Abstract: A W-shaped frangible seal line separating at least two chambers in a container or securing together two sheets of material. Outer legs of the W-shape preferably describe an angle of 170.degree. or less. Inner legs of the W-shape preferably describe an upside down chevron or V-shape that describes an acute angle.

Abstract: Blood and gas transfer apparatus comprises a substantially rigid receptacle; a collapsible bag in the receptacle, there being space formed between the bag and receptacle; structure in the receptacle forming first porting communicating with the bag and via which blood may be transferred into and out of the bag, and second porting communicating with that space between the bag and receptacle for selectively transferring gas into and out of the space; whereby in a first mode of operation blood may be drained into the bag via the first porting, and gas may be removed from the space via the second porting, and in a second mode of operation, blood may be drained from the bag via the first porting, and gas may be introduced into the space via the second porting, the structure including neck means on the receptacle and a cap received on the neck and forming the first and second porting.

Abstract: Systems and methods for collecting blood substantially free of undesired matter assure that accurate crossmatching and typing of cellular blood components can be done prior to transfusion, even though the cellular components are collected and stored in different containers. The blood containing the undesired matter is collected in a blood collection container. The blood collection container includes a tube that is sealed for retaining samples of the collected blood for later analysis. The collected blood is conveyed out of the blood collection container for removal of undesired matter. The blood substantially free of the undesired matter is collected in a separate transfer container for storage. The distal end of the sealed tube containing the blood samples is attached to the transfer container, while the other end of the sealed tube is disconnected from the original blood collection container.

Abstract: A flexible container is provided for the storage and mixing together of diluents and medicaments. The container incorporates multiple compartments, separated by frangible seals, in which the diluents and medicaments are stored. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through a standard IV arrangement to a patient.

Abstract: A plastic composition is disclosed which has particular application in the manufacture of blood bags and other medical products. The composition has anti-hemolytic effects when used in the storage of red blood cells. In connection with one aspect of the present invention, the plastic composition comprises the combination of a non-PVC plastic and a selected quantity citrate ester sufficient to suppress hemolysis of red blood cells. The non-PVC material is preferably a polyolefin copolymer. Materials other than citrate ester may also be used with polyolefin as a hemolysis suppressant.

Abstract: Plastic blood bag system including a bag having a generally longitudinal seal extending from the top of the bag and between two blood bag ports downwardly to at least the lower half of the bag but not to the bottom of the bag, thereby leaving the sole passageway within the bag and between two ports located in the lower half of the bag.

Abstract: A sample of a body fluid, such as blood, is collected in a cartridge having a sample chamber for storing the sample and one or more calibration chambers, each for storing a respective calibration fluid. The fluid sample is drawn ino the sample chamber by placing the sample chamber in fluid communication with a needle inserted into the fluid sample and applying a vacuum to the chamber using either a syringe or internal vacuum. A body fluid sample may also be drawn into the sample chamber from a syringe or capillary tube containing the fluid sample. The cartridge may be either planar or cylindrical. The chambers of a cylindrical cartridge may be either elongated voids symmetrically positioned about the longitudinal axis of the cartridge or axially spaced annular voids.

Abstract: A method for the separation of blood into the components and apparatus thereof, characterized by subjecting the blood to strong centrifugation thereby separating said blood into an upper layer (A) of platelet-deficient blood plasma, an intermediate layer (B) of a mixture of platelets and white blood corpuscles, and a lower layer (C) of a red blood corpuscle concentrate, adjusting the hematocrit value of said red blood corpuscle concentrate of (C) to not more than 80% by diluting said red blood corpuscle concentrate with part of said platelet-deficient blood plasma of (A), and subjecting said mixture of (B) to weak centrifugation thereby separating said mixture into a lower layer of white blood corpuscles and an upper layer of a platelet concentrate, and if desired, subjecting the remaining platelet-deficient blood plasma to the treatments of freezing, thawing, and centrifugation thereby separating said platelet-deficient blood plasma into cryoprecipitate and cryoprecipitate-deficient blood plasma, and anaratu

Abstract: The present invention describes package units for medical purposes, in particular for receiving and/or storing sterilizable preparations for parenteral uses or dialysis solutions, comprising a container having at least one discharge spout and consisting of polyamide 66 or a laminate of polyamide 66 sheet and polyolefin sheet, the polyolefin sheet being disposed on the side facing the liquid to be stored and the sheet of polyamide 66 being disposed on the outside and the two sheets being bonded together in usual manner by means of an adhesive. The package units may further comprise an inner container or an outer container. The package unit is made in that a container having at least one discharge spout is made from polyamide 66 or the aforementioned laminate, said container filled with the liquid to be stored, then sealed and sterilized and possibly subsequently surrounded after cooling and drying with an outer container of polymeric material.

Abstract: Systems and methods of collecting blood cells use a first container connected to initially collect blood. A filtration system is provided that uses two flow paths, the first being a dual purpose path that is initially used to convey plasma and platelets to a pair of transfer/storage containers. A second flow path leads to a temporary transfer container through a filtration device. The dual purpose fluid path is next used to convey blood cells, now substantially free of undesired matter, from the temporary storage container to a storage container. The filtration system is then detached from the blood collection system.

Abstract: A blood bag of the present invention comprises a blood collection container; a tube communicating with the blood collection container and provided with a blood collecting needle at its distal end; and a blood collecting tube receiving member attached to the tube detachably or movably along the tube. Before labels are stuck on, a blood collecting tube into which blood has been collected from this blood bag is not confused with another blood collecting tube into which blood has been collected from another blood bag, or after labels are stuck on, blood is not collected from another blood bag into a blood collecting tube in which has been stuck a label having the same as serial number as a label stuck on this blood bag, so as to avoid a danger that blood having an infectious disease is transfused for mistaking it for safe blood.

Abstract: A disposable container/dispenser assembly for the extended storage and direct intravenous administration of a medicament includes a syringe barrel defining a main chamber for containing a liquid, the barrel including an upper opening in communication with the main chamber; an auxiliary barrel defining an auxiliary chamber for containing a drug to be mixed with the liquid, the auxiliary barrel including second and third spaced and opposing openings in communication with the auxiliary chamber; a first impermeable membrane for sealing the first opening of the main body; a second impermeable membrane for sealing the second opening of the auxiliary body; the first and second openings being in line with each other when the auxiliary body is connected with the main body; a third impermeable membrane secured to the auxiliary body for covering and sealing the third opening; and a plunger slidably positioned outside of the auxiliary body for rupturing the first through third membranes.

Abstract: Disclosed herein is a filled and sealed, self-contained mixing container. The container has compartments which are isolated from each other. Plural substances which contain components susceptible to mutual reaction unless isolated from each other are contained in the respective compartments. In use, these compartments are communicated together so that the individual contents can be mixed within the container. A flow passage or passages, each of which has an isolator for the contents and is adapted to communicate the compartments with each other, and is formed by a side channel provided on an outer surface of a wall of the container. Mixing of the contents without exposure to the external atmosphere can be realized by irreversible destruction of the isolator upon use. The container is suited particularly for a closed therapy system.

Abstract: A method of preparing neocytes and gerocytes in a closed blood bag system useful for the filtration of leukocytes from a red blood cell concentrate followed by the preparation and long term storage of neocytes and, preferably, gerocytes from the filtered concentrate. In very preferred embodiments, the system also provides containers for the expression of plasma and the preparation and long term storage of platelets.

Abstract: A sterile fluid mixing reservoir for storing premeasured quantities of fluids for subsequent combination is disclosed. The reservoir has a flexible outer bag which fully encloses one or more inner containers. The inner containers have self-opening mechanisms thereon which are manipulable through the outer bag. The bottles can be manufactured from a flexible material which facilitates intermixing of the fluids contained within the bag and inner containers.

Abstract: Blood bag system for separating whole blood into upper, middle, and lower components which can then be isolated from each other in an automated manner. The system comprises a primary or main blood bag having first and second outlet ports. The first outlet port communicates via tubing with a first satellite bag. The second outlet port communicates via tubing with a second satellite bag at one end and at the other end communicates with a tubular member extending into and toward the bottom of the main bag. In use whole blood is drawn into the main bag through an inlet port and centrifuged to form an upper, less dense plasma portion, a lower, more dense red blood cell (RBC) portion and an intermediate portion of buffy coat (including platelets). Pressure is then applied to the bag with the first outlet open and the second outlet closed to express all of the upper plasma through the first outlet port after which the first outlet port is closed and the second outlet is opened.

Abstract: A flexible plastic container made from a flexible, autoclavable, non-PVC polymer composition capable of suppressing the hemolysis of red blood cells. The polymer contains a material selected from the group consisting of either triethylhexyltrimellitate (TEHTM) and citrate ester. In the preferred embodiment, the non-PVC plastic is comprised of a polyolefin copolymer containing a central block of ethylene and butylene units with terminal blocks of polystyrene.

Abstract: This invention is a switch bag type blood-gathering set used for transfusing blood gathered from a blood donor to the same blood donor again, and for newly gathering predetermined amount of blood from the blood donor. This switch bag type blood-gathering set comprises a liquid transferring member for introducing a physiological saline solution into the blood-gathering set, a blood transfusing member for introducing blood from a blood bag into the blood-gathering set, a blood-transfusing and gathering member for supplying blood to or gathering blood from the donor, a washing solution storing member for containing a waste liquor after priming in the blood-gathering set, and a blood storing member for storing blood gathered from the donor, and these constituents are connected by connecting tubes so as to not contact with the air outside.

Abstract: A closed blood filter system comprising a filter connected to at least one blood bag, the filter comprising a housing having peripheral support means adapted to hold the filter in place on top of a blood bag centrifuge bucket (cup) and above the blood bags during centrifugation of blood bag contents. In a preferred embodiment the filter is connected between two blood bags by blood bag tubing. A preferred filter housing is generally disk-like and includes an annular projection adapted to fit snugly on the shoulder of a cylindrical centrifuge bucket (cup) while allowing passage of a tubing connecting the top side of the filter with a blood bag held in the centrifuge cup and below the filter.

Abstract: A medical drip-feed bag for dispensing fluids made of polyolefin polymer having flexible walls defining therein a collapsible space for storing said fluids, said bag comprising a sealable inlet for introducing fluids into the bag and an outlet for dispensing said fluid, said outlet comprising hermetically sealed connector means sandwiched between said walls, the connector means comprising a substantially lenticularly shaped body with integral nipple, said connector means further comprising a bore going through the body and nipple and forming a channel for fluid to flow out of the bag.

Abstract: Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter disposed between a first blood bag and at least two empty secondary bags. A fourth bag may be included in the closed system to contain a platelet additive solution. System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.

Abstract: A plastic bag for collection of a human fluid specimen for chemical analysis and testing. The plastic bag includes a plurality of subcompartments for collecting a urine specimen and other biological specimens for analysis to ascertain the presence or controlled drug substances or other undesired chemicals or diseases. The plastic bag includes the features of a nonreusable plastic seal around each subcompartment containing redundant fluid specimens to enable a legally secure, reliable characterization of the fluid specimen.

Abstract: Blood and gas transfer apparatus comprises a substantially rigid receptacle; a collapsible bag in the receptacle, there being space formed between the bag and receptacle; structure in the receptacle forming first porting communicating with the bag and via which blood may be transferred into and out of the bag, and second porting communicating with that space between the bag and receptacle for selectively transferring gas into and out of the space; whereby in a first mode of operation blood may be drained into the bag via the first porting, and gas may be removed from the space via the second porting, and in a second mode of operation, blood may be drained from the bag via the first porting, and gas may be introduced into the space via the second porting, the structure including neck means on the receptacle and a cap received on the neck and forming the first and second porting.

Abstract: Container systems employing a diluent container having an extractor that is helically threaded and is used to engage a resilient undercut vial stopper of an additive container.

Abstract: A blood reservoir device comprising a generally flexible blood collection chamber having an inlet portion and a main portion. The inlet portion is preferably sized and configured such that blood entering the inlet portion will avoid turbulence and will undergo generally laminar flow through the inlet portion, into the main portion of the chamber. A vent tube is provided for venting coalesced or collected gas bubbles from the top edge of the chamber. Additionally, one or more filter elements may be positioned within the chamber to further facilitate removal of air bubbles from blood passing through the chamber.

Abstract: A disposable, self-sealing pouch assembly defines a specimen-receiving enclosure and an associated pocket for receiving an identification card or the like. The assembly preferably includes first, second, and third rectangular piles of transparent plastic film. The first and second plies are joined at peripheral portions thereof to define a specimen-receiving enclosure with an access opening defined by the second ply providing access to the interior enclosure. The third ply is joined to the second ply and defines a card-receiving pocket therewith. Pressure-sensitive adhesive provided at the access opening effects self-sealing of the assembly, with the assembly configured to close the card-receiving pocket upon closing and sealing of the specimen-receiving enclosure.

Abstract: The instant invention relates to an apparatus for floating animal cells in a double-bag container, where an outer bag containing culture media and a volume of air houses an inner bag of a semipermeable film containing cells suspended in a culture media. The semipermeable film has pores of sufficient size so as to prohibit cells within the inner bag from passing therethrough but allowing culture liquid and air to pass through it. To optimize the exchange of nutrients between the interiors of the two bags, a protective mesh surrounds the inner bag and the double-bag container is fastened to an agitator which provides either a rotating or shaking motion.

Abstract: A blood reservoir is formed with a hard outer shell housing defining at least one blood compartment. A flexible bag is mounted in the outer shell and is connected to the reservoir inlet port to allow blood to directly enter the flexible bag. The bag includes two oppositely positioned ends, one of which includes a mircoporous screen and is situated to lie partially below a minimum level attained by blood in the reservoir. The second bag end is substantially open, and includes a porous element partially coated with an antifoaming agent. The coated portion of the element is positioned above a maximum level attained by the blood in the hard shell. The potential of excessive mixing between the blood and air is reduced by controlling the expansion of the bag during blood flow.

Abstract: The present invention relates to a system for use in the preparation of autologous or single-donor fibrin sealant. The invention further relates to a method of preparing fibrin sealant.

Abstract: A plastic composition is disclosed which has particular application in the manufacture of blood bags and other medical products. The composition has anti-hemolytic effects when used in the storage of red blood cells. In connection with one aspect of the present invention, the plastic composition comprises the combination of a non-PVC plastic and a selected quantity citrate ester sufficient to suppress hemolysis of red blood cells. The non-PVC material is preferably a polyolefin copolymer. Materials other than citrate ester may also be used with polyolefin as a hemolysis suppressant.

Abstract: Methods are disclosed for sterilizing a selected portion of a product and for assembling a sterile product from two or more parts which can not be sterilized with the same form of sterilization. A sterile product produced by these methods is also disclosed. The method for sterilizing may include sterilizing a selected portion of the product by exposing the selected portion to an electron beam, while shielding the remainder of the product from the radiation of the electron beam. The method of assembling a sterile product from two or more component parts may include the steps of sterilizing the first part of the product, isolating a portion of the first part from the remainder of the first part, attaching the second part to the isolated portion of the first part, and exposing the isolated portion to a form of sterilization which is deleterious to the remainder of the first part, while shielding the remainder of the first part from such form of sterilization.

Abstract: The container (1) is intended for the separate storage of active compositions, especially of liquids or solutions, and for their subsequent mixing just before use.It comprises at least three compartments (3, 4, 5) separated from one another by leakproof seams (6) of the material of the envelope (2), sealable inlet passages (7, 8), sealed transfer passages (10, 11) and a sealable outlet passage (9). The envelope is made of a polymerized and homogeneous flexible material which is chemically inert to each of said compositions and to their mixtures.

Abstract: Systems and methods of collecting blood cells, substantially free of undesired matter, use a first container, that forms a part of a blood collection system, to initially collect a quantity of blood cells. A filtration system is then attached to the first container. The filtration system includes a second container, a first fluid path that leads to the second container through a filtration device, and a second fluid path that leads to the second container bypassing the filtration device. The blood cells are conveyed from the first container through the first fluid path and filtration device and into the second container to separate the undesired matter from the blood cells. The blood cells, now substantially free of the undesired matter, are then conveyed from the second container through the second fluid path, bypassing the filtration device, and back into the first container. The filtration system is then detached from the blood collection system.

Abstract: An apparatus for collecting, storing and providing multiple transfusions of blood in small quantities to premature infants from a single donor or a limited number of donors without wasting or discarding unused blood of such donor or donors, including a primary reservoir for collecting and storing a predetermined amount of blood from a donor, which amount is substantially less than is usually collected for adult transfusions. The apparatus is provided with a plurality of sterile, deformable satellite administering reservoirs for receiving blood from the primary reservoir in an amount corresponding to the need of the premature child. Each of the satellite reservoirs is provided with graduations thereon so that the amount of blood required by the premature infant can be collected and measured therein for subsequent transfusion to the infant. A method of providing a prolonged, continuous supply of blood for infusion to a premature infant from a single donor or a restricted number of donors is also disclosed.

Abstract: A unit dose medicament storing and mixing system is described having a dual compartmented and collapsible container for use in an intravenous administration system. One of the compartments contains unit dose measurements of sterile medicament (in powder or liquid form), the second compartment to contain sterile intravenous fluid to be used as a diluent. The two compartments are separated by a closure which is separable and resealable. An external clamping device is used to lock the resealable closure and keep the compartments separate. Prior to the infusion of the activated medicament to the patient, the drug is prepared by removing the external clamp and separating the resealable membrane device, thereby providing fluid communication between chambers and effecting intermixing of the contents thereof. The membrane can then optionally be resealed in order to separate the medicament to be delivered from any residual air left in the container.

Abstract: A method for separating blood into blood components aseptically in a closed system first filters whole blood through a filter for removing leukocytes or removing leukocytes and platelets, to produce filtered blood, which is passed to and collected in a primary bag fluid-tightly connected to the filter through a sealable, cuttable conduit, and the conduit is sealed and cut to disconnect the primary bag from the filter. The disconnected primary bag is subjected to centrifugation to separate the filtered blood into blood components. The method is useful for separately collecting leukocyte-removed blood components, particularly leukocyte-removed erythrocytes, leukocyte-removed plasma, leukocyte-removed platelets, etc., from the whole blood of a healthy human. A blood components separation unit which can advantageously be used in the practice of the above method is also disclosed.

Abstract: In a blood reservoir comprising a container casing defining a space for accommodating blood, the casing having a generally rectangular contour defining a pair of top and bottom sides and a pair of laterally opposed sides, provided that the casing assumes a vertically upright attitude, an inlet port is disposed in one lateral side of the casing for introducing blood into the space, an outlet port is disposed in the bottom side of the casing for discharging blood from the space, and a vent port disposed in the top side of the casing in fluid communication with the space. In another form, a partition separates the space into upper and lower compartments, and apertures are formed in the partition for allowing partial fluid communication between the compartments. The inlet port and the vent port are in communication with the upper compartment, and the outlet port is in communication with the lower compartment.

Abstract: A fluid collection, storage and infusion apparatus particularly adapted for collecting, storing and infusing or reinfusing a substance such as blood taken from a patient including a flexible bag-like device having an opposed inlet and outlet, a fluid storage compartment communicating with the inlet and outlet for the collected fluid and a compartment into which a source of fluid such as a gas under pressure can be introduced to exert pressure on the collected fluid to force the fluid out of the fluid storage compartment through the outlet.

Abstract: Blood and blood component container having in continuous communication therewith a receptacle adapted to receive and define a given component or sub-component when contents in the container are separated. In preferred embodiments, the container is a flexible bag having a tapered portion adjacent the receptacle to assist migration of a given component or sub-component into the receptacle during centrifugation and at least a portion of the container is supported by a cup-like device, the inner surface of which conforms to the outer surface of the bag and communicating receptacle.

Abstract: A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then separated, the tapering end portion expands to form a funnel-like guide for directing a separated component from the bag through the tubing in a substantially unobstructed manner. Bag is especially useful for separating and isolating the components of a neocyte/gerocyte red blood cell mixture.

Abstract: A blood collection system and method are disclosed in which a neutralizing agent for pathogens such as HTLV-III virus is added to the blood collected in a standard blood bag or group of connected bags. Conveniently, the neutralizing agent, which can be in liquid or powder form, is held in a small container attached to the blood bag and released into the collected blood or alternatively, prepositioned in the collecting or satellite bag.

Abstract: Improved flexible ratchet teeth are provided for allowing relative rotational movement of one peripheral surface relative to an encompassing peripheral surface. Such teeth allow relative rotational movement in one direction of rotation only during which the ratchet teeth of one peripheral surface slide over the ratchet teeth of the other. The flexible teeth which may be disposed on either or both peripheral surfaces prevent distortion of the encompassing peripheral surface obtained in the prior art when ratchet teeth of solid construction are employed.

Abstract: A set for the isolation of cryoprecipitate includes a hollow vessel with a closed first end, a second end and a longitudinal axis, and a nipple extending from and closing the second end, said nipple enclosing a volume of approximately 2 to 5 percent of the volume of the hollow vessel. In one embodiment, the vessel is formed of a semi-rigid material and the first end is closed by a cap containing a micro-porous filter for venting the vessel. In another or further embodiment, the nipple has a tapered tip portion which may be sliced off to permit extrusion of the isolated cryoprecipitate by squeezing the vessel. In a different further embodiment, the nipple has a twist-lockable connector, for attachment to a syringe or to an applicator tip. In yet another embodiment a piston mounts on the cap within the vessel for directly extruding separated cryoprecipitate from the nipple.

Abstract: A set for the isolation of cryoprecipitate includes a hollow vessel with first and second ends and a tapered body extending to a narrow sump closing the second end, said sump enclosing a volume of approximately 2 to 5 percent of the volume of the hollow vessel. A port enters the vessel in the tapered body above the sump. In one embodiment, the vessel is formed of a rigid or semi-rigid material and the first end is closed by a cap containing a micro-porous filter for venting the vessel. In another or further embodiment, the sump has a tapered tip portion which may be sliced off to permit extrusion of the isolated cryoprecipitate by squeezing the vessel. In a different embodiment, the vessel contains an inner filter column, or bag with a filter matrix, accessible via an access port. Cellular material placed in the column is frozen, thawed and centrifuged to separate out antigen-free platelet growth factor with the cryoprecipitate.

Abstract: A fluid delivery system has a container with an integrally attached sample cell. A selected fluid can be accumulated in the container. The sample cell can be filled with part of the fluid in the container and then isolated from the container by heat or dielectric sealing. The fluid in the sample cell can be brought into contact with selected test reagents. The test reagents can provide a visual indicia of the presence of selected characteristics in the fluid.

Abstract: A valve adapted for pooling blood components comprising a valve housing and a valve plug, with channels through the valve plug. By rotating the valve plug, selected ports in the valve housing may be brought into communication so that fluids may flow between the ports in communication. To facilitate transfusions of blood components, the valve may be used to pool multiple units of blood components and to resuspend masses of component particles, enabling them to be drawn out of the blood component bag. The risk of infection is decreased, and a more efficient use of the contents of the blood component bags is obtained. A method for producing a blood component pooling device is also disclosed.

Abstract: There is disclosed a blood components collector unit comprising a cannula, a blood collection bag and a membrane type blood components separator which are connected in this order through tubes, and also comprising a plasma collection reservoir and a blood cell collection reservoir, both of which are connected to the blood components separator through tubes, wherein each connection through each tube is in a fixed fashion, thereby providing a unified connection, and wherein the blood collector unit is packed in a container in a sterile state. By the use of the unit of the present invention, whole blood can be collected and separated into blood components easily at a shortened period of time without any cumbersome preparatory operations. In addition, since the unit of the present invention is compact and light in weight and can be used without any other auxiliary apparatus, the unit can be conveyed to and used in any places, such as in automobiles and outdoors.

Abstract: Disclosed is a method for stabilizing an aqueous solution of phosphoenolpyruvic acid and its salt, which comprises placing the solution under the condition of pH 10 to 13.Disclosed is also a container for phosphoenolpyruvic acid, comprising an outer bag comprising a polyvinyl chloride type resin and an inner bag comprising an alkali resistant resin for storing an aqueous solution of phosphoenolpyruvic acid or its salt under the condition of pH 10 to 13 therein.According to the present invention, a method for stabilizing phosphoenolpyruvic acid in an aqueous solution and a container for housing the stabilized phosphoenolpyruvic acid accompanied therewith can be obtained.

Abstract: Blood and blood component container having in continuous communication therewith a receptacle adapted to receive and define a given component or sub-component when contents in the container are separated. In preferred embodiments, the container is a flexible bag having a tapered portion adjacent the receptacle to assist migration of a given component or sub-component into the receptacle during centrifugation and at least a portion of the container is supported by a cup-like device, the inner surface of which conforms to the outer surface of the bag and communicating receptacle.

Abstract: In a blood bag system for plasma transfusion and cell return including two or more blood bags containing anticoagulant and connected to a puncture needle through two or more branch tubes and a common main tube, a cell return port is connected to the branch and a breakable flow path closure is inserted in one branch tube adjacent the branch. When broken, the flow path closure allows fluid communication through the branch tube. Blood is first collected in the first blood bag, which bag is sealed when filled and separated from the system. Then, the flow path closure is manually broken to permit blood collection into the second blood bag.