Phenolic Hydroxy Or Metallate Patents (Class 562/478)
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Patent number: 11493516Abstract: The present invention relates to a metabolic biomarker set for use in assessing breast cancer in a mammalian subject. In particular, the invention relates to a metabolic biomarker set for screening and/or diagnosing breast cancer, the metabolic biomarker set including at least (a) one amino acid selected from glutamine, glutamate and serine, and one lipid, or (b) glutamine and glutamate. Further, the invention relates to a metabolic biomarker set for prediction of therapeutic response to breast cancer neoadjuvant chemotherapy. Moreover, the present invention relates to a method for assessing breast cancer, which includes obtaining a biological sample, preferably blood, from a mammalian subject and measuring in the biological sample the amount and/or ratios of metabolites. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess breast cancer.Type: GrantFiled: March 9, 2021Date of Patent: November 8, 2022Assignee: Metabolomycs, IncInventors: Andre Lopes Carvalho, Rene Aloisio Da Costa Vieira, Ismael Dale Cotrim Guerreiro Da Silva, Edson Guimaraes Lo Turco, Therese Koal
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Publication number: 20150105338Abstract: The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C1 or C2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH, for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow.Type: ApplicationFiled: July 17, 2014Publication date: April 16, 2015Applicant: PROVEXIS NATURAL PRODUCTS LIMITEDInventor: Niamh O'Kennedy
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Publication number: 20150045389Abstract: The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in compositions and methods for ameliorating or treating a respiratory disease such as cystic fibrosis or secondary infection thereof.Type: ApplicationFiled: April 9, 2013Publication date: February 12, 2015Inventors: Dean R. Madden, Christopher D. Bahl, Bruce D. Hammock, Christophe Morisseau
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Patent number: 8912332Abstract: The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalization of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. The remaining fourth bridgehead position is easily suitable to be further functionalized via so-called click reactions, e.g. with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents.Type: GrantFiled: September 7, 2011Date of Patent: December 16, 2014Assignee: Justus-Liebig-Universitaet GiessenInventors: Wolfgang Maison, Faiza Khalil, Elisa Franzmann
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Publication number: 20140308733Abstract: The present application relates to a method for inducing germination of a spore forming bacterium, specifically, a method for inducing germination of a spore forming bacterium, comprising: using one or more compounds having a phenolic backbone to induce germination of a spore forming bacterium selected from the group consisting of the genus Bacillus, the genus Geobacillus, and the genus Aeribacillus; to a germination inducer for a spore forming bacterium; and to a kit for use in germination of a spore forming bacterium.Type: ApplicationFiled: September 6, 2012Publication date: October 16, 2014Inventors: Toki Nishiyama, Nobuhisa Ashida, Gentaro Yasuda, Yukie Tadano
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Publication number: 20140275236Abstract: This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Inventors: Ming Yuen LEE, Zaijun ZHANG, Guohui LI
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Patent number: 8754285Abstract: The invention relates generally to thin-film adhesive materials suitable for various applications. In particular, the present invention provides pliable viscoelastic thin-films configured to form strong water-resistant adhesive bonds to various surface types.Type: GrantFiled: July 14, 2010Date of Patent: June 17, 2014Assignee: Kensey Nash CorporationInventors: Bruce P. Lee, Jediah White, Fangmin Xu, John L. Murphy, Laura Vollenweider
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Patent number: 8614168Abstract: The invention relates to the use of at least one compound, selected from the group consisting of tebuconazole, epoxiconazole, metconazole, cyproconazole, prothioconazole and any mixtures thereof, for increasing the resistance of plants to abiotic stress factors.Type: GrantFiled: July 24, 2009Date of Patent: December 24, 2013Assignee: MonheimInventors: Jan Dittgen, Isolde Häuser-Hahn, Heinz Kehne, Stefan Lehr, Jörg Tiebes, Marco Busch
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Publication number: 20130217869Abstract: A method for the preparation of lignin, characterized in that an acid is added to an alkaline alcoholic solution of lignin and the precipitated lignin is separated, and, optionally, from the filtrate alcohol is removed in order to get further lignin; as well as a method for the preparation of a concentrated alkaline, alcoholic solution of lignin by membrane filtration; the use of the lignin thus prepared; and the isolation of hydroxy cinnamic acids from the solution, from which the lignin has been separated.Type: ApplicationFiled: October 28, 2011Publication date: August 22, 2013Applicant: ANNIKKI GMBHInventors: Thomas Ters, Halim Fuqaha, Anton Friedl, Ewald Srebotnik, Florian Zikeli, Kurt Messner
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Patent number: 8470831Abstract: Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R?, R?, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.Type: GrantFiled: September 23, 2009Date of Patent: June 25, 2013Assignee: Cogenia SRLInventors: Daniele Fancelli, Mario Varasi, Simon Plyte, Marco Ballarini, Anna Cappa, Giacomo Carenzi, Saverio Minucci, Gilles Pain, Manuela Villa
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Patent number: 8426623Abstract: A surface modified nanoparticle includes a nanoparticle and a phenol compound used for modifying the nanoparticle. The phenol compound has a formula of (a) or (b), wherein n=1˜9, X is selected from the group consisted of NH2, OH, PH4, COOH and SH, R1 is selected from the group consisted of C1-C5 alkyl group, aryl group, alkenyl group, alkynyl group, alkylamino group and alkoxy group. Each carbon atom of the phenol group may be independently substituted or non-substituted. The substituent of the carbon atom of the phenol may be selected from the group consisted of halogen, C1-C5 alkyl group, cyano (CN), trifluoromethyl (CF3), alkylamino group, amino and alkoxy group. The present invention may be used for anti-oxidant and/or decreasing the toxicity of the nanoparticle. A preparation method of surface modified nanoparticle is also herein provided.Type: GrantFiled: August 30, 2010Date of Patent: April 23, 2013Assignee: National Tsing Hua UniversityInventors: Yuh-Jeen Huang, Kuan-Yi Chen
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Publication number: 20130053573Abstract: New triaminophenol compositions and related compounds are disclosed, as are processes for their preparation and for the preparation of novel salts and diacid complexes from such compounds. Polymers prepared from these compositions can be made into high strength fiber, film, and tape and are useful in applications such as protective apparel, aircraft, automotive components, personal electronics, and sports equipment.Type: ApplicationFiled: December 21, 2010Publication date: February 28, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Rajiv Dhawan, Joachim C. Ritter
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Publication number: 20130023056Abstract: A monitoring test for recurrent breast cancer with a high degree of sensitivity and specificity is provided that detects the presence of a panel of multiplicity of biomarkers that were identified using metabolite profiling methods. The test is capable of detecting breast cancer recurrence about a years earlier than current available monitoring diagnostic tests. The panel of biomarkers is identified using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GC×GC-MS) to produce the metabolite profiles of serum samples. The NMR and GC×GC-MS data are analyzed by multivariate statistical methods to compare identified metabolite signals between samples from patients with recurrence of breast cancer and those from patients having no evidence of disease.Type: ApplicationFiled: September 21, 2012Publication date: January 24, 2013Applicant: PURDUE RESEARCH FOUNDATIONInventor: PURDUE RESEARCH FOUNDATION
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Patent number: 8278332Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold.Type: GrantFiled: October 27, 2011Date of Patent: October 2, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20120238638Abstract: This invention pertains to a method of modifying biocides obtained from biological sources, namely polyphenols. The modified biocide may have protective groups to reduce or prevent the oxidation of these phenols. The protective groups may also control the rate of hydrolyzation with regards to biocide efficacy. This invention also includes a method wherein the modified biocide may be incorporated and stabilized into a substrate like plastic.Type: ApplicationFiled: March 19, 2012Publication date: September 20, 2012Inventor: Jorma Antero Virtanen
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Patent number: 8263051Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from resveratrol compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of resveratrol compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the resveratrol compound is concentration dependent, with the amount of resveratrol photostabilization increasing with the concentration of the alkoxycrylene compound.Type: GrantFiled: April 5, 2011Date of Patent: September 11, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20120201803Abstract: A process for forming a solid electrolytic capacitor and an electrolytic capacitor formed by the process. The process includes: providing an anode wherein the anode comprises a porous body and an anode wire extending from the porous body; applying a thin polymer layer onto the dielectric, and forming a dielectric on the porous body to form an anodized anode; applying a first slurry to the anodized anode to form a blocking layer wherein the first slurry comprises a first conducting polymer with an median particle size of at least 0.05 ?m forming a layer of crosslinker on the blocking layer; and applying a layer of a second conducting polymer on the layer of crosslinker.Type: ApplicationFiled: September 15, 2011Publication date: August 9, 2012Applicant: WELLSTAT THERAPEUTICS CORPORATIONInventors: Shalini Sharma, James Dennen O'Neil, Reid W. von Borstel, Ramchandran Arudchandran
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Publication number: 20120179083Abstract: The invention relates generally to thin-film adhesive materials suitable for various applications. In particular, the present invention provides pliable viscoelastic thin-films configured to form strong water-resistant adhesive bonds to various surface types.Type: ApplicationFiled: July 14, 2010Publication date: July 12, 2012Applicant: KNC NER ACQUISITION SUB, INC.Inventors: Bruce P. Lee, Jediah White, Fangmin Xu, John L. Murphy, Laura Vollenweider
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Publication number: 20120156139Abstract: The invention relates to a neurochemical agent comprising at least one isotopically labeled carbon atom directly bonded to at least one deuterium atom, uses thereof for the manufacture of a composition for diagnosing and evaluating a condition or disease and kits comprising said agent. The invention further encompasses methods for diagnosing and evaluating a condition or disease in a subject utilizing a composition of the invention.Type: ApplicationFiled: January 14, 2010Publication date: June 21, 2012Inventor: Rachel Katz-Brull
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Publication number: 20120138789Abstract: Phosphonium-based room temperature ionic liquids (“RTILs”) were prepared. They were used as matrices for Matrix-Assisted Laser Desorption Ionization (MALDI) mass spectrometry and also for preparing samples of dyes for analysis.Type: ApplicationFiled: December 2, 2010Publication date: June 7, 2012Applicant: Los Alamos National Security, LLCInventors: Rico E. Del Sesto, Andrew T. Koppisch, Katherine S. Lovejoy, Geraldine M. Purdy
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Publication number: 20120088784Abstract: The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.Type: ApplicationFiled: November 4, 2011Publication date: April 12, 2012Inventors: Boulos Zacharie, Christopher Penney, Lyne Gagnon, Jean-François Bienvenu, Valérie Perron, Brigitte Grouix
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Patent number: 8101793Abstract: Are described compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.Type: GrantFiled: July 18, 2002Date of Patent: January 24, 2012Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Lucio Merlini, Sabrina Dallavalle, Sergio Penco, Giuseppe Giannini, Claudio Pisano, Loredana Vesci
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Publication number: 20110295030Abstract: A surface modified nanoparticle includes a nanoparticle and a phenol compound used for modifying the nanoparticle. The phenol compound has a formula of (a) or (b), wherein n=1˜9, X is selected from the group consisted of NH2, OH, PH4, COOH and SH, R1 is selected from the group consisted of C1-C5 alkyl group, aryl group, alkenyl group, alkynyl group, alkylamino group and alkoxy group. Each carbon atom of the phenol group may be independently substituted or non-substituted. The substituent of the carbon atom of the phenol may be selected from the group consisted of halogen, C1-C5 alkyl group, cyano (CN), trifluoromethyl (CF3), alkylamino group, amino and alkoxy group. The present invention may be used for anti-oxidant and/or decreasing the toxicity of the nanoparticle. A preparation method of surface modified nanoparticle is also herein provided.Type: ApplicationFiled: August 30, 2010Publication date: December 1, 2011Applicant: National Tsing Hua UniversityInventors: Yuh-Jeen Huang, Kuan-Yi Chen
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Publication number: 20110281949Abstract: Use of alkyl phenol and monocyclic monoterpene-derived compounds in the treatment of neuronal damage and in inhibiting activity of TRPC and non-thermo-TRPM channels, and use of bicyclic monoterpene-derived compounds in activating TRPC and non-thermo-TRPM channels.Type: ApplicationFiled: February 3, 2011Publication date: November 17, 2011Inventors: Baruch Minke, Moshe Parnas
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Publication number: 20110251242Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from resveratrol compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of resveratrol compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the resveratrol compound is concentration dependent, with the amount of resveratrol photostabilization increasing with the concentration of the alkoxycrylene compound.Type: ApplicationFiled: April 5, 2011Publication date: October 13, 2011Applicant: HALLSTAR INNOVATIONS CORP.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20110217783Abstract: Cleavable compositions that comprise a polar head, cleavable linker, and a hydrophobic tail; and methods for using them to isolate hydrophobic molecules.Type: ApplicationFiled: November 15, 2010Publication date: September 8, 2011Inventors: Richard M. Caprioli, Ned A. Porter, Jeremy L. Norris
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Publication number: 20110212913Abstract: The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C1 or C2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH; for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation.Type: ApplicationFiled: November 2, 2009Publication date: September 1, 2011Applicant: PROVEXIS NATURAL PRODUCTS LIMITEDInventor: Niamh O'Kennedy
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Publication number: 20110195977Abstract: Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R?, R?, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.Type: ApplicationFiled: September 23, 2009Publication date: August 11, 2011Inventors: Daniele Fancelli, Varasi Mario, Simon Plyte, Marco Ballarini, Anna Cappa, Giacomo Carenzi, Saverio Minucci, Gilles Pain, Manuela Villa
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Publication number: 20110152222Abstract: The present invention relates to the use of a compound of Formula (I??) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of arthritis and pain.Type: ApplicationFiled: August 15, 2007Publication date: June 23, 2011Inventors: Pedro Cuevas Sànchez, Guillermo Gimenez Gallego
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Publication number: 20110028758Abstract: A compound of formula (I) or its pharmaceutically acceptable salt is prepared by ring opening of osthol under basic condition. The compound of formula (I) or its pharmaceutically acceptable salt has activity of selectively inhibiting tumor cells and lower toxicity, and can be used for preparing anti-tumor drugs.Type: ApplicationFiled: June 4, 2008Publication date: February 3, 2011Inventors: Wei Wang, Jun Ying, Wenzhan Chen, Xuebin Liu, Kui Xu, Qingchun Ni
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Publication number: 20100319091Abstract: A method of enhancing production of a phenylpropanoid compound in a plant or plant cell is disclosed. The method comprising: (a) expressing in the plant or plant cell a heterologous polynucleotide which produces a myb gene of the phenylpropanoid pathway; and (b) contacting the plant or plant cell with at least one substrate of the phenylpropanoid pathway, the substrate being upstream to the production of the phenylpropanoid compound, thereby enhancing the production of a phenylpropanoid compound in the plant or plant cell.Type: ApplicationFiled: November 13, 2008Publication date: December 16, 2010Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWInventors: Alexander Vainstein, Michal Moyal-Ben-Zvi, Ben Rimon-Spitzer
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Publication number: 20100247434Abstract: An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.Type: ApplicationFiled: March 22, 2010Publication date: September 30, 2010Inventors: Frank L. Greenway, Zhijun Liu, Eugene A. Woltering
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Publication number: 20100234555Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.Type: ApplicationFiled: October 11, 2009Publication date: September 16, 2010Applicant: Rutgers, the State UniversityInventors: Durgadas Bolikal, Don K. Brandom, Lioubov Kabalnova, Ernest G. Baluca, Joachim Kohn
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Publication number: 20100217027Abstract: A process in which a phenol derivative is iodinated to produce a 2-iodophenol or 2,6-diiodophenol derivative substituted with iodine at an ortho position thereof is provided, which does not require any step of recovery of iodine but can produce it at low cost, in high yield and with high quality. A phenol derivative is mixed with a pyridine and hydrogen peroxide or iodic acid as an oxidizing agent, and reacted with molecular iodine. As a result, iodination can be performed very efficiently with iodine in an amount close to the theoretical amount relative to the phenol derivative, and the 2-iodophenol or 2,6-diiodophenol derivative can be obtained in high yield and with high quality.Type: ApplicationFiled: August 28, 2008Publication date: August 26, 2010Applicant: Mitsubishi Gas Chemical Company, Inc.Inventor: Kazuo Tanaka
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Publication number: 20100105771Abstract: The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.Type: ApplicationFiled: October 29, 2008Publication date: April 29, 2010Inventors: Mitchell A. deLong, Jill Marie Sturdivant
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Publication number: 20100062131Abstract: The use of a compound for the reduction or elimination of bitterness caused by flavan-3-ols is provided. Compositions having greater than 0.01 wt % flavan-3-ols and that comprise an effective amount of the compound are also provided.Type: ApplicationFiled: September 3, 2009Publication date: March 11, 2010Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Robertus Johannes Gouka, Afrodite Lourbakos
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Publication number: 20090240078Abstract: Multifunctional alcohols, polyols derived from cardanol containing at least 3 hydroxyl groups are disclosed. Such alcohols allow for synthesis of multifunctional crosslinkers such as acrylates, epoxies, and vinyl ethers and flame retardants such as >phosphates. The multifunctional alcohols or polyols can be used in polyurethanes and polycarbonates. The multifunctional crosslinkers can be used in optical coating and waveguide compositions to increase curing speed and crosslink density. The multifunctional phosphates can be used in flame resistant plastics as the highly pendant phosphorus containing phosphate non-halogen flame retardant additives.Type: ApplicationFiled: December 30, 2005Publication date: September 24, 2009Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Vadakkethonippurathu Sivankutty Nair Prasad, Chennakkattu Krishna Sadasivan Pillai
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Publication number: 20090068126Abstract: The molecules capable of absorbing ultraviolet radiation from the cashew nut shell liquid changes are the object of the present invention; it is also described the compositions responsible for protecting the surfaces and chemical processes for the referred molecules production.Type: ApplicationFiled: October 21, 2005Publication date: March 12, 2009Inventors: Luiz Antonio Soares Romeiro, Viviane Candida da Silva, Maria Marcia Murta, Gouvan Cavalcante Magalhaes, Lucio Paulo Lima Logrado, Maria Lucilia dos Santos, Ines Sabioni Resck, Emeli de Araujo Moura, Sheila Garcia, Gisela Maria Dellamora-Ortiz, Alvaro Augusto da Costa Leitao, Celia-Santos da Silva, Zaida Maria Faria de Freitas, Elisabete Pereira dos Santos
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Patent number: 7427691Abstract: The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solvents.Type: GrantFiled: July 6, 2005Date of Patent: September 23, 2008Assignee: Degussa GmbHInventors: Dieter Most, Kai Rossen, Michael Schwarm
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Patent number: 7402713Abstract: Tyrosine was converted to p-hydroxystyrene in a two-step reaction without purification of individual intermediates. Conditions were determined for bromination of tyrosine in which reactive intermediates were formed. The mixture of these intermediates was used directly in a second step reaction to produce p-hydroxystyrene. The p-hydroxystyrene was further acetylated to produce p-acetoxystyrene in the second step reaction vessel.Type: GrantFiled: March 7, 2006Date of Patent: July 22, 2008Assignee: E.I. du Pont de Nemours and CompanyInventors: Steven W. Shuey, Mukesh C. Shah
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Publication number: 20080139843Abstract: Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.Type: ApplicationFiled: February 5, 2008Publication date: June 12, 2008Inventor: Joachim C. Ritter
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Patent number: 6930197Abstract: This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched.Type: GrantFiled: March 22, 2002Date of Patent: August 16, 2005Assignee: Aventis Pharmaceuticals Inc.Inventor: Timothy A. Ayers
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Patent number: 6849762Abstract: The invention relates to a method for the production of trifluoroethoxy-substituted benzoic acids, by reaction of a corresponding halogenated benzoic acid with trifluoroethanol in the solvent tetrahydrofuran, in the presence of a base and a copper salt, followed by an acidic work-up.Type: GrantFiled: May 23, 2001Date of Patent: February 1, 2005Assignee: Merck Patent GmbHInventors: Kai Fabian, Steffen Enke, Herbert Tilly
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Patent number: 6680345Abstract: The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their useType: GrantFiled: September 12, 2002Date of Patent: January 20, 2004Assignee: Boehringer Ingelheim Pharma KGInventors: Guenter Linz, Rainer Soyka, André Steiner
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Publication number: 20030069310Abstract: The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their useType: ApplicationFiled: September 12, 2002Publication date: April 10, 2003Applicant: Boehringer Ingelheim Pharma KGInventors: Guenter Linz, Rainer Soyka, Andre Steiner
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Publication number: 20030032842Abstract: 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high potency of sweetness, can be easily and efficiently prepared on an industrial production from such an aldehyde derivative, via a reductive alkylation reaction with aspartame. Therefore, 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde is extremely excellent as an intermediate for the production of N-[N-[3-(3-methyl-4-hydroxyphenyl)-3- methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester.Type: ApplicationFiled: July 19, 2002Publication date: February 13, 2003Applicant: Ajinomoto Co., Inc.Inventors: Kenichi Mori, Shigeru Kawahara, Tadashi Takemoto
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Patent number: 6437179Abstract: A method is disclosed for preparing a fluorogenic phenolic compound with improved optical qualities for use in formulating a substrate solution for assay of peroxidase or peroxide activity. The method involves forming a solution under anoxic conditions which contains the phenolic compound and an aminopolycarboxylic acid or aminopolyphosphonic acid, or salt thereof, metal chelating agent and, while the solution is maintained under anoxic conditions, recovering the compound from the solution in an optically enhanced condition. A composition of matter is also disclosed which includes the fluorogenic phenolic compound in crystal form and a trace quantity of the metal chelating agent.Type: GrantFiled: August 18, 2000Date of Patent: August 20, 2002Assignee: Pierce Chemical CompanyInventors: M. Dean Savage, Edward K. Fujimoto
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Patent number: 6417178Abstract: Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.Type: GrantFiled: November 6, 1997Date of Patent: July 9, 2002Assignee: University of PittsburghInventors: William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
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Publication number: 20010016664Abstract: New phenolic compounds of formula (I) 1Type: ApplicationFiled: February 7, 2001Publication date: August 23, 2001Applicant: Clariant (France) S.A.Inventors: Didier Wilhelm, Florence Esmard
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Publication number: 20010014756Abstract: The present invention provides aromatic diamine/aromatic dicarboxylate having the following formula (I)Type: ApplicationFiled: December 15, 2000Publication date: August 16, 2001Inventors: Kiyoshi Hotta, Fuyuhiko Kubota