Oximes (hch=n-oh, I.e., Wherein Substitution May Be Made For Hydrogen Only) Patents (Class 564/253)
  • Patent number: 6255353
    Abstract: Certain simple chemical agents, referred to herein as nitrone related therapeutics or “NRTs”, when administered to a patient susceptible to neovascularization (angiogenesis), can intervene and inhibit the disease's progress. Methods for therapeutically and prophylactically inhibiting angiogenesis by administering one or more NRTs are disclosed as are pharmaceutical compositions for use in such methods of treating. NRTs useful in these compositions and therapeutic methods are also disclosed.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: July 3, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Lowell D. Waterbury, Kenneth W. Narducy, Allan L. Wilcox
  • Patent number: 6207863
    Abstract: Disclosed is an improved method for the preparation of highly pure haloformimine compounds in high yields by reacting a formimine compound in a solvent with a halogenating agent while maintaining the pH of the halogenation reaction in the range of 2 to 5. The pH of the reaction may be maintained by a variety of means, such as by the addition of a base.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: March 27, 2001
    Assignee: Rohm and Haas Company
    Inventors: John Vincent Berrier, Ashutosh Sumantrai Umarvadia
  • Patent number: 6197825
    Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: March 6, 2001
    Assignee: Florida International University
    Inventor: David Alan Becker
  • Patent number: 6197999
    Abstract: The invention relates to a process for the preparation of cyclododecanone oxide consists in photochemically reacting cyclododecane, dissolved in chloroform, a nitrosating agent and hydrogen chloride in a virtually anhydrous medium, that is to say under conditions such that the water content in the reaction medium does not exceed 1000 ppm.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: March 6, 2001
    Assignee: Atofina
    Inventors: Jean Ollivier, Damien Drutel
  • Patent number: 6194570
    Abstract: A process for the preparation of lauryllactam comprises: (a) photochemically reacting cyclododecane solubilized in an organic solvent, a nitrosing agent and hydrogen chloride in the presence of an acid in order to form cyclododecanone oxime, and (b) subjecting said oxime to a Beckmann rearrangement in the presence of an acid, said process being characterized in that the acid used comprises methanesulphonic acid.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: February 27, 2001
    Assignee: Atofina
    Inventors: Jean Ollivier, Damien Drutel
  • Patent number: 6187808
    Abstract: This invention provides 6-amino-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one oximes and hydrazones which are useful in treating Parkinson's disease.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: February 13, 2001
    Assignee: Warner-Lambert Company
    Inventors: Stephen Joseph Johnson, Leonard Theodore Meltzer, Lawrence David Wise
  • Patent number: 6166254
    Abstract: Amidoximes are prepared from aqueous hydroxylamine and nitrites to yield amidoximes. Reaction of acetonitrile with aqueous hydroxylamine at ambient temperature yields acetamidoxime crystals.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: December 26, 2000
    Assignee: Silicon Valley Chemlabs, Inc.
    Inventors: Javad J. Sahbari, Jin Wang Russell
  • Patent number: 6130246
    Abstract: The compounds of formula I ##STR1## wherein: a) X is O, andY is OC.sub.1 -C.sub.4 alkyl; orb) X is O or S, andY is NHCH.sub.3have fungicidal properties and can be used in plant protection for controlling and preventing disease infestation.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: October 10, 2000
    Assignee: Novartis Crop. Protection Inc.
    Inventors: Hugo Ziegler, Rene Zurfluh
  • Patent number: 6111139
    Abstract: A compound having the formula 3,3,3-trifluoropropanal oxime, and an improved process for forming 3,3,3-trifluoropropanal and its oxime. The process for producing 3,3,3-trifluoropropanal involves reacting an alkali or alkaline earth metal salt of an alcohol, which alcohol has the formula ROH, where R is a C.sub.1 -C.sub.4 alkyl, with CF.sub.3 CH.dbd.CHCl under conditions sufficient to yield a product mixture comprising at least one of CH.sub.3 CH.dbd.CHOR and CF.sub.3 CH.sub.2 CH(OR).sub.2 ; and then reacting the product mixture of with a C.sub.3 -C.sub.16 alkanoic acid, and heating under conditions sufficient to form 3,3,3-trifluoropropanal. The oxime is prepared by reacting hydroxylamine with 3,3,3-trifluoropropanal under conditions sufficient to produce 3,3,3-trifluoropropanal oxime.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: August 29, 2000
    Inventor: Michael Van Der Puy
  • Patent number: 6096930
    Abstract: The present invention relates to novel cyclohexane-1-3-dione derivatives of formula (1) useful as herbicides and plant-growth regulants, ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 haloalkyl, nitro, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulfinyl, C.sub.1 -C.sub.6 alkylsulfonyl, C.sub.1 -C.sub.6 sulfamoyl, and N, N-di(C.sub.1 -C.sub.6 alkyl)sulfamoyl group; (X)n represents the number of X substituents which may be substituted on benzene ring, wherein n is 1, 2 or 3. Also, cyclohexyl moiety, one of the substituents on benzofuran ring, is substituted at C-4, C-5, C-6 or C-7 position on benzene ring; R.sup.1 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl group; R.sup.2 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl and C.sub.2 -C.sub.6 alkynyl group; R.sup.3 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: August 1, 2000
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Eung Kul Ryu, Kyoung Mahn Kim, Jae Nyoung Kim, Jin Seog Kim
  • Patent number: 6008257
    Abstract: Hydroxamic derivatives of the formula (I): ##STR1## in which A represents hydrogen or a grouping which can be readily eliminated;A.sup.1 represents hydrogen or alkyl;Ar represents optionally substituted arylene or heteroarylene;E represents a 1-alkene-1,1-diyl grouping which contains a radical R.sup.1 in the 2-position, or represents a 2-aza-1-alkene-1,1-diyl grouping which contains a radical R.sup.2 in the 2-position, or represents an optionally substituted imino grouping ("azamethylone", N--R.sup.3);G represents a bridge member as defined herein; andZ represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heterocyclyl;are useful as fungicides. Also disclosed is a process for preparing the compounds of formula (I).
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: December 28, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Kruger, Lutz Assmann, Herbert Gayer, Peter Gerdes, Ulrich Heinemann, Dietmar Kuhnt, Thomas Seitz, Bernd Gallenkamp, Ralf Tiemann, Gerd Hanssler, Heinz-Wilhelm Dehne, Stefan Dutzmann
  • Patent number: 6004724
    Abstract: New oximsulfonate compounds of the formulae I or II, ##STR1## wherein m is 0 or 1; x is 1 or 2; R.sub.1 is, for example phenyl, which is unsubstituted or substituted or R.sub.1 is a heteroaryl radical that is unsubstituted or substituted, or, if m is 0, R.sub.1 additionally is C.sub.2 -C.sub.6 alkoxycarbonyl, phenoxycarbonyl or CN; R'.sub.1 is for example C.sub.2 -C.sub.12 alkylene, phenylene; R.sub.2 has for example one of the meanings of R.sub.1 ; n is 1 or 2; R.sub.3 is for example C.sub.1 -C.sub.18 alkyl, R'.sub.3 when x is 1, has one of the meanings given for R.sub.3, or R'.sub.3 in the formula IV and when x is 2 in the formula 1, is for example C.sub.2 -C.sub.12 alkylene, phenylene; R.sub.4 and R.sub.5 are independently of each other for example hydrogen, halogen, C.sub.1 -C.sub.6 alkyl; R.sub.6 is for example hydrogen, phenyl; R.sub.7 and R.sub.8 are independently of each other for example hydrogen or C.sub.1 -C.sub.12 -alkyl; R.sub.9 is for example C.sub.1 -C.sub.12 alkyl; A is S, O, NR.sub.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: December 21, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hitoshi Yamato, Hartmut Bleier, Jean-Luc Birbaum, Martin Kunz, Kurt Dietliker, Christoph De Leo, Toshikage Asakura
  • Patent number: 5955632
    Abstract: New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: September 21, 1999
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mauro Gobbini, Sergio De Munari, Giorgio Fedrizzi, Patrizia Ferrari, Piero Melloni, Marco Santagostino, Marco Torri
  • Patent number: 5935986
    Abstract: There are described compounds of the general formula I ##STR1## in which the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4;R is nitro, cyano, halogen,unsubstituted or substituted alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy orin the event that n is greater than 1 additionally an unsubstituted or substituted bridge which is bonded to two adjacent ring atoms;R.sup.1, R.sup.2 are alkyl;R.sup.3 is a substituted pyrazole ?sic! or triazole ?sic! radical of the formulae A.1 to A.3 ##STR2## where the bond marked .circle-solid. is the bond to the oxygen, processes for their preparation, and their use.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: August 10, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Muller, Reinhard Kirstgen, Hartmann Konig, Michael Rack, Klaus Oberdorf, Franz Rohl, Hubert Sauter, Gisela Lorenz, Eberhard Ammermann, Siegfried Strathmann, Volker Harries
  • Patent number: 5929279
    Abstract: A process for the preparation of largely isomerically pure .alpha.-bisoximes of the formula IaR.sup.1 O--N.dbd.CR.sup.2 --CR.sup.3 .dbd.N--OR.sup.4 Iawhere the groups R.sup.1 O-- and R.sup.2 on the N.dbd.C bond are cis to one another and where the radicals have the following meanings:R.sup.1 and R.sup.4 are hydrogen or a C-organic radical;R.sup.2 is hydrogen, cyano, nitro, hydroxyl, amino, halogen or an organic radical which can be bonded to the structure directly or via an oxygen, sulfur or nitrogen atom;R.sup.3 is hydrogen, cyano, nitro, hydroxyl, amino, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino, dialkylamino or cycloalkyl,from a mixture of the isomers of the a-bisoximes Ia and Ib ##STR1## is described.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: July 27, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Ruth Muller, Remy Benoit, Herbert Bayer, Norbert Gotz, Hubert Sauter
  • Patent number: 5883106
    Abstract: Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar.sup.1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, indolyl, indazolyl and benzimidazolyl, which is bonded to X.sup.1 through a ring nitrogen atom, and which may be optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino, and C.sub.1-4 alkyl; X.sup.1 is a direct bond or C.sub.1-4 alkylene; Ar.sup.2 is phenylene optionally substituted with halo, hydroxy, cyano, and amino X.sup.2 is --A--X-- or --X--A-- wherein A is a direct bond or C.sub.1-4 alkylene and X is oxy, thio, sulfinyl or sulfonyl; Ar.sup.3 is phenylene, pyridylene, thienylene, furylene, oxazolylene or thiazolylene optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino and C.sub.1-4 alkyl; R.sup.1 and R.sup.2 are each C.sub.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: March 16, 1999
    Assignee: Pfizer Inc.
    Inventors: Rodney W. Stevens, Takashi Mano, Kazunari Nakao, Yoshiyuki Okumura
  • Patent number: 5877190
    Abstract: A compound of formula (I): ##STR1## wherein: R.sub.1 represents unsubstituted or substituted cycloalkyl, phenyl, naphthyl, heterocyclic, alkyl or alkenyl,A represents a bond, oxygen, sulphur, a group ##STR2## a group ##STR3## or a group ##STR4## wherein Rc represents hydrogen, alkyl or cycloalkyl, R.sub.2 represents halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, formyl, carboxy, alkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkyloxycarbonyl, optionally substituted carbamoyl, optionally substituted amino, formylamino, cyano, optionally substituted amidino, hydroxyaminomethyl, amide oxime, hydrazono, or a group selected from: ##STR5## wherein R.sub.21, R.sub.22 and R.sub.23 are as defined in the description, R.sub.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: March 2, 1999
    Assignee: Adir et Compagnie
    Inventors: Alain Dhainaut, Guillaume Poissonnet, Emmanuel Canft, Michel Lonchampt
  • Patent number: 5877340
    Abstract: The invention relates to processes for preparing substituted aromatic amino compounds which contain at least one unsaturated --CN bond or carbonyl group on the aromatic radical or in a side chain, by catalytic hydrogenation of appropriate substituted aromatic nitro compounds in the presence of a modified noble metal catalyst of platinum which is modified with a metal selected from lead, mercury, bismuth, germanium, cadmium, arsenic, antimony, silver and gold.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: March 2, 1999
    Assignee: Novartis Consumer Health S.A.
    Inventors: Peter Baumeister, Urs Siegrist
  • Patent number: 5874596
    Abstract: A titanosilicate catalyst and method for preparing the same, comprising primary titanosilicate particles which are combined with one another, wherein the titanosilicate catalyst comprises pores having a pore diameter of from 50 to 300 .ANG.. The inventive catalyst exhibits activity in a hydroxylation reaction of an aromatic compound, or an epoxidation reaction of an olefin, or an ammoximation reaction of a ketone using hydrogen peroxide as an oxidant.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: February 23, 1999
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Takashi Onozawa, Osamu Kondo
  • Patent number: 5861533
    Abstract: A process for nitrosating C-H-acidic compounds. The process substantially avoids producing polluted wastewater.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: January 19, 1999
    Assignee: Huels Aktiengesellschaft
    Inventors: Frank Bauer, Marcel Feld
  • Patent number: 5808091
    Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: September 15, 1998
    Assignee: Bracco International B.V.
    Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
  • Patent number: 5780624
    Abstract: A process for preparing oxime ethers of the general formula I ##STR1## where R.sup.1 is a C-organic radical,R.sup.2 is hydrogen, alkoxy, cyano, nitro, SOR.sup.4, SO.sub.2 R.sup.4, CO.sub.2 -alkyl, P(O)(OR.sup.4).sub.2 or a C-organic radical, andR.sup.3 and R.sup.4 are unsubstituted or substituted C.sub.1 -C.sub.6 -alkyl, entails converting an oxime of the general formula II ##STR2## where the substituents R.sup.1 and R.sup.2 have the abovementioned meanings, in the presence or absence of an organic diluent, with a base into the corresponding salt, and reacting the latter with a dialkyl carbonate of the general formula III ##STR3## where R.sup.3 has the abovementioned meanings.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: July 14, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Wingert, Michael Keil
  • Patent number: 5756531
    Abstract: The present invention provides a class of substituted indole and indene iminoxy derivatives of the formula ##STR1## which inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: May 26, 1998
    Assignee: Abbott Laboratories
    Inventors: Clint D. W. Brooks, Richard A. Craig, David E. Gunn, Teodozyji Kolasa, Jimmie L. Moore, Andrew O. Stewart
  • Patent number: 5747542
    Abstract: Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: May 5, 1998
    Assignee: Allergan
    Inventors: Vidyasagar Vuligonda, Alan T. Johnson, Richard L. Beard, Min Teng, Tae K. Song, Harold N. Wong, Roshantha A. Chandraratna
  • Patent number: 5741912
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 21, 1998
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5723666
    Abstract: Compounds of the formula ##STR1## have retinoid-like or retinoid antagonist-like biological activity.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: March 3, 1998
    Assignee: Allergan
    Inventors: Vidyasagar Vuligonda, Richard L. Beard, Alan T. Johnson, Min Teng, Tae K. Song, Roshantha A. Chandraratna
  • Patent number: 5719316
    Abstract: The subject-matter of the invention is a process for the preparation of cyclododecanone oxime by photonitrosation of cyclododecane in the presence of hydrochloric acid, characterized in that the nitrosing agent is trichloronitrosomethane.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: February 17, 1998
    Assignee: Elf Atochem S.A.
    Inventor: Jean Ollivier
  • Patent number: 5705531
    Abstract: 1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): ##STR1## where eitherthe symbol - - - - represents a single bond,the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, andA is (CH.dbd.CH).sub.m (CH.sub.2).sub.n OR, (CH.dbd.CH).sub.m (CH.sub.2).sub.n NR.sup.1 R.sup.2, (CH.dbd.CH).sub.m (CH.sub.2).sub.p B, OH, O(CH.sub.2).sub.q OR, O(CH.sub.2).sub.q NR.sup.1 R.sup.2 or O(CH.sub.2).sub.r B;q is an integer from 2 to 5;r is an integer from 1 to 2;orthe symbol - - - - represents a double bond,A is oxygen, CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n OR,CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n NR.sup.1 R.sup.2 orCH(CH.dbd.CH).sub.s (CH.sub.2).sub.p B; andL is ?CH.dbd.C(R.sup.3)!.sub.s CH.dbd.NR.sup.4 or ?CH.dbd.C(R.sup.3)!.sub.s CH.sub.2 NHR.sup.4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: January 6, 1998
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Nicoletta Almirante, Giuseppe Bianchi, Patrizia Ferrari, Piero Melloni
  • Patent number: 5696075
    Abstract: Described herein are compounds of the formula ##STR1## wherein R represents a hydrogen atom or a methyl radical and X stands for a --CHO, or a --CN group, are useful as perfuming ingredients for preparing perfuming compositions and a variety of perfumed articles, to which they impart sandalwood-type odor notes, together with marine, ozone type odor characters, such that said compositions and articles thus acquire a "transparent" connotation. The aldehydes of formula (I) are also useful as starting products for the preparation of the corresponding fragrant alcohols and nitriles.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: December 9, 1997
    Assignee: Firmenich SA
    Inventors: Christian Chapuis, Pierre-Alain Blanc
  • Patent number: 5684201
    Abstract: Aliphatic or cycloaliphatic oximes are prepared by treating aliphatic or cycloaliphatic imines with oxygen or with an oxygen-containing gas in the presence of a catalyst.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: November 4, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Norbert Rieber, Peter Lingelbach, Tom Witzel, Ulrich Muller
  • Patent number: 5675038
    Abstract: The invention is directed to a process for reducing or reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at least two amino groups, selected from the group consisting of primary and secondary amino groups and mixtures thereof, e.g. ethylenediamine and R--NH.sub.2, optionally containing a lower alkyl alcohol, wherein R is chosen from the group consisting of ethyl, propyl, and butyl, including all straight and branched chain isomers thereof, for a time sufficient to effect reduction.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: October 7, 1997
    Assignee: Allergan
    Inventors: Lloyd J. Dolby, Nestor A. Fedoruk, Shervin Esfandiari, Natalie C. Chamberlain, Michael E. Garst
  • Patent number: 5665329
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 9, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5656254
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 12, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5650444
    Abstract: A compound of the following structure: ##STR1## wherein, when R.sub.8 =H: R.sub.1 =alkyl, cycloalkyl, arylalkyl, aryl;R.sub.2 =cycloalkyl, aryl, C.sub.3 -C.sub.10 alkyl;X,Y=O, S(O).sub.n, NH;Z=CHO, CO.sub.2 R.sub.3, CONHR.sub.4 R.sub.5, CN, COR.sub.6, H, halo, HCN, NHCONR.sub.4 R.sub.5, CONR.sub.4 OR.sub.5, CONR.sub.4 NR.sub.5 R.sub.6, 1-tetrazole, S(O).sub.n OH, S(O).sub.n NR.sub.3 R.sub.4, C.dbd.NOH, C(.dbd.N(OH)NH.sub.2, OCONR.sub.7 R.sub.6, P(O)(OR.sub.4).sub.2, C(.dbd.N(YR.sub.3))R.sub.4, NH.sub.2, SH, OH, OS(O).sub.2 R.sub.3, C(.dbd.NYC(.dbd.O)R.sub.3)R.sub.4, C(O)CO.sub.2 R.sub.3, C(O)CONR.sub.3 R.sub.4, CH(OH)CO.sub.2 R.sub.3, CHFCO.sub.2 R.sub.3, CF.sub.2 CO.sub.2 R.sub.3, CH(OH)CONR.sub.3 R.sub.4, CF.sub.2 CONR.sub.3 R.sub.4, C.dbd.NNH.sub.2, C(.dbd.NOC(.dbd.O)R.sub.3)R.sub.4, C(.dbd.NNHC(.dbd.O)R.sub.3)R.sub.4, C(.dbd.NOH)R.sub.3, C(.dbd.NNR.sub.3)R.sub.4, NHC(.dbd.O)R.sub.6 or C(O)CONH.sub.2 ;R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 22, 1997
    Assignee: American Home Products Corporation
    Inventors: Thomas J. Caggiano, Joseph Prol, Jr.
  • Patent number: 5637715
    Abstract: A catalyst includes or consists essentially of the oxides of silicon, aluminum and titanium, characterized in that the catalyst particles are built up from a core with the composition (SiO.sub.2).sub.y (AlO.sub.2).sub.y M.sub.y, wherein x/y=10 to .infin. and M=H, Na, K, NH.sub.4, or NR.sub.4, wherein R is a C.sub.1-8 -alkyl, and a shell with the composition (SiO.sub.2).sub.n (TiO.sub.2).sub.m, wherein n/m=12 to 1000. Both the core and the shell have a crystal structure of MFI or MEL. The catalyst can be prepared by preparing a synthesis gel for the preparation of a titanium silicalite, thereafter introducing an aluminosilicata of the MFI or MEL structural type into this synthesis gel, and working up the synthesis gel in a known manner to obtain the product.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: June 10, 1997
    Assignee: Degussa Aktiengesellschaft
    Inventors: Georg Thiele, Eckehart Roland
  • Patent number: 5627286
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 6, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5608110
    Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: March 4, 1997
    Assignee: Bracco International B.V.
    Inventors: Kondareddiar Ramalingam, Natarajan Raju
  • Patent number: 5597466
    Abstract: Salt-free aqueous solutions of bisaminoxyalkanes (I) are prepared by a process in whicha) a dihaloalkane (II) is converted with a ketoxime (III) in an aqueous solution of a strong mineral base into the alkylene bisoxime ether (IV),b) the alkylene bisoxime ether (IV) is cleaved with a strong mineral acid and water to give the ketone and the salt of the mineral acid with the bisaminoxyalkane (I), and the ketone is separated off in a conventional manner,c) an alkali metal hydroxide is added to the remaining aqueous solution to liberate the bisaminoxyalkane (I) andd) the ionic components are removed from the resulting aqueous solution by electrodialysis.
    Type: Grant
    Filed: July 26, 1994
    Date of Patent: January 28, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Bauer, Roland Baumstark, Kaspar Bott, Hartwig Voss
  • Patent number: 5538986
    Abstract: Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl;R.sup.4 is H, alkyl, alkenyl, alkoxy, or --OH.Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: July 23, 1996
    Assignee: Schering Corporation
    Inventors: Pauline C. Ting, Daniel M. Solomon, Richard J. Friary, Frank J. Villani, John J. Piwinski, Joe F. Lee, Dhiru B. Vashi
  • Patent number: 5466879
    Abstract: A method of making hexafluoroacetone from hexafluoroacetone oxime comprising heating hexafluoroacetone oxime (or solvent complex thereof) with a concentrated mineral acid to yield hexafluoroacetone. Also a method of making hexafluoroacetone oxime from hexafluoroisobutyroyl carbanion alkylammonium salts. The oxime can be prepared by reacting the salts in solvent with an alkali or alkaline earth metal nitrite and subsequently decarboxylating and hydrolyzing the reaction product, or alternatively, reacting the salts in a solvent with dinitrogen tri- or tetra-oxide and subsequently decarboxylating and hydrolyzing the reaction product.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: November 14, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Yuri Cheburkov
  • Patent number: 5462963
    Abstract: The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents having the structure: ##STR1## wherein each --R.sup.1 is independently selected from the group consisting of alkyl, aryl, heteroaryl and heterocycle, or the --R.sup.1 's are covalently bonded together to form a cyclic alkyl or heterocyclic ring; --R.sup.2 and --R.sup.3 are --OR.sup.4, in which case there is no bond or a polar bond between --R.sup.2 and the nitrogen covalently bonded to --R.sup.3, each --R.sup.4 being independently selected from the group consisting of hydrogen, alkyl and aryl, except that both --R.sup.4 's are not methyl when both --R.sup.1 's are furyl; or --R.sup.2 is --O-- and is covalently bonded to the nitrogen which is covalently bonded to --R.sup.3, and --R.sup.3 is --O-- (there being a + charge on the nitrogen to which it is bonded) or nil;wherein the .alpha.
    Type: Grant
    Filed: August 2, 1991
    Date of Patent: October 31, 1995
    Assignee: The Procter & Gamble Company
    Inventors: Rodney D. Bush, Donald L. Bissett
  • Patent number: 5387692
    Abstract: Agents for the diagnosis or treatment of hypoxic cells comprise a bioreductive moiety such as 2-nitroimidazole, and a metal chelating moiety which is a bis-amine oxime of which a carbon atom adjacent a nitrogen atom is linked to the bioreductive moiety. A chelated metal atom or ion preferably Technetium-99m. The agent diffuses into cells where the 2-nitroimidazole is reduced thus trapping the chelated metal in the cell.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: February 7, 1995
    Assignee: Amersham International plc
    Inventors: Anthony L. Riley, James D. Kelly
  • Patent number: 5340810
    Abstract: The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt or solvate thereof wherein R.sup.1 represents a hydrogen atom or a halogen atom or a group selected from C.sub.1-6 alkyl and C.sub.1-6 alkoxy;R.sup.2 represents a phenyl group substituted by a group selected from ##STR2## and optionally further substituted by one or two substituents selected from halogen atoms, C.sub.1-6 alkoxy, hydroxy, and C.sub.1-6 alkyl;R.sup.3 represents the group ##STR3## R.sup.4 and R.sup.5, which may be the same or different each independently represent a hydrogen atom or a halogen atom or a group selected from hydroxy, C.sub.1-6 alkoxy and C.sub.1-6 alkyl;R.sup.6 represents a hydrogen atom or a group selected from --NR.sup.9 R.sup.10 and a C.sub.1-6 alkyl group optionally substituted by one or two substituents selected from C.sub.1-6 alkoxy, hydroxy, C.sub.1-6 acyloxy and --SO.sub.2 R.sup.11 ;R.sup.7, R.sup.8 and R.sup.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: August 23, 1994
    Assignee: Glaxo Group Limited
    Inventors: John W. Clitherow, Malcolm Carter
  • Patent number: 5315039
    Abstract: Thermal decomposition of cycloalkanone oximes is inhibited by allowing nitrogen-containing compounds represented by the following formula (1) to coexist with the cycloalkanone oximes:NR.sub.1 R.sub.2 R.sub.3 (1)(wherein R.sub.1, R.sub.2 and R.sub.3 each represents a hydrogen atom or a lower alkyl group).
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: May 24, 1994
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Kajikuri, Masaru Kitamura, Yasuhiko Higashio
  • Patent number: 5312987
    Abstract: Two-step process in the liquid phase for producing oximes at 60.degree.-100.degree. C. and 1.5-5 bars, which comprises:(a) in a primary step, ammoximating a carbonylic compound with H.sub.2 O.sub.2 and NH.sub.3 in the presence of a silicon, titanium and oxygen based catalyst;(b) oximating the residual carbonylic compound with a solution of hydroxylamine, obtained in its turn by oxidizing ammonia with H.sub.2 O.sub.2, having a concentration comprised within the range of from 0.01 to 3%, preferably of from 0.5 to 2% by weight, in such a way as to have a molar ratio of hydroxylamine to the carbonylic compound comprised within the range of from 0.9 to 3, preferably of from 1 to 2.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: May 17, 1994
    Assignee: Enichem Anic S.r.l.
    Inventors: Maria A. Mantegazza, Guido Petrini, Alberto Cesana
  • Patent number: 5266726
    Abstract: Sterically hindered oximes provide polyolefin compositions, including those also containing a phenolic antioxidant, with improved resistance to discoloration during processing at elevated temperatures.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: November 30, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen D. Pastor, Paul A. Odorisio
  • Patent number: 5254584
    Abstract: Certain N-acetonylbenzamides exhibit low phytotoxicity and are useful for control of a wide range of fungi, including phytopathogenic fungi of the classes Oomycetes, Ascomycetes, Deuteromycetes and Basidiomycetes.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: October 19, 1993
    Assignee: Rohm and Haas Company
    Inventors: Enrique L. Michelotti, Robert R. Raney, David H. Young
  • Patent number: 5227525
    Abstract: A multistep process for the liquid phase ammoximation of carbonyl compounds with H.sub.2 O.sub.2 and NH.sub.3, at 60.degree.-100.degree. C., at 1.5-5 bar and in the presence of a catalyst based on silicon, titanium and oxygen, characterized in that:a) in one or more primary steps, the H.sub.2 O.sub.2 : carbonyl compound molar ratio ranges from 0.9 to 1.15 by mols and the carbonyl component conversion is carried out up to at least 95%;b) in a last (exhaustion) step the H.sub.2 O.sub.2 : carbonyl compound ratio is in a higher range, i.e. from 1.5 to 3.0 by mols.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: July 13, 1993
    Assignee: Enichem Anic s.r.l.
    Inventors: Sergio Tonti, Paolo Roffia, Vittorio Gervasutti
  • Patent number: 5134167
    Abstract: 1-Azabutadienes of the formula ##STR1## where R.sup.1 and R.sup.2 are each phenyl, biphenyl, naphthyl or pyridyl, and these radicals may be substituted, or are each alkyl which is unsubstituted or substituted, R.sup.3 is substituted or unsubstituted phenyl or a radical OR.sup.4, where R.sup.4 is hydrogen, alkyl or an aromatic or aliphatic acyl group, or R.sup.3 is a radical NHR.sup.5, where R.sup.5 is hydrogen, substituted or unsubstituted phenyl, or the carbamide group, and fungicidal agents containing these compounds.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: July 28, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Lauer, Bernhard Zipperer, Norbert Goetz, Gisela Lorenz, Eberhard Ammermann
  • Patent number: 5134183
    Abstract: Sterically hindered oximes provide polyolefin compositions, including those also containing a phenolic antioxidant, with improved resistance to discoloration during processing at elevated temperatures.
    Type: Grant
    Filed: October 22, 1990
    Date of Patent: July 28, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen D. Pastor, Paul A. Odorisio