Abstract: A connector for connecting a medical injection device, including a barrel and a needle extending from a distal tip of the barrel, to a container including a septum includes an inner deformable cover and an outer rigid cover. The inner deformable cover extends along a cover axis and includes a proximal connection part configured to engage the distal tip of the barrel and a distal portion. The outer rigid cover encloses the inner deformable cover and includes a distal adaptor configured to engage the container. The outer cover is configured so the needle tip extends into the distal adaptor when the proximal connection part of the inner deformable cover engages the distal tip of the barrel. The outer rigid cover is fixed to the inner deformable cover. The inner deformable cover is compressible between a relaxed configuration and a compressed configuration.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: This disclosure relates to stable aqueous pharmaceutical formulations comprising a therapeutically effective amount of an incretin-insulin conjugate as well as methods of using the same, and aqueous pharmaceutical formulations containing an incretin-insulin conjugate which are stable and which provide a protracted pharmacodynamics profile, which include L-arginine HCl and phenol (or m-cresol) as stabilizing agents. The invention also provide a method of treating a patient or individual having a metabolic disease, comprising administering to the patient or individual an effective amount of any of the aqueous pharmaceutical formulations described herein.

Abstract: An illustrated view of an exemplary emergency kit for use in an emergency medical condition and a method for automating the ordering of the emergency kits for dentist is presented. The emergency kit is useful for providing short-term medical relief in an emergency while waiting for ambulance or other emergency medical personnel to arrive at the scene. The emergency kit provides a useful medical syringe for use by a dentist in a mouth of a patient experiencing an emergency medical condition.

Abstract: The present invention is a Laparoscopic Eye Cleaner that can be used intra-abdominally. This laparoscopic instrument will save time and money. The instrument is a handle connected to a flat, thin stem and made of plastic or stainless steel with a soft absorbable tip. It only takes two fingers to use it. The tip that cleans the eye of the lens without the need for the laparoscope having to be removed.

Abstract: A housing includes a body and a cartridge holder. The body can accommodate a drive mechanism including a piston rod to operably engage with a piston of a cartridge filled with a liquid injectable medicament. The cartridge holder has a cartridge receiving space. The cartridge holder has an insert section at a proximal end. The body has a receptacle to receive the insert section. The cartridge holder includes a first latch element located on the insert section. The body includes a second latch element located in the receptacle and protruding inwardly from a side wall section of the receptacle. A radial extension of the first latch element is less than a thickness of the side wall of the insert section or of the receptacle. A radial protrusion of the second latch element is less than a thickness of the side wall sections of the insert section or of the receptacle.

Abstract: A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.

Abstract: A spring force assembly for biasing a displaceable stopper of a liquid medicament cartridge including a spring element arranged along a longitudinal axis, with brace elements and coupling elements, with the coupling elements restricting the distance between the brace elements which also restricts the possible expansion of the spring element.

Abstract: A syringe assembly including a syringe barrel defining a chamber having a stopper therein is disclosed. The syringe assembly includes a plunger rod associated with the stopper, the plunger rod includes an outer sleeve having a distal end interconnected to the stopper and a sidewall portion defining an opening therein. The plunder rod also includes an inner sleeve disposed within the outer sleeve including a longitudinally extending track in alignment with the opening in the outer sleeve. The inner sleeve is adapted for telescopic movement with respect to the outer sleeve. The plunger rod also includes a spring mounted in association with the inner sleeve. The syringe assembly further includes a holding mechanism associated with the plunger rod and configured for cooperation with the inner and outer sleeves. Relative movement between the inner and outer sleeves causes the plunger rod to transition from a collapsed position to an extended position.

Abstract: The invention provides a syringe assembly comprising a syringe barrel having an inside surface defining a chamber, an open proximal end, and a distal end having an opening therethrough. An elongated plunger rod extends between a first end and a second end, with a cap or guard disposed on the first end of the plunger rod. A plunger head extends within the chamber of the syringe barrel, and is adapted for slidable movement within the syringe barrel between the proximal end and the distal end, with the second end of the plunger rod connected with the plunger head through a pivotable connection. The plunger rod is adapted to pivot with respect to the plunger head between a first position in which the guard is adjacent the distal end of the syringe barrel and a second position in which the plunger rod is in general axial alignment with the syringe barrel, and is further adapted for axial movement so as to cause sliding movement of the plunger head through the syringe barrel to expel contents thereof.

Abstract: A pre-filled vial assembly adapted for dispensing and delivering a fluid includes: a body member having a distal end, a proximal end, and a sidewall extending therebetween defining an interior; and a transitionable stopper disposed within the interior of the body member. At least a portion of the body member is engageable with a source of air or fluid for advancing the transitionable stopper from an initial position to an activated position in which at least a portion of a fluid contained within the interior of the body member is advanced therefrom.

Abstract: A syringe assembly includes a syringe barrel having an exterior surface, an inside surface defining a chamber, an open proximal end, a distal end, and an outlet disposed adjacent the distal end in fluid communication with the chamber; and a plunger assembly disposed at least partially within the syringe barrel. The plunger assembly includes an elongated plunger rod and a plunger head. The elongated plunger rod is associated with the plunger head to move the plunger head within the chamber of the syringe barrel through an injection cycle. The plunger rod is adapted to move from a collapsed position extending alongside the exterior surface of the syringe barrel to an extended position engaging the plunger head to move the plunger head through the injection cycle.

Abstract: A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5?, 6, 6?) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27?, 28?) on the distal end of a cartridge assembly (20).

Abstract: A vial adaptor for releasably holding a vial (1010) and releasable connection to an injector (1008) comprising: a dual-sleeved member (11) comprising a forward facing sleeve (12) and a rearward facing sleeve (16) adapted to operably engage a front end of a forward housing (1040) of said injector (1008), and comprising a vial stopper piercing member (46); and a vial engaging element (60) adapted to slidingly translate within said forward facing sleeve (12) and releasibly hold said vial (1010) in a position whereby said vial stopper piercing member (46) pierces a stopper of said vial (1010), said vial engaging element (60) adapted to allow forward movement of a plunger of said injector (1008) when said vial (1010) is in said position. In other aspects, a vial-stopper piercing spike and a method of manufacturing same is described.

Abstract: The present invention relates to a cartridge holder for a drug delivery device comprising: a distal portion for receiving a cartridge filled with a medicament to be dispensed by the drug delivery device, wherein the distal portion comprises a mount for a piercing assembly, a proximal portion adapted to at least partially receive a drive mechanism having a piston rod to become operably engaged with a piston of the cartridge for expelling a dose of the medicament from the cartridge, wherein the drive mechanism comprises at least first fixing means corresponding with fixing means of the drive mechanism for directly interconnecting cartridge holder and drive mechanism.

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: An apparatus for administering a substance, e.g. a medicinal, pharmaceutical, or cosmetic substance, includes a driving member movably mounted within the apparatus to administer the substance, and the driving member includes a holding feature or components of a holding feature which holds or retains at least one additional element of the apparatus in a position relative to the apparatus. In some embodiments, the additional element is a carpule or ampoule containing the substance, and the holding feature retains the carpule or ampoule in a position within a carpule or ampoule holder.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: A combining syringe wherein multiple fluids are dispensed through a primary plunger into a primary cylinder when a force is applied to the secondary plunger shaft. The fluids are combined and dispensed from the primary cylinder's attaching end when a force is applied to the primary plunger shaft. The primary plunger shaft has a primary plunger attaching end opposite a primary pressure applying end. The primary plunger is connected to the primary plunger attaching end. The primary plunger shaft accepts a secondary cylinder and secures it with an attaching element. The secondary cylinder has a secondary plunger receiving end opposite a dispensing end. The secondary cylinder's dispensing end is inserted into an opening of the primary plunger. The secondary plunger shaft has a secondary plunger attaching end opposite a secondary pressure applying end. The secondary plunger is connected to the secondary plunger attaching end.

Abstract: An injection device with a housing and an operating element or coupling element mounted in the housing in such a way that the operating element or coupling element may be retained in a first position by a first holding connection and may be displaced into a second position that is axially offset relative to the first position after introducing an ampoule. In some embodiments, the operating element or coupling element may be retained by a second holding connection in the second position.

Abstract: A product container holder for accommodating a product container, wherein the product container holder can be separately handled and can be inserted into an injection device, and includes an engaging member that can be moved transversely to the longitudinal axis of the product container holder and which can block a movement of the product container relative to the product container holder in the distal direction, and a securing structure which can be moved relative to the engaging member from an initial position to a securing position in which it restricts the mobility of the engaging member. In some embodiments, a method of making and a method of using the product container holder is encompassed, as is a container and an injection device with which the holder can be used.

Abstract: A drug delivery device is provided. The device is a wearable active transdermal drug delivery device which facilitates drug delivery using one or more vaccine cartridges having microneedles as the point of drug delivery. The device may be used to perform multiple vaccine deliveries to the intradermal layer of a patient.

Abstract: A dispenser device comprising a pistol housing, a needle direction control mechanism, a boost mechanism, a quantification control mechanism, and a combination of the pistol housing, the needle direction control mechanism, the boost mechanism, and a syringe positioning mechanism or a holding ring embodies the present invention with features and advantages shown as follows, (1) Uniform injection of agents synchronously mixed by not less than two contents; (2) Mixed agents not exposed in air; (3) Uniform injection, high air tightness, injection direction controlled by easy turning, smooth and convenient operation, high powerful operation via shifts of a push rod driven by a pressed trigger, promoted yield rate, assembly easily constructed, reduced manufacture cost, and convenient maintenance.

Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, and jacket completely enveloping the base in the longitudinal axial direction.

Abstract: An actuating mechanism for a hypodermic syringe comprises a flexible tongue (48) allowing the actuating mechanism to be bent to receive a cartridge (10) of injectant closed at its forward end with a septum (14) and at its rearward end with a slidable bung (18). The forward end of the cartridge (10) is fitted into a socket (36) wherein the tail (34a) of a hypodermic needle (34) pierces the septum (14) to access the injectant. With the cartridge (10) fitted, the tongue (48) is straightened, and a spring clip (50) holds the cartridge (10) in position. A plunger (38) can then be depressed, though a guide (42), to drive the bung (18) forward and make the injection. The cartridge (10), which may be a conventional cartridge of any kind, keeps the assembly rigid in use, and the whole assembly is disposed of after a single use, without dismantling.

Abstract: A refillable injection device (1) having a dose setting mechanism with a dose setting member (4) and a dose rod (11). The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge. The dose setting member and the dose rod need to be moved into engagement when a new cartridge is inserted in the injection device. Thereby there is a risk that stress is build-up in the piston rod. In order to prevent this, the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an axial direction, at least while the dose setting member and the dose rod are moved into engagement.

Abstract: A disposable clip (10) is used to releasably attach an ampoule (13) to a syringe (11). The clip (10) includes an ampoule engaging portion (19) and a syringe engaging portion in the form of a recess (17). The ampoule engaging portion (19) comprises a compressible projection which is inserted into the neck (21) of the ampoule (13). The ampoule engaging portion (19) is thereby compressed and frictionally engages the inside of the neck (21) to secure the ampoule (13) firmly to the clip (10). The clip (10) does not obscure the label on the ampoule (13).

Abstract: The present invention includes a harvesting and irrigation device, a method and a kit for the collection of viable fat cells and/or adipose tissue with decreased handing and improved yield and viability.

Abstract: A mucous suction device, comprising in combination, a longitudinally elongated, generally tubular, one-piece plastic body, the body having an axially elongated tapered, first portion extending toward an inlet proximate one end of the body, the body having an axially elongated second portion extending toward an outlet proximate an opposite end of the body, radially outwardly extending annular retention rings in said body second portion, said rings having sharp annular peripheries and said rings being axially resiliently flexible and axially spaced apart, and there being body side porting between said body first and second portions, said side porting being manually controllable to control suction exertion.

Abstract: The present invention relates to an injection device (1) comprising:—a container (5) receiving a product, and provided with an injection needle (6),—a housing (9, 11) receiving said container, said container being movable relative to said housing between an initial position, an insertion position, and a final position,—retaining means (12, 15), for maintaining said container in said insertion position,—deactivating means (20), for releasing said retaining means, said device being characterized in that it comprises:—temporizing means (19, 26, 27), for controlling the release of said retaining means until substantially all of the product contained within said container has passed through said injection needle before said container moves to said final position, and—a needle shield (2) coupled with said housing (9, 11) removal of said needle shield being with limited or no rotation of said needle shield. The invention also concerns a kit comprising such a device.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab configured to move radially between a first radial position in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The tab includes an opening. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position then to penetrate the opening thereby allowing the tab to return to the first radial position. The pusher or the casing, respectively, further includes at least one stop region against which the tab abuts when the tab is brought into the second radial position by the projection. The stop region occurring just before the projection being opposite the opening.

Abstract: An injection device for injecting selectable amounts of a substance includes an activating mechanism including an axially moveable operating button which can rotated in a resting position only, a tubular drive element non-rotatably connected to the operating button, an axially fixed and non-rotatable guiding element, and an axially moveable driven member held non-rotatably in the device. A rotational grid is operationally between rotatable and non-rotatable components of the injection device such that the operating button can be moved two rotational directions when in the resting position whereby a selected amount of the substance to be injected can be selectively varied. For example, a dosage inadvertently selected too large by rotating the operating button too far in one direction can, in accordance with the present invention, be reduced by rotating the operating button in the opposite direction.

Abstract: The present invention relates to a volume-adjustable micro-injection device. The device includes a base structure having a syringe positioning structure and a grip, in which the syringe positioning structure can flexibly accommodate injection syringes with different volumes; a holding structure capable of flexibly adjusting an injection angle of syringe content for easier operation; a qualitative controller capable of accurately controlling injection volume; a pressure pushing structure to hold and push a plunger; an injection controller interlinked with the qualitative controller and the pressure pushing structure; and an eject structure facilitating simple operation and easy replacement of injection syringes.

Abstract: A relatively stiff syringe pressure applicator having a pair of ears, the ears are overmolded with a relatively soft elastomer. A port extends through the syringe pressure applicator and is connected to friction fittings on either side of the pressure applicator. The external fitting is suitable for connecting to a source of pressurized air. The other fitting is sized and shaped to receive an elastomeric seal that may be inserted into the open end of a syringe to seal the syringe air tight.

Abstract: The present invention includes a harvesting and irrigation device, a method and a kit for the collection of viable fat cells and/or adipose tissue with decreased handing and improved yield and viability.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused. To this end, a medicament cartridge is provided comprising a sleeve having a bottleneck providing a flange at a first end, a fluid impermeable membrane secured across the first end by a metal cap beaded beneath the flange, and a displaceable piston located internally of the sleeve towards a second end of the sleeve, a collar located against an external periphery of the cartridge housing beneath the flange and an adaptor top press fit over the cap and the collar, the adaptor top being provided with means to act upon the collar thereby to retain the adaptor top on the sleeve.

Abstract: An injection device for injection of a medicament from a medicament cartridge 40 having a neck portion is disclosed. The injection device further comprises a main housing 4 in which the medicament cartridge 40 is releasably retained by first and second retaining means 92,94. The retaining means 92,94 are each moveable between a first position in which the neck portion is engaged thereby to retain the medicament cartridge 40 in the main housing 4 and a second position which allows the medicament cartridge 40 to be removed from the main housing 4.

Abstract: The invention is directed to an apparatus, or system, for applying a multi-component liquid liner composition to an inner surface of a conduit. The system comprises a first reservoir having a first liquid liner component; a second reservoir having a second liquid liner component, the second liquid liner component being different from the first liquid liner component; a first liquid liner component transmission line in communication with the first reservoir; a second liquid liner component transmission line in communication with the second reservoir; and an applicator in communication with the first and second liquid liner component transmission lines. Methods of applying multi-component liquid liner compositions to the inner surface of conduits are also disclosed.

Abstract: A safety syringe employs a mechanical logic arrangement to control the movement of a spring-biased protective shield that covers the needle except during an injection, and which limits the number of injection cycles. The mechanical logic arrangement can include a series of parallel gated tracks, and a track follower pin disposed on the slide portion of the protective shield. There are one-way gates and redirection gates, which can be formed as flaps with a radial hinge in respect to the barrel axis. An alternative arrangement can employ a rotary cam. The number of injection cycles can be two or more, and the penetration depth for a given injection cycle can be controlled.

Abstract: A cartridge type dental injection device capable of easily and quickly mounting or removing a cartridge loaded barrel in or from a socket therein and capable of altering orientations of a viewing window in the barrel and of a cut surface of a needle as desired.

Abstract: Rubbery products having a transition temperature that shrink from a second shape and size toward their original shape and size upon application of energy equivalent in result to raising the temperature of the rubbery product above the transition temperature. Also, hypo-allergenic rubbery products made from polybutadiene and its copolymers, trans-1,4-polybutadiene and its copolymers, synthetic isoprene and its copolymers, or synthetic cis-1,4-polyisoprene and its copolymers. Such rubbery products (not all of which need to be made to shrink) can be used in condoms, gloves, catheters, baby-bottle nipples, and dental dams, to name just a few.

Abstract: An improved guard for a medical cartridge, such as a unit dose pre-filled glass syringe, comprising a body for receiving the cartridge, and a shield slidably attached to the body which are pre-assembled and ready to receive a cartridge therein. The body has a locking mechanism on a proximal end thereof which holds the cartridge therein. The body and shield have cooperating detents and detent pockets which allow the shield to be directed distally, from an unguarded position in which the needle on the cartridge is uncovered for delivery of medication, to a guarded position in which the needle is permanently covered for disposal. The body may also include a substantially rectangular-shaped finger grip on its proximal end for receiving a similarly shaped proximal flange on the cartridge, whereby the cartridge is received in a predetermined orientation. The body may also include one or more ribs within the cavity for accommodating a cartridge with a large needle cap, such as a 0.5 mL capacity pre-filled syringe.

Abstract: A medication delivery pen having a vial retainer with a side opening have flexible snap wings that spread to receive and retain a standard or threaded vial within the vial retainer. The vial retainer also includes an improved means of attaching the vial retainer to a pen injector body, using a cam and cam follower design together with a ratcheting mechanism to prevent removal of the vial from the medication delivery pen. Alternatively, a release mechanism could be used so that the vial may be removed from the medication delivery pen. In addition, the vial retainer includes an opening for receiving the vial defined by a pair of flexible snap wings.

Abstract: A syringe for injection of doses of a medicine from an exchangeable cartridge has a housing comprising a cartridge holder and a dosing mechanism by which a dose is set and injected by successively advancing a piston rod to press a piston into the cartridge. The dosing mechanism comprises a threaded spindle and a nut member cooperating with the spindle. A dose is set by relative rotation of the spindle and nut member whereby the nut member is moved along the spindle. The position of the nut member on the spindle defines how far the piston rod is advanced. The spindle and the nut are locked against relative rotation when the dosing mechanism is not operated to set a dose. Access to the cartridge holder is obtained by opening a lid connected to the housing and coupled to the dosing mechanism in such a way that the locking of the nut element in its position on the spindle is released when the lid is opened, and the opening movement of the lid is transmitted to a piston rod retraction mechanism.

Abstract: A veterinary syringe with a dosing device for administering medications in different preselectable amounts, comprises a piston rod which projects into a syringe cylinder by a piston provided at a first end of the piston rod and which is supported at a handle at its other end by an actuating lever which is fastened to the other end so as to be swivelable. The piston rod is supported so as to be displaceable longitudinally in a holder which is rigidly connected with the handle. A dosing device is provided between the holder on one side and the piston rod on the other side. At least two longitudinal grooves are arranged parallel to one another and which have different lengths compared with one another are distributed along the outer circumference of the piston rod. An engagement member is provided which is arranged so as to be rotatable about the piston rod and can be moved into one of the grooves.

Abstract: A medicament container has a body having an open mouth defining an axis, a pierceable plug engaged over and sealing the mouth, a ring engaged around the mouth and over the plug and formed with a hole through which an outer surface of the plug is exposed, and a cap engageable around the mouth over the ring and plug. The cap holds an elastomeric element bearing elastically through the hole against the plug outer surface.

Abstract: A modular trocar system which includes an obturator assembly, and a cannula assembly defining a longitudinal passageway therethrough configured and dimensioned to slidably receive the obturator assembly, the cannula assembly including a housing which includes a valve assembly and a first mating portion, and a cannula defining a passageway of a predetermined dimension therethrough, the cannula and housing movable alternately between a spaced apart relative orientation and an attached orientation wherein the first and second mating portions are engaged.

Abstract: Converters for use with commercially available syringe cartridges to produce novel syringe assemblies. The converters engage with the plunger end of the syringe cartridge. The converter has a body piece with a receptacle. The ampule of a syringe cartridge is inserted into and secured within the receptacle. A plunger shaft allows manual displacement of the plunger. In some embodiments, dose regulating features are preferably included as part of the converter assembly. In one form the dose regulating features include removable collars.