Plural Amino Nitrogens Containing Patents (Class 564/511)
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Patent number: 6924315Abstract: The present invention provides compounds useful as surfactants having formula (1), including isomers thereof: wherein a and b are integers independently selected from about 3 to about 6; x is an integer from about 1 to about 12; (m+n) is from about 1 to about 4; the R1 groups are independently selected from the group consisting of linear, cyclic, and branched alkyl, alkenyl, aryl, and alkylaryl groups having from about C3 to about C30 atoms; and when (m+n) is equal to or greater than 2, each R1 may be independently R2 or R3, wherein R2 and R3 are independently selected from the group consisting of linear, cyclic, and branched alkyl, alkenyl, aryl, and alkylaryl groups having from about C3 to about C30 atoms. The invention also provides a method for reducing surface tension in a waterborne composition or an industrial process by the incorporation of a surfactant having formula (1) and an aqueous composition comprising a surfactant having formula (1).Type: GrantFiled: March 13, 2003Date of Patent: August 2, 2005Assignee: Air Products and Chemicals, Inc.Inventors: Christine Peck Kretz, Michael Edward Ford, Kevin Rodney Lassila
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Patent number: 6919483Abstract: The synthesis and use of a novel class of tumor necrosis factor (TNF?) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNF? and other involved cytokines. As pharmaceuticals, these compounds are used to treat inflammatory, infectious, autoimmune or other proliferative diseases and conditions related to the unwanted presence or activity of TNF? and/or one or more other involved cytokines, alone or in combination with other agents.Type: GrantFiled: May 23, 2003Date of Patent: July 19, 2005Assignee: Mediquest Therapeutics, Inc.Inventors: Mark R. Burns, Maralee McVean, Kevin J. Kennedy, Arthur Yeung, Bruce H. Devens
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Publication number: 20040181077Abstract: The present invention relates to novel tertiary alkanolamines useful as catalysts for preparing polyurethane foams and as additives to reduce the dynamic surface tension of aqueous solutions.Type: ApplicationFiled: December 10, 2003Publication date: September 16, 2004Applicant: Air Products and Chemicals, Inc.Inventors: William R. Raymond, Juan Jesus Burdeniuc, Khalil Yacoub
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Patent number: 6762325Abstract: When the reaction solution formed during the addition of an alkylene oxide to an active hydrogen-containing compound has viscosity of not less than 10 mPa·s, this invention provides a method for stirring the reaction solution by the rotation of a vane or vanes continuously disposed in the vertical direction within an agitating reaction vessel in such a manner that the numerical value C represented by the following formula (1): C=A/(h2−h1) (1) (wherein A denotes the length (m) of the vane or the vanes newly immersed by the supply of alkylene oxide, h1 denotes the height (m) of the liquid level before the supply of alkylene oxide, and h2 denotes the height (m) of the liquid level after the supply of alkylene oxide) may be not less than 0.5. By employing the method of this invention, it is made possible to effect addition of an alkylene oxide to the active hydrogen-containing compound with high efficiency.Type: GrantFiled: May 13, 2002Date of Patent: July 13, 2004Assignee: Nippon Shokubai Co., Ltd.Inventors: Toru Inaoka, Yasuhiko Sato, Yoshiyuki Onda, Hiromichi Tanaka, Tsuyoshi Hirata
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Patent number: 6716882Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: April 23, 2002Date of Patent: April 6, 2004Assignee: Invitrogen CorporationInventors: Alberto Haces, Valentina C. Ciccarone
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Patent number: 6713653Abstract: A polyamine having the formula: H2N—A[NR—B]aNH2 or salt thereof, wherein A and B, which may be the same or different, are selected from aliphatic or aromatic substituents provided that at least four carbon atoms separate any two nitrogen groups, R is an aliphatic or aromatic group, and a is 2 to 5. In addition, a polymer having the formula: or salt thereof, wherein A, B and Q, which may be the same or different, are selected from aliphatic or aromatic substituents provided that at least four carbon atoms separate any two nitrogen groups, R is an aliphatic or aromatic group, a is greater than 1 to about 5, and n is 3 to about 1,000. The polymers are useful for improving acid-dyeability of polymer compositions, fibers, fabrics, films and other articles.Type: GrantFiled: August 24, 2001Date of Patent: March 30, 2004Assignee: E. I. du Pont de Nemours and CompanyInventor: David P. Higley
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Publication number: 20040048834Abstract: New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, CN, halogen, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, or two groups X may together form ═O; Y is NR1, OR1, PR1, SR1, or halogen, wherein the number of substituents R1 is selected to suit the valency and each R1 is independently selected of H, OH, C(═O)R′, P(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, and wherein the dotted line indicates an optional double bond; each Z is the same different, and represents H, OH,Type: ApplicationFiled: August 18, 2003Publication date: March 11, 2004Inventors: Jose Luis Acena, Javier Adrjo, Carmen Cuevas, Pilar Gallego, Ignacio Manzanares, Simon Munt, Ignacio Rodriguez
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Publication number: 20040015004Abstract: The invention relates to a method for removing, by distillation, 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine, by a) removing the hexamethylenediamine from the mixture while obtaining a mixture (I) that has a hexamethylenediamine content of less than 1 wt.-%, b) removing completely or partially the 6-aminocapronitrile from mixture (I) while obtaining a mixture (II) whose content in substances that have a higher boiling point as 6-aminocapronitrile under distillation conditions and that cannot be formed by dimerization reactions when 6-aminocapronitrile is thermally treated is less than 1 wt.-%, and c) completely or partially removing from mixture (II) the hexamethylenediamine that might be present while obtaining a mixture (IV) whose hexamethylenediamine content is higher than that of mixture (II), and a mixture (V) whose hexamethylenediamine content is lower than that of mixture (II).Type: ApplicationFiled: December 16, 2002Publication date: January 22, 2004Inventors: Hermann Luyken, Frank Ohlbach, Rolf-Hartmuth Fischer, Johann-Peter Melder, Peter Bassler, Andreas Ansmann, Gunther Achhammer
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Patent number: 6667382Abstract: The present invention provides an amine or polyamine, which has a surface activity not inferior to a solid tallow-based amine and an excellent workability. A salt of the amine is suited for emulsifying asphalt and the like, and also provides an asphalt emulsion composition which is obtained by using the salt and which has a quick setting property. Namely, the prevent invention provides a polyamine represented by the formula (1), a process for producing the amine, and an asphalt emulsion composition containing a water-soluble salt of the amine. wherein R is a straight or branched hydrocarbon group having 8 to 22 carbon atoms; x is a number of 1 to 5; and each of y and z is a number of 0 to 5 with the proviso that both of y and z are not 0 at the same time.Type: GrantFiled: November 1, 2000Date of Patent: December 23, 2003Assignee: Kao CorporationInventors: Kazuo Isobe, Ryoichi Tamaki, Keiichiro Tomioka, Wataru Yoshida, Tetsuaki Fukushima, Uichiro Nishimoto
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Publication number: 20030162978Abstract: Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality includes a first protecting group, which can be aralkyl, methyl, allyl or tertiary alkyl group. The other of the amine protecting groups can be the same as the first protecting group. Alternatively, the second protecting group can be different from the first protecting group, in which case it is selected to have differential stability to agents used to remove the aralkyl, methyl, allyl or tertiary alkyl protecting group.Type: ApplicationFiled: December 18, 2002Publication date: August 28, 2003Inventors: Thorsten Werner Brockmann, Randy W. Hall
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Patent number: 6605645Abstract: Nobel polyamine compounds and polyamine compounds having carcinostatic action are provided. There are also provided anticancer agents containing as active ingredient at least one of polyamine compounds represented by the following Formula (I) or (III) and/or pharmaceutically acceptable salts thereof. Specifically, there are provided anticancer agents containing as active ingredient at least one of 1,18-bis(ethylamino)-5,14-diazaoctadecane, 1,16-bis(cyclopropylmethylamino)-5,12-diazahexadecane, 1,17-bis(cyclopropylmethylamino)-5,13-diazaheptadecane and/or pharmaceutically acceptable salts thereof.Type: GrantFiled: October 16, 2001Date of Patent: August 12, 2003Assignee: RikenInventor: Masaaki Iwata
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Patent number: 6590106Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: R1, R2, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 is —NR4R5 or —N+≡C−. Alternatively, R1, and R2, taken together with the methine group to which they are bonded, are a moiety represented by the following structural formula: R3 is —NH2, —OH, —OC(O)H or —OR9. R5, R6 and R7 are independently —H or an amine protecting group. R8 is —H, —OH or —OR8. R9 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.Type: GrantFiled: June 21, 2002Date of Patent: July 8, 2003Assignee: Pharm-Eco Laboratories, Inc.Inventors: Richard L. Gabriel, Jurjus Jurayj
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Publication number: 20030096864Abstract: The present invention is substituted amines of formula (X) 1Type: ApplicationFiled: June 29, 2001Publication date: May 22, 2003Inventors: Lawrence Y. Fang, Roy Hom, Varghese John, Michel Maillaird
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Patent number: 6555959Abstract: A material for a light emitting device which is a compound represented by the following formula (I): wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic group; R2, R3, R7 and R8, which are the same or different, each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group; R4a, R5a, R9a and R10a, which are the same or different, each represents a hydrogen atom or a monovalent group, and at least one of R4a, R5a, R9a and R10a represents an electron withdrawing group having a Hammett's &sgr;p value of 0.Type: GrantFiled: September 29, 2000Date of Patent: April 29, 2003Assignee: Fuji Photo Film Co., Ltd.Inventor: Kazumi Nii
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Publication number: 20030045755Abstract: Novel cytotoxic polyamine analogues are disclosed. These analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury.Type: ApplicationFiled: September 23, 2002Publication date: March 6, 2003Inventor: Mark R. Burns
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Patent number: 6492561Abstract: Alkaline earth metal alkylene diamides of Ba, Sr, Ca and a method for their production.Type: GrantFiled: January 25, 2002Date of Patent: December 10, 2002Assignee: Chemetall GmbHInventors: Wilfried Weiss, Dirk Dawidowski
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Patent number: 6492560Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.Type: GrantFiled: September 24, 2001Date of Patent: December 10, 2002Assignee: The University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare
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Publication number: 20020151752Abstract: Alkaline earth metal alkylene diamides of Ba, Sr, Ca and a method for their production.Type: ApplicationFiled: January 25, 2002Publication date: October 17, 2002Inventors: Wilfried Weiss, Dirk Dawidowski
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Patent number: 6462220Abstract: A process for the coproduction of 6-aminocapronitrile and hexamethylenediamine starting from adiponitrile by a) hydrogenating adiponitrile in the presence of a catalyst comprising an element of the eighth transition group as catalytically active component, to obtain a mixture comprising 6-aminocapronitrile, hexamethylenediamine, adiponitrile and high boilers, b) distillatively removing hexamethylenediamine from the mixture comprising 6-aminocapronitrile, hexamethylenediamine, adiponitrile and high boilers, and either cl) distillatively removing 6-aminocapronitrile, and then d1) distillatively removing adiponitrile, or c2) simultaneously distillatively removing 6-aminocapronitrile and adiponitrile into separate fractions is characterized by base of column temperatures below 185° C. in steps d1) or c2).Type: GrantFiled: February 26, 2001Date of Patent: October 8, 2002Assignee: BASF AktiengesellschaftInventors: Hermann Luyken, Frank Ohlbach, Andreas Ansmann, Peter Bassler, Rolf Fischer, Johann-Peter Melder, Martin Merger, Alwin Rehfinger, Guido Voit, Günther Achhammer
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Patent number: 6458837Abstract: The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are stable lipophilic diesters comprising a covalent conjugate of a BAPTA and a pharmaceutically acceptable alcohol. The diesters are useful in a method for treating a condition or disease related to an excess of divalent metal ions, and in particular for the treatment of a condition or disease related to elevated levels of intracellular calcium ions, such as in brain or cardiac ischemia, stroke, epilepsy, Alzheimer's disease or cardiac arrhythmia and in open heart surgery.Type: GrantFiled: March 27, 2000Date of Patent: October 1, 2002Assignee: D-Pharm Ltd.Inventors: Alexander Kozak, Israel Shapiro
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Patent number: 6444633Abstract: The present invention relates to laundry detergent compositions which provide enhance hydrophilic soil cleaning benefits, said compositions comprising: a) from about 0.01% by weight, of a zwitterionic hexamethylene diamine; b) from about 0.01% by weight, of a surfactant system comprising one or more surfactants selected from the group consisting of nonionic, anionic, cationic, zwitterionic, ampholytic surfactants, and mixtures thereof; and c) the balance carriers and adjunct ingredients. The preferred embodiment of the present includes laundry detergent compositions in the form of a water soluble or dispersible tablet.Type: GrantFiled: February 21, 2001Date of Patent: September 3, 2002Assignee: The Procter & Gamble CompanyInventor: Kenneth Nathan Price
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Patent number: 6441240Abstract: Ethyleneamine compound(s), or mixtures thereof, are used in effective amounts to reduce or inhibit the deposition of white pitch on the paper making equipment during the processing to recycle coated paper.Type: GrantFiled: September 20, 2000Date of Patent: August 27, 2002Assignee: Huntsman Ethyleneamines Ltd.Inventor: Alan P. Croft
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Patent number: 6399663Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: August 25, 2000Date of Patent: June 4, 2002Assignee: Invitrogen CorporationInventors: Alberto Haces, Valentina C. Ciccarone
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Patent number: 6395713Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.Type: GrantFiled: July 21, 1998Date of Patent: May 28, 2002Assignee: Ribozyme Pharmaceuticals, Inc.Inventors: Leonid Beigelman, Jasenka Matulic-Adamic, Alex Karpeisky, Peter Haeberli, David Sweedler, Mark Reynolds, Nilabh Chaudhary, John Min
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Patent number: 6369268Abstract: Described are diester amine adducts of formula (1) wherein R1, R2, R3, R4 are each independently of one another C4-C22alkyl; C2-C22alkenyl; or C5-C7cycloalkyl; X1 and X2 are each independently of the other hydrogen, C1-C4alkyl; C2-C4hydroxyalkyl or C2-C4hydroxyhaloalkyl; Y is a radical of formula (1b); A1 is C2-C3alkylene or 2-hydroxy-n-propylene; X3 is hydrogen; C1-C4alkyl, C2-C4hydroxyalkyl; or C2-C4hydroxyhaloalkyl; (A) is an asymmetrical carbon atom in the R- or S-configuration, wherein, if C1=R, C2=R; C1=S, C2=S; and C1=R; C2=S; m1 is 1 or 2; and n is an integer from 1 to 4; p is 0 or 1; which adducts may be in the form of free bases or ammonium salts. Said compounds are precursors of compounds having good complex-forming properties and are thus able to effectively bind heavy metal ions such as iron, zinc, magnesium or copper ions and to prevent metal-initiated oxidations after enzymatic or chemical cleavage.Type: GrantFiled: May 1, 2000Date of Patent: April 9, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Thomas Ehlis, Peter Frankhauser, Dietmar Hüglin
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Patent number: 6342534Abstract: Polyamines having the formula: or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen; N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's; a and b may be the same or different and are integers from 1 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines: (i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and (ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell; the polyamines, upon binding to the biological counter-anionType: GrantFiled: October 17, 2000Date of Patent: January 29, 2002Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Patent number: 6322996Abstract: Transglutaminase is allowed to act upon both a physiologically active protein (inclusive of a fused protein thereof with a peptide through acid amide bonding) and an amino group donor containing the polyethylene glycol, polysaccharide, polyamino acid or branched type sugar derivative moiety, whereby the physiologically active protein is modified without spoiling its inherent physiological activities, and may be improved in its qualification as a drug.Type: GrantFiled: November 29, 1995Date of Patent: November 27, 2001Assignee: Drug Delivery System Institute, Ltd.Inventors: Haruya Sato, Keiji Yamamoto, Kokichi Suzuki, Masahiro Ikeda, Masahiro Sakagami, Makoto Taniguchi
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Patent number: 6294697Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.Type: GrantFiled: April 17, 1998Date of Patent: September 25, 2001Assignee: The University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare
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Patent number: 6281371Abstract: The present invention relates to new lipopolyamines (including salts thereof) characterised by a symmetrical, highly flexible lipophilic moiety having buffering capacity at physiological pH, and to the use thereof for the in vivo or in vitro introduction of biologically active materials, such as, for example, DNA, RNA, ribozymes, antisense DNA, PNA, peptides and proteins, into eukaryotic cells.Type: GrantFiled: March 29, 2000Date of Patent: August 28, 2001Assignee: Biontex Laboratories GmbHInventors: Roland Klösel, Stephan König
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Patent number: 6265597Abstract: A magnesium amide for use as a magnesium donor not having any Mg—C bonds. The compound is useful for doping GaN with Mg+2. The compound of the present invention is a high molecular weight dimer, preferably a diamide containing one or more silicon substituent groups. Alternatively, the compounds of the present invention may contain amino nitrogens weakly bonded to Mg. The compounds must have sufficient volatility to be useful in chemical vapor deposition.Type: GrantFiled: February 2, 2000Date of Patent: July 24, 2001Assignee: Georgia Tech Research Corp.Inventors: William S. Rees, Jr., Henry A. Luten, III
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Patent number: 6258976Abstract: Disclosed are processes for the preparation of compounds of the formula (I): H2N—(CH2)n—A—(CH2)m—NH2, or (II): H2N—(CH2)n—NH—C(═NR1)—NH—(CH2)m—NH2, wherein n and m are each independently an integer from 2 to 8; A is selected from the group consisting of —NR1—, —NR1—(CH2)r—NR1— and —NR1—(CH2)r—NR1—(CH2)z—NR1—, wherein r and z are an integer ranging from 2 to 8; and R1 is hydrogen or a protecting group having a carbonyl group.Type: GrantFiled: March 19, 1999Date of Patent: July 10, 2001Inventors: Francis Johnson, Ramesh C. Gupta
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Patent number: 6255277Abstract: A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.Type: GrantFiled: May 10, 1995Date of Patent: July 3, 2001Assignees: Brigham and Women's Hospital, NitroMed, Inc.Inventors: Jonathan Stamler, Joseph Loscalzo, John D. Folts
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Patent number: 6252116Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.Type: GrantFiled: January 21, 2000Date of Patent: June 26, 2001Assignee: Merck & Co., Inc.Inventors: Edward G. Corley, Ian W. Davies, Robert D. Larsen, Philip J. Pye, Kai Rossen
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Patent number: 6239183Abstract: A method for controlling the rheology of aqueous systems, particularly for those intended for underground use, includes injecting an aqueous fluid containing a surfactant gelling agent into the system. The surfactant gelling agents are, for example, fatty aliphatic amidoamine oxides, salts of an alkoxylated monoamine with an aromatic dicarboxylic acid, and salts of an alkyldiamine with an aromatic dicarboxylic acid. The surfactant gelling agents can be adsorbed onto particulate supports to facilitate delivery of the gelling agent. The additives may be incorporated in the viscoelastic fluid to tailor its use in hydraulic fluids, drilling muds, fracture fluids, and in applications such as permeability modification, gravel packing, cementing, and the like.Type: GrantFiled: December 19, 1997Date of Patent: May 29, 2001Assignee: Akzo Nobel NVInventors: Robert F. Farmer, Andress K. Doyle, Glenda Del Carmen Vale, James F. Gadberry, Michael D. Hoey, Randy E. Dobson
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Patent number: 6222059Abstract: A process for preparing aliphatic alpha,omega-amino nitrites by partial hydrogenation of aliphatic alpha,omega-dinitriles in the presence of a catalyst, wherein the catalyst used for the partial hydrogenation comprises (a) iron or a compound based on iron or mixtures thereof and (b) from 0.01 to 5% by weight, based on (a), of a promoter based on 2,3,4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium and (c) from 0 to 5% by weight, based on (a), of a compound based on an alkali metal or alkaline earth metal.Type: GrantFiled: March 10, 1999Date of Patent: April 24, 2001Assignee: BASF AktiengesellschaftInventors: Klaus Ebel, Rolf Fischer, Klemens Flick, Martin Merger, Guido Voit
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Patent number: 6207121Abstract: Alkanolamines of the formula R—NHCH2CH(OH)CH2CH3 (I) or mixtures thereof wherein R is H, —CH2CH(OH)CH2CH3, an alkyl group having from 1 to 6 carbon atoms, an aryl group having from 6 to 12 carbon atoms, an aralkyl group having from 6 to 12 carbon atoms, or a cycloalkyl group having from 3 to 6 carbon atoms in combination with a tertiary alkano/amine are effective in the removal of acidic gases from a fluid stream containing same and show superior degradation properties as compared to alkanolamines conventionally used in the gas purification applications.Type: GrantFiled: September 30, 1998Date of Patent: March 27, 2001Assignee: The Dow Chemical CompanyInventor: Peter C. Rooney
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Patent number: 6184232Abstract: Polyamines having the formula: or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen; N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's; a and b may be the same or different and are integers from 1 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines: (i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and (ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell; the polyamines, upon binding to the biological counter-anionType: GrantFiled: June 22, 1993Date of Patent: February 6, 2001Assignee: University of FloridaInventor: Raymond J. Bergeron, Jr.
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Patent number: 6169064Abstract: The disclosure involves a novel amine ether acid salt surfactant. The amine constituent of the surfactant may include ether amines or fatty-based amines. The ether acid constituent of the surfactant, in particular, imparts liquidity to the surfactant. Hydrophobic regions may be included on both the amine and ether acid enhancing the surfactancy of the composition. The novel surfactant is versatile and is useful in many different applications.Type: GrantFiled: July 18, 1997Date of Patent: January 2, 2001Assignee: Tomah Products, Inc.Inventors: James A. Krogh, Michael R. Sipe
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Patent number: 6156917Abstract: A magnesium amide for use as a magnesium donor not having any Mg--C bonds. The compound is useful for doping GaN with Mg.sup.+2. The compound of the present invention is a high molecular weight dimer, preferably a diamide containing one or more silicon substituent groups. Alternatively, the compounds of the present invention may contain amino nitrogens weakly bonded to Mg. The compounds must have sufficient volatility to be useful in chemical vapor deposition.Type: GrantFiled: July 10, 1997Date of Patent: December 5, 2000Assignee: Georgia Tech Research CorporationInventors: William S. Rees, Jr., Henry A. Luten, III
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Patent number: 6156222Abstract: Perfluoroalkyl-allyloxy- and perfluoroalkyl-iodopropyloxy-substituted polyaminoacids or poly-R.sub.F -fluoroallyl-substituted polyaminoacids which contain, in random distribution, q units of A-1, r units of A-2, s units of A-3 and t units of A-4 in which A-1 and A-2 are perfluoroalkyl-substituted amino groups of the formulae ##STR1## A-3 is a hydrophilically substituted amino or amido group of the formula ##STR2## and A-4 is a substituted amino or amido group of the formula ##STR3## where the variables are as defined herein, are useful to provide oil repellency to paper and as foam stabilizers in alcohol resistant--aqueous fire-fighting foam fire-fighting foam compositions.Type: GrantFiled: January 20, 1999Date of Patent: December 5, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: John Jennings, Ted Deisenroth, Marlon Haniff
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Patent number: 6147247Abstract: A process for coproduction of 6-aminocapronitrile and hexamethylenediamine starting from a mixture comprising a phosphorus-containing compound and essentially adiponitrile and obtained by reaction of butadiene with hydrocyanic acid in the presence of a catalyst comprising a phosphorus-containing compound comprises(1) reducing the weight proportion of phosphorus-containing compound, calculated as phosphorus, in the mixture,(2) partially hydrogenating the resulting mixture in the presence of a catalyst to form an .alpha.,.omega.-aminonitrile, and(3) removing 6-aminocapronitrile and hexamethylenediamine from the mixture.Type: GrantFiled: March 10, 1999Date of Patent: November 14, 2000Assignee: BASF AktiengesellschaftInventors: Guido Voit, Klemens Flick, Hermann Luyken, Alwan Rehfinger, Peter Bassler
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Patent number: 6147208Abstract: Caprolactam and hexamethylenediamine are prepared simultaneously starting from adiponitrile.Type: GrantFiled: June 16, 1998Date of Patent: November 14, 2000Assignee: BASF AktiengesellschaftInventors: Gunther Achhammer, Peter Bassler, Rolf Fischer, Eberhard Fuchs, Hermann Luyken, Werner Schnurr, Guido Voit, Lutz Hilprecht
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Patent number: 6030946Abstract: Cysteine protease inhibitors are provided.Type: GrantFiled: June 3, 1996Date of Patent: February 29, 2000Assignee: Axys Pharmaceuticals, Inc.Inventors: Jeffrey L. Klaus, David Rasnick, James T. Palmer, Elaine Yee-Lin Kuo
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Patent number: 6005144Abstract: Reaction products of polyisobutenes having an average degree of polymerization P of from 10 to 100 and a content E of from 60 to 90% of double bonds which can react with maleic anhydride, E=100% corresponding to the theoretical value for the case where each molecule of the polyisobutene has such a reactive double bond, with oxides of nitrogen or mixtures of oxides of nitrogen and oxygen, are suitable as additives for fuels, in particular for gasoline engines, and for lubricants.Type: GrantFiled: November 5, 1998Date of Patent: December 21, 1999Assignee: BASF AktiengesellschaftInventors: Rudolf Kropp, Eckhard Hickmann, Klaus Ebel, Wolfgang Gunther, Hans Peter Rath, Harald Schwahn
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Patent number: 6005146Abstract: The present invention provides improved adhesion promoters for latex paints. The adhesion promoters are enamines of acetoacetate esters, or substituted acetoacetate esters. The invention also provides two new compounds which are useful as adhesion promoters: 2-butyl-2-ethyl-1,3-propanediol bis(3-amino-2-butenoate) and trimethyl propane tris(3-amino-2-butenoate), and which are stable to hydrolysis on prolonged storage.Type: GrantFiled: November 20, 1998Date of Patent: December 21, 1999Assignee: Eastman Chemical CompanyInventors: Douglas Grant Atkins, Jonathan Stewart Witzeman
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Patent number: 5994585Abstract: The present invention relates to an amination process for the manufacture of polyamines. The purpose of the process is to increase the selectivity of linear aminated products and to prevent the formation of discoloring by-products or by-products which may later cause discoloration. According to the process this is achieved by performing, in a first part of the process, the amination to a conversion degree of between 50 and 98% by weight, calculated on the total yield of polyamines, at a proportionally time-weighted average temperature, which is at least 15.degree. C. higher than the proportionally time-weighted average temperature in the remaining part.Type: GrantFiled: November 12, 1998Date of Patent: November 30, 1999Assignee: Akzo Nobel N.V.Inventor: Johan Gunther-Hanssen
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Patent number: 5976202Abstract: Reaction products of polyolefins having predominantly a terminal double bond and a number average molecular weight of from 250 to 10,000, which possess an aliphatic hydrocarbon skeleton which is straight-chain or carries C.sub.1 -C.sub.4 -alkyl side chains, with from 1 to 10 mol, per equivalent of double bond, of one or more vinyl esters I ##STR1## are obtainable by reacting the stated polyolefins with the vinyl esters I in the presence of a free radical initiator at from 80 to 200.degree. C., it being possible for these reaction products subsequently to have been hydrolyzed to the corresponding alcohols or converted into the corresponding amines by reductive amination with amines II ##STR2## .Type: GrantFiled: July 20, 1995Date of Patent: November 2, 1999Assignee: BASF AktiengesellschaftInventors: Hans Peter Rath, Helmut Mach, Harald Schwahn, Hans-Joachim Muller, Wolfgang Reif, Thomas Ruhl
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Patent number: 5929283Abstract: The present invention relates to an amine derivative represented by the following general formula (1): ##STR1## wherein R.sup.2 and R.sup.3 mean individually an alkyl or alkenyl group which may have --OH and has 1-24 carbon atoms, A denotes an alkylene or alkenylene group which may have at least one --OH, --COOH or --SO.sub.3 H and has 1-6 carbon atoms, y.sup.1 is --COOH, --SO.sub.3 H or --OSO.sub.3 H, y.sup.2 means --OH, --OSO.sub.3 H or --OCO--A--COOH, n stands for a number of 0 or 1, and p is an integer of 1-8, or a salt or quaternized product thereof, and a detergent composition containing such a compound. This compound is low in irritativeness to the skin and hair and excellent in foamability, and can give a pleasant feeling to the user's skin and the like.Type: GrantFiled: September 23, 1997Date of Patent: July 27, 1999Assignee: Kao CorporationInventors: Mitsuru Uno, Tomohito Kitsuki, Katsumi Kita, Yoshiaki Fujikura, Akiko Okutsu
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Patent number: 5919934Abstract: Disclosed are bisaminothiol and amino compounds with appended pharmacophores, complexes of these compounds with .sup.99m Tc(V)0, Re(V)0, In.sup.+3, .sup.67 Ga.sup.+3, .sup.90 Y.sup.+3, .sup.109 Pd.sup.+2 or .sup.105 Rh.sup.+3, and pharmaceutical compositions containing the complexes. Also disclosed are methods of diagnosing a mammal for the presence of a mammalian tumor, methods for in vitro detection of a cancer cell in a mammalian tissue sample, and methods of treating a mammal having a tumor.Type: GrantFiled: February 19, 1997Date of Patent: July 6, 1999Assignee: The George Washington UniversityInventors: Christy Seith John, Benjamin Byung-Duk Lim
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Patent number: RE38417Abstract: The present invention relates to anti-neoplastic and anti-psoriasis pharmaceutical compositions and methods of treatment and to insecticidal compositions and methods of controlling the growth of insects.Type: GrantFiled: August 2, 2002Date of Patent: February 3, 2004Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.