Having -c(=x)-, Wherein X Is Chalcogen, Attached Indirectly To Silicon By Nonionic Bonding Patents (Class 556/418)
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Publication number: 20130281695Abstract: Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.Type: ApplicationFiled: December 1, 2011Publication date: October 24, 2013Applicant: ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD.Inventors: Xianhua Pan, Weijin Li, Qunhui Zhang, Libo Ruan, Wansheng Yu, Fei Deng, Tianhua Ma, Mingwang Huang, Minhuan He
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Publication number: 20130230676Abstract: Compositions are disclosed that comprise at least one compound of formula IV: wherein the variable are as defined in the specification. The compositions are antimicrobial and optionally curable, and useful, inter alia, in dental, medical, and industrial applications for reinforcement and/or adhering two surfaces together.Type: ApplicationFiled: August 24, 2012Publication date: September 5, 2013Inventors: John D. Blizzard, Kirk Kimmerling, Joseph P. Rapp
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Publication number: 20130165682Abstract: The present invention relates to a method for the synthesis of an ? amino acetal, comprising (i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or (ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a solvent.Type: ApplicationFiled: July 6, 2011Publication date: June 27, 2013Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Teck Peng Loh, Jiesheng Tian
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Publication number: 20130059818Abstract: Highly branched macromolecules synthesized from a polyfunctional core, preferably silicon, or polyphenolic, with a carbosilane structure at its periphery functionalized with groups, preferably anionic, giving to the macromolecule a net negative charge. Furthermore, the invention relates to the procedures for their synthesis and their uses as antiviral agents, antibacterial and antifungal agents.Type: ApplicationFiled: February 17, 2011Publication date: March 7, 2013Applicant: UNIVERSIDAD DE ALCALA DE HENARES (UAH)Inventors: Javier De La Mata De La Mata, Rafael Gómez Ramírez, Ma Ángeles Muñoz Fernández, Javier Sánchez-Nieves Fernández, Paula Ortega López, Louis Chonco Jimenez, Beatriz Rasines Moreno, Eduardo Arnaiz Garrido, Ma Jesús Serramia Lobera
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Patent number: 8388859Abstract: A composition comprising a blocked and/or unblocked isocyanate compound and surface-modified nanoscale solid particles that comprise on the surface thereof organic radicals which comprise groups with an active hydrogen or precursors of such groups.Type: GrantFiled: December 5, 2005Date of Patent: March 5, 2013Assignee: Leibniz-Institut fuer Neue Materialien Gemeinnuetzige GmbHInventors: Carsten Becker-Willinger, Martin Kluke, Helmut Schmidt
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Patent number: 8378094Abstract: Coupling-initiator compounds are described that include a silicon-containing coupling moiety and at least one polymerization initiator moiety. The coupling moiety may be linked to the at least one polymerization initiator moiety by at least one linking moiety. The coupling moiety is capable of coupling the compound to a substrate, while the one or more polymerization initiator moieties are capable of initiating a polymerization of a monomer under polymerization conditions. The coupling-initiator compounds may be included in fiber reinforced polymer composites, where the compounds are coupled to the fibers in the composites and participate in the polymerization of the surrounding polymer.Type: GrantFiled: March 15, 2010Date of Patent: February 19, 2013Assignee: Johns ManvilleInventors: Kiarash Alavi Shooshtari, Jawed Asrar, Rajappa Tadepalli, Thomas Burghardt, Klaus Friedrich Gleich
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Publication number: 20130032763Abstract: Diallcoxysilane and monoalkoxysilane functionalized polymers were applied as scale control agents in Bayer process. The polymer inhibitors reduced the quantity of aluminum silicate scale formed in spent liquor while significantly changed the morphology of the scale. Also a method is provided for reducing aluminum silicate scale of Bayer process by adding the dialkoxysilane and monoalkoxysilane functionalized polymer into the Bayer liquor stream.Type: ApplicationFiled: October 5, 2012Publication date: February 7, 2013Applicant: NALCO COMPANYInventor: Nalco Company
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Patent number: 8367740Abstract: An asymmetric organomodified disiloxane surfactant having the formula: MM? wherein M comprises branched hydrocarbon substituents and M? comprises a cationic, anionic or zwitterionic substituent and a polyether substituent that may be combined as one moiety, wherein the disiloxane surfactant has an enhanced resistance to hydrolysis between a pH of about 3 to about 12.Type: GrantFiled: December 26, 2008Date of Patent: February 5, 2013Assignee: Momentive Performance Materials Inc.Inventors: Mark D. Leatherman, George A. Policello, Wenqing N. Peng, Liping Zheng, Roland Wagner, Suresh K. Rajaraman, Xia Zijun
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Publication number: 20120330044Abstract: The invention is directed to chelating agent modified graphene oxides having the following formula G(AB)x; wherein G is graphene oxide, A is selected from the group consisting of —(CH2)m—, —NH—, —S—, —O—Si(—OR1)2(—CH2)m—, —C(?O)—, —C(?O)—O—, —C(?O)—O(CH2)m—, —C(?O)—NH—, —C(?O)—NH—(CH2)m—, —P(?O)2—O—, wherein m is 1-12 and R1 is H, or C1-C12 alkyl; and B is a chelating moiety; wherein the ratio of basic graphene oxide units:x is from about 1:0.00001 to about 1:0.5. Such chelating modified graphene oxides have broad applications in diverse technical fields.Type: ApplicationFiled: June 28, 2012Publication date: December 27, 2012Applicant: MONTCLAIR STATE UNIVERSITYInventor: Shifeng HOU
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Publication number: 20120309713Abstract: This invention discloses N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs, and specifically N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1?-hydroxyvitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.Type: ApplicationFiled: May 16, 2012Publication date: December 6, 2012Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: DeLuca F. Hector, Clagett-Dame Margaret, Plum A. Lori, Chiellini Grazia
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Patent number: 8308971Abstract: Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics.Type: GrantFiled: April 30, 2012Date of Patent: November 13, 2012Assignee: Wildcat Discovery Technologies, Inc.Inventors: Vinay V. Bhat, Gang Cheng, Steven Kaye, Bin Li, Risa Olugbile, Jen-Hsien Yang
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Publication number: 20120282210Abstract: The invention relates to a method for producing siloxanes selectively carrying primary amino groups by reacting them with ammonia, and to compounds produced in this way.Type: ApplicationFiled: December 29, 2010Publication date: November 8, 2012Applicant: Evonik Goldschmidt GmbHInventors: Frauke Henning, Wilfried Knott, Horst Dudzik
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Patent number: 8304568Abstract: Polyhydroxyamido group-containing polyorganosiloxanes contain from 20 to 90% of end groups which are polyhydroxyamido groups, and are free flowing.Type: GrantFiled: July 25, 2008Date of Patent: November 6, 2012Assignee: Wacker Chemie AGInventor: Christian Herzig
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Patent number: 8304553Abstract: A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R1-R3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R4, R11 and R12 are H, a silyl-group, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. 3,4-Dihydropyran compound (9): with R5 and R6 being suitable protecting groups, is reacted to form aldehyde (4): which is oxidized and converted to N-substituted carbamate (3): with R7 being a suitable protecting group. (3) is, via oxazolinidone (13): converted to azido carboxylate ester (2): and then to 4,5-diamino cyclohexene carboxylate ester (1).Type: GrantFiled: December 10, 2008Date of Patent: November 6, 2012Assignee: Nanyang Technological UniversityInventors: Xuewei Liu, Jimei Ma
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Publication number: 20120271051Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.Type: ApplicationFiled: July 3, 2012Publication date: October 25, 2012Applicant: SANOFIInventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
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Publication number: 20120232301Abstract: The present invention relates to the field of organic synthesis, and provides an organosilicon betaine type antimicrobial compound having a general formula I and preparation thereof: the antimicrobial compound provided by the present invention has a reactive functional group—siloxane, which can be subjected to chemical bonding with many material interfaces, thereby endowing a material or article surface treated with the antimicrobial compound I persistent antimicrobial activity. Also, the preparation of the compound has a simple process and easily controlled conditions, and is easy to be industrialized, which facilitates its wide applications.Type: ApplicationFiled: April 7, 2010Publication date: September 13, 2012Applicant: SHENZHEN UNIVERSITYInventors: Shiguo Chen, Zaochuan Ge, Fei Xiao, Yangmiao Mo, Qianzhen Huang, Song Jiang
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Publication number: 20120230932Abstract: The present invention relates to organosilicon polymers containing benzoic acid esters in form of particles, process for their preparation, cosmetic or dermatological composition comprising them, as well as their use for protecting a human or animal living body from UV radiation.Type: ApplicationFiled: October 14, 2010Publication date: September 13, 2012Applicant: INTERQUIM, S.A.Inventors: Adaya Gallardo Sanchez, Santiago Nonell Marrugat, Francisco Marquillas Olondriz, Joan Sallares, Ricardo Miralles Bacete
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Publication number: 20120209020Abstract: Novel amino acid-modified silane compounds having a weakly acidic amino group and a weakly basic carboxyl group are useful as a surface treating agent or textile treating agent.Type: ApplicationFiled: February 10, 2012Publication date: August 16, 2012Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Yoichi Tonomura, Tohru Kubota, Takayuki Honma
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Patent number: 8217050Abstract: The invention provides a compound which is (a) an amino acid derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein R1, R2, L1, Het, A, x, y and W are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.Type: GrantFiled: November 5, 2007Date of Patent: July 10, 2012Assignee: Chroma Therapeutics LimitedInventors: David Festus Charles Moffat, Simon Christopher Hirst, Stuart Thomas Onions
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Patent number: 8138277Abstract: Disclosed are silane-modified urea derivatives which can be produced by reacting diisocyanates with aminosilanes, hydroxysilanes, or mercaptosilanes. The inventive silane-modified urea derivatives are suitable especially for use as auxiliary rheological agents, preferably as thixotropic agents for silane-crosslinking systems, particularly for single-component and two-component adhesives and sealants, paint, lacquers, and coating while causing substantially no increase in viscosity, not being subject to discoloring, being reactive, and positively influencing mechanics.Type: GrantFiled: June 6, 2006Date of Patent: March 20, 2012Assignee: Construction Research & Technology GmbHInventors: Tobias Austermann, Michael Duetsch, Marc Laurent, Helmut Mack, Michael Porsch, Konrad Wernthaler
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Publication number: 20120022266Abstract: The present invention is directed to a fluorosilane represented by (L)3-Si—(CH2)n—(Z1)a—[C(X1)]x—(Z2)l-Q1-Rf where each n is independently an integer from 1 to 12; L is independently chosen from a hydrolysable or non-hydrolysable monovalent group; Rf is chosen from a C2-C12 perfluoroalkyl provided that: i) one fluorine atom of the perfluoroalkyl can be optionally replaced by hydrogen, and/or ii) the perfluoroalkyl can be optionally interrupted by at least one oxygen, methylene, or ethylene; Q1 is chosen from the group consisting of a C2-C12 hydrocarbylene optionally interrupted by at least one divalent organic group; X1 is chosen from O or S; —Z2 is —NH— and Z1 is from the group consisting of —O—, and —S—; each R1 is independently chosen from hydrogen, phenyl, or a monovalent C1-C8 alkyl optionally terminated by —C6H5, preferably H or CH3.Type: ApplicationFiled: September 23, 2011Publication date: January 26, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Axel Hans-Joachim Herzog, Gerald Oronde Brown
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Publication number: 20120022267Abstract: The present invention is directed to a fluorosilane represented by (L)3-Si—(CH2)n—N(-Q3-Rf)-Q1-Rf where each n is independently an integer from 1 to 12; L is independently chosen from a hydrolysable or non-hydrolysable monovalent group Rf is chosen from a C2-C12 perfluoroalkyl provided that: i) one fluorine atom of the perfluoroalkyl can be optionally replaced by hydrogen, and/or ii) the perfluoroalkyl can be optionally interrupted by at least one oxygen, methylene, or ethylene; Q1 is chosen from the group consisting of a C2-C12 hydrocarbylene optionally interrupted by at least one divalent organic group; X1 is chosen from O or S; and b) Q1 and Q3 are independently chosen from the group consisting of a C2-C12 hydrocarbylene interrupted by at least one of —C(O)—O— or —O—C(O)—, and optionally further interrupted by at least one divalent organic group.Type: ApplicationFiled: September 23, 2011Publication date: January 26, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Axel Hans-Joachim Herzog, Gerald Oronde Brown
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Publication number: 20120010168Abstract: A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X?C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.Type: ApplicationFiled: November 3, 2009Publication date: January 12, 2012Inventors: Jeffrey Laskin, Diane Heck, Mou-Tuan Huan, Karine Fabio, C. Jeffrey Lacey, Sherri Young, Pramod Mohanta, Christophe Guillon, Ned Heindel
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Patent number: 8076441Abstract: The present invention relates to a process for cross-linking a silane with the structure (IIa) for the preparation of a product, comprising component (III) twice, in triplicate or in a higher quantity, where the radicals B, R1, Ra, R?, X1 and the indices a and b are defined as above for structure (IIa) and can be identical or different in each case, or for the cross-linking of a condensate, a partial condensate, a polymer or a partial polymer comprising structural units with the structure (IIb) via the bond R1—, characterized in that a silane with the structure (IIa), or an isomer, a re-esterification product or a condensation product of said silane, which condensation product was formed by loss of an alcohol molecule, or a condensate, a partial condensate, a polymer, or a partial polymer comprising structural units of structure (IIb) is reacted with a compound having the structure (IV) Q-R5[-Q?]c,??(IV).Type: GrantFiled: April 18, 2006Date of Patent: December 13, 2011Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventor: Herbert Wolter
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Publication number: 20110282081Abstract: Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.Type: ApplicationFiled: January 21, 2010Publication date: November 17, 2011Applicant: EMORY UNIVERSITYInventors: Lanny S. Liebeskind, Ethel C. Garnier-Amblard, Dennis C. Liotta
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Publication number: 20110245477Abstract: The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.Type: ApplicationFiled: February 8, 2011Publication date: October 6, 2011Applicants: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Amir H. Hoveyda, Simon J. Meek, Robert V. O'Brien, Josep Llaveria Cros, Richard R. Schrock
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Publication number: 20110232178Abstract: Compounds and methods that release 1-methylcyclopropene, 1-trifluoromethylcyclopropene, and other substituted cyclopropenes are disclosed. The compounds and methods overcome present limitations for storage, transportation, and application of the cyclopropene containing compounds by using light, including sunlight, and/or heat as the primary release trigger. Additional products released include innocuous gases and value added aryl-group compounds.Type: ApplicationFiled: March 23, 2011Publication date: September 29, 2011Inventors: John Perrin Davis, Cheryl D. Stevenson
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Publication number: 20110217783Abstract: Cleavable compositions that comprise a polar head, cleavable linker, and a hydrophobic tail; and methods for using them to isolate hydrophobic molecules.Type: ApplicationFiled: November 15, 2010Publication date: September 8, 2011Inventors: Richard M. Caprioli, Ned A. Porter, Jeremy L. Norris
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Publication number: 20110216392Abstract: The present invention relates to the preparation and use of (colored) organic particles carrying electric charge as electrophoretic (image) displaying particles, to electrophoretic dispersions comprising the organic particles carrying electric charge, electrophoretic (image) devices (especially displays) comprising the colored organic particles carrying electric charge, to the novel functionalized particles, and to their use. The particles are obtainable according to a method represented by the reaction scheme as given in FIG. 1.Type: ApplicationFiled: June 25, 2007Publication date: September 8, 2011Inventors: Gabriele Baisch, Reinhold Öhrlein, Peter Simmendinger, Gerardus De Keyzer, Margherita Fontana, Vilas N. Mumbaikar
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Patent number: 7994356Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.Type: GrantFiled: July 9, 2009Date of Patent: August 9, 2011Assignee: Bausch & Lomb IncorporatedInventors: Alok Kumar Awasthi, Jason K. Stanbro, Jay F. Kunzler, Jeffrey G. Linhardt
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Publication number: 20110190525Abstract: Polyhydroxyamido group-containing polyorganosiloxanes contain from 20 to 90% of end groups which are polyhydroxyamido groups, and are free flowing.Type: ApplicationFiled: July 25, 2008Publication date: August 4, 2011Applicant: WACKER CHEMIE AGInventor: Christian Herzig
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Publication number: 20110180195Abstract: Alkoxy-modified silsesquioxane compounds are described. The alkoxy-modified silsesquioxane compounds contain an alkoxysilane group that participates in an alkoxysilane-silica reaction as a silica dispersing agent in rubber, with the release of zero to about 0.1% by weight of the rubber of volatile organic compounds (VOC), especially alcohol, during compounding and further processing. Further described are methods for making alkoxy-modified silsesquioxanes, methods for making vulcanizable rubber compounds containing alkoxy-modified silsesquioxanes, vulcanizable rubber compounds containing alkoxy-modified silsesquioxanes, and pneumatic tires comprising a component that contains alkoxy-modified silsesquioxanes.Type: ApplicationFiled: September 16, 2010Publication date: July 28, 2011Applicant: Bridgestone CorporationInventors: William L. Hergenrother, Chenchy J. Lin, Terrence E. Hogan, Ashley S. Hilton
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Patent number: 7977404Abstract: A dental composite containing a nanoparticulate filler has a resin matrix with structural element (Ib) R is an open-chain and/or cyclic alkylene, arylene, or alkylene arylene with 1-10 C, optionally modified by oxygen, sulfur, carboxyl or amino, R1 is an open-chain and/or cyclic alkylene, arylene, or alkylene arylene with 1-10 C, optionally modified by oxygen, sulfur, carboxyl or amino; R? is an open-chain and/or cyclic alkyl, alkenyl, aryl, alkyl aryl, or aryl alkyl with 1-20 C; B and B? are identical or different and are a straight-chain or branched organically polymerizable group with (meth)acrylate residue; R3 are identical or different and a bond to another Si or hydrogen, alkyl with 1-10 C, or a bond to another metal atom; a is 1 or 2 and b is 0 or 1.Type: GrantFiled: April 19, 2006Date of Patent: July 12, 2011Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Herbert Wolter, Carsten Gellermann, Werner Storch
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Publication number: 20110143967Abstract: Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.Type: ApplicationFiled: December 14, 2010Publication date: June 16, 2011Inventors: Glenn H. McGALL, Anthony D. BARONE, Randall J. TRUE
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Publication number: 20110143966Abstract: Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.Type: ApplicationFiled: August 2, 2010Publication date: June 16, 2011Applicant: Affymetrix, INC.Inventors: Glenn H. McGall, Anthony D. Barone
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Patent number: 7956209Abstract: The invention relates to polyisocyanates containing allophanate groups and silane groups, to a process for preparing them and to their use as a starting component in the production of polyurethane polymers, more particularly as a crosslinker component in polyurethane paints and coatings.Type: GrantFiled: July 11, 2008Date of Patent: June 7, 2011Assignee: Bayer MaterialScience AGInventors: Hans-Josef Laas, Reinhard Halpaap
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Publication number: 20110110998Abstract: Disclosed are oligo- or polysiloxanes, which are characterized by containing at least 3, for example 4-3000, Si atoms in the main chain, and wherein at least one thereof is contained in a moiety of the formula (I) whose open bond of the O atom is linked to another Si atom of the oligo- or polysiloxane main chain, and whose open bond of the Si atom is linked either to another O atom of the oligo- or polysiloxane main chain or to R?1, where R1 and R?1 independently are C1-C10alkyl, R2 and R3 independently are C1-C18alkylene, X is a divalent spacer group selected from O, NR4, N(COR?5), CONR?4, OCONR?4;.Type: ApplicationFiled: July 4, 2007Publication date: May 12, 2011Inventors: Sophie Marquais-Bienewald, Olof Wallquist, Andrea Preuss, Stewart Todd Elder
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Publication number: 20110105779Abstract: Novel crosslink agents are described that provide for the copolymerization of at least one hydrophilic monomer with at least one lens monomer typically used to prepare materials for ophthalmic lenses. The new crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer.Type: ApplicationFiled: January 11, 2011Publication date: May 5, 2011Inventors: Ivan M. Nunez, Joseph A. McGee, David E. Seelye
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Patent number: 7935395Abstract: A liquid crystal molecule is disclosed, having a structure represented by the following general formula (1): wherein X1 is a group selected among groups represented by the following formula (2): X2 is represented by the following formula (3): R1 represents a linear or branched hydrocarbon group or an alkoxy group each having from 4 to 16 carbon atoms; R2 represents an optionally branched organosiloxane or organosilane having from 1 to 6 silicon atoms; other variables in formulae are defined therein.Type: GrantFiled: October 5, 2009Date of Patent: May 3, 2011Assignee: Sony CorporationInventors: Rika Kotake, Hidehiko Takanashi, Ken Kobayashi
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Patent number: 7932414Abstract: The invention relates to silane of formula (Ia), wherein the radicals and indices have the following meaning: R is an alkylene, arylene or alkylenearylene group that can be interrupted by one or more oxygen or sulfur atoms or carboxyl or amino groups or can carry said atoms/groups on their ends opposite the silicon atom; R1 is a Z?-substituted alkylene, arylene or alkylenearylene group, which can be interrupted by one or more oxygen or sulfur atoms or carboxyl or amino groups or can carry said atoms/groups on one of their ends; R? is an alkyl, alkenyl, aryl, alkylaryl or arylalkyl group; B and B? can be identical or different, both radicals can have the meaning of a straight-chained or branched organic group with at least one C?C double bond and at least 2 carbon atoms; B? can mean instead thereof but also —R2aSi(OR3)4-a or —R2aR?bSi(OR3)4-a-b, wherein R2 is an alkylene group and R? has the meaning defined above; X represents a group that can enter into a hydrolytic while forming Si—O—Si bridges; Z? means —NHType: GrantFiled: October 25, 2004Date of Patent: April 26, 2011Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventor: Herbert Wolter
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Publication number: 20110077396Abstract: In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.Type: ApplicationFiled: May 21, 2010Publication date: March 31, 2011Applicant: General Electric CompanyInventors: Brian James Grimmond, Michael James Rishel, Michael Todd Luttrell
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Publication number: 20110037012Abstract: The invention relates to the use of polyamino and/or polyammonium polysiloxane copolymer compounds or aqueous emulsions thereof for initial configuration of fibrous materials, aqueous emulsions of polyamino and/or polyammonium polysiloxane copolymer compounds and a method for initial configuration of fibrous materials.Type: ApplicationFiled: March 5, 2009Publication date: February 17, 2011Applicant: MOMENTIVE PERFORMANCE MATERIALS GMBHInventors: Roland Wagner, Albert Schnering, Karl-Heinz Sockel, Annette Moller, Anita Witossek, Christopher Roos, Jurgen Krott
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Publication number: 20110021762Abstract: A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R1-R3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R4, R11 and R12 are H, a silyl-group, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. 3,4-Dihydropyran compound (9): with R5 and R6 being suitable protecting groups, is reacted to form aldehyde (4): which is oxidized and converted to N-substituted carbamate (3): with R7 being a suitable protecting group. (3) is, via oxazolinidone (13): converted to azido carboxylate ester (2): and then to 4,5-diamino cyclohexene carboxylate ester (1).Type: ApplicationFiled: December 10, 2008Publication date: January 27, 2011Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Xuewei Liu, Jimei Ma
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Publication number: 20110009658Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.Type: ApplicationFiled: July 9, 2009Publication date: January 13, 2011Inventors: Alok Kumar Awasthi, Jason K. Stanbro, Jay F. Kunzler, Jeffrey G. Linhardt
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Patent number: 7855301Abstract: The invention relates to silane of formula (Ia), wherein the radicals and indices have the following meaning: R is an alkylene, arylene or alkylenearylene group that can be interrupted by one or more oxygen or sulfur atoms or carboxyl or amino groups or can carry said atoms/groups on their ends opposite the silicon atom; R1 is a Z?-substituted alkylene, arylene or alkylenearylene group, which can be interrupted by one or more oxygen or sulfur atoms or carboxyl or amino groups or can carry said atoms/groups on one of their ends; R? is an alkyl, alkenyl, aryl, alkylaryl or arylalkyl group; B and B? can be identical or different, both radicals can have the meaning of a straight-chained or branched organic group with at least one C?C double bond and at least 2 carbon atoms; B? can mean instead thereof but also —R2aSi(OR3)4-a or —R2aR?bSi(OR3)4-a-b, wherein R2 is an alkylene group and R? has the meaning defined above; X represents a group that can enter into a hydrolytic while forming Si—O—Si bridges; Z? means —NHType: GrantFiled: October 25, 2004Date of Patent: December 21, 2010Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventor: Herbert Wolter
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Publication number: 20100317819Abstract: Color filter comprising a surface-modified nanoparticle wherein a cationic colorant is covalently attached to the surface of said nanoparticle, a polymerizable mixture for making color filters, a surface-modified nanoparticle and its use.Type: ApplicationFiled: February 20, 2008Publication date: December 16, 2010Applicant: CIBA CORPORATIONInventors: Gerardus De Keyzer, Bernd Lamatsch, Andreas Muehlebach, Francois Rime, Gregor Schmitt
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Publication number: 20100286427Abstract: A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(COR6)—CO—, —CO—N(COR7)— (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents —Y—CH(R12)—COOH, —CHO, —CH?CH—COOH, or —COOR13 (Y represents a single bond, —CH2—, —CH(OH)—, —CO—, —CO—NH—, or —CO—NH—CH2—CO—NH—, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, —CH(R14)—COOH(R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), —[CH2CH2—O]n—CH2—CH2—OH, —CH2—O—[CH2CH2—O]m—CH2—OH, or —[CH(CH3)—CO—O]p—CH(CH3)—COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.Type: ApplicationFiled: October 31, 2007Publication date: November 11, 2010Applicant: RESEARCH FOUNDATION ITSUU LABORATORYInventors: Hideaki Muratake, Koichi Shudo
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Publication number: 20100280239Abstract: Coupling-initiator compounds are described that include a silicon-containing coupling moiety and at least one polymerization initiator moiety. The coupling moiety may be linked to the at least one polymerization initiator moiety by at least one linking moiety. The coupling moiety is capable of coupling the compound to a substrate, while the one or more polymerization initiator moieties are capable of initiating a polymerization of a monomer under polymerization conditions. The coupling-initiator compounds may be included in fiber reinforced polymer composites, where the compounds are coupled to the fibers in the composites and participate in the polymerization of the surrounding polymer.Type: ApplicationFiled: March 15, 2010Publication date: November 4, 2010Inventors: Kiarash Alavi Shooshtari, Jawed Asrar, Rajappa Tadepalli, Thomas Burghardt, Klaus Friedrich Gleich
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Patent number: 7825273Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymeric compositions comprise polymerized cationic hydrophilic siloxanyl monomers prepared by the process disclosed herein.Type: GrantFiled: December 15, 2006Date of Patent: November 2, 2010Assignee: Bausch & Lomb IncorporatedInventors: Derek A. Schorzman, Joseph C. Salamone, Daniel M. Ammon, Jr.
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Publication number: 20100256404Abstract: The present invention provides a contrast agent which ensures 1) high contrast performance, 2) low toxicity, and 3) a simple production process. The present invention provides a contrast agent containing a silsesquioxane represented by General Formula (I), wherein R1, the same or different, is a substituent bonded to Si through a carbon atom, the substituent having, at its terminal, a group represented by General Formula (II), wherein p represents an integer of from 1 to 5; q is the same or different, and represents an integer of from 1 to 5; R2 is the same or different, and represents hydrogen atom, alkyl group, aralkyl group or acyl group, or a group represented by General Formula (III), wherein p, q and R2 are the same as above.Type: ApplicationFiled: September 3, 2008Publication date: October 7, 2010Inventors: Yoshiki Chujo, Kazuo Tanaka, Kensuke Naka