Abstract: A syringe is described with a plunger assembly that is adapted to have a dispensing stroke sized to dispense a fluid therapeutic product from the syringe without dispensing any air or headspace. The syringe includes a plunger rod having a stop feature that stops a dispensing stroke of the plunger rod at a distance corresponding to a level of air or headspace within the syringe avoiding additional air dispensing steps from a healthcare provider.

Abstract: Syringe assemblies having a passive disabling system to prevent reuse are provided. According to one or more embodiments, the syringe assembly comprises a barrel, plunger rod and stopper wherein the plunger rod further comprises a flexible protrusion that locks the plunger rod within the barrel. Certain embodiments further include a frangible portion on the plunger rod that breaks when reuse is attempted.

Abstract: The present invention relates to a medicament delivery device (10) comprising a front housing (12) and a rear housing (14) connected to each other; a medicament container (18) disposed within the front housing (12), wherein the container (18) has a front opening with or for a delivery member for delivering the medicament therethrough and at least one movable stopper (25); and a compression spring (26) having a predetermined compressed length and a predetermined outer diameter, wherein the compressed length is the length of the spring when it is in a pre-tensioned state; wherein the device further comprises a first guide means comprising a front part (28) having a predetermined first length (61), a middle part (42) having a predetermined second length (62), and a rear part (34) having a predetermined third length (63), wherein said predetermined third length corresponds to the predetermined compressed length of the compression spring, wherein the front part (28) is arranged to be in contact with the movable st

Abstract: A method for coating a substrate surface such as a syringe part by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising an organosilicon precursor and optionally an oxidizing gas by providing plasma-forming energy adjacent to the substrate, thus forming a coating on the substrate surface by plasma enhanced chemical vapor deposition (PECVD). The plasma-forming energy is applied in a first phase as a first pulse at a first energy level followed by further treatment in a second phase at a second energy level lower than the first energy level. The lubricity, hydrophobicity and/or barrier properties of the coating are set by setting the ratio of the O2 to the organosilicon precursor in the gaseous reactant, and/or by setting the electric power used for generating the plasma.

Abstract: A braking mechanism for a retractable safety syringe is disclosed herein. In a first embodiment, the braking mechanism is disposed about the distal end of a piston. The braking mechanism may comprise a friction material about a post attached to a piston. The friction material is displaced from a seat to a landing when the piston is traversed to a fully extended position to disengage the braking mechanism. In a second embodiment, the braking mechanism is disposed at a proximal end of a syringe body. The braking mechanism has a friction member which engages an outer surface of a rigid shaft of a plunger. The friction member is selectively pivotable to disengage the braking mechanism.

Abstract: An autoinjector comprising a housing in which can be mounted a syringe comprising a barrel for holding a volume of medicament, a needle at one end of the barrel in fluid communication with the medicament and a plunger axially-moveable in the barrel to a forwardmost position, the autoinjector further comprising a syringe support means for supporting the barrel at an axial location at or forward of the forwardmost position of the plunger and having a reaction surface for the syringe, whereby in use said reaction surface (109) provides an axial compressive force on said barrel when a forward axial force is applied to the plunger.

Abstract: A medication delivery device (1) comprises a housing (4) having a proximal end (P) and a distal end (D), a cartridge (3) for holding a medication (M), the cartridge (3) having an outlet (2), a moveable piston (5) being retained within the cartridge (3), a drive member (17) moveable in a proximal direction with respect to the housing (4) for setting a dose of medication (M) to be delivered and in the distal direction with respect to the housing (4) for delivering the dose and a piston rod (10) adapted to drive the piston (5) in a distal direction with respect to the cartridge (3) for delivering the dose. The drive member (17) is releasably coupled to the piston rod (10). The medication delivery device (1) further comprises a resilient member (21) which is arranged to move the drive member (17) in the proximal direction with respect to the housing (4) after dose delivery, thereby reducing pressure of the piston rod (10) on the piston (5).

Abstract: A system to minimize fluid turbulence inside a tissue cavity during endoscopic procedures. A body tissue cavity of a subject is distended by continuous flow irrigation using a solenoid operated pump on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by the outflow positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss into the subject's body system during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate.

Abstract: The present invention relates to damper for a medicament delivery device, which device comprises a container containing medicament, a stopper arranged in said container and movable for expelling said medicament through a dose delivery means, a plunger rod having opposing proximal and distal ends and capable of acting on said stopper, and force means capable of exerting a force on said plunger rod, wherein said damper comprises a tubular sleeve having opposing proximal and distal ends; said sleeve comprises a compartment formed by a closed end wall at the proximal end of the sleeve and the proximal end of the plunger rod which is positioned in an open end at the distal end of the sleeve; and wherein said compartment comprises a sealable and resilient pad, a fluid, and at least one passage for expelling said fluid in an annular space between said sleeve and an inner wall of said container, thereby creating a dampening force, upon movement of said plunger rod.

Abstract: A hypodermic syringe includes a barrel, the barrel having two stop portions in the rear side, a radially compressible constraint member mounted in the barrel and stopped between the stop portions of the barrel, and a plunger holding a rubber stopper and axially movably inserted through the constraint member into the inside of the barrel, the plunger having a breaking portion, and front stop flange, which is stopped against the constraint member upon back stroke of the plunger after use of the syringe for enabling the user to break the breaking portion.

Abstract: A safety syringe has a barrel, a needle hub movably received in the barrel and having a hollow cone with a flange formed on an inner periphery of the hollow cone and a plunger with a hook formed to correspond to the flange of the needle hub such that when the hook engages with the flange of the needle hub, the needle hub is ready to be pulled back into the barrel by a rearward movement of the plunger so that the syringe is ready to be disposed of safely.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: A syringe comprising a barrel and a plunger rod having a proximal portion and a distal portion is provided. The distal portion includes a stopper slidably positioned in fluid-tight engagement with the inside surface of the barrel. The structure is provided for holding the proximal portion and the distal portion together during normal use of the syringe and breakable upon application of an additional force applied to the proximal portion. Structure is also provided for preventing the proximal portion from applying distally directed force to the distal portion after the breakable connection is broken.

Abstract: A pre-filled syringe assembly is achieved which prevents, with a strong force, a stopper provided therein from being pulled out, and wherein the stopper can be prevented from being scratched.

Abstract: A prefilled syringe has a tubular body which has an open front end and an open rear end. A front assembly is mounted on an outer periphery of a front end portion of the tubular body. A finger grip is mounted on an outer periphery of a rear end portion of the tubular body. A front sealing member is provided in the tubular body so as to be disposed forwardly of injection liquid and a rear sealing member is provided in the tubular body so as to be disposed rearwards of the injection liquid. A plunger rod is provided so as to be movable in the tubular body. A temporary stop member temporarily stops the plunger rod through retention of the temporary stop member by the finger grip such that the rear sealing member is temporarily stopped at a predetermined position of the tubular body. A retention canceling member cancels the retention of the temporary stop member by the finger grip without moving the plunger rod.

Abstract: The invention relates to a process for the monitoring of the pressure of a product fluid to be administered in dosed amounts during an infusion or injection, which is dispensable from a container that is received in or formed by a housing, by advancement of a piston received in the container. The reaction force exerted by the piston onto the housing, which serves as a measure for the fluid pressure, is hereby measured and fed to a control for a drive of the piston. The control compares the measured reaction force with a predetermined reference force and controls the drive of the motor under consideration of the result of the comparison. The reference force is a nominal value for the reaction force and a direct nominal/actual comparison is carried out between the measured reaction force and its nominal value. The invention further relates to an apparatus which is especially suited for carrying out the process.

Abstract: Safety syringe with retractable standard needle including a syringe barrel, a plunger and an injection needle. A commonly used standard medical injection needle can be firmly fitted with the needle holder in accordance with the requirement of a user. The inner wall of the internal chamber at the open end of the syringe barrel is formed with an entrance recess extending along the axis of the internal chamber. The operating end of the plunger is formed with a radially outward projecting stopper section for preventing the needle pulling mechanism of the plunger from being accidentally latched with the needle pulling mechanism of the syringe barrel.

Abstract: A hand-held dispenser for delivering small, precisely controllable amounts of fluid or semi-fluid adhesives includes an elongated container having a hollow cylindrical barrel section terminated at the rear end thereof by a pair of diametrically opposed flange wings protruding radially outwards from opposite sides of the barrel, a reduced diameter front tubular outlet section extending forward from the barrel, and a flexible capillary delivery tube protruding outwards from the outlet section. A piston longitudinally slidably located within the bore of the barrel displaces adhesive within the bore forward of the piston by the turning of a lead screw which contacts the rear wall of the piston and which is threadably held within a support member attached to the rear portion of the barrel section.

Abstract: An improved angiographic control syringe for use in high-pressure medical procedures. An oblong locking ring disposed on a plunger stem. The oblong locking ring has two circular end segments at the far opposing ends of the ring, and comprises two flat segments at the narrow diameter opposing sides of the ring. A plurality of grooves are vertically spaced on the upper part of the plunger stem. Notches extend inwardly from the flat segments of the locking ring. The exertion of a pinching force on the circular end segments of the locking ring causes convex radial expansion of the flat segments, thereby permitting detachable engagement of the notches with any groove. The plunger head has a highly angular frustoconical head. The syringe barrel has a less angular frustoconical seat that receives the plunger head when the plunger head is fully depressed within the syringe barrel.

Abstract: A vial holding syringe (84) includes a barrel (6) having a bore (12), a sealable needle end (8) and an open plunger end (10). A plunger (16) is mounted within the bore and includes an elongated hollow stem (18), having an interior (36) sized to hold a conventional vial (4), and a piston (20). The stem includes a hollow piercing member (46) having a piercing end (48), opposite the membrane (42) covering the vial ,and an outer end (50), adjacent a one-way valve (70) to permit passage of the medication (80) within the vial from the vial, through the hollow piercing member and through the one-way valve into a variable volume region (67) of the bore between the needle end of the barrel and the piston. An opening (14) at the needle end of the barrel is initially sealed by a cap (66). To use, the plunger is pulled part way from the bore to create a partial vacuum within the variable volume region. During this process, the diaphragm of the vial is driven onto the piercing end of the piercing member.

Abstract: An automatic injector having a glass container protecting sleeve of thin plastic material assembled in an operative position within the injector housing with respect to the glass medicament container when the stressed spring actuating assembly is in an unreleased condition so as to protect the glass container against fracture (1) due to handling impacts prior to release of the stressed spring assembly and (2) due to the force transmitted to the plunger following the release of the stressed assembly. The sleeve includes a cylindrical portion disposed in engagement with a cylindrical periphery of the glass container when the protective sleeve is in its operative position and an annular flange extending from the rear end of the cylindrical portion disposed in rearwardly adjacent relation to the rear end edge of the glass container when the protective sleeve is in its operative position.