Bicyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/546)
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Patent number: 11952438Abstract: A 1,3-dipolar compound including an epoxide group is provided. The epoxide group is a 3-membered ether ring in which a first member is a carbon atom having an attachment to the dipole of the 1,3-dipolar compound and a second member is a tertiary or quaternary carbon. The use of the 1,3-dipolar compound in the modification of a diene polymer makes it possible to improve the rupture properties of a rubber composition comprising the modified polymer, without the expense of its hysteresis properties, while at the same time improving its implementation.Type: GrantFiled: November 20, 2018Date of Patent: April 9, 2024Assignee: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELINInventors: Anne-Frédérique Salit, Benoît Schnell, Sophie Gander, Sergey Ivanov, Etienne Fleury
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Patent number: 11932723Abstract: To provide 3,4-epoxycyclohexylmethyl methacrylate that is highly pure and that is useful as a raw material for functional materials or optical members having excellent transparency and heat resistance. An alicyclic epoxy compound product having a purity of 3,4-epoxycyclohexylmethyl methacrylate of 98.0 wt. % or greater and a total content of a compound represented by Formula (a) below and a compound represented by Formula (b) below of 1.3 wt. % or less. This alicyclic epoxy compound product preferably has a Hazen color number of 25 or less.Type: GrantFiled: December 24, 2019Date of Patent: March 19, 2024Assignee: DAICEL CORPORATIONInventors: Hirose Suzuki, Yoshito Nakai
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Patent number: 11802217Abstract: The present invention relates to a composition comprising a binder comprising one or more siloxane polymers, silicone resins, silicone based elastomers, and mixtures thereof, wherein said binder optionally comprises one or more cross-linker components comprising a silane and/or a siloxane containing silicon-bonded hydrolysable groups; and a hydrophilic powder and/or gel selected from one or more amorphous, porous hydrophilic silica(s), one or more hydrophilic silica aerogel(s) and mixtures thereof, said amorphous, porous hydrophilic silica and/or said hydrophilic silica aerogel having a BET surface area from 100 m2/g to 1500 m2/g or greater and a thermal conductivity from 0.004 to 0.05 W/m·K at 20° C. and atmospheric pressure. The invention also relates to the use of said composition as or in thermally or acoustically insulating materials and to coatings, products and articles made therefrom.Type: GrantFiled: January 23, 2019Date of Patent: October 31, 2023Assignees: WORLEE-CHEMIE GMBH, DOW SILICONES CORPORATIONInventors: Thorsten Adebahr, Joachim Müller, David Pierre
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Patent number: 11492337Abstract: An epoxy compound of formula (1) is provided. A resist composition comprising the epoxy compound is capable of adequately controlling the diffusion length of acid generated from an acid generator without sacrificing sensitivity.Type: GrantFiled: February 25, 2020Date of Patent: November 8, 2022Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Masayoshi Sagehashi, Ryosuke Taniguchi, Takeru Watanabe, Yoshinori Matsui
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Patent number: 10287277Abstract: The present disclosure relates to salts and polymorphs of aminoalkylfumagillol carbamates (e.g., fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate benzenesulfonic acid salt and fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate hydroxynaphthoic acid salt). The polymorphs are characterized by X-ray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis, among other methods. The polymorphs and salts can be used as intermediates in the production of fumagillol derivatives (e.g., polymer-conjugated fumagillol derivatives) as well as therapeutic agents for the treatment of various diseases and conditions such as cancer.Type: GrantFiled: April 6, 2018Date of Patent: May 14, 2019Assignee: SynDevRx, Inc.Inventor: John S. Petersen
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Patent number: 9969722Abstract: The present disclosure relates to salts and polymorphs of aminoalkylfumagillol carbamates (e.g., fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate benzenesulfonic acid salt and fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate hydroxynaphthoic acid salt). The polymorphs are characterized by X-ray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis, among other methods. The polymorphs and salts can be used as intermediates in the production of fumagillol derivatives (e.g., polymer-conjugated fumagillol derivatives) as well as therapeutic agents for the treatment of various diseases and conditions such as cancer.Type: GrantFiled: December 9, 2016Date of Patent: May 15, 2018Assignee: SynDevRx, Inc.Inventor: John S. Petersen
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Patent number: 9447062Abstract: A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1? release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.Type: GrantFiled: December 15, 2014Date of Patent: September 20, 2016Assignees: BIOLOGY CENTRE AS CR, V.V.I., INSTITUTE OF MICROBIOLOGYH AS CR, V.V.I., INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINEInventors: Miroslav Petricek, Katerina Petrickova, Stanislav Pospisil, Marek Kuzma, Alica Chronakova, Vaclav Kristufek, Ilja Striz
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Patent number: 9249256Abstract: Provided are: a novel triepoxy compound capable of forming, through polymerization, a cured article having excellent heat resistance; a production method thereof; a curable composition including the triepoxy compound; and a cured article obtained by curing the curable composition. The triepoxy compound according to the present invention is represented by Formula (1). The triepoxy compound represented by Formula (1) may be obtained typically by oxidizing a compound represented by Formula (2) with an oxidizing agent. In Formulae (1) and (2), R1 to R2° are the same as or different from one another and each represent hydrogen atom, methyl group, or ethyl group.Type: GrantFiled: September 4, 2012Date of Patent: February 2, 2016Assignee: DAICEL CORPORATIONInventors: Kyuhei Kitao, Hideyuki Takai, Michihiro Sugahara
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Patent number: 9199952Abstract: A method for producing a composition containing fucoxanthin includes a first step of adding a water-soluble solvent containing 0 to 80% by weight of water to seaweed to obtain a seaweed component extract, and then adding water and/or a water-soluble solvent to the seaweed component extract in such a manner that the concentration of the water-soluble solvent is 20 to 45% by weight and also adding a diluent thereto to obtain a diluent-containing extract, and a second step of stirring the diluent-containing extract, and then collecting a substance aggregating into the diluent-containing extract as a composition containing fucoxanthin by separation.Type: GrantFiled: February 27, 2013Date of Patent: December 1, 2015Assignee: KANEKA CORPORATIONInventors: Ken Uekita, Tadashi Moroshima
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Patent number: 9056091Abstract: The present invention provides a composition for the regulation of Liver X Receptor (LXR) in a cell, and the composition comprises fucoxanthin and its metabolite, fucoxanthinol. The composition of the present invention regulates the transactivation activity of LXR in cell, and antagonizes the transactivation activity of LXR? and/or LXR? induced by LXR agonists. In other aspects, the present invention also provides a method of regulating a liver X receptor. The composition for the regulation of liver X receptor and the application thereof according to the present invention can regulate the transactivation activity of LXR in cell, and can further be used as alternatives for LXR agonist or antagonist, or supplements, for enhancing LXR-related symptoms.Type: GrantFiled: June 16, 2014Date of Patent: June 16, 2015Assignee: NATIONAL TAIWAN UNIVERSITYInventors: Ching-jang Huang, Meng-ting Wu, Hong-nong Chou, Mei-ling Chang
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Publication number: 20150140619Abstract: A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.Type: ApplicationFiled: January 17, 2015Publication date: May 21, 2015Inventors: Christopher M. Reddy, Gregory W. O'Neil
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Patent number: 8993210Abstract: A salt represented by the formula (I): wherein R1 and R2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group which can have one or more fluorine atoms and in which one or more —CH2— can be replaced by —O— or —CO—, R3 represents a group having a cyclic ether structure, and Z1+ represents an organic cation.Type: GrantFiled: February 15, 2011Date of Patent: March 31, 2015Assignee: Sumitomo Chemical Company, LimitedInventors: Koji Ichikawa, Hiromu Sakamoto
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Process for preparing cis-5-[1-(4-chlorophenyl)-methylene]-1-hydroxymethyl-2,2-dimethylcyclopentanol
Publication number: 20150018560Abstract: The present invention relates to a process for preparing a diol of the formulae (Ia) or (Ib), or a mixture thereof, comprising the reaction of an epoxy alcohol of formulae (Va) or (Vb), or a mixture thereof, with alkali metal borohydride or earth alkaline borohydride, in particular sodium borohydride, and anhydrous aluminum(III) chloride. The invention also relates to processes and intermediates for preparing an epoxy alcohol of formulae (Va) or (Vb). The invention furthermore relates to processes for preparing cis-metconazole in which a diol of the formulae (Ia) or (Ib) is applied as a precursor.Type: ApplicationFiled: February 7, 2013Publication date: January 15, 2015Applicant: BASf ARGO B.V. ARNHEM (NL). ZURICH-BRANCHInventors: Thomas Zierke, Paul Kemper -
Patent number: 8912350Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: GrantFiled: May 24, 2012Date of Patent: December 16, 2014Assignee: The Procter & Gamble CompanyInventors: Hugo Robert Germain Denutte, Johan Smets, An Pintens, Koen Jeanne Alfons Van Aken, Freek Annie Camiel Vrielynck
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Publication number: 20140243537Abstract: The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (?)-methyl 3-epi-shikimate.Type: ApplicationFiled: October 25, 2012Publication date: August 28, 2014Applicant: Council of Scientific & Industrial ResearchInventors: Varun Rawat, Soumen Dey, Sudalai Arumugam
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Patent number: 8809558Abstract: The invention provides novel synthetic intermediates and synthetic methods that are useful for preparing compounds of the xenicane family. Certain compounds of the invention may also possess anti-cancer properties.Type: GrantFiled: August 23, 2011Date of Patent: August 19, 2014Assignee: Rutgers, The State University of New JerseyInventors: Lawrence J. Williams, Michael Drahl, Madhuri Manpadi
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Publication number: 20130236832Abstract: There is disclosed an acid generator generating a sulfonic acid represented by the following general formula (1) in response to high-energy beam or heat: As a result, there is provided a novel acid generator which is suitably used as an acid generator for a resist composition, which solves the problems of exposure margin and MEF particularly without degradation of resolution and can be effectively and widely used, a chemically amplified resist composition using the same, and a patterning process.Type: ApplicationFiled: February 19, 2013Publication date: September 12, 2013Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Masaki OHASHI, Takayuki NAGASAWA, Ryosuke TANIGUCHI
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Patent number: 8530681Abstract: The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: GrantFiled: May 30, 2012Date of Patent: September 10, 2013Assignee: Alliant Techsystems Inc.Inventors: Susan Knox, Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde, Shoucheng Ning, Lynn M. Oehler
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Publication number: 20130189382Abstract: Use of fucoxanthin in the preparation of a product having neuroprotective effect associated with neurodegenerative disorder and improving memory is disclosed in the disclosure. A product having neuroprotective effect associated with neurodegenerative disorder is also disclosed in the disclosure. Fucoxanthin can inhibit oxidative stress of cells and has the effect of preventing or treating Alzheimer's disease and improving memory.Type: ApplicationFiled: September 30, 2010Publication date: July 25, 2013Applicant: Beijing Gingko Group Biological Technology Co., Ltd.Inventors: Yanmei Li, Liang Li
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Publication number: 20130143228Abstract: An activity based probe (ABP) comprising a glycosidase inhibitor, and a detection-group. The ABPs of the inventions are used for diagnosing storage disorder for screening of compounds suitable for preventing and/or treating a storage disorder, for monitoring of therapeutic enzymes for lysosomal storage disorders, and for ultra-sensitive visualization of glycosidase-fusion proteins in molecular imaging.Type: ApplicationFiled: March 10, 2011Publication date: June 6, 2013Inventors: Johannes Maria Franciscus Gerardus Aerts, Herman Steven Overkleeft
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Patent number: 8455061Abstract: An optically active compound having a polymerizable group which is represented by formula (1) or (2). P1-Q1-(A1-Z1)m—X1—(Z1-A1)m-Q1-P2??(1) P1-Q1-(A1-Z1)m—X2??(2) For example, A1 is independently divalent group having ring; Z1 is independently bonding group; m is independently an integer from 1 to 5; Q1 is independently alkylene having 1 to 20 carbons; X1 is a divalent group having chirality; X2 is a monovalent group having chirality, and P1 and P2 are polymerizable groups; and concerns a polymerizable liquid crystal composition, a polymer, an optical device and an article.Type: GrantFiled: March 25, 2011Date of Patent: June 4, 2013Assignees: JNC Corporation, JNC Petrochemical CorporationInventors: Daisuke Ootsuki, Junichi Inagaki
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Patent number: 8431612Abstract: The present disclosure provides analogs and derivatives of phorbol compounds for the treatment of viral infections, neoplastic diseases, inflammatory reactions, and use as analgesics.Type: GrantFiled: June 21, 2011Date of Patent: April 30, 2013Assignee: Salvia Sciences, Inc.Inventors: Rensheng Xu, Weiman Zhao, Chun Jiang
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Patent number: 8404316Abstract: A polymerizable liquid crystal compound represented by formula (1): wherein Al and A2 are each a cyclic-structure group; Z1 is a bonding group; m is an integer from 0 to 5; P1 is a polymerizable group represented by formula (2-1); Q1 is alkylene having 1 to 20 carbons; P2 is a polymerizable group represented by any one of formula (2-1) to formula (2-4), hydrogen, fluorine, chlorine, —CN, —CF3, —OCF3, alkyl having 1 to 20 carbons or alkoxy having 1 to 20 carbons; Q2 is a group defined in Q1 when P2 is a polymerizable group and, and Q2 is a single bond when P2 is not a polymerizable group; and in formula (2-2) to formula (2-4), Ra is hydrogen, halogen or alkyl having 1 to 5 carbons.Type: GrantFiled: September 30, 2010Date of Patent: March 26, 2013Assignees: JNC Corporation, JNC Petrochemical CorporationInventors: Daisuke Ootsuki, Junichi Inagaki
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Patent number: 8344163Abstract: There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to 4; Q represents a C1-C4 fluoroalkyl group; Z represents an optionally substituted C2-C6 alkynyl group or a ?N—OR3 group; R1 and R2 independently represent a monovalent C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and A represents an optionally substituted monovalent C1-C6 chain hydrocarbon group, etc.Type: GrantFiled: March 18, 2009Date of Patent: January 1, 2013Assignee: Sumitomo Chemical Company, LimitedInventor: Hiromasa Mitsudera
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Publication number: 20120258927Abstract: This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.Type: ApplicationFiled: June 19, 2012Publication date: October 11, 2012Applicant: Millenium Pharmaceuticals, Inc.Inventors: Steven P. Langston, Edward J. Olhava, Stepan Vyskocil
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Patent number: 8283481Abstract: A compound of formula (I): wherein: R1 is —SR10, —O—C(O)—R11, —NR12R13, where R10 is a C1-8-alkyl group or a phenyl group unsubstituted or substituted by a C1-4-alkyl group, R11 is a thiophenenyl, furanyl or pyrrolyl group, R12 is H or a C1-4-alkyl group and R13 is a C1-8-alkyl group or a phenyl group unsubstituted or substituted by a C1-4-alkyl group; R2 is H or a C1-4-alkyl group; R3 and R4 are independently H or C1-4-alkyl groups; R5 and R6 are independently H, OH or OR14, or taken together are ?O, where R14 is a protecting group; R7 is H or a C1-4-alkyl group; and, R8 is H, R9 is OH and R15 is H, or R15 is H and R8 and R9 taken together are —O—, or R9 is OH and R8 and R15 taken together form a bond; and, R18 and R19 are both H, or R18 and R19 taken together form a bond, or a plant physiologically acceptable salt thereof is useful for inhibiting 9-cis-epoxycarotenoid dioxygenase (NCED) in a plant or seed and is therefore useful for regulating ABA biosynthesis in the plant or seed.Type: GrantFiled: July 22, 2009Date of Patent: October 9, 2012Assignee: National Research Council of CanadaInventors: Suzanne R. Abrams, Michele C. Loewen, Jason Boyd, Adrian John Cutler, Yuanzhu Gai, Kenneth M. Nelson
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Publication number: 20120220580Abstract: Compounds having the structure of general formula I or pharmaceutically acceptable salts thereof which are derivatives of fucoxanthin and fucoxanthol are disclosed. A preparation method of the compound and its use in weight reducing are also disclosed.Type: ApplicationFiled: April 19, 2012Publication date: August 30, 2012Applicant: BEIJING GINGKO GROUP BIOLOGICAL TECHNOLOGY CO., LTD.Inventors: YANMEI LI, QINGHUA LIU
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Publication number: 20120149886Abstract: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.Type: ApplicationFiled: April 10, 2009Publication date: June 14, 2012Applicant: MICROBIA, INC.Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
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Publication number: 20120088827Abstract: The invention relates to compounds of formula (I), formula (II), formula (III) and formula (IV), and pharmaceutically acceptable salts thereof for the treatment of cancer, inflammation, auto-immune diseases, diabetes and diabetic complications, infection, cardiovascular disease and ischemia-reperfusion injuries.Type: ApplicationFiled: June 16, 2010Publication date: April 12, 2012Applicant: Profectus Biosciences, Inc.Inventors: Jie Zhang, Drago Robert Sliskovic, Charles E. Ducker
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Publication number: 20120046357Abstract: The invention relates to compounds of formula (1) and formula (2), and pharmaceutically acceptable salts thereof for the treatment of cancer, inflammation, auto-immune diseases, diabetes and diabetic complications, infection, cardiovascular disease and ischemia-reperfusion injuries, wherein R1 is defined herein.Type: ApplicationFiled: April 29, 2010Publication date: February 23, 2012Applicant: Profectus Biosciences, Inc.Inventors: Jie Zhang, Drago Robert Sliskovic, Charles E. Ducker
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Publication number: 20110301028Abstract: A method of stimulating germination in plant seeds and/or releasing plant tissue or plant organs from dormancy, comprising applying to a seed, plant, plant organ or plant tissue a compound of formula (I): where: R1 is alkyl or H; R2, R3, R4 and R5 are independently selectable from H, halide, —NO2, —SO2R?, —OH, —Oalkyl where R? is alkyl or aminoalkyl; and/or R1 and R5 are joined as —O(CH2)m—, where m is 1, 2, 3 or 4; R6 is a substituted or non-substituted alkyl, and/or substituted or non-substituted aryl; and n is an integer of 1 to 4.Type: ApplicationFiled: November 17, 2009Publication date: December 8, 2011Applicant: SYNGENTA CROP PROTECTION, LLCInventors: Andrew Thompson, Timothy Bugg
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Publication number: 20110251068Abstract: Disclosed is a parasitic plant control agent which can control a parasitic plant effectively. Also disclosed is a parasitic plant control method. A parasitic plant can be controlled by inhibiting the metabolism of gentianose in the parasitic plant to inhibit the germination of the parasitic plant.Type: ApplicationFiled: October 5, 2009Publication date: October 13, 2011Applicant: OSAKA UNIVERSITYInventors: Atsushi Okazawa, Joseph Benesh
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Patent number: 8022103Abstract: Ester prodrugs of phorbol compounds for the treatment of viral infections, neoplastic diseases, inflammatory reactions, and use as analgesics, wherein the phorbol compounds are derivatized with a -x-o-c(o)-R? group linked to the 6-carbon of the phorbol residue.Type: GrantFiled: July 13, 2006Date of Patent: September 20, 2011Assignee: Salvia Sciences, Inc.Inventors: Rensheng Xu, Weimin Zhao, Chun Jiang
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Publication number: 20110200936Abstract: A salt represented by the formula (I): wherein R1 and R2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group which can have one or more fluorine atoms and in which one or more —CH2— can be replaced by —O— or —CO—, R3 represents a group having a cyclic ether structure, and Z1+ represents an organic cation.Type: ApplicationFiled: February 15, 2011Publication date: August 18, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Koji ICHIKAWA, Hiromu SAKAMOTO
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Publication number: 20110021627Abstract: There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to 4; Q represents a C1-C4 fluoroalkyl group; Z represents an optionally substituted C2-C6 alkynyl group or a ?N—OR3 group; R1 and R2 independently represent a monovalent C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and A represents an optionally substituted monovalent C1-C6 chain hydrocarbon group, etc.Type: ApplicationFiled: March 18, 2009Publication date: January 27, 2011Applicant: Sumitomo Chemical Company, LimitedInventor: Hiromasa Mitsudera
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Patent number: 7786314Abstract: Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.Type: GrantFiled: November 3, 2004Date of Patent: August 31, 2010Assignee: Taisho Pharmaceutical Co., LtdInventors: Frederick W. Hartner, Lushi Tan, Nobuyoshi Yasuda, Naoki Yoshikawa
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Publication number: 20100160166Abstract: A compound of formula (I): wherein: R1 is —SR10, —O—C(O)—R11, —NR12R13, where R10 is a C1-8-alkyl group or a phenyl group unsubstituted or substituted by a C1-4-alkyl group, R11 is a thiophenenyl, furanyl or pyrrolyl group, R12 is H or a C1-4-alkyl group and R13 is a C1-8-alkyl group or a phenyl group unsubstituted or substituted by a C1-4-alkyl group; R2 is H or a C1-4-alkyl group; R3 and R4 are independently H or C1-4-alkyl groups; R5 and R6 are independently H, OH or OR14, or taken together are ?O, where R14 is a protecting group; R7 is H or a C1-4-alkyl group; and, R8 is H, R9 is OH and R15 is H, or R15 is H and R8 and R9 taken together are —O—, or R9 is OH and R8 and R15 taken together form a bond; and, R18 and R19 are both H, or R18 and R19 taken together form a bond, or a plant physiologically acceptable salt thereof is useful for inhibiting 9-cis-epoxycarotenoid dioxygenase (NCED) in a plant or seed and is therefore useful for regulating ABA biosynthesis in the plant or seed.Type: ApplicationFiled: July 22, 2009Publication date: June 24, 2010Inventors: Suzanne R. Abrams, Michele C. Loewen, Jason Boyd, Adrian John Cutler, Yuanzhu Gai, Kenneth M. Nelson
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Publication number: 20100152286Abstract: The present invention provides a method for producing fucoxanthin extract, said method comprising: performing absorption of the fucoxanthin extract by using absorbent and then performing elution to remove heavy metals and arsenic salt contained in the fucoxanthin extract, wherein the absorbent is selected from a group having macroporous resin, polyamide, activated carbon, alumina and a combination thereof. The method for producing fucoxanthin extract according to the present invention, the content of heave metal in the fucoxanthin extract can be reduced, while the content of fucoxanthin in the fucoxanthin extract can increase. In addition, the present invention also provides a fucoxanthin extract obtained by the above method, as well as fucoxanthin products containing the fucoxanthin extract.Type: ApplicationFiled: November 16, 2009Publication date: June 17, 2010Applicant: Beijing Gingko Group Biological Technology Co., Ltd.Inventors: Yanmei Li, Liang Li
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Publication number: 20100093847Abstract: [Problem] Fucoxanthin extracted from wakame seaweed (Undaria pinnatifida) is effective as an anti-obesity active agent. However, fucoxanthin is contained in mature (adult) brown algae in a small amount, and accordingly, it takes a long time and high cost to obtain fcoxanthin in an amount sufficient for practical use. Further, an anti-obesity active agent showing a stronger effect has been desired. It is, therefore, an object of the present invention to specify a carotenoid exhibiting anti-obesity activity stronger than that of fucoxanthin and to provide an anti-obesity active agent and an anti-obesity method which use the caritenoid. [Means to Solve the Problem] Intensive and extensive studies have been made as to what carotenoid has an anti-obesity activity stronger than that of fucoxanthin and what material should be used in order to economically obtain such a carotenoid. As a result, the answer has been found that the carotenoid is fucoxanthinol.Type: ApplicationFiled: March 16, 2006Publication date: April 15, 2010Inventors: Kazuo Miyashita, Masashi Hosokawa, Tokutake Sashima
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Patent number: 7696366Abstract: There is provided a novel method for producing a bifunctional epoxy monomer which comprises reacting diolefin with a hydrogen peroxide aqueous solution, in the presence of molybdenum or tungsten oxide as a catalyst to selectively epoxidize a double bound at a specific position. The bifunctional epoxy monomers provided by the present invention are substances widely used in various industrial fields such as chemical industry, as materials for resist materials (particularly solder resist materials), and intermediates of agrochemicals and medicines, and various polymers such as plasticizers, adhesives and coating resins.Type: GrantFiled: May 16, 2006Date of Patent: April 13, 2010Assignee: Showa Denko K.K.Inventors: Hiroshi Uchida, Yuko Sakata, Ritsuko Hirakawa, Kazuhiko Sato, Masanori Ookoshi
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Patent number: 7678798Abstract: The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.Type: GrantFiled: April 12, 2005Date of Patent: March 16, 2010Assignee: Incyte CorporationInventors: Chu-Biao Xue, Ganfeng Cao, Taisheng Huang, Lihua Chen, Ke Zhang, Anlai Wang, David Meloni, Rajan Anand, Joseph Glenn, Brian W. Metcalf
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Publication number: 20090305928Abstract: A mixture of 17-oxabicyclo[14.1.0]heptadec-8-ene and its isomers as an odoriferous substance and an odoriferous or aroma substance mixture comprising 17-oxabicyclo[14.1.0]heptadec-8-ene and one or more further odoriferous or aroma substances are described.Type: ApplicationFiled: January 10, 2007Publication date: December 10, 2009Applicant: Symrise GmbH & Co. KGInventors: Heiko Oertling, Horst Surburg
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Patent number: 7612123Abstract: An object of the present invention is to provide a cyclohexene oxide compound that gives a cured resin having a low refractive index and excellent transparency, curability, mold release properties, and mechanical properties, and that can be used as a component of an actinic radiation curing composition and/or heat curing composition. The present invention is a cyclohexene oxide compound having a cyclohexyl group or a long-chain alkyl group, represented by Formula (1) below (in Formula (1), A denotes a cyclohexyl group, Formula (2) below, or an optionally branched alkyl group having 8 to 16 carbons) (in Formula (2), R1 denotes a hydrogen atom or an optionally branched alkyl group having 1 to 4 carbons and R2 denotes a hydrogen atom or an optionally branched alkyl group having 1 to 4 carbons).Type: GrantFiled: October 4, 2005Date of Patent: November 3, 2009Assignee: Toagosei Co., Ltd.Inventors: Hisao Kato, Yoji Horie, Hiroshi Sasaki
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Publication number: 20090136667Abstract: Method of forming a low dielectric k porous film on a substrate, comprising reacting at least a film matrix precursor compound having silicon, carbon, oxygen and hydrogen atoms, and either at least a pore-forming compound, of the formula (I) wherein R represents: either a linear or branched, saturated or non saturated hydrocarbon radical, or a cyclic saturated or unsaturated hydrocarbon radical, or at least one of the following pore-forming compounds: 1-methyl-4-(1-methyl ethyl)-7-oxabicyclo[2.2.1.]heptane, 1,3,3-trimethyl-2-oxabicyclo[2.2.1.]octane or 1,8-cineole, or 1-methyl-4-(1-methyl ethenyl)-7-oxabicyclo[4.1.0.]heptane; New precursor precursor mixture, and the use of a compound of formula (I), as a pore-forming compound in a chemical vapor deposition of a low dielectric k film on a substrate.Type: ApplicationFiled: March 20, 2007Publication date: May 28, 2009Inventors: Joanne Deval, Manon Vautier
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Patent number: 7501535Abstract: The invention provides novel six and seven-carbon termini-differentiated polypropionate stereotetrads and stereopentads useful in syntheses of natural products. The invention also provides a novel alkylative sulfenylation-desulfonylation process that efficiently transforms enantiopure epoxyvinyl sulfones to syn and anti dienylsulfides in two operations.Type: GrantFiled: September 15, 2003Date of Patent: March 10, 2009Assignee: Purdue Research FoundationInventors: Philip L. Fuchs, David J. Meyers, Eduardo Torres, Taesik Park, In C. Kim, Yuzhong Chen, Douglas Lantrip, Jerry B. Evarts, Jr.
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Publication number: 20080251935Abstract: The invention is based on the discovery that a certain polyester compounds are useful as b-stageable adhesives for the microelectonic packaging industry. The polyester compounds described herein contain ring-opening or ring-forming polymerizable moieties and therefore exhibit little to no shrinkage upon cure. In addition, there are provided well-defined b-stageable adhesives useful in stacked die assemblies. In particular, there are provided assemblies wherein the b-stageable adhesive encapsulates a portion of the wiring members contained within the bondline gap between the stacked die.Type: ApplicationFiled: April 11, 2007Publication date: October 16, 2008Inventor: Stephen Dersham
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Publication number: 20080234455Abstract: Disclosed is an oxetane-containing vinyl ether compound including one or more aromatic or non-aromatic carbocycles and/or two or more vinyl ether structures, such as a compound of Formula: wherein Ring Z1 is non-aromatic carbocycle; Ra is vinyl group of Formula: wherein each of R1, R2, and R3 is hydrogen or C1-C4 alkyl; Wa is single bond or organic group having a valence of (m+1); X1 is, for example, hydrocarbon; “m” and “q” are each 1 or 2; and “p” is 0 to 5. Also disclosed is an alicyclic epoxy-containing vinyl ether compound of Formula: wherein Ring Z2 is non-aromatic carbocycle; Rb is vinyl group of Formula: wherein R4, R5 and R6 are each hydrogen or C1-C4 alkyl; Wb is single bond or organic group having a valence of (r+1); Rc and Rd are hydrogen or alkyl; and “r” and “s” are 1 or 2.Type: ApplicationFiled: March 20, 2008Publication date: September 25, 2008Inventors: Takahiro Iwahama, Tatsuya Nakano, Keizo Inoue, Hiroto Miyake, Tsukasa Yoshida, Mitsuru Ohno, Yoshinori Funaki
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Publication number: 20080173213Abstract: There is provided an ink composition that includes a compound represented by the following formula (I) and that includes a single oxirane fragment, as a partial structure in at least one bicyclic or tricyclic ring, wherein, in the formula (I), A represents a group of atoms forming a bicyclic or tricyclic ring.Type: ApplicationFiled: July 24, 2007Publication date: July 24, 2008Applicant: FUJIFILM CORPORATIONInventor: Kotaro Watanabe
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Publication number: 20080108725Abstract: An object of the present invention is to provide a cyclohexene oxide compound that gives a cured resin having a low refractive index and excellent transparency, curability, mold release properties, and mechanical properties, and that can be used as a component of an actinic radiation curing composition and/or heat curing composition. The present invention is a cyclohexene oxide compound having a cyclohexyl group or a long-chain alkyl group, represented by Formula (1) below (in Formula (1), A denotes a cyclohexyl group, Formula (2) below, or an optionally branched alkyl group having 8 to 16 carbons) (in Formula (2), R1 denotes a hydrogen atom or an optionally branched alkyl group having 1 to 4 carbons and R2 denotes a hydrogen atom or an optionally branched alkyl group having 1 to 4 carbons).Type: ApplicationFiled: October 4, 2005Publication date: May 8, 2008Inventors: Hisao Kato, Yoji Horie, Hiroshi Sasaki
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Publication number: 20080008943Abstract: The present invention provides an ink composition comprising a compound having a fragment containing a cyclic ether group having at least one bicyclo or tricyclic substituent.Type: ApplicationFiled: June 28, 2007Publication date: January 10, 2008Applicant: FUJIFILM CORPORATIONInventor: Kotaro WATANABE