Abstract: A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.

Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

Abstract: A bag-shaped drug container comprises a bag-shaped container body made of a flexible film, and a mouth provided at one end of the container body. The mouth is provided on a side of an open end thereof with a Luer locking means to liquid-tightly connect it with a tip of a syringe, and closed by a closing means such as cap or a male Luer portion.

Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

Abstract: A filling/discharge port 10 which includes a port cap 20, a plug 40 which is slidably fitted in the inside of the port cap 20, and a plug cap 50 which is removably fitted to the tip of the plug 40 is provided for use in a liquid medicament containing chamber 563 of a container body 560 which is partitioned into a plurality of chambers 562 and 563 via a partitioning portion 561 which allows communication when the internal pressure of the container body 560 is increased, and the plug 40 is slidable from a closed position to a discharge position owing to an increase in the internal pressure. The filling/discharge port 10 reliably prevent medicaments in a medical container which contains a plurality of medicaments from being administered to a patient without being mixed so that they can be mixed during use.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: Containers and methods for storing medical solutions are provided. More specifically, containers and methods for storing components that are to be admixed, together to create a final solution, one of the components comprising a lipid. In an embodiment, a container including an interior defining at least two chambers. The first chamber includes a lipid containing liquid. The second chamber includes a liquid that does not include a lipid. The first and second chambers are separated by an openable seal.

Abstract: The present invention provides an improved kit for the collection of umbilical cord blood and placental blood, and collection of the placenta from which such blood is obtained. The kit improves upon existing kits in that it provides for improved user convenience, provides for the collection of the placenta itself, and better maintains the internal temperature of the container in which the collected blood and placenta are shipped to a blood bank or registry. The invention further provides a method of collecting umbilical cord and placental blood, and the placenta from which such blood is obtained, comprising using the kit described herein.

Abstract: The invention relates to a placental blood collection line including a collection bag (1) in fluid communication with at least one collection needle (4, 5) via a first tube (2) associated with an inlet orifice (3) of the bag (1), said line further including a bag (6) containing a rinsing solution and which is connected to or is organized to be connected to said first tube (2) via a second tube (7). The invention also relates to a method of collecting placental 10 blood by using such a line.

Abstract: Gel and gel composites health care articles, including masks, pads, blood bags, tubings, male and female tubing connectors, and needle protector sheath.

Abstract: A polymeric film, multiple-compartment, pouch having an internal frangible seal for confining a fluid and related beverage container with a re-closable fitment for storing and delivering two different flavored liquids or the like. The frangible seal of the clear plastic pouch will burst when sustained squeezed thus allowing the flavors to swirl and mix within the pouch.

Abstract: The disclosure includes a flexible bag (1) intended to receive a biological fluid with a view to its centrifugation. The bag includes an external enclosure (2) formed by two sheets of flexible plastic (3, 3?) connected at their periphery (4) so as to define an internal volume (5) for the fluid. The external enclosure (2) is provided with at least one inlet (6) and/or outlet (7) orifice for the fluid. The bag (1) also includes means (8) for the temporary association of at least one component with the bag (1). The means (8) is disposed on the external enclosure (2), in which the temporary association means are assembled on the bag (1) on a part of the periphery (4) of the enclosure (2) and are arranged to allow the insertion of the component between the means (8) and the enclosure (2) so as to provide temporary association during the centrifugation of the bag (1).

Abstract: A holder for receiving a sampling tube of a blood sampling system is disclosed. The holder has an interior pocket which can be conformed from a closed position to an open position for receiving the sampling tube.

Abstract: A system for transferring blood product between a blood storage bag and a processing bag. The system includes an airtight containment chamber for supporting therein one or more blood storage bags. A door is provided for access to the chamber and there is included an airtight fixture that allows tubing from the blood storage bag to exit the chamber. A fluid pump is coupled to the containment chamber for establishing either pressure or vacuum within the containment chamber. A controller controls the air pump to, in turn, control the transfer of a blood product.

Abstract: A system for collecting and processing donated bone marrow comprises a closed and/or sealable collection container and a closed and/or sealable satellite container. The system may also include at least one porous medium interposed between the collection container and the satellite container. The porous medium is a size gradient depletion media. The system may also include at least one third container in fluid communication with the collection container. The system may also include at least one manifold interposed in the fluid flow path between the collection container and the third container.

Abstract: A transfer set in particular for delivering a mixture of liquids for medical purposes, from a so-called flexible main bag containing a first liquid and from at least a so-called auxiliary bag containing a second liquid, connectable to the main bag through a pair of Luer-Lock connectors respectively male and female. Each of the two connectors has, at one end, a frangible section engaged in the end of a tubing connected to one of the bags and, at the other end, elements for being coupled to the other connector, provided with elements for locking the connectors in coupled position. The invention is useful for delivering liquids for medical purposes.

Abstract: A reconstitution device is disclosed and includes a first container receiver having a first component cannula disposed therein, the first component cannula having a withdrawal port and a first transfer port formed thereon, a second container receiver having a second component cannula disposed thereon, the second component cannula having a vent port and a second transfer port formed thereon, a device body coupling the first container receiver to the second container receiver and having a transfer lumen formed therein, the transfer lumen in fluid communication with the first and second transfer ports, a selectively sealing interface secured to the device body and in fluid communication with the withdrawal port, and a venting member in communication with the vent port through a vent lumen.

Abstract: Methods and systems for preparing blood products that are ready for treatment in established pathogen inactivation procedures are disclosed. The methods include providing a source of a blood component and combining the blood component with a synthetic medium in a selected ratio of the blood component to the synthetic media, whereby the resulting blood product is treatment-ready.

Abstract: The invention relates to a centrifuge provided with a blood bag system having an upper and lower outlet for separation of blood constituents, containing a rotor which can be driven in a rotative manner about a hub, wherein at least one conventional whole blood bag equipped with an upper outlet and with a lower outlet can be positioned vertically in this blood bag, while the whole blood bag can be arranged on the rotor in such a way that one outlet of the whole blood bag is bent in a radial direction, and the opposite outlet of the whole blood bag is bent in the other radial direction, so that the entire whole blood bag and the outlets thereof adopt an approximately Z- or S-shaped form in its functional position. In this case it is preferred that the upper outlet of the whole blood bag lie radially toward the interior and the lower outlet of the whole blood bag lie radially toward the exterior of the whole blood bag.

Abstract: Flexible impervious bag for medical use containing a pharmaceutical preparation of liquid oxaliplatinum said flexible bag is constructed from plastic materials, with the proviso that any portion to the bag in direct contact with said pharmaceutical preparation of liquid oxaliplatinum does not contain polyvinylchloride-based plastic material.

Abstract: A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament.

Abstract: A centrifuge is provided for the separation and/or treatment of cells in a substantially annular or partially annular separation bag connected by at least one tube to at least one secondary bag. The centrifuge comprises a rotor bowl connected at the upper end of a rotor shaft. The rotor shaft includes a hollow upper portion defining a central compartment for receiving the at least one secondary bag. The rotor bowl includes a separation compartment for receiving the separation bag and an expandable hydraulic chamber located within the separation compartment for selectively squeezing the separation bag within the separation compartment so as to transfer a separated component from the separation bag into a secondary bag in the central compartment. A hydraulic system is connected to the hydraulic chamber by a duct extending through the rotor shaft for pumping a hydraulic liquid to and from the hydraulic chamber.

Abstract: A bag system for the collection and sampling of a biological fluid such as blood is described. The system may include a fluid collection bag and a first tube connected on one end to a collection means and on the other end to the collecting bag. It may also include a flexible sampling bag defining an internal volume having a bottom side and an introduction side which is opposite to the bottom and has an inlet orifice. The system also has a second tube, a first end part of which is connected to the first tube and a second end part of which is inserted in the inlet orifice of the sampling bag, so as to extend inside the sampling bag over a distance of between 25% and 60% of the distance between the bottom and the introduction side of the internal volume of the sampling bag.

Abstract: This invention relates to a container for use in dialysis, containing a certain amount of a salt concentrate in the form of a powder, granules or tablets or mixtures thereof, having an inlet for the water and an outlet that is connectable to a dialysis machine. According to this invention both the inlet and the outlet are situated on one side of the container.

Abstract: The invention is an improved container for collecting, freeze-drying, storing, reconstituting, and administering biological solutions and, in particular, blood products. The container features a pliable bottom wall providing intimate thermal contact with the cooling/heating shelf of the lyophilizer; a top wall incorporating a hydrophobic membrane providing a path for water vapor and a bacterial barrier; and side walls sufficiently stiff to support the ceiling but preferably also sufficiently flexible to collapse and minimize storage space especially once lyophilization is complete. The walls incorporate sealable ports that can be used to load the solution for processing and/or adding reconstituting liquids and/or administering the reconstituted solution to a patient. The top wall may incorporate a removable cover that protects the membrane before freeze-drying takes place.

Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10) and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).

Abstract: A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament.

Abstract: A multiple-chamber medical container comprising a container body 3 having two chambers 10 and 11 for storing medicaments and a partition seal 20 separating the chamber 10 from the chamber 11, and an outlet 32 attached to the container body 3 for allowing the medicaments to be discharged from the chamber 11, the partition seal 20 being openable so that the chambers 10 and 11 may communicate with each other at the time of use, wherein the container body 3 comprises a discharge-control seal 21 separating the chamber 11 from the outlet 32 and being openable at the time of use, and the force required to open the partition seal 20 is lower than that required to open the discharge-control seal 21.

Abstract: Devices, systems and methods for treating a biological fluid are provided comprising placing the fluid in contact with a complement filter capable of depleting at least one complement fragment from the fluid while at least one component of the biological fluid is being stored.

Abstract: The claimed invention relates to a method and a device for processing blood concentrate products before they are exposed to a continued process for extracting those remaining medicinally interesting sub-components. The appropriate pre-processing, in relation to the invention, primarily entails a mechanically powered resolution of the viscous flowing concentrate products in a diluting solution for the adaptation of the total products for a renewed centrifuging. The device includes a centrifuge machine containing one or more suspended product bags that can be oscillated forwards and backwards in an incomplete pendulum swing by operation of a motor mounted in a lid of the machine. The product bag(s) are connected to a ring bag for subsequent processing and to a bag containing diluting solution by a multi-way connector.

Abstract: The present invention provides an improved dialysis solution. The improved dialysis solution provides for the use of specific polypeptides as an osmotic agent with an additional osmotic agent such as dextrose. To this end, the present invention provides, in an embodiment, a peritoneal dialysis solution comprising as osmotic agents approximately 0.25 to about 4.0% (w/v) polypeptides and approximately 0.5% to about 4.0% (w/v) dextrose. The polypeptides have well defined characteristics.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: To produce a two-chamber arrangement having a first chamber, which is filled with a first component, and a second chamber, which is filled with a second component, two separate bags are sterilized and filled independently of each other with the first/second component. Only after the bags have been sterilized and filled are they connected to each other in such a way that the component contained in one chamber can be transferred into the other chamber so as to be able to mix the two components together. Once they have been filled, the first and second bags are preferably sealed with an openable peel seam, after which the bag ends are welded together.

Abstract: The present invention provides a biochip comprising, in sequence from one end of a blood collection bag formed into a flat, pouch-like shape using a flexible material:

Abstract: A fluid transfer and mixing device for use in the aseptic intermixing of a powder component with a fluid component. The device is of a simple, compact construction that includes a first adapter that can be easily connected to a container containing the powder component and a second adapter that can be removably interconnected with the first adapter and can also be readily connected to a container containing a fluid such as a diluent so as to permit aseptic intermixing of the diluent with the powder. In use a conventional needleless syringe can be easily connected to the first adapter so that the mixture of the powder and diluent can be aseptically aspirated from the first container for subsequent delivery to the patient.

Abstract: This invention discloses a donor blood sampling apparatus attached to a tubing branch, a donor needle attached to an upstream tube, the donor needle being adapted for drawing blood from a body and a main collection bag attached to a donor tube, characterized by a flow controller.

Abstract: A centrifuge with an associated container system in the form of cassettes for separation and treatment of blood or blood components has been developed. The centrifuge includes a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around the cavity at the upper part thereof. A first container system is arranged in the rotor, for washing of blood cells, includes a round bag and two or more flexible secondary containers connected thereto, one of which contains a treatment liquid and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers are arranged in the sleeve to rest against each other and the round bag is mounted on a projecting flange at the upper part of the sleeve.

Abstract: A solution, in particular for hemodialysis or peritoneal dialysis that permits attaining a desired glucose concentration without affecting the concentrations of other components in the solution. The solution consists of at least three individual solutions that are combined and administered after heat sterilization. The first solution contains calcium ions, electrolyte salts and optionally glucose in a concentration of 0-1000 mM and is acidified to a pH of less than 4.0 with a physiologically tolerable acid. The second solution contains glucose in a concentration different from that of the first solution and the remaining components of the first solution in the same concentration. The third solution contains a buffer in the physiological range. Also provided is a method of preparing a solution according to the invention, where the desired mixing ratio of the separate solutions is automatically established by a dialysis machine or peritoneal dialysis cycler.

Abstract: A plural-compartment medical container, wherein said container is a pouch formed of a synthetic resin and has an open member at least one end of upper and lower ends thereof for filling or withdrawing a drug solution, and the inner surface of said container is divided into plural compartments in a liquid-tight manner by a blocking seal portion, characterized in that when a melting temperature curve of a resin of said blocking seal portion is determined using differential scanning calorimeter, a height ratio (h2/h1) between a height (h1) of a peak at a temperature of main melting peak and a height (h2) of said temperature curve at a temperature of 115° C., is within a range of 0.05 to 0.4, the blocking seal portion thereof peeling well by pushing operation to the pouch, provides a plural-compartment medical container having excellent flexibility and transparency.

Abstract: The invention is a novel cell freezing and storage bag assembly and method for using the assembly in the seed train expansion of mammalian cells. The bag is constructed principally of polytetrafluoroethylene fabric. The bag is designed to hold enough cells that a bioreactor can be inoculated directly. The bag is designed to be filled to a fraction of its maximum capacity so that the cell suspension has a very thin cross-section (less than about 10 millimeters). The bag design includes a transfer set that can be sterilely welded to the source of the mammalian cells. This sterile-weldable transfer set allows the bags to be filled quickly with minimal risk of contamination. In the method, once each bag is filled, it is sealed below the connection with the transfer set and the bag is cut “above” the new seal (on the same side of the seal as the transfer set). When a bioreactor is to be inoculated, the contents of the bag are drained via a sterile-weldable inoculation line.

Abstract: Methods and apparatus are disclosed for reducing the degradation of heat sensitive components contained in a medical substance during heat sterilization of a heat sterilizable container including a first chamber including a first amount of a first medical substance and a second chamber including a second amount of a second medical substance, the first amount being greater than the second amount. The method includes heating the heat sterilizable container to a first predetermined temperature for sterilizing the first and second medical substances, thermally insulating the second chamber during at least a portion of the heating of the heat sterilizable container to the first predetermined temperature, holding the heat sterilizable container at the first predetermined temperature for a first predetermined time period, and cooling the heat sterilizable container thereafter.

Abstract: A bag arrangement for intermixing two, separately stored substances. The bag arrangement includes a bag having a jacket defining an inner chamber for accommodating a first substance and a piercing device having a chamber in which the jacket is received. A single piercing member is provided on one side of the jacket and a hollow abutment is located opposite the piercing member on an opposite side of the jacket and forms a receptacle for accommodating a second substance. Upon actuation of the piercing device, the piercing member pierces the opposite sides of the jacket providing for intermixing of the first and second substances.

Abstract: A blood collection system has a container for holding blood and a filter communicating with the container, mutually arranged for handling as a unit. The filter (20) contains a fibrous filter medium (28) housed within two flexible sheets (32, 34) of plastic. A first seal (36) joins the sheets (32, 34) directly to the filter medium (28) inboard of the peripheral edge (40) of the filter medium (28), and a second seal (38) joins the sheets (32, 34) outboard of the peripheral edge (40) of the filter medium (28). A region (42) of the filter medium (28) extends between the first and second seals (36, 38) to cushion contact with the filter housing during handling.

Abstract: A multi-chamber renal dialysis container having at least two compartments and containing concentrated glucose in a first compartment and a hydrochloric acid solution containing electrolytes in a second compartment. The compartments are separated from one another during storage and transportation by separable peel seals, and the solutions can only be mixed with one another by the opening of the peel seals. An outlet of the multi-chamber container is separated by a further peelable seal, whereby a substantially empty third chamber is formed.

Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

Abstract: Light-protective container assembly for a light-sensitive fluid includes a translucent container defining an inner reservoir to contain the fluid, and a flexible sleeve connected to the container. The sleeve has a tubular configuration sized to substantially cover at least the reservoir of the container, and is made of a material capable of substantially preventing the transmission therethrough of an identified range of wavelengths from the electromagnetic spectrum. Preferably, the sleeve is made of a mixture of a base material and a colorant capable of substantially preventing the transmission of undesired energy through a predetermined thickness of the base. material. The sleeve is connected indirectly to the container by providing the container with at least one passageway therethrough, and by positioning the sleeve such that a first portion of the sleeve is on one side of the container, and a second portion is on an opposite side of the container.

Abstract: An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included.

Abstract: A method is disclosed for collecting and processing whole blood. Whole blood is collected at several remote donor sites and transported to a central blood-processing center, where information regarding demand for blood products is used to direct processing of whole blood into blood products. Whole blood is initially collected in collection bags unattached to satellite bags instead of commonly used multiple bag sets. When the determination is made at the blood processing center as to which blood products are to be made, the appropriate satellite bags and/or other system components are sterile docked to the blood-collection bag and the whole blood is processed. The use of blood-collection bags initially unattached to satellite bags eliminates waste and simplifies the transportation and processing of whole blood. Also disclosed are blood collection systems that remove leukocytes and collect whole blood into blood-collection bags unattached to satellite bags.

Abstract: A single use system and kit for producing blood platelet concentrates is described herein. In a preferred form, the kit includes a bag set in which compartments containing blood components are adjacent to to separate compartments which can be inflated to express the blood components after their separation by centrifuging.

Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10) and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).