Abstract: Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like.

Abstract: A system includes a tubing set and a drive assembly. The tubing set includes inlet tubing couplable to a source of fluid, a valve coupled to the inlet tubing, a syringe coupled to the inlet tubing via the valve, and outlet tubing coupled to the valve. The valve is configured to allow fluid to be drawn from the source of fluid via the inlet tubing into a syringe body of the syringe and to be expelled from the syringe body and through the outlet tubing, and to prevent fluid from being drawn from the outlet tubing into the syringe body and to prevent fluid expelled from the syringe body from flowing through the inlet tubing. The drive assembly is configured to reversibly receive the tubing set such that a drive mechanism is engaged with a plunger of the syringe to reciprocally translate the plunger relative to the syringe body.

Abstract: An infusion device configured to implant a cannula and a sensor in a user. The infusion device includes a first unit defining a first housing and a second unit defining a second housing. The second housing is configured to engage the first housing. The infusion device includes a first insertion needle configured to implant the cannula in the user and a second insertion needle configured to implant the sensor in the user when the second unit engages the first unit. The infusion device includes processing circuitry in electrical communication with the sensor and a fluid reservoir in fluid communication with the cannula. In examples, the first unit and the second unit are configured to engage using an inserter.

Abstract: An automatic injection device including a reusable driving assembly having a forward injection end and an engagement element and a disposable cassette assembly including an injectable liquid to be injected at an injection site, wherein the disposable cassette assembly is removably insertable into the reusable driving assembly at the forward injection end and is removably retained within the reusable driving assembly by snap fit engagement therewith, the snap fit engagement being effected at least partially by the engagement element, which is displaced rearwardly by insertion of the disposable cassette assembly in the reusable driving assembly.

Abstract: A medicament delivery device including a housing for receiving a syringe, the housing having first and second casing parts separably attachable to one another. The device further includes a sleeve receivable within the housing and including a tubular wall having an inner surface delimiting a bore and an opposing outer surface. A locking member is receivable within the second casing part such that the locking member is axially movable between first and second axial positions relative to the second casing part. In the first axial position the locking member is engageable with the outer surface to inhibit an axial movement of the sleeve relative to the first casing part. In the second axial position the locking member is disengageable from the outer surface. The device, in one or more embodiments, includes an application as an autoinjector.

Abstract: An assembly comprising a drug delivery device and an add-on device adapted to be releasably mounted thereon, the drug delivery device comprising a rotatable dose setting member with an outer surface and at least one axially oriented drive groove. The add-on device comprises a drive portion adapted to be mounted in engagement with the dose setting member and comprises a drive structure adapted to engage a drive groove and being biased in a radially inwards direction. This arrangement allows the drive structure to rotationally slide on the dose setting member outer surface and into engagement with the drive groove(s).

Abstract: An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.

Abstract: The present specification relates to a drug delivery device including a housing adapted to receive a primary container with a piston, a plunger slidably disposed in the housing and adapted to drive the piston for delivering a medicament, a drive spring pre-loaded between the housing and the plunger so as to urge the plunger in a distal direction, an audible and/or tactile indicator, and a trigger mechanism arranged between the indicator and the plunger. The trigger mechanism is configured to support the indicator in an initial state of the device and during delivery of the medicament and to couple with the plunger to activate the audible and/or tactile indicator at or near an end of delivery.

Abstract: The present invention concerns a drug delivery device (1) comprising: a housing (2) extending along a main axis, a torsion spring (5) comprising a first spring end (4) arranged stationarily with respect to the housing (2) and a second spring end (6) capable of rotation about the main axis, a rotatable shaft (80) extending along the main axis, the rotatable shaft (80) having a non-self-locking thread (81) and being axially fixed with respect to the housing (2), a spring end retainer (82) to which the second spring end (6) is attached, the spring end retainer (82) being rotationally fixed relative to the rotatable shaft (80), and a nut member (45) engaged with the non-self-locking thread (81), the nut member (45) being axially movable by translation relative to the housing (2) to thereby travel the non-self-locking thread (81) between a first position in which the torsion spring (5) is in a relaxed state and a second position in which the torsion spring (5) is in a strained state.

Abstract: An automatic injection device including a housing element, at least one resilient element arranged to be located within the housing element, a syringe including at least one syringe piston, a needle guard adapted for selectable positioning with respect to the housing element and a selectable driving element adapted, when actuated, to be driven by the at least one resilient element for initially displacing the syringe relative to the housing element from a non-penetration position to a penetration position and thereafter displacing the at least one syringe piston in the syringe to effect drug delivery and displacing the needle guard into a needle guarding position.

Abstract: An add-on device for a drug delivery device comprises a camera for capturing an image of a scale drum, and a processor for determining the value of a captured image using a first image analysis process, the value corresponding to a set dose amount. If the determined value belongs to a pre-defined group of values, the determined value is confirmed using a second image analysis process in which for a given value from the pre-defined group of values one or more partial image areas and an associated nominal content thereof are pre-defined. If the captured content for each image area corresponds to the nominal content, the determined value is confirmed.

Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position in which the recess is exposed to receive the injection device, and a closed position in which the cover at least partially closes the recess to hold the injection device in the body portion. The accessory further comprises a cap remover comprising a grip adapted to hold the needle cap. The cap remover is moveable with respect to the body portion.

Abstract: Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug to be used in a drug or substance overdose.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector also has, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector, and a trigger button is used for releasing the control spring on actuation.

Abstract: A needle insertor for a medicament delivery device is presented having a driver having a first part movably arranged within the case and a second part connected to the base, a needle assembly movably held by the first part in the case, a rotator arranged in the case and configured to engage the first part for moving the driver, an energy accumulation member configured to interact with the rotator for applying a rotational force on the rotator, a movable stop arranged on the base and configured to interact with the rotator for preventing the rotator from rotating. The first part has a first position where the needle assembly is held inside the case, a second position where the needle portion is positioned outside the case after being moved to pass through the injection site end, and a third position where the needle portion is positioned inside the case.

Abstract: A method and system for providing a drug delivery device. The drug delivery device comprises a dose setting mechanism comprising a spindle and a cartridge holder coupled to the dose setting mechanism. The cartridge holder comprising a cartridge having a movable bung at one end of the cartridge. The cartridge holder must be rotated before a dose may set with the dose setting mechanism.

Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.

Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position in which the recess is exposed to receive the injection device, and a closed position in which the cover at least partially closes the recess to hold the injection device in the body portion. The accessory further comprises a cap remover comprising a grip, the cap remover having an expanded configuration in which the needle cap can pass between the grip, and a constricted configuration in which the grip holds the needle cap to at least partially remove the needle cap from the injection device.

Abstract: The present invention relates to an injection device comprising a torsion spring operatively connected to a dose setting member being adapted to set a dose to be ejected from the injection device. A rotatably mounted display member adapted to display the dose to be ejected in accordance with a setting of the dose setting member is also provided. The rotatably mounted display member is adapted to be rotated over an angle corresponding to at least one revolution of the display member. The display member may be implemented as a dose indicator barrel having numerals arranged along a helical path on an outer surface thereof, or alternatively, as a counting device having two or more display wheels having numerals arranged on an outer surface thereof.

Abstract: An exemplary embodiment of an injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger mechanism can include a floating trigger member having a retaining portion, a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

Abstract: A data collection device is configured to capture images of a dosage indicator of a medicament delivery device and, if an injection is administered without prior confirmation of a dosage amount, to prompt the user to set a value for the delivered medicament dosage amount for storing in a dosage log. For example, the determination may be based on specific confirmation from the user or detecting a zero dosage amount in captured images. A suggested dosage amount may be displayed to the user, for example a highest or more recently programmed dosage amount prior to the injection or based on one or more previously confirmed dosage amounts. The data collection device may use one or more of optical character recognition, optical pattern recognition and determination of direction of rotation of a dosage adjustment component to determine whether an injection is being, or has been, administered and/or a suggested dosage amount.

Abstract: A drug delivery system includes a reservoir and a drug delivery device coupled to the reservoir. The drug delivery device also may include at least one temperature-sensitive component and a lock having locked and unlocked states. The system further includes an output device, and a controller coupled to the lock and the output device. The controller may also include a temperature sensor, or may be coupled to the temperature sensor. The controller is programmed or configured to determine if the temperature of a drug in the reservoir or of the temperature-sensitive component exceeds an upper limit or is below a lower limit, and to activate the lock in either event. The controller is also programmed or configured to determine, directly or indirectly, if the temperature subsequently is between the upper and lower limits, and to unlock lock as a consequence.

Abstract: An injection device includes a housing, a dosing member held so as to be rotatable and fixed in the housing and an injection sleeve held so as to be rotationally fixed in relation to the housing and displaceable therein. A latching unit of the injection device is configured to act between two components thereof which, during setting of an amount of injection fluid to be dispensed, move relative to one another. A set amount of injection fluid is unequivocally assigned to each relative position of the two components.

Abstract: An injection device includes a housing, a dosing member held so as to be rotatable and fixed in the housing and an injection sleeve held so as to be rotationally fixed in relation to the housing and displaceable therein. A latching unit of the injection device is configured to act between two components thereof which, during setting of an amount of injection fluid to be dispensed, move relative to one another. A set amount of injection fluid is unequivocally assigned to each relative position of the two components.

Abstract: A medicament delivery device and a controller is disclosed. The medicament delivery device includes a medicament container, plunger rod and a resilient member. The plunger rod is in contact with a slidable stopper within the medicament container for expelling a medicament. The resilient member is used for applying a force to the plunger rod upon a delivery of the medicament. In addition, the controller is configured to detect a completion of a delivery stroke of the plunger rod according to an inductive property of the resilient member.

Abstract: A medicament injection device is disclosed comprising a housing containing a medicament cartridge holder; a rotatable cap assembly; a needle holder holding a needle, the needle holder being releasably supported by the cap assembly, a pre-stressed spring coupled to the medicament cartridge holder; wherein the cap assembly is arranged so that rotation thereof releases the pre-stressed spring, causing the medicament cartridge holder to move axially in a distal direction towards the needle. A method of operating the device is also disclosed.

Abstract: An injection device comprising a housing having a longitudinal axis, a dose selector (16) capable of being rotated about said longitudinal axis with respect to said housing by a user to set a dose of medicament to be ejected from the injection device and a spring (20) capable of storing energy necessary for ejecting the dose of medicament from the injection device. The spring is coupled to the dose selector such that a charging force can be transferred from the dose selector to the spring to increase the energy stored by the spring. The injection device further comprises a ratchet arrangement (25) moveable between an engaged state in which the spring is limited from unwinding from a currently selected dose and a disengaged state in which the spring is able to unwind and a drive assembly including a plunger element (23) capable of providing an axial force for ejecting a dose of medicament from the injection device.

Abstract: A device for filling and priming syringes is provided and comprises a support base, an engagement seat defined on the support base to receive a rear end of a syringe barrel of a syringe provided with a sliding plunger, engaging means defined at the engagement seat to cooperate with the syringe barrel for firmly holding the syringe to the engagement seat, a first vacuum pump or compressor which is provided with a suction opening communicating with the engagement seat to generate an under-pressure in the volume comprised between the plunger and the engagement seat when the syringe is firmly engaged in the engagement seat, and a second vacuum pump or compressor which is provided with a discharge opening communicating with the engagement seat to generate an over-pressure in the volume comprised between the plunger and the engagement seat when the syringe is thinly engaged in the engagement seat.

Abstract: Described is a medicament container carrier adapted to hold a first medicament container having a first predetermined size and capable of containing more than a first volume of a medicament. The container carrier comprises a body, and an adapter coupled to the body. The adapter is adapted to hold a second medicament container having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.

Abstract: A medicament delivery device is presented having a housing configured to accommodate a medicament container filled with medicament, a drive unit comprising a plunger rod operable to act on the medicament container, a mechanical activation mechanism configured to interact with the drive unit, where the mechanical activation mechanism is movable between certain predetermined states when interacting with the drive unit, a recording unit capable of recording status changes of the medicament delivery device including the status of the mechanical activation mechanism, and detection elements operably connected to the recording unit and positioned such as to detect when the activation mechanism has been moved between certain predetermined states.

Abstract: An automatic injection device including an injection syringe equipped with a syringe body and with a piston rod mounted movably in this syringe body so as to cover an injection stroke, a piston control member capable of changing between a configuration in which it is in engagement with the piston rod and a configuration in which it is disengaged from this piston rod, mechanism for moving the piston control member between its two configurations with respect to the piston rod. The mechanism for moving the control member between its two configurations includes a camway carried by a disengagement member and a cam carried by the control member. The disengagement member is movable with respect to the piston rod and the syringe body after the end of the injection stroke, in such a way as to cause the camway to interact with the cam.

Abstract: A syringe assembly for administration of a neurotoxin, the syringe assembly comprising: a syringe comprising: a clear syringe barrel with dosage markings completely encircling the clear syringe barrel; and a plunger having a plunger body and a clear inverted plunger tip; and a needle assembly comprising a needle and a sealing hub for removably attaching the needle assembly to the syringe, wherein the needle is approximately 0.15 inches to approximately 0.3 inches in length and has a gauge of approximately 27 gauge to approximately 35 gauge.

Abstract: A drug delivery device comprising a rotatable scale drum, a trigger member, an actuation member, a trigger spring acting on the trigger member and being energized by movement of the actuation member, as well as an end-of-dose switch adapted to be actuated by movement of the trigger member. The trigger member is adapted to be arranged in an axially supported position against the action of the energized trigger spring, and released from the axially supported position when the scale drum is rotated from a set position to an end-of-dose position, whereby the trigger member is moved axially by the trigger spring, the end-of-dose switch thereby being actuated.

Abstract: The present disclosure is directed to a spring arrangement for use in a drug delivery device and a drug delivery device including such a spring arrangement. The spring arrangement includes a clutch spring which is located axially interposed between a stationary housing component and an axially movable sleeve. The sleeve includes clutch features adapted to engage corresponding clutch features of a clutch element. The clutch spring biases the clutch features and the corresponding clutch features into engagement. The sleeve is coupled to a button such that upon actuation of the button the sleeve is translated against the bias of the clutch spring from a proximal position in which the sleeve is rotationally locked to the housing component into a distal position in which the sleeve is rotationally un-locked from the housing component. Upon release of the button the clutch spring translates the sleeve and the button into the proximal position.

Abstract: A device that regulates, monitors, and provides data on the progress of a large-volume injector during its injection sequence. The device comprises an injector and a monitor assembly. The injector has a syringe having a plunger, and a biasing device that biases the plunger through the syringe. The monitor assembly comprises a resistance unit configured to resist movement of the plunger, a gear connected to the plunger by the resistance unit, and a control unit configured to monitor the position, and regulate the rotation, of the gear. Wherein linear movement of the plunger causes the gear to rotate so that the control unit generates information on the position of the plunger.

Abstract: An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw.

Abstract: A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Abstract: The present disclosure relates to a medicament delivery device comprising: a housing having a proximal and distal end; a medicament container positioned in the housing and having a medicament delivery member shield; a medicament delivery mechanism associated with the medicament container; an activation member operably connected to the medicament delivery mechanism and longitudinally movable in relation to the housing from an extended position to a retracted position to activate the medicament delivery mechanism; and a removable cap assembly comprising an outer tubular cap body and an inner tubular integrity lock member coaxially coupled to the outer tubular cap body; wherein in a first position of the removable cap assembly, a resilient structure of the inner tubular integrity lock member is engaged to a first engaging structure of the activation member and a second engaging structure of the housing for preventing the activation member from moving into the retracted position.

Abstract: The present disclosure relates to a medicament delivery device comprises: a housing having a proximal end and a distal end; a medicament container positioned in the housing and having a medicament delivery member shield; a medicament delivery mechanism associated with the medicament container; an activation member operably connected to the medicament delivery mechanism and longitudinally movable in relation to the housing from an extended position to a retracted position to activate the medicament delivery mechanism; and a removable cap assembly comprising a deshielder, an inner tubular integrity lock member having a resilient structure configured to interact with both a first engaging structure of the activation member and a second engaging structure of the housing for preventing the activation member from moving into the retracted position; and wherein the removable cap assembly further comprises an outer tubular cap body which is movable in relation to the housing and to the inner tubular integrity lock me

Abstract: A controlled delivery drive mechanism includes a drug container having a barrel and a plunger seal; a drive housing within which at least initially partially resides a piston having an interface surface and a drive rack; and a power spring. The piston is configured to contact and axially translate the plunger seal within barrel. The mechanism may be configured to convert rotational movement of a drive pinion to axial translation of the drive rack, or to convert axial force of a linear power spring into torsional motion of a drive pinion. A regulating mechanism meters the drive pinion such that the piston is axially translated at a controlled rate. The drug container may contain a drug fluid within a drug chamber for drug delivery at a controlled rate. The regulating mechanism may be an escapement regulating mechanism. A drug delivery pump includes such controlled delivery drive mechanisms.

Abstract: A medicament delivery device includes a housing having a longitudinal axis, a container holder, an axially movable plunger adapted to be displaced along the longitudinal axis into the container holder, and an energy accumulating member arranged inside the housing and adapted for displacing the plunger along the longitudinal axis. The plunger includes an outer plunger rod and an inner plunger rod arranged at least partially inside the outer plunger rod, the inner plunger rod being threadedly engaged with the outer plunger rod and manually rotatable to displace the inner plunger rod along the longitudinal axis into the container holder.

Abstract: An injector including at least one fluid reservoir having a needle, a surface attached to skin and coupled to the fluid reservoir by at least a first joint and a second joint at least a portion of one of the joints being slidable or having interlocking arms. At least a portion of a path of translation of a slidable portion of the first joint and a portion of a path of translation of the second joint are angled in respect to each another.

Abstract: A syringe assembly for administration of a neurotoxin, the syringe assembly comprising: a syringe comprising: a clear syringe barrel with dosage markings completely encircling the clear syringe barrel; and a plunger having a plunger body and a clear inverted plunger tip; and a needle assembly comprising a needle and a sealing hub for removably attaching the needle assembly to the syringe, wherein the needle is approximately 0.15 inches to approximately 0.3 inches in length and has a gauge of approximately 27 gauge to approximately 35 gauge.

Abstract: An auto-injector device comprises a cap removal mechanism which comprises a retractable component which is slidably mounted within a housing of the device, and a cap-removal actuator to push the retractable component out of the housing to remove a cap from the device; a dispense mechanism which comprises a driving element to expel a medicament from the device; and a dispense button which activates the cap removal mechanism when pressed a first time, engages with the dispense mechanism when released, and activates the dispense mechanism when pressed a second time. The dispense mechanism comprises an engaging element configured to engage with the dispense button when the dispense button has been pressed for a first time and released.

Abstract: A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if the dose limiting mechanism fails, the safety mechanism prevents ejection of a dose exceeding the set dose.

Abstract: An injector for ejecting an intraocular lens into an eye, comprises a longitudinal injector body, in which an injector piston rod can be guided in an axially displaceable manner, an injector nozzle at a front end of the injector body, in the direction of which the injector piston rod can be displaced, a displacement mechanism for pushing the injector piston rod forwards, and an actuating element for the manual actuation of the displacement mechanism. The displacement mechanism includes a transmission mechanism, by means of which the actuating element and the injector piston rod can be placed in an articulated driving connection, and an operating region for the actuation of the actuating element is formed at a longitudinal side of the injector body.

Abstract: A drive mechanism for a delivery device comprising a rotator comprising an outer surface and an inner surface, the rotator configured to rotate from a first position to a second position; and a needle cover comprising an inner surface that engages the outer surface of the rotator. An end of injection indication device is positioned at least partially within a plunger rod spring, the end of injection indication device providing a signal to a user of the drive mechanism that an injection has been completed.

Abstract: There is provided drug delivery devices comprising a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

Abstract: An autoinjector having a body (1) receiving a reservoir (S), the reservoir containing fluid and including a piston (P); a piston rod (5) adapted to co-operate with the piston (P) of the reservoir (S), the piston rod (5) movable by an injection spring (8) between a primed position and an injection position in which the piston rod (5) has moved the piston (P) of the reservoir (S); and an indicator device for indicating that the autoinjector may be removed from the injection site. The autoinjector includes a retarding system for delaying actuation of the indicator device relative to the end of injection, the retarding system including a dashpot (16) containing a fluid and a piston (19) arranged in the dashpot (16). The retarding system has the dashpot (16), the piston (19), a retarding spring (18), a locking key (20), and the piston rod (5), and the piston rod (5).

Abstract: An automatic injection device configured for injection of a material stored in a syringe into an injection site, the syringe including a generally cylindrical storage container and a piston disposed therewithin, whose exact initial axial position within the container is not predetermined, wherein axial forward displacement of the piston in the container forces the material forwardly out of the container, the automatic injection device including at least one spring drive assembly operative, when actuated, to initially apply a first axial force to the syringe, thereby to axially displace the syringe in a forward direction, and thereafter, responsive to driving engagement with the piston, to apply a second axial force, substantially greater than the first axial force, notwithstanding the fact that the exact axial position of the piston within the container is not predetermined, to the piston, thereby to axially forwardly displace the piston relative to the syringe.