Abstract: The invention relates to a therapeutic treatment device having a light source controlled by a microprocessor that can receive parameters for treatment that can hold treatment parameters and information about the patient, including a photograph of the patient either before or after treatment. The device may also display temperature distributions in the patient's tissue or blood vessels.

Abstract: Methods for tissue welding using solders incorporating biologically active agents, such as growth factors or hemostatic agents, have been developed. Improved solder compositions have also been defined, yielding greater bursting strength as a function of protein concentration, and through the use of protein unfolding prior to laser-mediated denaturation and coupling. A method for repair of fistulas has been discovered, using water as a chromophore, in combination with solder concentration, to form columns to fill defects where tissue apposition is not possible. Methods have also been adapted for use with other forms of directed energy, including bipolar electrosurgery and light. Examples demonstrate increased strength of repairs by incorporation of growth factors into solders, alone and as a function of solder concentration. Increased adhesion is obtained through prevention of bleeding by incorporation of hemostatic agents such as thrombin or epinephrine, a vasoconstrictor.

Abstract: A test substrate for the calibration of a laser used in ophthalmologic surgery. The test substrate is formed from a homogenous, relatively anhydrous material that ablates a rate approximately that of human corneal tissue. In one embodiment, the test substrate is formed from a plastic material such as acrylic or silicone. In another embodiment, the test substrate is formed from an organic gel or inorganic gel such as cross-linked collagen.

Abstract: An argon-fluoride excimer laser or other laser source capable of generating far-ultraviolet radiation at 193 nm is pulsed with energy densities of greater than 20 mj per cm.sup.2 at a repetition rate up to 25 pulses per second to direct its radiation through a mask and onto corneal tissue, or other biological matter, to form an ablation therein of predetermined configuration and depth by a process of ablative photodecomposition. The masks are formed with a slit, circular, crescent or other openings of widths between 30 and 800 microns, and may even be formed to provide a graded intensity center to edge. The mask is reflective or composed of or faced with an organic polymer to prevent heat build-up.

Abstract: A method for removing a thrombus or plaque deposit from the wall of a blood vessel of a patient is enhanced by synergistic action of two individual procedures. A catheter is introduced into a blood vessel from which a thrombus or plaque deposit is to be removed. The first procedure is application of laser energy through an optical fiber in the catheter, in a wavelength range selected for preferred absorption by red blood cells in the blood vessel to generate a plasma-based ultrasonic shock wave in the vessel. The shock wave impacts on the thrombus or plaque deposit to open fissures therein. In the second procedure, a thrombus- or plaque-dissolving medication is injected into the blood stream in the vicinity of the plaque deposit through a lumen in the catheter, promptly after completion of the first procedure.

Abstract: An apparatus for stabilizing a laser delivery device used during a surgical procedure by securing the laser delivery device to a surgeon's hand is defined by a finger mounting portion for securing at least one laser delivery device to at least one of the surgeon's fingers, and laser delivery device guide attached to the finger mounting portion for directing laser energy from the distal end of the laser delivery means. The finger mounting portion has at least one ring portion for removably encircling the surgeon's finger(s). Embodiments of the guide orient the laser delivery device either axially or trans-axially at a predetermined angle. The guide may be tubular with a preselected curvature, or tubular and adjustable so as to orient the laser delivery device into a plurality of positions. A locking mechanism couples the laser delivery device to the guide and rotating the guide may orient the laser delivery means into a plurality of predetermined positions.

Abstract: A laser micromanipulator for surgical applications includes an adaptor attachable to a laser and to a microscope which automatically maintains, preferably using phase detection, the laser beam in focus on tissue during any changes in the working distance by the surgeon manipulating the microscope.

Abstract: An apparatus for removing tissue from the eye performs various types of corrections using a relatively large beam, but oscillated or dithered to prevent the formation of ridges during the removal process. Various types of corrections are contemplated such as hyperopic and astigmatic using a large beam which is scanned over the area to be ablated using overlapping shots which are between 10% and 90% of the area of the total area to be ablated.

Abstract: A medical laser system is disclosed for ablating biological material. The system includes an Erbium:YAG gain medium capable of generating a pulsed output having a wavelength of 2.9 microns. The laser is optimized to generate a pulsed output having a repetition rate of at least 50 hertz and preferably at least 100 hertz. The output is delivered to the target tissue via an optical fiber. Preferably, a suction source is provided to aspirate the tissue as it is being ablated.

Abstract: A method and a device is described. The probe device is a leading probe for surgical procedures which includes both instrument access and illumination. The leading probe device includes an annular arrangement of a plurality of light transmission fibers about a central instrument-receiving working channel. The leading probe may be fixed on the outer wall of the eye by a notched footplate with suitable suture material. Alternatively, the present invention device may have an appropriate adhesive member for securing the leading probe at the surface of the eyeball.

Abstract: A two-pulse, lateral tissue illuminator in which a first pulse delivered by a first optical waveguide is used to irradiate a liquid-containing region to form a vapor bubble; a second pulse, delivered by a second optical waveguide, is then passed through the vapor bubble and used to incise a tissue of a patient. The illuminating device can be used to effectively deliver radiation to tissue positioned laterally relative to the axis of the delivery fibers, and allows a reduction in the attenuation of the radiation by the surrounding liquid.

Abstract: A method and system are provided for sensing eye movement, such as saccadic eye movement, in a non-intrusive fashion. An optical delivery arrangement converts a laser beam pulse into a plurality of light spots. The light spots are focused such that they are incident on a corresponding plurality of positions located on a boundary whose movement is coincident with that of eye movement. The boundary can be defined by two visually adjoining surfaces having different coefficients of reflection. Energy is reflected from each of the positions located on the boundary receiving the light spots. An optical receiving arrangement detects the reflected energy from each of the positions. Changes in reflected energy at one or more of the positions is indicative of eye movement.

Abstract: A dermatology handpiece delivers a treatment beam of optical energy to a lesion. The handpiece has the ability to selectively determine whether or not the treatment beam is delivering optical energy to a lesion or to healthy tissue. This is achieved without visual inspection of the skin surface by the physician. Slight variations in tissue, not readily discernable by the human eye, can be detected and treated. A base line, or threshold, is established for the treatment area. Normal tissue, falling below the base line, does not receive a dose of optical energy. A threshold or base line signal is created by taking a reading of healthy skin. The dermatology handpiece is adjusted so that the treatment beam is not delivered until a threshold or base line signal is exceeded. Substantially all of a lesion receives the proper amount of optical energy in the treatment beam, while healthy tissue does not receive a dosage of optical energy.

Abstract: An illuminated bougie in which the elongate bougie body is formed of flexible light-transmitting material. A socket for detachably attaching the light-transmitting end of a fiber optic bundle is formed in the proximal end of the bougie.

Abstract: A laser system for use in performing dental procedures is provided. The system includes a handpiece which is capable of being connected to a source of laser light, such as a fiber optic cable. The fiber optic capable carries laser light into the handpiece. For most of the purposes contemplated herein, the argon laser light is preferred. The handpiece includes a collimating lens such that the laser light is collimated and a collimated laser output exits said handpiece. Collimated laser light is found to be useful in initiating the curing of dental resin restorative materials. Also placed within the handpiece is a mirror for controlling the direction of laser light output from said handpiece and for directing the collimated laser light toward a dental work area. Finally, multiple detachable attachments are provided which are capable of being mounted on the exterior or at the proximal end of said handpiece for optionally modifying said collimated laser light output.

Abstract: Methods and systems are disclosed for corneal reprofiling employing an annular beam of ablative radiation to correct refractive errors in vision, and/or create "blend zones" in order to reduce any surface discontinuities on the cornea following hyperopia-correcting or astigmatism-correcting procedures. Preferably, the methods and systems of the present invention also operate to change the intensity distribution of the light beam, such that the annulus of radiation has a varying intensity as a function of radius and, thereby, achieves a blending or other desired effect with the least number of pulses.

Abstract: A method of disinfecting or sterilizing tissues of the oral cavity or a wound or lesion in the oral cavity is provided. The method comprises applying a photosensitizing compound to said tissues, wound or lesion and irradiating said tissues, wound or lesion with laser light at a wavelength absorbed by said photosensitizing compound.

Abstract: A combination handpiece and surgical laser tool is disclosed for use in laser surgery. The handpiece comprises a hollow body having an internal wall which is mounted about the probe of the laser tool. A layer which contains optical fibers is mounted about the internal wall with the fibers have outlet ends at the tip of the handpiece. A light source directs visible white light along the fibers with the light being projected in a pattern which illuminates a portion of an anatomical structure in a path about a spot at which the laser beam impinges. In one embodiment a handpiece is releasably fitted about the laser tool so that the handpiece can be detached and used as a flashlight to explore the wound. In another embodiment the optical fibers are formed into discrete clusters which are spaced about the circumference of the annular layer of the handpiece. Visible light can then be projected from the clusters in discrete spots about the laser beam.

Abstract: The surgical tool is used in conjunction with a direct contact laser that is powered through a small diameter laser power tube. In one embodiment, the tool includes a bendable, rigid tube having a lumen sufficiently larger than the laser power tube such that upon application of an axial, inboard directed force, the laser power tube is axially compressed within the lumen of the bendable tube. The contact laser tip, located at the end of the power tube, is powered by a laser core which is retained within the lumen of the laser power tube. The laser core is flooded by irrigation and cooling fluid flowing through the laser power tube. This fluid is ejected or emitted from the distal end of the laser power tube immediately behind the laser contact tip. In one embodiment, the bendable tube includes a handle and a bendable, rigid nozzle made of plastic. A longitudinally actuated suction control valve is disposed in the handle.

Abstract: Myocardial revascularization is performed by an apparatus and method which forms channels in the myocardium from inside the ventricular cavity without penetrating the full thickness of the ventricular wall. A catheter has a fiber optic connected at its handling end to a laser, and terminates at the insertable end of the catheter. A servomotor controls the advancing of the fiber to stop positions relative to the catheter. At each stop position another channel is created. An aiming beam aids in directing the channel forming fiber end to different desired channel positions.

Abstract: A stent in an implanted site is subjected to pulses of laser or sonic energy from external means thereby altering its physical structure without substantially altering or damaging tissue surrounding the implanted site.

Abstract: A radiation device for therapeutic use in the human body allows the application of light waves to an affected area of the body. A bulb, preferrably a xenon bulb, produces light which is passed through a lens module having silicon and carbon granules therein. By applying different lenses to the device, a variation in the wavelengths of light and radiation applied to an area is achieved. The device has a pistol-like housing to allow for controlled application of the radiation.

Abstract: A thin flexible probe that combines illumination and aspiration includes a rigid, two-section housing for accommodating a flexible fiber optic cable and a flexible aspiration conduit. The fiber optic cable terminates at a distal end in an angle of less than 90 degrees relative to its longitudinal dimension so as to emit light in a radial direction through a transparent cover, which forms part of the first section of the housing. The aspiration conduit is connected in fluid communication with an aspiration tip, which forms part of the second section of the housing. A flexible tubular body surrounds the fiber optic cable and aspiration conduit and is sealed to the housing.

Abstract: An operating microscope has extensions on which are mounted neon lasers which focus beams through the focal point on the optical axis of the operating microscope. The beams produce two spots on an object when the object is away from the focal point, and a single spot on an object at a the focal point. Lightweight laser ring gyroscopes are connected to the operating microscope to determine spatial changes in the position and direction of the operating microscope and the focal point of the microscope.

Abstract: A light diffuser for the radial emission of light, which has been fed into the diffuser in axial direction, comprises an optical waveguide, which itself comprises a core and a cladding. The core of the waveguide is exposed at an active region at the distal end. The exposed active region of the core is optically separated from a substance containing scattering particles. In a preferred embodiment, the core is roughened and is embedded in a first layer of an elastic substance, which has a refractive index similar to the refractive index of the cladding and which does not contain any scattering particles. This first layer is embedded in at least one further, second layer of an elastic substance comprising the scattering particles. This substance is surrounded by the outer tube.

Abstract: For an interstitial thermotherapeutic treatment of biological tissue in which, for generating a coagulation necrosis, the radiation of the laser within a radiation period is guided into the tissue by way of a fiber optic waveguide, the laser power is reduced continuously or in steps during the radiation period.

Abstract: A method of treating vascular lesions is disclosed which includes using a focused beam from a high energy, carbon dioxide laser to irradiate a spot on the surface of the skin over the vessel to be treated. The carbon dioxide output wavelength is highly absorbed by the tissue. By using short, high energy pulses, a small volume of skin can be vaporized or ablated with each pulse with little thermal damage beyond the ablated region. Using multiple pulses, a small channel is drilled in the skin until the vessel is reached. The laser energy absorbed by the blood in the vessel will cause it to coagulate and collapse. This procedure is then repeated at multiple sites along the length of the vessel so that it will collapse and no longer carry any blood.

Abstract: An apparatus and method for irradiating an inflamed joint of a patient having rheumatoid or psoriatic arthritis are presented. A noncoherent source of radiation having a predetermined wavelength range is utilized to transilluminate affected tissues of the subject for a predetermined duration. The radiation source has sufficient intensity and is applied for sufficient duration to reducing inflammation and substantially halt disease progression.

Abstract: Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fibreoptic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue.

Abstract: The invention contemplates an inventory of disposable elements adapted for selective placement in the path of laser-beam delivery to the cornea. Each of the disposable elements carries a membrane which is opaque to the laser beam and which is designedly subject to ablation when exposed to the laser beam, the thickness of the membrane being a precharacterized function of local area such that a given laser-beam course of exposure will require greater or lesser time to locally ablate the membrane and thus permit laser-beam exposure past the membrane and into correspondingly localized ablating impingement with the cornea. Stated in other words, varying-spot size at the cornea is achieved by a time-release function of the membrane, on a predetermined area-controlled basis that is designed to achieve the diopter change specifically identified with each particular selectable element.

Abstract: A dual wavelength laser is disclosed for use in dental therapeutic applications. The dual wavelength laser includes a laser cavity in which a laser crystal is disposed and preferably the laser crystal is an Nd:YAG laser, which, upon excitation, lases at two different wavelengths, each of which has a different gain. A shutter, or alternatively an optical filter, is selectively disposed within the optical path of the laser crystal whereupon the higher gain wavelength is selectively suppressed. Thus, with the shutter or optical filter removed from the optical path, the laser lases at its higher gain wavelength. Conversely, with the shutter or filter positioned within the optical path, the higher gain wavelength is effectively suppressed so that the laser crystal lases at the lower gain wavelength.

Abstract: A thin, pliable mat to enhance visualization of corneal topography during rastostereography or videokeratoscopy. The mat is approximately 20 microns or less in thickness and constructed from hydrophobic material. In one preferred embodiment, the mat has a pattern etched thereon. In an alternative embodiment, a pattern is projected onto the mat. For rastostereography the pattern is a grid. For videokeratoscopy the pattern is concentric circles. The mat conforms to the surface of the cornea and the pattern is analyzed using conventional technology to determine corneal topography.

Abstract: An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin including the stratum corneum, transparent hydrogel for covering the dermal treatment site and containing hydration agent and photopharmaceutical, the transparent hydrogel couples the hydration agent to the stratum corneum to hydrate and soften the stratum corneum to enhance its optical transmissiveness to facilitate the transmission of light therethrough and to enhance its chemical transmissiveness to facilitate the transmission therethrough of the photopharmaceutical for treatment of the dermal lesion; and light delivery means are included for delivering light through the transparent hydrogel and the hydrated stratum corneum to photoactivate the photopharmaceutical to treat the dermal lesion.

Abstract: An apparatus is provided for treating cutaneous vascular lesions in a target area of a patient. The apparatus has a lower housing having a bottom with an opening therethrough, and an upper housing adapted to be connected in liquid tight engagement to the lower housing. The upper housing has a top with an opening therethrough and substantially in alignment with the opening of the lower housing. A pair of glass windows are provided one positioned in the opening of the lower housing, and the other positioned in the opening of the upper housing. The apparatus further comprises at least one fenestrated wall adapted to be removably positioned in the lower housing to form a first and a second chamber when the upper and lower housings are connected together. The first chamber is adapted to receive a cooling medium, and the second chamber prevents the cooling medium from obstructing the passage of a laser beam between the pair of glass windows.

Abstract: An endoscopic instrument having a diode laser at the distal end of the instrument for cutting and/or coagulating tissue during an endoscopic procedure.

Abstract: A method of using rastophotogrammetry and Placido-disc videokeratoscopy in ophthalmological surgery to calibrate a surgical laser wherein the effect of laser ablation on various substrates is measured by performing rastophotogrammetry or Placido-disc videokeratoscopy on the substrate before and after laser ablation to determine whether there is a uniform ablation and no unwanted effects created by the laser. The substrate can be calibration block, an intraoccular lens implant, a contact lens, an artificial cornea, or cornea.

Abstract: A tissue penetrating apparatus including a surgical appliance having a sharp tip for penetrating tissue, a first optical element for emitting one or more selected monochromatic wavelengths of light, and a second optical element for sensing light corresponding to the one or more selected monochromatic wavelengths of light. The first and second optical elements are optical transmission fibers secured to the appliance proximate to the tip so that one fiber passes one or more monochromatic wavelengths of light into the tissue to be penetrated, and the other fiber passes the light sensed to a light detector. A control circuit is used to illuminate the one or more light sources to emit light out one of the first and second optical fibers, and to provide an electrical signal corresponding to the light sensed at the other of the first and second optical fibers. The electrical signal includes sensed light at each of the monochromatic wavelengths of light emitted, and sensed light in the absence of emitted light.

Abstract: A fiber optic catheter has a short guide wire lumen (less than 10 cm) extending in a proximal direction from its distal end and an intermediate portion reinforced with a tapered mandrel which provides optimal steerability and trackability characteristics. The distal end of the mandrel is coextensive with a proximal portion of the guide wire lumen. The intermediate portion of the catheter may have a marker for visual identification, and the tip of the catheter may include a radiopaque tip marker band for fluoroscopic identification. The short guide wire lumen catheter provides superior flexibility, a low profile, and low-friction engagement with the guide wire.

Abstract: Cardiovascular disease is the leading cause of death in the United States. Interpreting the relative danger of a lesion within the vasculature is limited by a lack of information on the composition of lesion. It is believed that a lesion which is high in lipids is more prone to rupture followed by thrombosis than a stable highly calcific, fibrotic, high grade stenosis. To address this recent hypothesis, a method of diagnosing and treating the most problematic vascular lesions is presented. The method employs the selective uptake of a lipophilic fluorescent compound by a lesion followed by the application of excitation light to the fluorescent compound-ladened lesion causing the fluorescent compound to emit fluorescence light.

Abstract: A hand-held portable arthroscope has a housing and a disposable cap removably attached to the distal end of the housing. A probe which includes a fiber optic image guide and a plurality of optical illuminating fibers is mounted on the cap, and is insertable into a body for imaging the internal structure of the body. The illuminating fibers extend through the cap and are connected in light communication with a quartz halogen lamp for illuminating the internal body structure being imaged. To gather light from the illuminated internal structure of a body into which the probe has been inserted, a GRIN rod is attached to the distal end of the image guide. Focussing optics are mounted in the housing in light communication with the image guide. These focussing optics are axially movable within the housing for focussing the image from the image guide. Light which passes through the focussing optics enters a camera head which is also mounted in the housing.

Abstract: A laser surgery method is disclosed for use in efficient ablation of tissue with little or no thermal damage to adjacent tissues. The wavelength of the surgical laser is tuned to an absorption peak of a proteinaceous material or functional groups contained therein, the amides for example. A suitable power level is chosen to either vaporize or liquify the targeted tissue.

Abstract: Disclosed is a method and apparatus for removing a polymethylmethacrylate or other cement plug from the medullary canal during hip-revision surgery. In accordance with the method, a portion of the PMMA plug is softened and a plug removal tool is advanced through the softened portion to become imbedded in the plug. The plug is permitted to harden around the tool, and the tool is withdrawn thereby pulling the plug with it. Softening may be accomplished by conducting ultrasonic energy through the removal tool tip, or by other means. Hardening is accomplished by removing the heat source and permitting passive cooling of the material, or by accelerating cooling of the material through the use of a heat sink or a circulating media such as a compressed gas. Also disclosed is a self-cooling tool tip.

Abstract: A method is disclosed for determining the biodistribution of substances using fluorescence spectroscopy. A photosensitizing agent or other intrinsically fluorescent agent, or an agent labeled with an extrinsic fluorophor is administered to a subject. A fiberoptic probe integrated with an excitation light source illuminates the examined tissue and causes fluorescence. The fluorescence is recorded by a spectrograph and plotted as a spectral curve. The intensity ratio (S1/S2) for the fluorescence from the photosensitizing agent (S1) and autofluorescence (S2) for the examined tissue is used as an index for drug presence and compared with the intensity ratio at the same wavelengths for various tissues.

Abstract: A fiberoptic stylet apparatus for assisting in the safe and effective intracorporeal placement of catheters comprises an elongate, light-emitting fiberoptic cable coupled to a conventional stylet body in a parallel alignment therewith. The distal extremities of the cable and stylet are positioned adjacent one another. A surgeon inserts the fiberoptic cable/stylet coupling into a catheter in much the same manner as a conventional stylet, so that the adjacent distal extremities reside within the catheter tip. A light source connected to the fiberoptic cable is activated to cause said cable to emit light which passes through the catheter tip. When the surgeon inserts the catheter into the coronary sinus or other body cavity of a patient, the light passes through the translucent tissue surrounding the catheter tip.

Abstract: It is the object of this invention to provide a new and highly flexible medical laser delivery device and system with the abilty to change the radiation pattern delivered without the need to change or modify the output end or output optics. The output optics or output end is frequently embodied in the body and/or is sterile and its change or modification or the change of the whole delivery device during the procedure is undesirable. Changing the input pattern while using conventional step index fibers cannot achieve the required result of control of the output pattern in a reliable manner because of beam spreading over the length of the device. The light becomes diffused over the length of the conventional step index fiber. It is therefore another object of the present invention to specify the requirements for the transmission fiber employed in the device and a method of making same.

Abstract: An apparatus, for simultaneous or selective treatment of an area of the skin and adjacent subcutaneous structure of a patient utilizing photo energy and therapeutic heat, which includes a plurality of juxtaposed diodes. Each diode has a longitudinal axis and is capable of projecting a non-coherent cone of light which overlaps the cone of light from each juxtaposed diode so that the light completely covers the treatment area. A flexible pad or appliance holds the diodes in juxtaposed position with each other. Each is held in contact with the skin and has a longitudinal axis which is in substantially perpendicular relationship to the skin. A resistor heats each diode, which acts as a heat sink, so that the treatment area of the skin and the adjacent subcutaneous structure of the mammal receive light and thermal treatment simultaneously. An adjustable control varies the light intensity of the diodes and the amount of heat generated by the resistor in a selected and controlled manner.

Abstract: A method of ablating atherosclerotic plaque by means of short-duration laser light pulses. A carotenoid, such as beta-carotene, is preferably administered to the patient by injection or ingestion prior to exposing the plaque with laser light. Research data obtained by analysis of the absorption characteristics of plaque and the healthy arterial tissue reveals that the plaque may be selectively ablated without damaging the surrounding normal tissue by illuminating the plaque with laser light having a wavelength of about 430 to about 510 nanometers such that the relative absorption coefficient exhibited by the plaque is more than 1.5 times the absorption coefficient of the arterial tissue. Short duration laser light pulses preferably illuminate the plaque for less than the thermal relaxation time of the volume of exposed material. The intensity of the laser light is preferably in the range from about 1 to about 9 joules/cm.sup.2 in order to ablate the plaque without endangering the surrounding tissue.

Abstract: The invention relates to a process of treatment in the field of dermatology, for the treatment of cutaneous angio dysplasias, using the energy emitted by a laser source, as well as to an apparatus for the treatment of skin angiomas implementing the process. The apparatus includes a laser source suitable for supplying laser radiation, a treatment instrument for receiving the laser radiation from the source and whereby a plurality of consecutive laser shots is effected to form a plurality of resulting impacts on the area of the body to be treated. Following each shot, the area of the body thus treated has, at the resulting impact, at least a given relaxation time. The apparatus includes a support frame, an optical fiber disposed in the frame. The optical fiber has two ends, the first of the ends being suitable for connection to the laser source via the connecting means, the second end being mobile and suitable for generating a displaceable laser spot.

Abstract: A unitary, flexible, substantially noncollapsible catheter tube of biocompatible material is comprised of hard and soft regions. The hard regions can be ring shaped or helical. The hard regions provide sufficient rigidity to the tube to prevent collapse under normal usage as the interior and exterior pressures vary. The soft regions provide sufficient flexibility to allow contoured placement of the tube. The hard regions can be created by exposing a polymer in the tube to radiation. The hard regions can also be created by periodically adding a harder material to the tube.

Abstract: The invention relates to a device for heat treatment of tissue. The device comprises a laser (20) provided with means enabling it to emit laser radiation in the form of a sufficient number of pulses to deliver a total energy that provides the heat treatment of the tissues, the device being characterized in that it includes means (30, 40) for adjusting the number and the duration of the pulses, said means enabling at least two pulse sequence groups to be emitted: a first pulse sequence group delivering about 70% to 80% of the total energy, and a second pulse sequence group delivering 30% to 20% of the total energy. The invention makes it possible to shorten the total time required for heat treatment of tissues.