Abstract: A single housing comprising a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein said reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.

Abstract: A medical pump, comprising a reservoir having a fluid enclosing portion and a tubular element, the inside of which is arrangeable in fluid communication with the fluid enclosing portion for allowing fluid to pass into the tubular element. The fluid enclosing portion contains a volume of fluid sealed from communication with air and the fluid enclosing portion is adapted to reduce in volume essentially to the same extent as any volume of fluid transferred into the inside of the tubular element. The invention also relates to a method of delivering a medical fluid.

Abstract: A syringe or cartridge having a hollow barrel with an open end and a second end suitable for attaching a needle assembly. A master plunger assembly that includes a master plunger and a plunger member is mounted in the barrel for longitudinal movement therein. A slave plunger is mounted in the barrel for longitudinal movement therein, and is located between the master plunger assembly and the second barrel end so as to define two chambers. The first chamber a liquid chamber and is between the slave plunger and the second barrel end, and the second chamber is a pneumatic chamber and is between the slave plunger and the master plunger assembly. The liquid-containing chamber is suitable for containing a liquid to be dispensed from the syringe, and the pneumatic chamber contains a gas such as air.

Abstract: A syringe (and a prefilled syringe) of a structure with ventilation means allowing a pusher to be easily pushed or pulled in use, providing an excellent operability of discharging (injecting) chemicals, making it hard for foreign matter such as dirt and dust to enter into a syringe outer tube when not in use during storage or transporation, capable of assuring, by itself, the sanitation of the syringe outer tube when not in use, and allowed to be shipped without individually packaging the syringe with packaging material, wherein, as more desirable embodiments, the aseptic condition in the outer tube can be surely maintained even if the push and pull operations of the pusher are performed and, even if the pusher is pushed when not in use, a gasket does not move in tip direction and the arrangement of the pusher at the time of shipping can be stably maintained.

Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.

Abstract: Filter cartridge assemblies and housings are provided and include a tubular housing having an inner wall, an outer wall, a first end, and a second end. The housings include inner walls with shoulders or other radially-inwardly extending flow directors at the intersections of adjacent sections of the tubular body. The assemblies include a plurality of filter media sections within the housing, and each of the plurality of filter media sections preferably has a different filter media composition. One or more of the filter media sections traverses one or more of the shoulders or other radially-inwardly extending flow directors such that the flow directors evenly direct the flow of fluid through the assembly. The assemblies find particular applicability in dialysis systems.

Abstract: A single housing comprising a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein said reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.

Abstract: A hand-held power syringe. The power syringe includes a handle with pivotally connected first and second members. The first member is also pivotally connectable to a syringe barrel, while the second member is pivotally connectable to a syringe plunger. These three pivotal connections provide leverage for forcing high viscosity fluids into and out of a receptacle of the syringe barrel. One or both c,f the first and second members of the handle may be bent to facilitate a user's gripping and movement of the first and second handle member. The power syringe may be used in any suitable injection, infusion, or sample-obtaining application, including angiography and angioplasty.

Abstract: Syringes of the invention include a barrel having a tapered outlet portion and a plunger that is conformingly tapered to enter the tapered portion of the barrel and to expel the fluid material contained within the tapered portion of the barrel. To help expel the material from the barrel, the syringes of the invention include sealing means that are configured to seal the stem of the plunger to the barrel. The sealing means may include one or more rings that circumferentially protrude away from the stem and slidably engage the inner surface of the barrel. In certain embodiments, the syringes also include applicator valves that are disposed at the outlet end of the barrel and that can be rotated between open and closed positions to control the flow of the fluid material out of the barrel.

Abstract: What is described herein is a mixing device having a plurality of chambers and at least one transferor for mixing components of a tissue sealant.

Abstract: A syringe or cartridge having a hollow barrel with an open end and a second end suitable for attaching a needle assembly. A master plunger assembly that includes a master plunger and a plunger member is mounted in the barrel for longitudinal movement therein. A slave plunger is mounted in the barrel for longitudinal movement therein, and is located between the master plunger assembly and the second barrel end so as to define two chambers. The first chamber a liquid chamber and is between the slave plunger and the second barrel end, and the second chamber is a pneumatic chamber and is between the slave plunger and the master plunger assembly. The liquid-containing chamber is suitable for containing a liquid to be dispensed from the syringe, and the pneumatic chamber contains a gas such as air.

Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.

Abstract: A liquid medication delivery device for, and a method of, delivering medication from a cartridge having a moveable piston at one end is disclosed. The piston has a first wall face that contacts the liquid in the cartridge and a second wall for engaging a piston rod that drives the piston. The first and second walls are moveable but the second wall tends to move more quickly then the first during administration of a dose of medication from the cartridge. To compensate for this difference in movement between the first and second wall faces, the rod first moves a distance corresponding to the amount that the first wall face must move to deliver the desired dose and then it continues to move past this position by an amount known as an overshoot distance. It is then retracted by a distance equal to the overshoot distance.

Abstract: A single housing includes a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein the reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.

Abstract: The present invention relates to a method for producing a prophylactically or therapeutically active protein, the syringe being filled with a body fluid and incubated, and the prophylactically or therapeutically active protein subsequently being formed in the body fluid.

Abstract: A syringe device includes a barrel in which a stopper connected to a plunger is movably received, and an engaging section extends from an end of the barrel. A base member is disengagably received in an engaging section of the barrel and a needle cannula is connected to the base member. The stopper has a protrusion which is engaged with a recess in the base member when the stopper is moved to a extreme position when pushing the plunger. The base member is disengaged from the engaging section and moved into the barrel together with the stopper when the plunger is pulled backward. A pushing device is located between the base member and the stopper to tilt the base member in the barrel.

Abstract: A safety syringe with a hollow barrel housing and a retraction trunk coaxially formed within the housing to forming an annular chamber between the inner surfaces of said outer elongated hollow barrel and the outer surface of said retraction trunk. A needle cannula carriage is held within the distal end of the retraction trunk by a latching means and a biasing means. A needle cannula module is suitably fixed to the distal end of the needle cannula carriage wherein a cannula or passage provides fluid communication from the needle cannula module, through the needle cannula carriage, through the retraction trunk and into the annular chamber. An annular plunger is provided between the inner surfaces of the outer elongated hollow barrel and the outer surface of the retraction trunk, wherein said annular plunger forces fluid through said annulus and into a body.

Abstract: A device for transferring cells present in fluid media is provided which is especially useful for in vitro fertilization techniques and intracytoplasmic sperm injection procedures.

Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.

Abstract: A safety hypodermic syringe is disclosed including a barrel and a needle cannula holder. The barrel comprises a stop ring suspended inside the front section thereof, and connecting ribs connected between the inside wall thereof and the stop ring. The needle cannula holder fastened to the front section of the barrel comprises a front extension hub holding a needle cannula, a plurality of wedge-like locating blocks protruded from the periphery of the front extension hub and stopped at the front side of the stop ring, and a shoulder stopped at the rear side of the stop ring. The needle cannula holder is constrained by an axial force exerted from the stop ring and connecting ribs of the barrel. After the service of the safety hypodermic syringe, the needle cannula holder is pushed more forwards to force the shoulder against the connecting ribs and to break the connecting ribs separate, for enabling the needle cannula holder and the needle cannula to be further pulled backwards into the inside of the barrel.

Abstract: The existing syringes in use today consist of a single barrel with only one chamber and one plunger. The “Single Barrel Double Chamber Syringe” is a modified version of the existing syringe in that it uses a single barrel syringe separated into two chambers by the use of a hollow cone shaped floating plunger. The hollow floating plunger creates two independent chambers capable of delivering two medications in one motion without mixing of the fluids. The hub of the syringe has also been modified with a needle that has a sharp point facing to the inside of the syringe and has a small hole bored into the side near the base. This will allow the hollow floating plunger to be pierced once the first chamber is emptied. The hole in the base of the needle will relieve the pressure in the first chamber after the needle has passed through the hollow floating plunger while allowing any remaining fluid to be expelled.

Abstract: A syringe with a cylinder (1) and a plunger (4) that slides into it is provided, which has a recess (13) in its front side (5) and at least two cylindrical sections (9, 10) on its barrel surface (6), between which a groove (12) reduces the diameter of plunger (4). The pressure that is applied in the syringe acts on outer side (14) of the recess and on an outside face section (15) in a gasket lip (16), which is pressed by this pressure or else by a previously introduced prestressing against the inside cylinder wall and thus seals the syringe contents from the environment.

Abstract: A pressure injection syringe (10) with an actuator (100) that includes a plunger (102) for pressurizing viscous fluid material within a chamber (14). The plunger distal tip (112) includes a high pressure seal (110) defined by a seal member (118) within a seal seat (116). The high pressure seal (110) is viscoselective to permit air passage therepast for aspiration, and to prohibit viscous material passage therepast during actuation of the actuator wherein high pressure is applied to the material within the chamber (14).

Abstract: A single-use syringe having a barrel and a plunger is provided. The plunger at least one vane, and the vane is provided with serrations or ratchet teeth. The serrations each have a vertical rear wall and a sloped top edge. A barbed clip is provided that fits on the serrated vane. The barbs on the clip engage the inner wall of the barrel.

Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.

Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.

Abstract: A prefilled syringe including a barrel having an opening at opposite ends and an inwardly projecting annular wall at a distal end and a plastic film tube hermetically bonded to a needle-connecting member and the plunger at each end.

Abstract: A low cost safety sterile cartridge injector apparatus comprising an injector and a safety needle sheath having elements which promote facile assembly and disassembly. An embodiment is disclosed which incorporates an integral needle hub and safety sheath which is displaced to protectively cover a medical needle after use. The sheath also incorporates patterns of rachet teeth which cooperate with a holder portion of the injector to lock a sterile cartridge in place for use in a medical procedure and to release the cartridge for facile disposal when the sheath is displaced to cover and protectively shroud the needle after use. Through this process, need for rotary collars to capture and hold the cartridge in place during use is eliminated, reducing injector cost and apparatus assembly steps and time.

Abstract: Non-reusable syringe having a syringe body, a hypodermic needle and a slidable piston for drawing and discharging fluid through the needle. In one embodiment, the non-reusable syringe includes a movable engagement member. A first position of the movable engagement member permits initial withdrawal of the piston, allowing fluid to be drawn into the syringe. Initial withdrawal of the piston moves the movable engagement member into a second position. After the fluid has been substantially discharged, the second position of the movable engagement member captures the piston and prevents the piston from being withdrawn again. In another embodiment, the movable engagement member is mounted on, and movable with respect to, the piston. The non-reusable syringe can also include a releasable connection between the piston and the piston driver. Once the piston has been captured, a second attempt to use the syringe will separate the piston from the piston driver, further preventing reuse of the syringe.

Abstract: A reagent cartridge for reacting a soluble reagent with a fluid diluent is disclosed having a fluid inlet for accepting a diluent and fluid outlet for expelling a solution. The cartridge casing also has fluid manifolds adjacent to the inlet and the outlet for directing fluid in a radial direction from the inlet to the outlet. The casing further defines a receptacle for a soluble reagent. A volumetric compensation means for volumetrically compensating for dissolution of the reagent upon introduction of the diluent into the fluid inlet is provided. The volumetric compensation means can take the form of a resilient sponge material having a compressed volume and an expanded volume, wherein the expanded volume is up to at least 500% of the compressed volume. The volumetric compensation means can also take the form of resilient coil springs. In other embodiments, a fluid permeable pressure plate is positioned adjacent to a free end of the coil spring and the reagent is positioned against the pressure plate.

Abstract: An injection cartridge (1) of the dual-chamber type having a bypass connection (12) between its two chambers (9, 10) which is arranged such that the interior wall of the cartridge is modified in a predetermined area in such a way that the movable wall (11) between the two chambers does not seal completely against the interior wall in said area. The modification of the wall is arranged as a plurality of lands and grooves (12) which have a direction that is inclined in relation to the longitudinal axis of the cartridge barrel.

Abstract: An automatic needle-retracting syringe (2,80), intended for single use applications, includes a barrel (4), having a needle end (6), a plunger end (8) and a bore (10), and a plunger (12) at the plunger end. A needle gasket (16) is slidably mounted within the bore to define a near region (18) and a far region (20). A hollow needle (28) is mounted to the needle gasket. A path (26) through the needle gasket connects the near region to the needle. A coil spring (40,82) biases the needle gasket from an extended position to a retracted position, the needle fully housed within the barrel at the latter. The extended position is maintained by a retaining capsule (44) wedged between a narrowed bore portion (42) and the needle gasket.

Abstract: An injection syringe for medical purposes, in which the syringe plunger or a plunger-side end of the syringe cylinder is shaped or provided with components to ensure at least one flow passage or connection between an inner cylindrical space of the cylinder and outer environment, when the plunger is partially, but not completely, introduced into the syringe cylinder.

Abstract: A non-reusable hypodermic syringe includes a body having a front end, a rear end and an inner wall extending from the front end to the rear end, a needle extending from the front end. A plunger assembly includes a rod member having a rearward end extending from the rear end of the body and a forward end within the body and a head portion integral with the forward end of the rod member. The head portion has an outwardly facing circumferential groove therearound. An O-ring is seated in and protrudes outwardly from the outwardly facing groove and engages the inner wall of the body. The body has an inwardly facing circumferential groove adjacent the front end of the body and positioned to receive the O-ring therein when the grooves confront each other, thereafter to resist movement of the rod member in the filling direction away from the front end of the body, thereby rendering the syringe non-reusable. A deflectable cap is affixed to the face of the head member or is seated in the front end of the body.

Abstract: An aspiration syringe suitable for one-handed operation has a barrel defining a bore, a plunger consisting of a small cross-section plunger shaft extending into the bore and a first seal within the bore, carried by the distal end of the shaft for axial movement within the bore, and an end closure across the bore proximal of the first seal, the plunger shaft extending in sliding, sealed engagement therethrough. The first seal engages the wall defining the bore in vacuum-tight sealing engagement. The transverse cross-sectional area of the shaft is much less than the transverse cross-sectional area of the bore to provide a syringe-actuating vacuum chamber of substantial volume within the bore between the seal and the end closure.

Abstract: Disposable syringe made of plastics, for medical purposes, consisting of a barrel (1), a piston (2) provided with a plunger shaft (3) guided at a distance from the barrel wall, and a closure cap (4), the piston (2) being releasably joined to the plunger shaft (3). The piston (2) is at least partially softly resilient due to the fact that on the piston periphery wall parts of greatly reduced wall thickness are present. The closure cap (4) contains a sufficiently long, stable slide bearing for the plunger shaft (3), so that deformation of the latter, arising out of off-center application of force in the retracted piston position, and out of the tendency of the relatively thin plunger shaft (3) to bow or buckle, will not be transferred to the piston (2).

Abstract: A blood extraction cannula cap is provided with a skirt which can be inserted over a tube for receiving the blood, the upper portion of the skirt being closed and having a cannula bore for receiving a needle and a push button resiliently mounted on the end of the cap with the push button being connected to a closing member which closes a bore connecting the cannula to the interior of the cap.