Having -c(=x)-, Wherein X Is Chalcogen, Attached Indirectly To Silicon By Nonionic Bonding Patents (Class 556/418)
  • Patent number: 5061817
    Abstract: The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: October 29, 1991
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Takeisa Ohashi, Kazunori Kan, Noboru Ueyama, Isao Sada, Akimasa Miyama, Kiyoshi Watanabe
  • Patent number: 5051409
    Abstract: 2-Aminodecalin derivatives of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are H or methyl,A is H, OH, O-alkylcarbonyl, O-benzoyl or O-CH.sub.3,R.sup.4 is H, cyclopropyl, alkyl, alkenyl, or alkynyl,R.sup.5 is alkyl, alkenyl or alkynyl which is substituted or unsubstituted,cycloalkyl or cycloalkenyl whic is substituted or unsubstituted, substituted phenylalkyl, substituted cycloalkyl-alkyl, substituted 5-membered heterocyclic ring, bicycloalkyl-alkyl orR.sup.4 and R.sup.5, together with the nitrogen atom, are a substituted or unsubstituted, saturated or unsaturated piperidine radical,their plant-tolerated salts and N-oxides, and fungicides containing these compounds.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: September 24, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Zipplies, Bernhard Zipperer, Hubert Sauter, Norbert Goetz, Franz Roehl, Eberhard Ammermann, Gisela Lorenz
  • Patent number: 5013854
    Abstract: An improved process for preparing trialkylsilyl ester and acid halide derivatives of carboxylic acids is provided along with novel trialkylsilyl ester intermediates of 2-(2-furyl)-2-methoximinoacetic acid.
    Type: Grant
    Filed: February 2, 1989
    Date of Patent: May 7, 1991
    Assignee: Eli Lilly and Company
    Inventor: Charles A. Bunnell
  • Patent number: 5008424
    Abstract: A polish formulation containing as components at least one member selected from the group consisting of waxes, solvents, surfactants, thickening agents, abrasives, dyes, odorants, and other ingredients normally used in making polishes, and as an improvement incorporating a composition which is the reaction product of an acid anhydride and an aminofunctional siloxane. The resulting zwitterionic aminofunctional siloxane can, if desired, be further reacted with a strong acid to provide an equilibrium of the zwitterion and a conjugate acid base pair of the zwitterion and the acid. The invention also includes a method of sheeting water on a surface with the polish, a method of making an aminofunctional siloxane zwitterionomer, and an aminofunctional zwitterionomeric siloxane compound which is the reaction product.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: April 16, 1991
    Assignee: Dow Corning Corporation
    Inventors: Daniel J. Halloran, Kenneth A. Kasprzak, Stefano G. Savastano, Terence J. Swihart
  • Patent number: 5008425
    Abstract: A process which comprises reacting under substantially anhydrous conditions a perfluoroalkyltrihydrocarbylsilane and a carbonyl compound in the presence of a catalyst such that the carbonyl compound is perfluoroalkylated.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: April 16, 1991
    Assignee: Ethyl Corporation
    Inventor: G. Patrick Stahly
  • Patent number: 4997965
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl, phenyl or benzyl,R.sub.2 is C.sub.1 -C.sub.4 alkyl, phenyl or benzyl,a is 0, 1 or 2,R.sub.3 is linear or branched unsubstituted or OH-substituted C.sub.1 -C.sub.12 alkylene or is phenylene,X is --O--, --X-- or --NR.sub.6, wherein R.sub.6 is H, C.sub.1 -C.sub.4 alkyl or --CO--R.sub.5 --OH,b is 0, orb is an integer from 1 to 6 and R.sub.4 is linear or branched unsubstituted or OH-substituted C.sub.1 -C.sub.12 alkylene,Y is --O--, --S-- or --NR.sub.7, wherein R.sub.7 is H or C.sub.1 -C.sub.4 alkyl,R.sub.5 is the divalent radical, diminished by the --CO--O group, of a lactone having a total of 4 to 7 ring members and containing at least one chiral carbon atom and corresponding predominantly to an optically active enantiomeric form, and e is an integer from 1 to 10.These compounds are suitable for the preparation of stationary phases for the chromatographic separation of chiral compounds.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: March 5, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Dieter Lohmann, Richard Dappen
  • Patent number: 4980442
    Abstract: A novel class of silicon-containing vinyl polymers having in its molecule at least one constitutent unit of the formula ##STR1## wherein R.sup.1 is a substituted or unsubstituted monovalent hydrocarbon residue; R.sup.2 is ##STR2## R.sup.3 is hydrogen or methyl group; R.sup.4 is a substituent directly bonded to silicon atom and is selected from a substituted or unsubstituted alkylene, or a substituted or unsubstituted alkylene containing hetero atoms; m and n each is a positive integer, which will fulfill the requirement of 2.ltoreq.m+m.ltoreq.4; A is a direct bond, ##STR3## phenylene or substituted phenylene; B is ##STR4## R.sup.5 and R.sup.6 each represents an alkylene, providing that when A is ##STR5## m+n is 2. The present vinyl polymers are very useful in various technical fields including preparation of lens and other molding products, paints and various industrial resins.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: December 25, 1990
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Hiroharu Ohsugi, Yoshio Eguchi, Satoshi Urano, Ryuzo Mizuguchi
  • Patent number: 4970313
    Abstract: A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## (.beta.-hydroxy lactones) in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: November 13, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Wess, Kurt Kesseler, Ekkehard Baader, Gerhard Beck
  • Patent number: 4943648
    Abstract: Process for preparing a silyl ketene acetal adduct, the process comprising contacting and reacting a silyl ketene acetal and an .alpha.,.beta.-unsaturated compound in the presence of a mercury- or Lewis acid-containing catalyst, for example, HgI.sub.2.
    Type: Grant
    Filed: April 1, 1988
    Date of Patent: July 24, 1990
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Ira B. Dicker
  • Patent number: 4939289
    Abstract: This invention relates to fiber surface treating agents containing a pyromellitate nucleus which have fungicidal, anti-microbial and anti-static properties, and blends of such agents with other types of surface modifiers.
    Type: Grant
    Filed: May 6, 1988
    Date of Patent: July 3, 1990
    Assignee: Allied-Signal Inc.
    Inventors: Bryce C. Oxenrider, David J. Long
  • Patent number: 4927952
    Abstract: Product of condensation of a silanol or a silanol derivative, which comprises an Si atom carrying two organic radicals and two oxygen atoms connected to organic groups other than the radicals; at least one of these organic groups carries at least one NH and a NH.sub.2.
    Type: Grant
    Filed: May 24, 1988
    Date of Patent: May 22, 1990
    Assignee: Exsymol S.A.M.
    Inventors: Jean Gueyne, Marie-Christine Seguin
  • Patent number: 4914221
    Abstract: The invention relates to dimethylsilyl-substituted benzoyl chlorides and a process for preparing the same, which comprises reacting a dihaloaromatic compound with dimethylchlorosilane and magnesium by the Grignard method to form halophenyldimethylsilanes, then reacting the halophenyldimethylsilanes with magnesium in the presence of carbon dioxide to form the corresponding dimethylsilyl-substituted benzoic acids, and thereafter reacting the dimethylsilyl-substituted benzoic acids with a halogenating agent, such as thionyl chloride, to form dimethylsilyl-substituted benzoyl chlorides.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: April 3, 1990
    Assignee: Consortium fur Elektrochemische Industrie GmbH
    Inventors: Peter-Paul Winkler, Franz-Heinrich Kreuzer
  • Patent number: 4912240
    Abstract: The invention relates to novel compositions of organofunctional betaine modified siloxanes having the general formula: ##STR1## wherein each R.sup.a and R.sup.b are lower alkyl groups, R.sup.c and R.sup.d are lower alkylene groups, x ranges from 1-4, and z ranges from 1-4. The compositions of the invention exhibit surfactant properties in that they are effective in lowering the surface tension of water. The invention also regards the process by which these modified siloxanes are made.
    Type: Grant
    Filed: August 1, 1988
    Date of Patent: March 27, 1990
    Assignee: Dow Corning Corporation
    Inventors: Michael J. Owen, Steven A. Snow
  • Patent number: 4898977
    Abstract: The invention relates to novel processes and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R.sup.1 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl or the radical of a natural amino acid, R.sup.2 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, amino, hydroxy, mercapto, sulphinyl, sulphonyl or the radical of a natural amino acid, and R.sup.3 represents optionally substituted hydroxy or amino, by sigmatropic rearrangement of a suitable allyl ester, halolactonisation of the resulting .gamma.,.delta.-unsaturated acid or of a suitable derivative thereof, exchange of halogen for a nitrogen-containing nucleophile, opening of the lactone ring and freeing of the amino group. Compounds of the formula I are starting materials for the preparation of renin-inhibitors which have an anti-hypertensive action.
    Type: Grant
    Filed: August 13, 1987
    Date of Patent: February 6, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Herold, Christof Angst
  • Patent number: 4898957
    Abstract: Organosilicon diamine antimicrobial compounds are described, particularly, ammonium chloride derivatives of multifunctional diamino quanternary salts, and salts containing a combination of amino, ester, and fluoroalkyl, functionality.
    Type: Grant
    Filed: June 7, 1989
    Date of Patent: February 6, 1990
    Assignee: Dow Corning Corporation
    Inventors: Edwin P. Pleueddemann, Anthony Revis
  • Patent number: 4892961
    Abstract: An amino acid derivative of the formula: ##STR1## wherein R.sup.1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: January 9, 1990
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Shiro Terashima, Yoshikazu Kimura, Yoshio Ito, Kunikazu Sakai, Tamejiro Hiyama
  • Patent number: 4891166
    Abstract: Compounds of the general formula ##STR1## are disclosed in which Z is ##STR2## R.sup.1, R.sup.2, R.sup.3 are alkyl groups with 1 to 22 carbon atoms or alkenyl groups with 2 to 22 carbon atoms, at least one of the R.sup.1, R.sup.2 or R.sup.3 groups having at least 10 carbon atoms,R.sup.4, R.sup.5, R.sup.7 are alkyl groups with 1 to 22 carbon atoms or alkenyl groups with 2 to 22 carbon atoms,R.sup.6 is --O-- or the NR.sup.8 group, R.sup.8 being an alkyl or hydroxyalkyl group with 1 to 4 carbon atoms or a hydrogen group,x is 2 to 4,M is a bivalent hydrocarbon group with at least 4 carbon atoms, which has a hydroxyl group and may be interrupted by an oxygen atom,n is a number from 0 to 200, andX.crclbar. is an inorganic or organic anion.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: January 2, 1990
    Assignee: Th. Goldschmidt AG
    Inventors: Dietmar Schaefer, Manfred Krakenberg
  • Patent number: 4888406
    Abstract: A novel class of polymerizable monomers containing silicons represented by the formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted monovalent hydrocarbon residue; R.sup.2 represents an alkylene attached to silicon atom and selected from an unsubstituted alkylene, a substituted alkylene, an unsubstituted alkylene containing hetero atoms or a substituted alkylene containing hetero atoms; m and n each represents a positive number which will fulfil the requirement of 2.ltoreq.m+n.ltoreq.4; R.sup.3 is hydrogen or methyl; A is a direct bond, ##STR2## or a substituted or unsubstituted phenylene; B is ##STR3## R.sup.4 and R.sup.5 each represents an alkylene, providing that when A represents ##STR4## m+n is 2. The invention also provides a preparation method thereof.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: December 19, 1989
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Hiroharu Ohsugi, Yoshio Eguchi, Satoshi Urano, Ryuzo Mizuguchi, Mitsuhiro Takarada
  • Patent number: 4888434
    Abstract: An antimicrobial agent which is a carboxyl group containing amine compound. The compound has the characteristics of an amphoteric surfactant and is silyl group containing. The compound is prepared by reacting an amine, a silane, and a carboxylic acid.
    Type: Grant
    Filed: May 23, 1988
    Date of Patent: December 19, 1989
    Assignee: Dow Corning K.K.
    Inventors: Fujio Sawaragi, Hiroo Taniguchi
  • Patent number: 4879398
    Abstract: A process for making 2,6-disubstituted tyrosine by the noble metal coupling of a disubstituted aromatic halide or diazonium salt with an amino-protected 2-aminoacrylic acid to form a (Z)-.beta.-(disubstituted phenyl)-.alpha.-acylaminoacrylate, and asymmetrically hydrogenating the acrylate to produce the 2,6-disubstituted tyrosine.
    Type: Grant
    Filed: December 31, 1987
    Date of Patent: November 7, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Roy A. Periana, Dennis P. Riley
  • Patent number: 4866192
    Abstract: Organosilicon quaternary ammonium antimicrobial compounds are described, particularly, ammonium chloride derivatives of multifunctional diamino quaternary salts, and salts containing a combination of amino, ester, and fluoroalkyl, functionality.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: September 12, 1989
    Assignee: Dow Corning Corporation
    Inventors: Edwin P. Plueddemann, Anthony Revis
  • Patent number: 4847397
    Abstract: A method of preparing silyl group containing carboxylic acid type amphoteric surfactants in which a hydrocarbon substituted amine compound (1) is reacted with a silane compound (2) to produce a reaction product having at least one amino or imino group in the molecule. The reaction product of (1) and (2) is in turn reacted with a functionalized carboxylic acid to produce the desired amphoteric surfactant material.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: July 11, 1989
    Assignee: Dow Corning Kabushiki Kaisha
    Inventors: Fujio Sawaragi, Hiroo Taniguchi
  • Patent number: 4845258
    Abstract: Quinones may be perfluoroalkylated by means of perfluoroalkyltrihydrocarbyl silane using quaternary ammonium bifluorides, quaternary phosphonium bifluorides or alkali metal bifluorides as catalysts. The reaction--which is conducted under essentially anhydrous conditions, preferably in a suitable liquid phase reaction medium, most preferably a dipolar aprotic solvent--results in the formation of gem-disubstituted cyclohexadienones in which the gem substituents are a perfluoroalkyl group and a trihydrocarbylsiloxy group. These gem-disubstituted compounds in turn can be readily converted to perfluoroalkyl substituted aromatics, thus circumventing the traditional need for photochlorination followed by halogen exchange using hydrogen fluoride as a means of preparing perfluoroalkyl aromatic compounds.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: July 4, 1989
    Assignee: Ethyl Corporation
    Inventor: G. Patrick Stahly
  • Patent number: 4845257
    Abstract: A method of producing a 4-halo-2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid ester or amide, which is a synthetic intermediate of value for the production of cephalosporins containing an aminothiazole group, characterized by reacting a 2-(substituted or unsubstituted)-hydroxyimino-3-oxobutyric acid or an ester or amide thereof with a silylating agent and reacting the resulting novel 2-(substituted)hydroxyimino-3-silyloxy-3-butenoic acid ester or amide with a halogenating agent.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: July 4, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kenzo Naito, Yukio Ishibashi
  • Patent number: 4831177
    Abstract: Compounds of formula X ##STR1## in which R.sub.6 is aryl, R.sub.7 is hydrogen, --OH or alkyl, R.sub.8 is alkyl, R.sub.9 is hydrogen, alkyl, alkenyl, aryl, furyl or --CCl.sub.3, when n is 1, R.sub.10 is alkyl, aryl, camphoryl, --CF.sub.3 or fluoro, or when n is 2, R.sub.10 is alkylene or arylene are latent curing catalysts for acid-curable stoving varnishes. On irradiation, the active curing catalysts which lead to acid-catalysed curing of the resins are formed from the compounds of the formula x.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: May 16, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Rudolf Kirchmayr, Werner Rutsch
  • Patent number: 4824950
    Abstract: This invention relates to chiral compositions.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: April 25, 1989
    Assignee: Sandoz Pharm. Corp.
    Inventor: Sandor Barcza
  • Patent number: 4822901
    Abstract: Novel substituted organosilicon carboxylates characterized by the following formula: ##STR1## wherein M is a monovalent cation: Z represents a moiety hydrolyzable to silanol; R.sup.
    Type: Grant
    Filed: November 30, 1987
    Date of Patent: April 18, 1989
    Assignee: Union Carbide Corporation
    Inventors: Paul H. Mohr, Enrico J. Pepe
  • Patent number: 4820829
    Abstract: There are disclosed novel substituted o-phthalaldehydes of formula I ##STR1## wherein at least one of the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 is Q(alkyl).sub.3, --CH.sub.2 --Q(alkyl).sub.3, --O--Q(alkyl).sub.3, --Q(aryl).sub.3 or --Q(alkylenearyl).sub.3, wherein Q is Si, Sn or Ge, the alkyl moieties contain 1 to 12 carbon atoms, the aryl groups contain 6 or 12 ring carbon atoms and the alkylene radicals contain 1 to 4 carbon atoms, and each of the remaining substituents R.sub.1 to R.sub.4 is a hydrogen or halogen atom or a cyano, nitro, carboxyl or hydroxyl group, a C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or an alkoxycarbonyl group containing 1 to 4 carbon atoms in the alkoxy moiety.The novel o-phthalaldehydes can be polymerized to give polymers that can be used as photoresists.
    Type: Grant
    Filed: January 8, 1987
    Date of Patent: April 11, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Alfred Steinmann
  • Patent number: 4808741
    Abstract: Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reacted with an .alpha.-halo ester, at its amino function. Subsequently, the silyl protectant is removed, and the acid group is reacted with the amino function of an appropriate amino acid such as L-proline, to form the dipeptide product.
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: February 28, 1989
    Assignee: Torcan Chemical Ltd.
    Inventor: Jan Oudenes
  • Patent number: 4804774
    Abstract: Quinones may be perfluoroalkylated by means of perfluoroalkyltrihydrocarbyl silane using trialkylphosphites or hexahydrocarbylphosphorous triamides, or both as catalysts. The reaction --which is conducted under essentially anhydrous conditions, preferably in a suitable liquid phase reaction medium, most preferably a dipolar aprotic solvent--results in the formation of gem-disubstituted cyclohexadienones in which the gem substituents are a perfluoroalkyl group and a trihydrocarbylsiloxy group. These gem-disubstituted compounds in turn can be readily converted to perfluoroalkyl substituted aromatics, thus circumventing the traditional need for photochlorination followed by halogen exchange using hydrogen fluoride as a means of preparing perfluoroalkyl aromatic compounds.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: February 14, 1989
    Assignee: Ethyl Corporation
    Inventor: G. Patrick Stahly
  • Patent number: 4804773
    Abstract: Quinones may be perfluoroalkylated by means of perfluoroalkyltrihydrocarbyl silane using an aminopyridine as catalyst. The reaction--which is conducted under essentially anhydrous conditions, preferably in a suitable liquid phase reaction medium, most preferably a dipolar aprotic solvent--results in the formation of gem-disubstituted cyclohexadienones in which the gem substituents are a perfluoroalkyl group and a trihydrocarbylsilyloxy group. These gem-disubstituted compounds in turn can be readily converted to perfluoroalkyl substituted aromatics, thus circumventing the traditional need for photochlorination followed by halogen exchange using hydrogen fluoride as a means of preparing perfluoroalkyl aromatic compounds.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: February 14, 1989
    Assignee: Ethyl Corporation
    Inventor: G. Patrick Stahly
  • Patent number: 4804772
    Abstract: Quinones may be perfluoroalkylated by means of perfluoroalkyltrihydrocarbyl silane using certain active alkali metal salt catalysts devoid of fluorine (e.g., LiN.sub.3, NaN.sub.3, KN.sub.3, NaCN KCN, CsCN, NaOH, KOH, K.sub.2 CO.sub.3, and Cs.sub.2 CO.sub.3). The reaction--which is conducted under essentially anhydrous conditions, preferably in a suitable liquid phase reaction medium, most preferably a dipolar aprotic solvent--results in the formation of gem-disubstituted cyclohexadienones in which the gem substituents are a perfluoroalkyl group and a trihydrocarbylsiloxy group. These gem-disubstituted compounds in turn can be readily converted to perfluoroalkyl substituted aromatics, thus circumventing the traditional need for photochlorination followed by halogen exchange using hydrogen fluoride as a means of preparing perfluoroalkyl aromatic compounds.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: February 14, 1989
    Assignee: Ethyl Corporation
    Inventor: G. Patrick Stahly
  • Patent number: 4789710
    Abstract: A process for the preparation of a room-temperature curable resin comprises reacting a compound (A) containing at least two acryloyl groups and/or methacryloyl groups in a molecule, and having from 100 to 100,000 of number-average molecular weight, with an aminosilane compound (B) represented by formula, ##STR1## (wherein X is a hydrolyzable group selected from the group consisting of halogen, alkoxy, acryloxy, ketoxymate, amino, acid amide, aminoxy, mercapto, alkenyloxy groups; R.sub.1 is C.sub.1 -C.sub.10 alkyl group, aryl group, or aralkyl group; n is an integer of from 1 to 3, and m is an integer of from 1 to 10),at the ratio of at least 0.2 equivalents of primary amino groups contained in the compound (B) to equivalent of acryloyl groups and/or methacryloyl groups contained in the compound (A), under substantially water-free condition, subsequently reacting the reaction product of aminosilane-modified resin and, furtherwith a monofunctional isocyanate compound (C) represented by formula,R.sub.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: December 6, 1988
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hisao Furukawa, Jo Kawamura
  • Patent number: 4778909
    Abstract: Fast high resolution separations of biopolymers with retention of biological activity have been achieved by hydrophobic interaction chromatography using trialkoxy silyl ethers of the general formula(RO).sub.3 Si--(CH.sub.2).sub.m --O--(CH.sub.2 CH.sub.2 O).sub.n --(CH.sub.2).sub.p R'chemically bonded to silica-based chromatographic supports. In the formula R is alkyl of from one to five carbons, m is an integer from two to five, n is an integer from one to five, p is an integer from zero of ten, and R' is methyl, phenyl, or substituted phenyl. Stable and reproducible bonded phases are prepared in a novel solventless procedure by a bonding process which uses a defined and controlled amount of water on the silica surface and a gaseous or volatile basic catalyst such as ammonia to produce a controlled amount of silane polymerization and cross-linking in addition to extensive bonding between silane and silica.
    Type: Grant
    Filed: May 11, 1984
    Date of Patent: October 18, 1988
    Assignee: Northeastern University
    Inventors: Barry L. Karger, Binyamin Feibush, Neil T. Miller, Alvaro Figueroa
  • Patent number: 4764640
    Abstract: 1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: August 16, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Alex Alder, Jaroslaw Stanek, Daniel Bellus
  • Patent number: 4744812
    Abstract: Substituted diphenyl ethers of the formula ##STR1## where Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen, halogen, nitro, cyano, carboxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylmercapto, haloalkylmercapto, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl or haloalkylsulfonyl, Z.sub.4 is hydrogen, cyano, alkyl, alkoxy, acetoxy or alkylmercapto, Y is hydrogen, halogen, cyano or nitro, X is oxygen, sulfur, sulfinyl or sulfonyl, and A is hydrogen, unsubstituted or substituted alkyl ##STR2## and can also be sulfonyl ##STR3## when X is oxygen, and, when Z.sub.4 is alkoxy or alkylmercapto, can also be a methylene chain --(CH.sub.2).sub.m -- by which the radicals Z.sub.4 --CH--X-- are bonded to form a ring, R.sub.1 is hydrogen, methyl, ethyl or n-propyl, R.sub.2 is cyano, methoxy, ethoxy or ##STR4## where B is OH, ONa, O--alkyl, unsubstituted or substituted phenoxy, --NH.sub.2, --NH--alkyl or --N(alkyl).sub.2, n is 1, 2 or 3, R.sub.3 and R.sub.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: May 17, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Adolf Parg, Bruno Wuerzer, Gerhard Hamprecht
  • Patent number: 4728746
    Abstract: .beta.-Aminothiol ester having the general formula (I): ##STR1## which is useful as an intermediate in the preparation of carbapenen beta-lactam antiobiotics, wherein R.sup.1 is alkyl or aryl and R.sup.2 and R.sup.3 are protective groups. The .beta.-Aminothiol ester of formula (I) is prepared by reacting a .beta.-hydroxythiol ester having the general formula (III): ##STR2## wherein R.sup.1 is as above, with a boron compound having the general formula (IV): ##STR3## wherein each of R and R' is alkyl or cycloalkyl, or R and R' taken together, form a ring including the boron atom in the presence of a tertiary amine, the obtained reaction mixture being reacted with an imine having the general formula (V): ##STR4## Wherein R.sup.2 and R.sup.3 are protective groups, followed by treating the resultant product with hydrogen peroxide.
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: March 1, 1988
    Assignee: Sagami Chemical Research Center
    Inventors: Masakatsu Shibasaki, Takamasa Iimori
  • Patent number: 4723022
    Abstract: A new class of substituted 2,3-naphthalenedicarboxaldehydes (NDA) is disclosed. Such compounds are of the formula: ##STR1## wherein one or more of R.sub.1 -R.sub.8 are various substituting groups. The above compounds react, in the presence of cyanide ion, with compounds containing primary amino groups to form adducts which exhibit a high fluorescent yield and thus are readily detected and measured by fluorometric assaying techniques.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: February 2, 1988
    Assignee: Oread Laboratories, Inc.
    Inventors: Richard S. Givens, Robert G. Carlson, Kasturi Srinivasachar, Takeru Higuchi, Osborne S. Wong, Takeru Higuchi
  • Patent number: 4709064
    Abstract: .beta.-N-substituted aminothiol ester represented by the general formual (I): ##STR1## wherein R.sup.1 is an alkyl group or an aryl group and R.sup.2 is an aralkyl group, a process for preparing the same, and an azetidinone derivative represented by the general formula (VI): ##STR2## wherein R.sup.2 is as above. The .beta.-N-substituted aminothiol ester (I) of the present invention can be an excellent intermediate for preparing the .beta.-lactam (II).
    Type: Grant
    Filed: July 23, 1986
    Date of Patent: November 24, 1987
    Assignee: Sagami Chemical Research Center
    Inventors: Masakatsu Shibasaki, Takamasa Iimori
  • Patent number: 4697026
    Abstract: Acryl functional silicone compounds are made by reacting an amine functional silicon compound with a di- or multi-functional acryl compound by a Michael-type addition reaction. These acryl functional silicone compounds are purer than others because no catalyst is used and no by-products are formed. These acryl functional silicone compounds can be used as adhesion promoters and as coating compositions which can be cured by ultraviolet radiation.
    Type: Grant
    Filed: January 6, 1986
    Date of Patent: September 29, 1987
    Assignee: Dow Corning Corporation
    Inventors: Chi-long Lee, Michael A. Lutz
  • Patent number: 4689422
    Abstract: A novel ligand system useful in preparation of dimethyl carbonate is prepared by complexing a metal salt such as cuprous chloride Cu.sub.2 Cl.sub.2 with a ligand formed by reacting a carbonyl-containing compound such as ethyl formate with an organosilicon compound such as ethyl formate with an organosilicon compound containing alkoxy and amine functionality, such as 3-aminopropyltriethoxysilane or [3-(2-aminoethyl)aminopropyl]trimethoxysilane.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: August 25, 1987
    Assignee: Texaco Inc.
    Inventors: Robert A. Sawicki, Harry Chafetz
  • Patent number: 4683296
    Abstract: A new process is provided for preparing the key carbapenem intermediates of the formula ##STR1## wherein R.sup.5 and R.sup.6 each independently represent hydrogen or methyl and R.sub.1 represents a conventional carboxyl-protecting group.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: July 28, 1987
    Assignee: Bristol-Myers Company
    Inventors: Yasutsugu Ueda, Guy Roberge
  • Patent number: 4670421
    Abstract: This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: June 2, 1987
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Janis Upeslacis
  • Patent number: 4661611
    Abstract: Polyfunctional acyl silanes of the formula ##STR1## are disclosed as novel crosslinking agents. Composition and processes involving the same are also disclosed.
    Type: Grant
    Filed: December 6, 1985
    Date of Patent: April 28, 1987
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Subhash C. Narang, Richard Vicari, Juesheng Gu
  • Patent number: 4649156
    Abstract: The present invention provides a novel 6-nitroprostaglandin derivatives of the formula (I) ##STR1## wherein A, n, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in claim 1.The 6-nitroprostaglandin derivatives is useful as medicines because of its excellent pharmacological activities including platelet aggregation inhibiting activity, blood pressure lowering activity and anti-ulcerous activity, and useful as intermediate for other pharmaceutically active compounds such as 6-oxoprostaglandin derivatives, prostaglandin E.sub.1 derivatives, etc.
    Type: Grant
    Filed: July 19, 1985
    Date of Patent: March 10, 1987
    Assignee: Teijin Limited
    Inventors: Toshio Tanaka, Atsuo Hazato, Seizi Kurozumi
  • Patent number: 4594446
    Abstract: The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: June 10, 1986
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Ikuo Ueda, Takao Takaya, Masakazu Kobayashi, Takashi Masugi, Hisashi Takasugi, Hiromu Kochi, Tadashi Kitaguchi
  • Patent number: 4590224
    Abstract: Siloxane modified isocyanurate polymers are disclosed which are the reaction product of a siloxane containing polyahl and a polyisocyanate in the presence of a catalyst for a trimerization of the isocyanate to form isocyanurate rings.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: May 20, 1986
    Assignee: The Dow Chemical Company
    Inventor: Kurt C. Frisch, Jr.
  • Patent number: 4574153
    Abstract: Antibacterial activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein, R.sub.1 is an acyl group derived from a carboxylic acid;R.sub.2 is hydrogen, methoxy, or formamido ##STR2## and one of R.sub.3 and R'.sub.3 is hydrogen and the other is ##STR3## and R.sub.4 is hydrogen alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl.
    Type: Grant
    Filed: March 1, 1985
    Date of Patent: March 4, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Kronenthal, Paula L. Kuester, William H. Koster
  • Patent number: 4562278
    Abstract: Organosilicon compounds which are silanes or siloxanes characterized by the presence of silicon-bonded groups of the formula ##STR1## in which X represents --OH, --OCH.sub.3 or OC.sub.2 H.sub.5 when p=1 or --OH or dialkylamino when p=0, n can be 0 or 1 and p=0 or 1.
    Type: Grant
    Filed: October 12, 1984
    Date of Patent: December 31, 1985
    Assignee: Dow Corning, Ltd.
    Inventor: Michael P. Hill
  • Patent number: 4554369
    Abstract: Organosilicon compounds which are silanes or siloxanes characterized by the presence of silicon-bonded groups represented by the general formula ##STR1## in which R' is a divalent hydrocarbon group which may contain ether oxygen, R" represents --CHBCH.sub.2 -- or --C.sub.6 H.sub.9 B-- in which B is OH or the group ##STR2## a and n are each 0 or 1 and Y is --OH, lower alkoxy or --NX.sub.2 wherein X represents hydrogen or lower alkyl.The compounds are prepared by the reaction of an organosilicon compound having an organic substituent which contains an epoxy group, and the appropriate acid or acid chloride. They absorb ultra violet radiation and are useful as cosmetic and other sunscreen agents.
    Type: Grant
    Filed: August 16, 1984
    Date of Patent: November 19, 1985
    Assignee: Dow Corning Ltd.
    Inventors: Michael P. Hill, Gilbert H. Pittet