidine blue O, the oxidizing agent and an effervescent agent. These compositions are preferably buffered to improve shelf stability and clinical consistency. Compositions for intra-oral application contain a flavoring agent.Type: GrantFiled: June 7, 1993Date of Patent: December 13, 1994Assignee: CTM Associates, Inc.Inventors: Mark K. Malmros, Raymond J. Tucci, Pier J. Cipriani
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Patent number: 5344928Abstract: There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.Type: GrantFiled: April 14, 1992Date of Patent: September 6, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirotomo Masuya, Hiroshi Shimadzu, Toshio Miyawaki, Marvin A. Motsenbocker
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Patent number: 5269954Abstract: The present invention relates to the preparation of antioxidant additives to lubricants and to their use in lubricating compositions. The additives according to the invention have the formula:ArAr'(H)N--(R--X).sub.a --R'Ywhere--Ar and Ar' are identical or different aromatic radicals, R and R', which are identical or different, denote a C.sub.2 -C.sub.18 linear or branched alkylene radical, X denotes an oxygen or sulphur atom or an --NH group, a is an integer between 0 and 5 and Y is chosen from the group consisting of --NR.sub.1 R.sub.2, where R.sub.1 and R.sub.2, which are identical or different, denote a hydrogen atom or a C.sub.1 -C.sub.12 alkyl, alkenyl, cycloalkyl or arylalkyl radical --N.dbd.CH--Ar.sub.1 where Ar.sub.1 is an aryl radical containing at least one phenolic group --NR.sub.1 --CO--Ar.sub.1 and ##STR1## where R.sub.3 denotes a saturated or unsaturated, linear or branched alkyl radical.Type: GrantFiled: November 25, 1991Date of Patent: December 14, 1993Assignee: Elf FranceInventors: Laurent Germanaud, Patrick Azorin, Patrick Turello
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Patent number: 5262431Abstract: A novel prolinal derivative of general formula: ##STR1## [wherein A represents a group of the general formula: ##STR2## (wherein one of R.sup.1 and R.sup.2 represents hydrogen atom and the other represents alkyl group of from 2 to 5 carbon atoms, alkoxy group of from 1 to 5 carbon atom(s), phenyl group, benzyl group, cycloalkyl group of from 4 to 6 carbon atoms or (cycloalkyl group of from 4 to 6 carbon atoms)--methyl group or R.sup.1 and R.sup.2 each represents, same or different, alkyl group of from 1 to 4 carbon atom(s).) or a group of the general formula: ##STR3## (wherein m represents an integer of from 3 to 6.) n represents an integer of from 3 to 10.D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, nitro group, trifluoromethyl group, alkyl or alkoxy group of from 1 to 4 carbon atom(s).]possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.Type: GrantFiled: February 19, 1992Date of Patent: November 16, 1993Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Masaaki Toda, Shuichi Ohuchida, Hiroyuki Ohno
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Patent number: 5238936Abstract: The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents.A compound disclosed is 2,4-diallylamino-6-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl) methylamino]piperidin-1-yl}-1,3,5-triazine.Type: GrantFiled: March 6, 1992Date of Patent: August 24, 1993Assignee: Adir et CompagnieInventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre, Stephane Leonce
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Patent number: 5208332Abstract: An optical probe enables the study of enzyme activity by absorbance spectroscopy or by sensitive fluorescence methods. In particular, the probe provides the ability to monitor the activity of cytochrome P-450.sub.scc enzyme, the rate limiting enzyme for steroid biosynthesis. Located on the inner mitochondrial membrane, P-450.sub.scc catalyzes the conversion of cholesterol to pregnenolone and isocapraldehyde by sequential oxidations of the cholesterol side chain. The fluorogenic probe includes a cholesterol-like steroid linked to a chromophore through a linking group. The chromophore is selected to have little optical response when linked to the steroid substrate and an enhanced optical response when cleaved from the substrate and linking group. Thus, a fluorescent anion that can be optically detected is generated by the side-chain cleavage reaction during steroidogenesis.Type: GrantFiled: December 20, 1991Date of Patent: May 4, 1993Assignee: The United States of America as represented by the United States Department of EnergyInventors: Babetta L. Marrone, Daniel J. Simpson, Clifford J. Unkefer, Thomas W. Whaley
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Patent number: 5151520Abstract: A cationic dye-borate anion compound represented by the formula: ##STR1## where D+ is a cationic dye moiety selected from the group consisting of cationic cyanine, carbocyanine, hemicyanine, rhodamine, and azamethine dyes; R.sup.1 is alkyl; and R.sup.2, R.sup.3, and R.sup.4 are aryl. Such cationic dye-borate anion compounds are useful photoinitiators of free radical addition reactions.Type: GrantFiled: January 30, 1990Date of Patent: September 29, 1992Assignee: The Mead CorporationInventors: Peter Gottschalk, Douglas C. Neckers, Gary B. Schuster
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Patent number: 5086052Abstract: Pyridazinone, triazinone and oxapyridazinone compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.Type: GrantFiled: June 28, 1990Date of Patent: February 4, 1992Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, George W. Carter, Anwer Basha, Bruce P. Gunn, Richard D. Dyer
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Patent number: 5026846Abstract: Diaryl sulphides and diaryl selenides of formula:Ar--X--Arwhere X=S or Se and Ar=aryl are made by the action of sulphur and sulphur dioxide or selenium and selenium dioxide on a compound of formula:Ar--HThe process is especially useful for the preparation of phenothiazines of formula ##STR1## in which X=S or Se and Z and Z.sub.1, which may be identical or different, are each hydrogen, halogen, alkyl or alkoxy.Type: GrantFiled: August 15, 1989Date of Patent: June 25, 1991Assignee: Rhone-Poulenc SanteInventor: Jean-Pierre Duchesne
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Patent number: 4879383Abstract: Urea derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently a 4-disubstituted aminoaryl group or the like, and R.sup.3 is a carboxyalkyl group or the like, is soluble in water and effective as a color producing reagent for determining hydrogen peroxide or the like or the activity of peroxidase.Type: GrantFiled: June 29, 1987Date of Patent: November 7, 1989Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Yoshitsugu Sakata, Kazunari Hashidume, Tsutomu Iwata, Toyoharu Mukai, Masaaki Kida
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Patent number: 4873318Abstract: Novel adducts of oxazine urea chromophors or thiazine urea chromophors with organic substrates are provided which are useful in analytical techniques for the detection and measurement of biological and clinical compounds of interest.Type: GrantFiled: October 20, 1987Date of Patent: October 10, 1989Inventor: Spyros Theodoropulos
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Patent number: 4859667Abstract: Phenothiazone derivatives and analogs thereof, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.Type: GrantFiled: January 14, 1987Date of Patent: August 22, 1989Assignee: Merck Frosst Canada, Inc.Inventors: Cheuk K. Lau, Christiane Yoakim, Joshua Rokach, Rejean Fortin, Yvan Guindon
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Patent number: 4822878Abstract: Novel chromophor derivatives of cyclic anhydrides are provided which have the ability to react with a variety of organic substrates forming adducts which are useful in analytical techniques for the detection and measurement of biological compounds.Type: GrantFiled: May 27, 1988Date of Patent: April 18, 1989Assignee: Viomedics, Inc.Inventor: Spyros Theodoropulos
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Patent number: 4775754Abstract: Oxazine, thiazine and diazine leuco dyes are synthesized through a reaction using a dicyclohexylcarbodiimide adduct. The adducts are themselves novel compounds.Type: GrantFiled: October 7, 1987Date of Patent: October 4, 1988Assignee: Minnesota Mining and Manufacturing CompanyInventors: Kim M. Vogel, Roger A. Mader
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Patent number: 4714763Abstract: Novel urea derivatives of oxazine and thiazine chromophors have the structural formula I or II. ##STR1## wherein M is oxygen or sulfur, R.sub.1 and R.sub.2 are aliphatic alkyl groups or hydrogen; R.sub.3 is hydrogen or alkyl group; R.sub.4 is hydrogen, alkyl or amine group; R.sub.5 is hydrogen, amine or alkyl group; X.sup..crclbar. is an anion consisting of an organic (e.g. CH.sub.3 COO.sup..crclbar., CH.sub.3 CH.sub.2 COO.sup..crclbar. and the like) or inorganic specie (e.g. Cl.sup..crclbar., Br.sup..crclbar., I.sup..crclbar., ClO.sub.4.sup..crclbar., SO.sub.4 ", and the like); n is 0 to 20; Z is N.dbd.C.dbd.O, N.dbd.C.dbd.S, carboxylic, primary or secondary amine, and when n=0, Z may be ##STR2## wherein Q is hydroxyl, amino, carboxylic, sulfydryl, isocyanato, or isothiocyanato.The functional oxazine-urea and thiazine-urea derivatives react with compounds of interest to form adducts resulting in the fluorescent labeling of the compound.Type: GrantFiled: July 11, 1985Date of Patent: December 22, 1987Assignee: Viomedics Inc.Inventor: Spyros Theodoropulos
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Patent number: 4678499Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]-pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.Type: GrantFiled: January 30, 1986Date of Patent: July 7, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
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Patent number: 4667032Abstract: Phenothiazone derivatives and analogs thereof, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.Type: GrantFiled: October 10, 1985Date of Patent: May 19, 1987Assignee: Merck Frosst Canada, Inc.Inventors: Cheuk K. Lau, Christiane Yoakim, Joshua Rokach, Rejean Fortin, Yvan Guindon
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Patent number: 4652643Abstract: 3-(N--R.sup.2 --N-Acylamino)-7-(N--R.sup.3 --N--R.sup.4 -amino)-10-acylphenothiazines and phenoxazines useful as color formers, particularly in electrochromic recording systems, are prepared by the interaction of the corresponding 3-(N--R.sup.2 -amino)-7-(N--R.sup.3 --N--R.sup.4 -amino)phenothiazinium or phenoxazinium halide with a reducing agent to obtain the corresponding leuco compound and subsequently interacting the leuco compound with at least two molecular proportions of an acylating agent.Type: GrantFiled: April 3, 1986Date of Patent: March 24, 1987Assignee: The Hilton-Davis Chemical CompanyInventors: Michael B. Gunn, William M. Hung
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Patent number: 4636497Abstract: The present invention refers to novel anellated 4H-1,4-benzothiazines, several processes for the synthesis thereof, their use as pharmaceutical agents, in particular their use as lipoxygenase-inhibiting agents, pharmaceutical compositions containing the novel benzothiazines and a process for their manufacture.Type: GrantFiled: August 29, 1985Date of Patent: January 13, 1987Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Rudi Grutzmann, Mithat Mardin, Wolf-Dieter Busse, Horst Meyer
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Patent number: 4634783Abstract: Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.Type: GrantFiled: January 23, 1984Date of Patent: January 6, 1987Assignee: Torii & Co. Ltd.Inventors: Setsuro Fujii, Toyoo Nakayama, Shigeki Nunomura, Ryoji Matsui, Shin-ichi Watanabe, Kimio Sudo, Toshiyuki Okutome, Masateru Kurumi, Yojiro Sakurai, Takuo Aoyama
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Patent number: 4622395Abstract: Novel phenoxazine and phenothiazine dyes have the formula ##STR1## wherein X can be --S-- or --O--;each R can be the same or different and is independently selected from(1) hydrogen,(2) an unsubstituted aryl or alkyl group or these groups substituted by up to four groups selected from alkyl, alkoxy, cyano, hydroxy, halogen, nitro, mercapto, alkylsulfonyl, arylsulfonyl, and Z, where Z is as defined below, wherein all alkyl and alkoxy groups have 1 to 20 carbon atoms; and(3) Z, wherein Z can be ##STR2## wherein each Q can be the same or different and is independently selected from(1) hydrogen,(2) an unsubstituted aryl or alkyl group or these groups substituted by up to four groups selected from alkyl, alkoxy, cyano, hydroxy, halogen, nitro, mercapto, alkylsulfonyl, arylsulfonyl, and Z, where Z is as defined above, wherein all alkyl and alkoxy groups have 1 to 20 carbon atoms; andR' is the same or different and is independently selected from hydrogen, halogen, alkyl or alkoxy of 1 to 6 carbon atoms or these grouType: GrantFiled: October 1, 1984Date of Patent: November 11, 1986Assignee: Minnesota Mining and Manufacturing CompanyInventors: Peter A. Bellus, Roger A. Mader
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Patent number: 4604458Abstract: 3-(R-Carbonyloxy)-7-(N-R.sup.1 -N-R.sup.2 -amino)-10-(RCO)-phenothiazines useful as color formers, particularly in electrochromic recording systems, are prepared by the interaction of the corresponding 7-(N-R.sup.1 -N-R.sup.2 -amino)phenothiazin-3-one with a reducing agent to obtain the corresponding leuco compound and subsequently interacting the leuco compound with about two molecular proportions of an acylating agent.Type: GrantFiled: September 3, 1985Date of Patent: August 5, 1986Assignee: The Hilton-Davis Chemical Co.Inventor: William M. Hung
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Patent number: 4593116Abstract: Urethanes are made by reacting an organic nitro compound with an organic compound containing at least one hydroxyl group in the presence of carbon monoxide, hydrogen and a catalyst system. The carbon monoxide and hydrogen are used in quantities such that the molar ratio of CO to H.sub.2 is from 0.3:1 to 3:1. The catalyst system is made up of at least one noble metal or compound of a noble metal from Group VIIIB of the Periodic System of Elements, at least one organic nitrogen base and a co-catalyst combination of iron or copper oxidic or hydroxidic compound and a chloride compound. The product urethanes are useful in the production of isocyanates and pesticides.Type: GrantFiled: June 13, 1984Date of Patent: June 3, 1986Assignee: Bayer AktiengesellschaftInventors: Gunter Stammann, Johann Grolig, Robert Becker, Helmut Waldmann
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Patent number: 4529500Abstract: Hydrocarbon processing equipment is protected against fouling during the processing of hydrocarbons at elevated temperatures by adding to the equipment small amounts of the N,N'-dimer of phenothiazine or a substituted phenothiazine.Type: GrantFiled: August 10, 1984Date of Patent: July 16, 1985Assignee: Atlantic RichfieldInventors: Richard F. Miller, Michael P. Nicholson
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Patent number: 4487982Abstract: Vinyl aromatic compounds are stabilized against undesired polymerization by adding to the vinyl aromatic compounds small amounts of at least one N,N' dimer of phenothiazine or a substituted phenothiazine and at least one mono- or ditertiary alkylphenol.Type: GrantFiled: September 8, 1983Date of Patent: December 11, 1984Assignee: Atlantic Richfield CompanyInventors: Richard F. Miller, Michael P. Nicholson
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Patent number: 4487981Abstract: Vinyl aromatic compounds are stabilized against undesired polymerization by adding to the vinyl aromatic compounds small amounts of at least one N,N' dimer of phenothiazine or a substituted phenothiazine and at least one mono- or ditertiary alkyl catechol and/or at least one mono- or ditertiary alkylhydroquinone.Type: GrantFiled: September 8, 1983Date of Patent: December 11, 1984Assignee: Atlantic Richfield CompanyInventors: Richard F. Miller, Michael P. Nicholson
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Patent number: 4465881Abstract: Vinyl aromatic compounds are stabilized against undesired polymerization by adding to the vinyl aromatic compounds small amounts of the N,N'-dimer of phenothiazine or a substituted phenothiazine.Type: GrantFiled: September 8, 1983Date of Patent: August 14, 1984Assignee: Atlantic Richfield CompanyInventors: Richard F. Miller, Michael P. Nicholson
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Patent number: 4465882Abstract: Vinyl aromatic compounds are stabilized against undesired polymerization by adding to the vinyl aromatic compounds small amounts of at least one N,N-diarylhydroxylamine and at least one N,N' dimer of phenothiazine or substituted phenothiazine.Type: GrantFiled: September 8, 1983Date of Patent: August 14, 1984Assignee: Atlantic Richfield CompanyInventors: Richard F. Miller, Michael P. Nicholson
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Patent number: 4436920Abstract: Recording members having excellent light resistance are obtained by using as a dye precursor specific diarylaminofluoran compounds.Type: GrantFiled: March 11, 1982Date of Patent: March 13, 1984Assignee: Fuji Photo Film Co., Ltd.Inventors: Kozo Sato, Ken Iwakura, Akira Igarashi
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Patent number: 4362738Abstract: Compounds of the formula ##STR1## wherein each X, which may be identical or different from the other X, is oxygen or imino;R.sub.1 is hydrogen, fluorine, chlorine or bromine;R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms;R.sub.2 and R.sub.Type: GrantFiled: June 11, 1980Date of Patent: December 7, 1982Assignee: Dr. Karl Thomae GmbHInventors: Johannes Keck, Gerd Kruger, Helmut Pieper, Klaus Noll, Gunther Engelhardt, Norbert Promberger, Rainer Zimmermann
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Patent number: 4339592Abstract: A urethane is produced by reacting an organic nitro compound with carbon monoxide and an organic compound containing at least one hydroxyl group in the presence of a catalyst and a co-catalyst. This reaction is conducted in the liquid phase at elevated temperature and pressure. The catalyst employed is an element and/or compound of an element from the group of noble metals of the 8th Secondary Group of the Periodic Table. The co-catalyst used is formed from (1) a component taken from the group consisting of iron oxychloride, a mixture of iron compounds containing iron oxychloride and oxide-chloride combinations and (2) metallic iron or an iron alloy in finely divided or high surface form. The oxides which may be used in the oxide-chloride combinations of co-catalyst component (1) are the oxides and/or oxide hydrates of tetravalent tin, trivalent chromium, hexavalent molybdenum, hexavalent tungsten, pentavalent vanadium, divalent iron and trivalent iron.Type: GrantFiled: February 26, 1981Date of Patent: July 13, 1982Assignee: Bayer AktiengesellschaftInventors: Robert Becker, Christian Rasp, Gunter Stammann, Johann Grolig
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Patent number: 4302582Abstract: An improved process for preparation of a condensed product of phenothiazine and p-nitrosophenol which contains more than 60% by weight of indophenol S-oxide of the formula ##STR1## by condensing phenothiazine with p-nitrosophenol in sulphuric acid wherein the improvement comprises the phenothiazine being in 60 to 90% strength sulphuric acid at the time of addition of the p-nitrosophenol.Type: GrantFiled: January 31, 1980Date of Patent: November 24, 1981Assignee: Cassella AktiengesellschaftInventors: Gert Nagl, Joachim Ribka, Ulrich Gotsmann, Heinz Dickmanns
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Patent number: 4237281Abstract: Novel dyestuffs containing amino or imino groups and their preparation are provided.These dyestuffs have the general formula ##STR1## wherein R is --N(R.sub.3)CH.sub.2 --Z or --N.dbd.CH--Z, X is N or CR.sub.6 where R.sub.6 is a hydrogen atom or an optionally substituted alkyl or aryl group, Y is S.sup..sym., O.sup..sym., N or N.sup..sym. R.sub.7 where R.sub.7 is a hydrogen atom or an optionally substituted alkyl or aryl group, R.sub.1, R.sub.1 and R.sub.2 each represent a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, or R.sub.1 and R.sub.2 together with the nitrogen atom complete a heterocyclic ring, or one of R.sub.1 and R.sub.2 can be hydrogen and the other of R.sub.1 and R.sub.2 can be aryl, Z is a group which comprises both an activating group which contains at least one double bond system and also a ballasting group and R.sub.4 and R.sub.5 each represent optional substituents or form an annelated benzene ring.Type: GrantFiled: February 23, 1979Date of Patent: December 2, 1980Assignee: Ciba-Geigy AktiengesellschaftInventor: William E. Long
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Patent number: 4219661Abstract: This invention relates to an improved process for the production of urethanes (i.e. carbamic acid esters) by reacting organic nitro compounds with carbon monoxide and organic compounds containing at least one hydroxy group in the presence of a unique catalyst system. The catalyst system consists of palladium or a palladium compound and iron oxychloride or a mixture of iron compounds containing iron oxychloride.Type: GrantFiled: April 23, 1979Date of Patent: August 26, 1980Assignee: Bayer AktiengesellschaftInventors: Robert Becker, Johann Grolig, Christian Rasp, Gerhard Scharfe
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Patent number: 4218219Abstract: Green sulfur dyestuff is produced by reacting phenothiazine in sulfuric acid with an oxidizing agent, condensing the oxidized phenothiazine with p-nitrosophenol and thionating with sulfur and sodium sulfide the condensate in a bake or reflux process.Type: GrantFiled: October 30, 1978Date of Patent: August 19, 1980Assignee: Cassella AktiengesellschaftInventors: Gert Nagl, Joachim Ribka, Heinz Dickmanns, Ulrich Gotsmann