Abstract: An absorbent article includes an absorbent polymer and a ceragenin compound. The ceragenin compound has a sterol group and a plurality of cationic groups that mimic naturally occurring antimicrobial peptides. The ceragenin compound is associated with the absorbent polymer such that upon absorption of a fluid, the ceragenin compound is incorporated or maintained in the absorbent article.

Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Abstract: A wound dressing with a wound pad and a layer of vapour-permeable material arranged on top of the wound pad and extending peripherally outside the wound pad is described, wherein at least that part of the vapour-permeable layer extending peripherally outside the wound pad is coated with adhesive, and wherein the wound pad includes a liquid-retaining and liquid-transporting layer, and an upper distributing layer and lower distributing layer which bear against the top and underside, respectively, of the liquid-retaining and liquid-transporting layer.

Abstract: A wound dressing comprises in combination (i) a first wound contact layer which preferably has a positive effect on the healing of the wound, and (ii) a second layer of greater hydrophilicity than the first layer.

Abstract: According to the present invention, a disposable sterilized cupping therapy apparatus comprises: an expansion part consisting of a foldable material, the inner volume of which corresponds to the inner volume of a cupping therapy device when expanded; and a resilient coupling part configured on a perimeter of the expansion part, wherein the expansion part is arranged within the cupping therapy device, the coupling part is resiliently pressed against and coupled to a bottom of the cupping therapy device, and the skin of a person receiving therapy that is within the cupping therapy device is sealed from the air outside the expansion part by means of the latter.

Abstract: An apparatus and method are provided for visually monitoring, detecting, and/or determining the presence, absence, and/or growth of harmful or potentially harmful bacterial microorganisms beneath a wound dressing, in one example used to cover an indwelling central venous catheter or other catheter. A bacteria detection apparatus includes a barrier membrane, a permeable membrane for placement proximate a wound or a catheter insertion site, and an indicator between the barrier membrane and the permeable membrane for indicating the presence of bacteria proximate the permeable membrane. A method of using a bacterial growth detection apparatus is also provided.

Abstract: A wound dressing for managing wound fluids includes a porous contact layer for positioning adjacent a wound. An internal open window extends through the contact layer exposing a distal side of an absorbent member. The absorbent member is disposed in a superimposed relation to the window of the contact layer and is dimensioned to extend laterally beyond the window such that a portion of the absorbent member overlaps and is secured to the contact layer. A drape layer is disposed on a proximal side of the absorbent member, and is adhesively coated to fasten the drape layer to the absorbent member. A cover layer disposed over the drape layer defines an internal open window such that the open window is adjacent the absorbent member. A distal side of the cover layer is adhesively coated to secure the cover layer to the contact layer.

Abstract: A reduced pressure tissue treatment system includes an applicator having an aperture, a first pad section, and a second pad section substantially covering the aperture and positioned substantially adjacent the first pad section. A fabric layer is located at least partially between the second pad section and the drape, and the fabric layer includes a woven or non-woven fabric made from a fiber material. A drape substantially covers the first pad section, the second pad section, the fabric layer, and the applicator. A reduced pressure source is in fluid communication with at least one of the first pad section and the fabric layer for providing reduced pressure to the aperture.

Abstract: The subject invention includes devices for providing therapeutic pressure to a treatment site. The devices include a bladder portion and a dressing portion. The bladder portion has opposed upper and lower exterior walls sealed to one another along common peripheral edges thereof to form an interior pressure chamber therebetween, without a lip or flange extending around the perimeter of the peripheral edge. The dressing portion is integrated with the bladder portion or detachably provided so that none of the bladder material comes into contact with the patient's skin at the treatment site. The interior pressure chamber of the bladder portion may have a number of configurations and serves as a bolster for the dressing portion, used to aid in the healing process of the wound.

Abstract: A dressing for covering a wound of a patient comprises a sheet member adapted to be adhered to the patient's skin in use to provide an airtight seal around the wound, wherein the skin-adhesion is provided by a hydrogel layer 10 on the skin-facing face of the sheet member, wherein the sheet member defines in use a substantially enclosed space 5 above the wound, and wherein a plurality of mutually spaced-apart flutter valves formed by holes 5 in a thin film 13 overlying an upper face of a layer 12 of the sheet member permit one-way air, blood and/or other fluid flow communication from the space 5 above the wound to the exterior of the dressing.

Abstract: The present invention relates to a device consisting of cross-linked nanofibrillary fibrin supported on and rooted to a microporous nonwoven fabric consisting of a biocompatible synthetic polymer material. An active ingredient is advantageously dispersed in the fibrin layer. The fibrin layer does not have a haemostatic function, but is suitable for retaining the active ingredient and releasing it with controlled kinetics. The device forming the object of the invention, preferably in the form of patches, is useful for in vitro cell cultures or for treating tissues damaged by wounds or necrosis, such as cardiac walls bearing the sequelae of infarction, or a tissue damaged by a diabetic ulcer.

Abstract: A disposable wrap for treating a wound without tearing tender skin. The wrap is designed with an opening so that a band aid can be placed on top of it the opening so that the adhesive will not touch the skin. The soft wrap is fastened to fit with Velcro. When bandage needs changing, this complete wrap can be thrown away. This will keep the elderly patients skin from being torn with the removal of the band aid as the adhesive will never touch the skin. The wrap and band aid will be packaged together for convenience.

Abstract: The present invention provides a method for using a stabilized foam that is a crosslinked, closed cell polyolefin having a stabilizing layer and an adhesive layer. The method can be used for treating a wound, scrape, abrasion or skin puncture, for maintaining cleanliness of an operation incision site, suture site, catheter insertion site, or an intentional skin breach site, for monitoring electrical impulses during an EKG or for delivering electrical impulses in TENS or biofeedback therapy, and for reducing scar formation by softening collagen deposits.

Abstract: A medical closure screen device for a separation of first and second tissue portions is provided, which includes a mesh screen comprising tubular vertical risers, vertical strands with barbed filaments, and horizontal spacers connecting the risers and strands in a grid-like configuration. An optional perimeter member partly surrounds the screen and can comprise a perimeter tube fluidically coupled with the vertical risers to form a tubing assembly. Various input/output devices can optionally be connected to the perimeter tube ends for irrigating and/or draining the separation according to methodologies of the present invention. Separation closure, irrigation and drainage methodologies are disclosed utilizing various combinations of closure screens, tubing, sutures, fluid transfer elements and gradient force sources. The use of mechanical forces associated with barbed strands for repositionably securing separated tissues together is disclosed.

Abstract: Embodiments of the invention relate to a wound covering having a first strip-like element forming a first periphery and a second strip-like element that faces away from the first periphery, runs approximately parallel thereto, forming a second periphery, and is joined to the first strip-like element, there being formed between the first inner periphery of the strip-like element, facing away from the first periphery, and a second inner periphery of the second strip-like element, facing away from the second periphery, a drainage chamber, the depth of which in a depth direction extending at right angles to the periphery ensures a capillary action on bodily fluids received in the drainage chamber, in particular exudates.

Abstract: This present invention proposes a method of producing intrinsically colored, luminescent silk fibroin by feeding silkworms with feed comprising the luminescent dyes as well as the appropriate degumming process to remove sericin while retaining the dyes in silk fibroin are also described. Luminescent and functional molecular organic dyes with balanced hydrophobic/hydrophobic properties that can be effectively absorbed into silk glands of the silkworm are also described.

Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Abstract: A body shaped wound dressing wherein the dressing is a knitted or woven garment comprising a cellulosic yarn, which garment has been carboxymethylated at least in parts of its wound contacting surface.

Abstract: A protective skin covering has at least three distinct layers that can be worn on multiple parts of the human body. An inner layer substantially surrounds an area over which a protective skin covering is to be worn, and is constructed of soft, non-abrasive fabric. A middle layer provides padding to protect a wearer against impact with foreign objects. An outer layer is a durable, flexible, material (such as, for example, nylon or other similar material) that protects the middle layer, protects the skin of the wearer, resists wear and tear, and provides a surface for decorative designs or other attractive features.

Abstract: A wound dressing defines bodyside and backside surfaces. The dressing comprises a backing layer defining a center portion and a border portion surrounding the center portion. An absorbent core is connected to a surface of the backing layer within the center portion The absorbent core may be exposed along a bodyside surface of the wound dressing, or various adhesives and non-adhesive substrates may be applied along a surface of the absorbent core so as to define part of the bodyside surface of the wound dressing.

Abstract: A dressing for promoting healing and pain relief of the body of a living organism having a pathologic condition has at least one layer of conductive material having a resistance no greater than 1000 ?/cm2. When placed proximate a portion of the body of the living organism suffering from the pathologic condition, the dressing alters the electrodynamic processes occurring in conjunction with said pathologic condition to promote healing and pain relief in the living organism. When used as a wound dressing, the conductive material is placed in contact with tissue around the periphery of the wound and with the wound, lowering the electrical potential and resistance of the wound and increasing the wound current.

Abstract: Methods accelerate healing of a wound by applying a multilayer bandage to the wound. The multilayer bandage has a spun-bonded webbing comprising at least one partially or completely hydrolytically condensed silicon compound and a water-impervious or semi-permeable first membrane having at least one water-insoluble polymer. The webbing has a biologically degradable or biologically resorbable structure and is brought into direct contact with the wound by placing the webbing in or on the wound.

Abstract: This invention relates to a wound dressing (10). The wound dressing includes first and second absorbent layers (12, 14) of a non-woven fabric of viscose and polyester fibres. Each absorbent layer has an operatively inner face (20, 26) and an operatively outer face (18, 22). The first and the second absorbent layers are bonded together with their operatively inner faces in face-to-face relationship, such that the absorbent layers together form a pad. The bonding between the first and second absorbent layers may be effected by a needle-punching process in which the needle punching density is no more than 400 punches/cm2. The wound dressing further includes a third layer (16) sandwiched between and bonded to the first and second absorbent layers. The third layer is in the form of cotton gauze. The invention extends to a method of making a wound dressing, and to a method of treating a wound.

Abstract: A bandage includes a body portion and a gauze pad, the body portion being shaped, sized and configured depending upon the wound covering application, the gauze pad having three or four primary corners, the primary corners of the gauze pad in most instances being oriented towards edges of the body portion or length or width tangents of the body portion, preferably mid-points or mid-sections of the length or width tangents or body portion edges.

Abstract: The present invention relates to a wound packing material, suitable for use in negative pressure wound therapy, comprising a body of a porous material, the body comprising frangible regions defining a plurality of portions, the frangible regions allowing the portions to be selectively removed from the body. The invention further relates to methods of manufacturing the wound packing material, and to methods of its use.

Abstract: A wound dressing having a suction member adaptable for connection to a source of vacuum pressure. The wound dressing preferably has a hydrophobic or biodegradable base layer and one or more absorptive layers for absorbing fluid from the wound. The absorptive layers are preferably quilted with patches containing desiccant, adsorbent, or absorbent material. Alternatively, the wound dressing may allow fluid to pass through the suction member. A semi-permeable cover is provided for allowing the wound to breathe while protecting the wound from undesirable substances such as bacteria, viruses, or fluids. The cover may have a bladder for distributing contact pressure away from the wound. Various sensors may be provided in the wound dressing for sensing various physiological parameters in the wound, such as oxygen saturation, blood pressure, respiratory rate, blood glucose, and serous fluid turbidity. Medicine may also be applied to the wound through the wound dressing.

Abstract: A wound dressing comprising an absorbent pad, an adhesive layer, and a backing layer is described, along with a dressing support layer configured to retain and deliver the wound dressing to a wound, the dressing support layer having a radial configuration that forms a plurality of alternating covered and uncovered portions of the backing layer along the perimeter of the wound dressing.

Abstract: A dressing able to adhere to the skin and/or a wound for covering a portion of the anatomical surface of a living being and demonstrating considerably increased wearing time. The dressing has a backing layer and a layer of skin-friendly adhesive for adhering to the skin, and includes a pattern of connected indentations formed in a pattern that is not linear and which progresses in at least three main directions.

Abstract: A medical closure screen device for a separation of first and second tissue portions is provided, which includes a mesh screen comprising tubular vertical risers, vertical strands with barbed filaments, and horizontal spacers connecting the risers and strands in a grid-like configuration. An optional perimeter member partly surrounds the screen and can comprise a perimeter tube fluidically coupled with the vertical risers to form a tubing assembly. Various input/output devices can optionally be connected to the perimeter tube ends for irrigating and/or draining the separation according to methodologies of the present invention. Separation closure, irrigation and drainage methodologies are disclosed utilizing various combinations of closure screens, tubing, sutures, fluid transfer elements and gradient force sources. The use of mechanical forces associated with barbed strands for repositionably securing separated tissues together is disclosed.

Abstract: The present invention provides systems and methods for protecting a wound and managing exudate released from the wound comprising a dressing having a support cushion for surrounding the wound and periwound region; a wicking strip for application in the periwound region between the support cushion and the wound; and a reservoir for application over the wicking strip, the wicking strip configured to transfer exudate from the wound to the reservoir, where the exudate is sequestered. Various alternative embodiments are described in which the wicking strip may be custom-fit to approximate an irregular wound margin, to apply a preferred pressure gradient to the periwound regions, to periodically apply fluids to the wound bed or to apply negative pressure wound therapy. Methods of applying the dressing also are provided.

Abstract: An internal and external medical closure system for a separation of first and second tissue portions is provided, which includes a mesh screen comprising tubular vertical risers, vertical strands with barbed filaments, and horizontal spacers connecting the risers and strands in a grid-like configuration. An optional perimeter member partly surrounds the screen and can comprise a perimeter tube fluidically coupled with the vertical risers to form a tubing assembly. Various input/output devices can optionally be connected to the perimeter tube ends for irrigating and/or draining the separation according to methodologies of the present invention. Separation closure, irrigation and drainage methodologies are disclosed utilizing various combinations of closure screens, tubing, sutures, fluid transfer elements and gradient force sources. The use of mechanical forces associated with barbed strands for repositionably securing separated tissues together is disclosed.

Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Abstract: A method and device for treating wounds 10 of tissue 11 is disclosed. The method has the steps of applying a porous pad 12 upon the treatment surface of the tissue 11; covering the treatment surface and the porous pad 12 with a foil or sealing cover 14 for isolating the treatment surface and the porous pad 12 from the atmosphere; filling the volume under the foil or sealing cover 14 with fluid 100 and purging air from the volume under the foil or sealing cover 14 thereby fluid 100 saturating said porous pad 12: applying an acoustic shock wave treatment through the foil or sealing cover 14 or surrounding tissue 11 or a combination thereof sending acoustic shock waves 200 through the volume to the treatment surface and underlying tissue 11 and thereafter pulling a vacuum to create a sub-atmospheric pressure under the foil or sealing cover 14 wherein the combination of the applied acoustic shock waves 200 and sub-atmospheric conditions stimulates healing of the treatment surface and underlying tissue 11.

Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.

Abstract: A pad of elastomeric material having a softness of no more than about durometer 30 Shore 00. The pad may carry adhesive for adhering the pad to a surface, either directly or indirectly through an envelope which surrounds the pad and carries the adhesive. Such a pad exhibits hemostatic and leak prevention properties against needle puncture holes in the skin or the wall of a hollow medical device. Particularly, hemostasis may be prevented with low pressure application of the pad to the skin. The pad may be previously applied to the skin of the patient or a wall of a medical device such as tubing or a solution bag, and the needle may then penetrate both the pad and the skin or medical device wall, to make a resealable puncture with leakage reduction and hemostasis when the needle is withdrawn.

Abstract: Self-reinforced tissue shields are useful as ophthalmic shields, wound dressings, wound barriers, nerve repair, therapeutic drug delivery devices and the like. The self-reinforced tissue protective shields comprise gelatin, chitosan and reinforce and are made by a method comprising forming inter-molecular locking within a solution through electrostatic forces, eliminating the use of extra cross-linking methods, the solution mainly comprising natural existing polymers that are biodegradable and biocompatible.

Abstract: Dressings, systems, and methods for treating a tissue site on a patient involve allowing liquids from the tissue site or a priming fluid to evaporate and exit the dressing through a liquid-impermeable, vapor-permeable membrane. The dressing is able to process more liquids than would otherwise be possible without evaporation and potentially to create reduced pressure. Other dressings, systems, and methods are disclosed.

Abstract: A wearable article formed of a gelatinous elastomer composition having 100 parts by weight of triblock copolymer of the general configuration poly(styrene-ethylene-butyiene-styrene) wherein the styrene end block to ethylene and butylene center block ratio is within the range of from between 31;69 to 40:60, from about 300 Io about 1,600 parts by weight of a plasticizing oil and having a gel rigidity of about 20 gram to about 700 gram Bloom.

Abstract: A tunnel dressing for use in treating a tunneling wound using negative pressure wound therapy. The tunnel dressing includes an elongate permeable member having a closed distal end for entering the wound and an open proximal end into which an applicator is removably disposed for guiding the dressing into the wound. The tunnel dressing has a support structure adapted to transport wound exudates away from the wound and to resist compression under suction. The tunnel dressing also has a wound contact surface adapted to minimize tissue entanglement to facilitate removal. The support structure and wound contact surface may be formed from the same material or from two adjacent layers of different material.

Abstract: A wound dressing includes a wound-filling member attached to a hemostasis inducer that can be impregnated with an active compound, such as coagulants. The wound dressing can be placed in wounds to provide pressure, as well as chemical action, to promote blood coagulation and thereby arrest bleeding. A wrap can be attached to the wound dressing to provide an easy and quick method of securing the wound dressing. The wound dressing can be compressed in a small package for easy transport.

Abstract: The present invention relates to a layered membrane sandwich system. In its simplest form, the present invention is a three layer membrane sandwich having a center layer of polyester positioned between first and second layers of silicone. The present invention can be used generally as an anti-adhesion membrane or as a barrier to tissue reaction following surgery. In addition, the present invention may optionally be used as a pericardial patch.

Abstract: Systems, methods, and apparatuses are presented that involve forming patterns on neo-epithelium that allow increased functionality and may more nearly resemble the original epithelium. In one instance, a patterned neo-epithelium dressing for treating a tissue site having granulation tissue includes an interface member for placing proximate the granulation tissue and a plurality of three-dimensional features formed on a second, patient-facing side of the interface member. Other systems, methods, and apparatuses are disclosed.

Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of treating a wound comprises the steps of providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.

Abstract: The various embodiments herein provide a polymer wound dresser in which no drug is used and a method of producing the same. According to an embodiment, a wound dressing film comprises a base polymer film and a laminated backing layer on the base polymer film. The base polymer film includes a natural polymer, a biopolymer and an artificial water absorber polymer. The natural polymer is a chitosan having a preset weight percentage. The biopolymer comprises one or more element selected from a group comprising of a gelatin having a preset weight percentage and a collagen having a preset weight percentage or a combination thereof. The artificial water absorber polymer is selected from a group comprising of a hydrophilic material having a preset weight percentage. The wound dressing film is a single film or a double layered film or a three layered film.

Abstract: A disposable wound-healing device is disclosed that incorporates a housing having a fluid-impermeable material having a cavity and a perimeter that can be sealed in an air-tight manner over a wound region of a patient. The device is capable of producing a negative pressure over the wound region by either removing oxygen from within the cavity, or absorbing fluid into the cavity and then removing the fluid from the cavity. The oxygen may be removed via chemical absorption, by an electrochemical cell or by a chemical reaction that cannibalizes oxygen from the cavity. The fluid may be removed through the use of osmotic or electro-osmotic cells, or through a one-way valve. The negative partial pressure over the wound region promotes healing.

Abstract: The invention relates to a wound treatment item having a proportion of modified natural fibers or synthetic fibers with a high dehydrating capacity.

Abstract: A therapeutic adhesive film drape includes an outer transparent layer which has a printed grid across an outer surface thereof and an inner layer for application adjacent a wound which includes a semi-permeable transparent adhesive cover removably connected to the outer transparent layer. A method of treatment employs the therapeutic drape.

Abstract: The present disclosure relates to nitric oxide sensors and systems.

Abstract: A dressing for promoting healing and pain relief of the body of a living organism having a pathologic condition has at least one layer of conductive material having a resistance no greater than 1000 ?/cm2. When placed proximate a portion of the body of the living organism suffering from the pathologic condition, the dressing alters the electrodynamic processes occurring in conjunction with said pathologic condition to promote healing and pain relief in the living organism. When used as a wound dressing, the conductive material is placed in contact with tissue around the periphery of the wound and with the wound, lowering the electrical potential and resistance of the wound and increasing the wound current.