Plural Amino Nitrogens Containing Patents (Class 564/511)
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Publication number: 20110257334Abstract: A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO2, is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.Type: ApplicationFiled: October 28, 2010Publication date: October 20, 2011Inventors: Philip G. Jessop, Lam N. Phan, Andrew J. Carrier, Rui Resendes, Dominik Wechsler
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Patent number: 7973192Abstract: Hexamethylenediamine and aminocapronitrile are simultaneoussly produced by hemihydrogenation of adiponitrile, which includes a stage of separation of the hexamethylenediamine from the hydrogenate by distillation of the hexamethylenediamine, the distillation of the hexamethylenediamine being carried out from the hydrogenate containing a free acid and/or an alkali metal or ammonium acid salt, whereby a top fraction A recovered at the column top of the stage of distillation of the hexamethylenediamine is essentially crude hexamethylenediamine and a small amount of THA; the amount of THA (tetrahydroazepine) present in the crude hexamethylenediamine constitutes a small proportion of the THA present in the hydrogenate.Type: GrantFiled: October 16, 2006Date of Patent: July 5, 2011Assignee: Rhodia OperationsInventor: Philippe Leconte
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Patent number: 7947854Abstract: The present invention relates to bis-cationic compounds comprising quaternary ammonium groups and/or quaternary phosphonium groups. The invention also relates to the use of bis-cationic compounds as Phospholipase B inhibitors and the use of bis cationic compounds for the treatment or prevention of microbial infection.Type: GrantFiled: November 12, 2004Date of Patent: May 24, 2011Assignee: The University of SydneyInventors: Alfred Werner Widmer, Katrina Anne Jolliffe, Lesley Catherine Wright, Tania Christine Sorrell
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Patent number: 7919656Abstract: The present invention relates to linear amine-functionalized poly(trimethylene ether) compositions, and processes to produce these compositions.Type: GrantFiled: February 12, 2010Date of Patent: April 5, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Kai Qi, Hari Babu Sunkara
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Publication number: 20110060166Abstract: The present invention relates to a process for preparing N,N-substituted 1,3-propanediamine by a) reacting secondary amine with acrolein at a temperature of from (?50) to 100° C. and a pressure of from 0.01 to 300 bar, and b) reacting the reaction mixture obtained in stage a) with hydrogen and ammonia in the presence of a hydrogenation catalyst at a temperature of from 40 to 400° C. and a pressure of from 1 to 400 bar, wherein the molar ratio of secondary amine to acrolein in stage a) is 2:1 or more and the hydrogenation catalyst used in stage b) comprises cobalt. In a preferred embodiment, acrolein which has been obtained from glycerol based on renewable raw materials is used. The invention further relates to the use of N,N-dimethyl-1,3-propanediamine (DMAPA) based on renewable raw materials as a feedstock for lubricant soaps and other detergents, coagulants, polymers and comb polymers. In a further preferred embodiment, stage b) is performed in the presence of water.Type: ApplicationFiled: May 11, 2009Publication date: March 10, 2011Applicant: BASF SEInventors: Martin Ernst, Johann-Peter Melder, Christof Wilhelm Wigbers
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Patent number: 7875253Abstract: An object of the invention is to provide a decomposing system for polyisocyanate residues that is capable of suppressing reaction of polyisocyanate residues with high temperature and high pressure water to allow smooth start-up of the operation, and a start-up method for the decomposing system for the polyisocyanate residues. The decomposing system is used for hydrolyzing the polyisocyanate residues to polyamine using high temperature and high pressure water, comprising a hydrolyzer, a water feed pipe connected to the hydrolyzer, a residual feed pipe connected to the water feed pipe, a solvent feed line for filling an organic solvent in a solvent filling portion of the residual feed pipe, and a solvent draining line. Upon start-up of the operation, the organic solvent is previously filled in the solvent filling portion via the solvent feed line and the solvent draining line, first, and then, the high temperature and high pressure water is fed from the water feed pipe to the hydrolyzer.Type: GrantFiled: July 12, 2006Date of Patent: January 25, 2011Assignee: Mitsui Chemicals, Inc.Inventors: Tadashi Yoshida, Yasumichi Ooto, Akio Saito
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Patent number: 7871602Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.Type: GrantFiled: October 3, 2008Date of Patent: January 18, 2011Assignee: Alcon, Inc.Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
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Publication number: 20100292511Abstract: Impure hexamethylenediamines and more particularly those hexamethylenediamines containing contaminating amounts of tetrahydroazepine (THA), or more generally contaminating amounts of imines, are purified by distillation carried out with a short retention time of the impure hexamethylenediamine in the distillation column; the hexamethylenediamine obtained has a very low concentration of THA.Type: ApplicationFiled: October 3, 2008Publication date: November 18, 2010Inventors: Maria Ignez Broglio, Daniel Amoros, Jean Vannier, Didier Letourneur
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Publication number: 20100267989Abstract: Amino compounds are continuously prepared by hydrogenation of nitrile compounds in the presence of a catalyst, and more particularly diamines are prepared by the continuous hydrogenation of dinitrile compounds in the presence of a Raney metal catalyst and in the absence of an alcoholic solvent; the subject process includes extracting a portion of the catalyst present in the reaction medium, the extracted portion of the catalyst is submitted to a regeneration for providing a catalyst having a catalytic activity lower than that of a fresh catalyst but still high and the regenerated catalyst is recycled to the reaction medium together with fresh catalyst according to a predetermined ratio, whereby the consumption of catalyst is reduced per ton of amines produced.Type: ApplicationFiled: October 2, 2008Publication date: October 21, 2010Inventors: Didier Letourneur, Philippe Leconte, Jean-Francis Spindler, Patrick Lermusiaux, Vincent Boschat
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Publication number: 20100216958Abstract: Isobutene, isoprene, and butadiene are obtained from mixtures of C4 and/or C5 olefins by dehydrogenation. The C4 and/or C5 olefins can be obtained by dehydration of C4 and C5 alcohols, for example, renewable C4 and C5 alcohols prepared from biomass by thermochemical or fermentation processes. Isoprene or butadiene can be polymerized to form polymers such as polyisoprene, polybutadiene, synthetic rubbers such as butyl rubber, etc. in addition, butadiene can be converted to monomers such as methyl methacrylate, adipic acid, adiponitrile, 1,4-butadiene, etc. which can then be polymerized to form nylons, polyesters, polymethylmethacrylate etc.Type: ApplicationFiled: February 24, 2010Publication date: August 26, 2010Inventors: Matthew W. Peters, Joshua D. Taylor, Leo E. Manzer, David E. Henton
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Patent number: 7767774Abstract: This invention relates to a novel polymerization initiator capable of introducing an active amino proton into a polymerization starting terminal without losing polymerization activity, and a novel modified conjugated diene polymer being excellent in the interaction with a filler and capable of improving a low heat buildup of a rubber composition, and more particularly to a polymerization initiator being a diamine compound in which one amino group is protected with a silylating agent and an active proton of the other amino group is replaced with an alkali metal or an alkaline earth metal, and a modified conjugated diene polymer which can be produced by using such a polymerization initiator and is a homopolymer of a conjugated diene compound or a copolymer of a conjugated diene compound and an aromatic vinyl compound and has a residue derived from a diamine compound at its polymerization starting terminal.Type: GrantFiled: March 17, 2005Date of Patent: August 3, 2010Assignee: Bridgestone CorporationInventors: Eiju Suzuki, Yoichi Ozawa
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Patent number: 7767768Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: May 11, 2005Date of Patent: August 3, 2010Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7767858Abstract: This invention provides aromatic diimines which have imino hydrocarbylidene groups with at least two carbon atoms, and aromatic secondary diamines which have amino hydrocarbyl groups with at least two carbon atoms. Both the aromatic diimines and the aromatic secondary diamines either are in the form of one phenyl ring, or are in the form of two phenyl rings connected by an alkylene bridge; each position ortho to an imino group or an amino group bears a hydrocarbyl group. When in the form of one phenyl ring, there are two imino groups on the ring or two amino groups on the ring; the imino groups or amino groups are meta or para relative to each other. When in the form of two phenyl rings connected by an alkylene bridge, there is either one imino group or one amino group on each phenyl ring. Also provided are processes for forming diimines and secondary diamines.Type: GrantFiled: September 14, 2007Date of Patent: August 3, 2010Assignee: Albemarle CorporationInventors: Paul L. Wiggins, Judit Orgad, John Y. Lee, Mahmood Sabahi
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Publication number: 20100152085Abstract: A cleaning solution for semiconductor devices or display devices containing a polyamine of a specified structure having two or more amino groups in adjacent positions of a carbon chain or a salt thereof and a cleaning method of semiconductor devices or display devices using the subject cleaning solution are provided. The cleaning solution for semiconductor devices or display devices of the present invention has high safety, brings a little burden on the environment and is able to easily remove etching residues on a semiconductor substrate in a short time; on that occasion, it is possible to achieve microfabrication without utterly corroding wiring materials; and furthermore, rinsing can be achieved with only water without necessity for use of, as a rinse solution, an organic solvent such as alcohols.Type: ApplicationFiled: November 24, 2006Publication date: June 17, 2010Inventors: Kenji Shimada, Kojiro Abe
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Patent number: 7728175Abstract: The present invention relates to linear amine-functionalized poly(trimethylene ether) compositions, and processes to produce these compositions.Type: GrantFiled: December 23, 2008Date of Patent: June 1, 2010Assignee: E. I. du Pont de Nemours and CompanyInventors: Kai Qi, Hari Babu Sunkara
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Patent number: 7718746Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: GrantFiled: May 22, 2009Date of Patent: May 18, 2010Assignee: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han-Ting Chang, Florence Roger, Gerrit Klaerner, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
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Publication number: 20100093868Abstract: Disclosed are a water-soluble metal-processing agent and a coolant both of which have excellent microbial deterioration resistance and are less likely to go rotten, a method for preparing the agent or the coolant, and a metal processing method. The water-soluble metal-processing agent or the coolant comprises an N,N,N?,N?-tetraalkyldiamine compound. The metal processing method is characterized by processing a metal of interest by using the water-soluble metal-processing agent or the coolant.Type: ApplicationFiled: September 21, 2007Publication date: April 15, 2010Applicant: YUSHIRO CHEMICAL INDUSTRY CO., LTD.Inventors: Toru Kadokawa, Akio Saito
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Publication number: 20100076183Abstract: A nucleoside monomer that is protected by a thionocarbamate protecting group is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.Type: ApplicationFiled: May 14, 2009Publication date: March 25, 2010Inventors: Douglas J. Dellinger, Joel Myerson, Agnieszka Sierzchala, Geraldine F. Dellinger, Zoltan Timar
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Publication number: 20100047360Abstract: The present invention provides unbranched aliphatic polyamines for use in therapy, particularly for use in the treatment of psoriasis and compositions containing polyamines.Type: ApplicationFiled: March 14, 2007Publication date: February 25, 2010Applicant: Bioforskining Pharma ASInventors: Jo Klaveness, Geir Havard Kvalheim
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Publication number: 20090326176Abstract: The embodiments of the invention relate to a multifunctional lithiated amine-containing compound comprising at least two molecules of lithiated amine in a molecule of the compound. In one embodiment, the compound has a formula where x is an integer of 1 or more, Q is (a) an element selected from the group consisting of O, S, N, P and Si or (b) an alkylene group having from 1 to 20 methylene groups, and R1 and R2 are the same or different and are selected from the group consisting of alkyls, cycloalkyls and aralkyls containing from 1 to 20 carbon atoms. In another embodiment, the compound comprises cyclic lithio amines and has a formula: where x is 1 or more, R3, R4 and R5 are the same or different and represent alkylene groups containing from 3 to 20 carbon atoms.Type: ApplicationFiled: December 29, 2008Publication date: December 31, 2009Inventor: Yuan-Yong Yan
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Patent number: 7638650Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.Type: GrantFiled: August 6, 2007Date of Patent: December 29, 2009Assignee: E.I. du Pont de Nemours and CompanyInventor: Weiming Qiu
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Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7589238Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: GrantFiled: August 17, 2006Date of Patent: September 15, 2009Assignee: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han Ting Chang, Florence Roger, Gerrit Klaemer, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
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Publication number: 20090222088Abstract: Disclosed herein are polymers used to coat or form implantable medical devices. The polymers comprise secondary amines useful in binding nitric oxide (NO). After diazeniumdiolation, the polymers can sustain controlled release of NO. In one embodiment, the secondary amines are linked to a functionalized dendrimer. In another embodiment, secondary amines are chelated with copper (II) which in turn serve as a catalyst for NO production.Type: ApplicationFiled: February 29, 2008Publication date: September 3, 2009Applicant: Medtronic Vascular, Inc.Inventors: Mingfei Chen, Peiwen Cheng
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Publication number: 20090149314Abstract: Catalysts which are prepared by reducing catalyst precursors which comprise a) cobalt and b) one or more elements of the alkali metal group, of the alkaline earth metal group, of the group consisting of the rare earths or zinc or mixtures thereof, the elements a) and b) being present at least partly in the form of their mixed oxides, and a process for the preparation of these catalysts and the use thereof for the hydrogenation of unsaturated organic compounds. Furthermore, a process for regenerating these catalysts by treatment of the catalyst with a liquid is described.Type: ApplicationFiled: March 2, 2007Publication date: June 11, 2009Applicant: BASF SEInventors: Martin Ernst, Thilo Hahn, Johann-Peter Melder
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Publication number: 20090143515Abstract: Bridged graphite oxide material comprising graphite sheets bridged by at least one diamine bridging group. The bridged graphite oxide material may be incorporated in polymer composites or used in adsorption media.Type: ApplicationFiled: September 4, 2008Publication date: June 4, 2009Applicant: The Trustees of Princeton UniversityInventors: Margarita Herrera-Alonso, Michael J. McAllister, Ilhan A. Aksay, Robert K. Prud'Homme
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Publication number: 20090137847Abstract: An object of the invention is to provide a decomposing system for polyisocyanate residues that is capable of suppressing reaction of polyisocyanate residues with high temperature and high pressure water to allow smooth start-up of the operation, and a start-up method for the decomposing system for the polyisocyanate residues. The decomposing system is used for hydrolyzing the polyisocyanate residues to polyamine using high temperature and high pressure water, comprising a hydrolyzer, a water feed pipe connected to the hydrolyzer, a residual feed pipe connected to the water feed pipe, a solvent feed line for filling an organic solvent in a solvent filling portion of the residual feed pipe, and a solvent draining line. Upon start-up of the operation, the organic solvent is previously filled in the solvent filling portion via the solvent feed line and the solvent draining line, first, and then, the high temperature and high pressure water is fed from the water feed pipe to the hydrolyzer.Type: ApplicationFiled: July 12, 2006Publication date: May 28, 2009Applicant: Mitsui Chemicals Polyurethanes, Inc.Inventors: Tadashi Yoshida, Yasumichi Ooto, Akio Saito
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Patent number: 7501542Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: January 21, 2004Date of Patent: March 10, 2009Assignee: Invitrogen CorporationInventors: Alberto Haces, Valentina C. Ciccarone
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Patent number: 7495131Abstract: Tertiary amines useful as catalysts for preparing polyurethane foams are provided. Tertiary amines are employed to catalyze the trimerization reaction of isocyanates and the reaction between isocyanates and active hydrogen-containing compounds, such as a polyol and/or a blowing agent. Such tertiary amine has the general formula wherein R1, R2, Y, Z, and n are defined herein.Type: GrantFiled: March 18, 2005Date of Patent: February 24, 2009Assignee: Air Products and Chemicals, Inc.Inventors: Juan Jesus Burdeniuc, Ann Zdancewic Kamzelski
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Publication number: 20090023215Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.Type: ApplicationFiled: May 17, 2006Publication date: January 22, 2009Applicant: MOLECULAR TRANSFERInventors: Joel Jessee, Gulilat Gebeyehu
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Patent number: 7470817Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)I, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: December 28, 2006Date of Patent: December 30, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7449605Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: March 22, 2005Date of Patent: November 11, 2008Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7445771Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.Type: GrantFiled: December 9, 2004Date of Patent: November 4, 2008Assignee: Alcon, Inc.Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
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Patent number: 7393978Abstract: Process for the preparation of ethylenamines, in particular diethylenetriamine (DETA), by continuous reaction of ethylenediamine (EDA) in the presence of a heterogeneous catalyst, where the reaction is carried out in a reaction column.Type: GrantFiled: July 15, 2004Date of Patent: July 1, 2008Assignee: BASF AktiengesellschaftInventors: Matthias Frauenkron, Thomas Krug, Holger Evers, Johann-Peter Melder, Roderich Röttger, Markus Siegert, Till Gerlach, Jan Nouwen, Ellen Dahlhoff, Christian Miller
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Patent number: 7388112Abstract: The synthesis and use of a novel class of tumor necrosis factor (TNF?) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CHNH2, R1 and R2 each is a hydrogen or a C1 to C20 aliphatic; aliphatic amine; an alicyclic; aromatic; heterocycle; and halogenated forms thereof; and wherein, a, b and c are integers from 0 to 12; R1, R2, R3, and R4 each is a hydrogen or a C1 to C20; aliphatic amine; an alicyclic; aromatic; a heterocycle; and halogenated forms thereof.Type: GrantFiled: July 1, 2005Date of Patent: June 17, 2008Assignee: MediQuest Therapeutics, Inc.Inventors: Mark R. Burns, Maralee McVean, Kevin Kennedy, Arthur Yeung, Bruce H. Devens
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Patent number: 7388113Abstract: The present invention relates to a process for the synthesis of novel 1,3-diimine copper complexes using amino-imines and novel amino-imines.Type: GrantFiled: December 16, 2004Date of Patent: June 17, 2008Assignee: E.I. du Pont de Nemours and CompanyInventors: Alexander Zak Bradley, David Lincoln Thorn
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Patent number: 7335795Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: March 22, 2004Date of Patent: February 26, 2008Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7323594Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by -X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: December 28, 2006Date of Patent: January 29, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7226501Abstract: The present invention relates to an aqueous quick-setting bitumen-aggregate mix suitable for cold pavement of roads, parking places, sidewalks and the like. The bitumen-aggregate mix is manufactured by mixing a mineral aggregate, water, a de-emulsifier, containing hydraulic cement, and a cationic oil-in-water bitumen emulsion, containing, as an emulsifier, a salt of a tertiary diamine and a phosphoric acid. The diamine has the formula (I), where one or two of the groups R1, R2, R4 and R5 designate a hydrocarbon group of 6–22, preferably 8–20 carbon atoms, and the remaining R1, R2, R4 and R5 groups are an alkyl group with 1–4 carbon atoms, and/or a group —(A)2H, where A is an alkyleneoxy group with 2–3 carbon atoms, and s is a number from 1–4, R3 is an alkylene group with 2–4 carbon atoms and n is a number from 0–2.Type: GrantFiled: June 23, 2004Date of Patent: June 5, 2007Assignee: Akzo Nobel N.V.Inventors: Bengt-Arne Thorstensson, Keith Shaw, Thomas Wallin, Leif-Göran Ståhlgren
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Patent number: 7166745Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)1, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —CH2)p—D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: November 12, 1999Date of Patent: January 23, 2007Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7148024Abstract: Novel conjugates of busulfan and novel busulfan immunogens derived from ?-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.Type: GrantFiled: September 13, 2005Date of Patent: December 12, 2006Assignee: Saladax Biomedical Inc.Inventors: Salvatore J. Salamone, Jodi Blake Courtney, Shu He
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Patent number: 7132556Abstract: Chelate complexes of calcium, strontium and barium formed with ligands that are beta-ketiminate compounds having a scorpion tail; intermediate compounds useful in producing the aforementioned complexes; a method for producing such complexes, and the use of such complexes for depositing layers containing calcium, barium or strontium.Type: GrantFiled: December 28, 2004Date of Patent: November 7, 2006Assignee: Solvay Barium Strontium GmbHInventors: Federica Martina Benvenuti, Dominique Jan
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Patent number: 7094808Abstract: Polyamines having the formula: or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen; N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's; a and b may be the same or different and are integers from 1 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines: (i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and (ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell; the polyamines, upon binding to the biological counter-anion in the cell, functioType: GrantFiled: September 4, 2002Date of Patent: August 22, 2006Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Patent number: 7091285Abstract: A reaction product comprising an adduct of a mid-range vinylidene content PIB polymer composition and maleic anhydride, a phenolic compound or a compound having a reactive site for subsequent amination. The PIB composition comprises a relatively low molecular weight, mid-range vinylidene content PIB polymer product wherein at least about 90% of the PIB molecules present in the product comprise alpha or beta position isomers. The vinylidene (alpha) isomer content of the product may range from 20% to 70% thereof and the content of tetra-substituted internal double bonds is very low, preferably less than about 5% and ideally less than about 1–2%. The mid-range vinylidene content PIB polymer products may be prepared employing a liquid phase polymerization process conducted in a loop reactor at a temperature of at least 60° F. using a BF3/methanol catalyst complex and a contact time of no more than 4 minutes.Type: GrantFiled: July 22, 2004Date of Patent: August 15, 2006Assignee: Texas Petrochemicals LPInventors: C. Edward Baxter, Jr., Christopher Lobue, Gilbert Valdez, Daniel Herndon, Timothy Lowry
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Patent number: 7022214Abstract: Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric focusing.Type: GrantFiled: January 21, 2004Date of Patent: April 4, 2006Assignee: Bio-Rad Laboratories, Inc.Inventor: Lee Olech
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Patent number: 7002042Abstract: The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells.Type: GrantFiled: August 20, 2002Date of Patent: February 21, 2006Assignee: Vanderbilt UniversityInventor: Xiang Gao
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Patent number: 6972075Abstract: The invention relates to a method for removing, by distillation, 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine, by a) removing the hexamethylenediamine from the mixture while obtaining a mixture (I) that has a hexamethylenediamine content of less than 1 wt. -%, b) removing completely or partially the 6-aminocapronitrile from mixture (I) while obtaining a mixture (II) whose content in substances that have a higher boiling point as 6-aminocapronitrile under distillation conditions and that cannot be formed by dimerization reactions when 6-aminocapronitrile is thermally treated is less than 1 wt. -%, and c) completely or partially removing from mixture (II) the hexamethylenediamine that might be present while obtaining a mixture (IV) whose hexamethylenediamine content is higher than that of mixture (II), and a mixture (V) whose hexamethylenediamine content is lower than that of mixture (II).Type: GrantFiled: June 13, 2001Date of Patent: December 6, 2005Assignee: BASF AktiengesellschaftInventors: Hermann Luyken, Frank Ohlbach, Rolf-Hartmuth Fischer, Johann-Peter Melder, Peter Bassler, Andreas Ansmann, Günther Achhammer
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Patent number: 6951962Abstract: A water-dispersible oil/grease-sizing and water-sizing agent that provides oil/grease and water-sizing for paper and other cellulosic materials. The agent works effectively for both oil/grease and water sizing at high temperatures. The polymeric agent's key features include a polyamine component which is a repeating monomer unit with cellulose-reactive and fluorinated groups substituted on the polyamine.Type: GrantFiled: April 12, 2002Date of Patent: October 4, 2005Assignee: Hercules IncorporatedInventor: Kyle J. Bottorff
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Patent number: RE41316Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: June 27, 2008Date of Patent: May 4, 2010Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: RE41585Abstract: A method for controlling the rheology of aqueous systems, particularly for those intended for underground use, includes injecting an aqueous fluid containing a surfactant gelling agent into the system. The surfactant gelling agents are, for example, fatty aliphatic amidoamine oxides, salts of an alkoxylated monoamine with an aromatic dicarboxylic acid, and salts of an alkyldiamine with an aromatic dicarboxylic acid. The surfactant gelling agents can be absorbed onto particulate supports to facilitate delivery of the gelling agent. The additives may be incorporated in the viscoelastic fluid to tailor its use in hydraulic fluids, drilling muds, fracture fluids, and in applications such as permeability modification, gravel packing, cementing, and the like.Type: GrantFiled: May 30, 2002Date of Patent: August 24, 2010Inventors: Robert F. Farmer, Andress K. Doyle, Glenda Del Carmen Vale, James F. Gadberry, Michael D. Hoey, Randy E. Dobson