Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.

Abstract: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters.

Abstract: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters.

Abstract: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters.

Abstract: An ophthalmic laser ablation system is described with various optional features, some especially suitable for non-penetrating filtration on an eye. In one example, focusing of an ablation laser uses a movable lens coupled to a pair of converging light sources, which converge at the focal distance of the lens. In another example, laser ablation settings are selected for optimal ablation and minimal amount of thermal damage of a layer of percolating scleral tissue.

Abstract: A defect inspection apparatus including an illumination optical system, an image formation optical system, an image data conversion unit, a singular part detecting circuit, an optical path length adjusting mechanism, and a defect determining unit. The image formation optical system forms an optical image derived from light passing through first and second optical paths. The image data conversion unit converts, to image data, each of the optical images. The singular part detecting circuit detects a singular part in each of the image data. The optical path length adjusting mechanism equalizes the optical path lengths of the first and second optical paths. The defect determining unit determines a defect on the basis of singular part detection.

Abstract: A design for dynamically adjusting parameters applied to a surgical instrument, such as an ocular surgical instrument, is presented. The method includes detecting surgical events from image data collected by a surgical microscope focused on an ocular surgical procedure, establishing a desired response for each detected surgical event, delivering the desired response to the ocular surgical instrument as a set of software instructions, and altering the surgical procedure based on the desired response received as the set of software instructions.

Abstract: Treatments to improve ocular conditions such as presbyopia are provided. Structural (mechanical) weakening of the sclera is accomplished through the formation of a 3-D pattern of laser foci in the sclera resulting in an increase in the range of ocular accommodation.

Abstract: Embodiments of the present invention encompass the manufacture of pre-cut lenses and the use of such lenses in combination with laser surgical techniques, including femtosecond laser photodisruption or photoalteration treatments. These techniques further expand the capabilities of lasers, and allow their use for both incising and refractively altering the eye. In many instances, embodiments disclosed herein are suitable for the treatment or correction of regular refractive errors and an irregular refractive alterations (such as correcting an irregular refractive error of the eye), without having to resort to two separate laser systems.

Abstract: Techniques, apparatus and systems for laser surgery including imaging-guided surgery techniques, apparatus and systems.

Abstract: A computer-aided system include a data storage (18) with eye data (181), which defines a three-dimensional model of the eye, and a reference generator (113) for defining and storing a geometric reference in relation to the three-dimensional model of the eye. The system additionally includes a cut surface editor for defining and positioning cut surfaces in the three-dimensional model of the eye based on user instructions. Finally, the system includes a cut pattern generator (117) for, based on the positioned cut surfaces, generating and storing three-dimensional cut patterns for defining tissue cuts to be executed in a human eye by means of femtosecond laser pulses. The generation of a three-dimensional cut pattern permits the user to define tissue cuts made possible by femtosecond laser pulses in a targeted and efficient fashion in the three-dimensional model of the eye without having to undertake manipulations directly on the eye for this purpose.

Abstract: A method of transplanting a cornea from a donor to a recipient is disclosed. An undercut is incised within stromal tissue of the donor cornea. Following formation of the undercut, the donor cornea is grafted onto a recipient. The undercut may be formed before or after the cornea is removed from the donor, and is preferably formed by photoaltering the stromal tissue using a laser. A sidecut may also be incised in the donor cornea, thereby forming a corneal flap, prior to grafting. In addition, a corneal section may be excised from the donor cornea using a trephine, a laser, or other appropriate surgical equipment.

Abstract: An apparatus and method are provided for performing ocular laser surgery using a patient interface having a posterior contact surface that may include surface irregularities that were generated during manufacturing of the patient interface. A beam delivery system having a focusing lens, scanning subsystem and adaptive optic (e.g. deformable mirror) is provided for guiding the surgical laser beam through the patient interface and to a desired focal spot location. An optical detector generates image data representing the posterior patient interface surface which is then processed by a computer system to identify surface irregularities by comparing the image data to a reference surface or axis. In particular, a surface irregularity can be identified as having a z-axis component; a tilt component and a surface profile component. Each irregularity component can be compensated separately by sending an adjustment signal to one of the beam delivery system components.

Abstract: Systems and methods of laser treatment of the intact crystalline lens to increase ionic transport of antioxidants in specific areas where flexural changes and transparency reduction come from lens aging. Microchannels created in patterns and grids placed strategically in the inner lens carry antioxidants from the source—the anterior and the epithelium—into areas scarce or void of transport mechanisms (and thus scarce of antioxidants). A variety of patterns are utilized to facilitate ions traveling along new pathways.

Abstract: There is provided a system, apparatus and methods for developing laser systems that can create precise predetermined shot patterns for providing areas of varying softness in the lens of an eye. These areas of varying softness may have shapes that correspond to instruments used to remove material from the lens of the eye. There is further provided a multiplicity of spheres pattern, which may provide for bubble formation which in turn lubricates the lens material for removal after sectioning.

Abstract: An ophthalmological apparatus (1) for treating eye tissue (3) with laser pulses (P) comprises a laser source (100, an optical projection system (20) for projecting the laser pulses (P) onto the eye tissue (30), and a coupling part (12) for attaching mechanically to the optical projection system (20) an ophthalmological patient interface device (27) which is in contact with the eye (3) during treatment. The ophthalmological apparatus (1) further comprises a detector (13) for determining a device identifier (22) associated with the ophthalmological patient interface device (27), and a control module (14) for controlling the ophthalmological apparatus (1) using the device identifier (22). The detector makes it possible to use and detect different types of ophthalmological patient interface devices (27) and to adapt automatically the treatment of the eye tissue (30), depending on the ophthalmological patient interface device (27) that is presently attached to the ophthalmological apparatus (1).

Abstract: A system and method of replacing a lens to treat a cataract is disclosed. Cataractous tissue is ablated via a multi-photon process using focused, ultra-short laser pulses. Multi-photon ablation requires an energy intensity between 1013 to 1015 W/cm2. Using lasers having femto-second duration pulses, this intensity is achieved with 50 micro-Joules of energy, allowing material disruption with very little heating or shock. The multi-photon ablated material is removed through a micro-channel that leads from the multi-photon ablated region to at least the surface of the eye. Once the material is removed a pre-polymer fluid is injected in to fill the void. This polymerizes into a gel once inside the lens. The polymerized, transformed material matches both the transparency to visible light and the Young's modulus of healthy lens.

Abstract: In a method for generating an ablation program for ablation of material from a surface of a body according to a predetermined desired ablation profile by emission of pulses of a pulsed laser beam onto the surface, the ablation program is generated from the desired ablation profile as a function of the shape of a beam profile of the laser beam and of an inclination of the surface to be ablated and/or considering a water content of the material to be ablated.

Abstract: Configurations are described for conducting ophthalmic procedures to address cataract-related clinical challenges. In one embodiment, a one-piece patient contact interface may be utilized to couple a diagnostic and/or interventional system to a cornea of a patient; in another embodiment, a two-part configuration may be utilized; in another embodiment, a liquid interface two-part embodiment may be utilized.

Abstract: An apparatus for delivering energy, and in particular laser energy, to a tissue includes a protective quartz cap that is secured to a laser delivery fiber by a crimp sleeve. The fiber may have a conical tip, and the quartz cap may be secured to the crimp sleeve by a layer of epoxy.

Abstract: The invention relates to an apparatus, an algorithm and a method for providing a laser shot file for use in a laser. The laser may be an excimer laser. The shot file may be applied for performing a refractive laser treatment of an eye or for producing a customized contact lens or an intraocular lens. According to the invention information with respect to a desired ablation profile is provided and a first series of laser shot positions is calculated based on the desired ablation profile. A simulated ablation profile is generated using said first series of laser shot positions and using information about pulse characteristics of a single laser shot. The simulated ablation profile is compared with the desired ablation profile and residual structures are determined.

Abstract: Ultra-short pulsed laser radiation is applied to a patient's eye to create a row of bubbles oriented perpendicular to the axis of vision. The row of bubbles leads to a region of the eye to be ablated. In a second step, a femtosecond laser beam guided through the row of bubbles converts it to a channel perpendicular to the axis of vision. In a third step, a femtosecond laser beam is guided through the channel to ablate a portion of the eye. Using a femtosecond laser with intensity in the range of 1011-1015 W/cm2 for the second and third steps facilitates multi-photon ablation that is practically devoid of eye tissue heating. Creating bubbles in the first step increases the speed of channel creation and channel diameter uniformity, thereby increasing the precision of the subsequent multi-photon ablation.

Abstract: The invention provides an irradiating device and a program which can appropriately set a cross sectional shape of human tissue at a time of incising the human tissue by beam irradiation. For example, when a cornea (100) is incised by an irradiating device which outputs femtosecond laser, a cross sectional shape in an intersecting direction to a direction of advancing to a back surface side from a front surface side of the cornea in an incision (101) is set to a non-rectilinear shape, for example, a circular arc shape. As a result, there can be achieved effects such as suppression of drawing of the incision in the case of inserting the instrument by opening the incision, and self-closing of the incised site.

Abstract: According to an exemplary embodiment, a device (12) for assisting in the preparation of an operation on the human eye (14) for the purpose of generating a corneal flap by means of a microkeratome system (10) includes: an input interface arrangement (50) that permits at least the input of data relating to a set value of at least one flap parameter and also to at least one patient-related parameter; a computer (46) that has been set up to access a stored data collection (44) of several surgical data records, each of which includes a post-operative actual value of at least one flap parameter, a value for at least one patient-related parameter and configuration data of the microkeratome system, the computer (46) having been set up to ascertain, on the basis of the data collection (44) in a manner depending on the input data, configuration information that represents a proposed configuration of the microkeratome system (10); an output interface arrangement (48) for outputting the configuration information.

Abstract: An optical blade and a hair cutting device is configured to cut a hair near skin of a human body part or animal body part. The optical blade maybe used in a hair cutting device and includes a blade body configured to guide optical radiation, and a tapered end configured to allow the optical radiation to exit the optical blade. The tapered end includes a reflector configured to redirect the optical radiation before it exits the optical blade.

Abstract: Embodiments of this invention generally relate to systems and methods for wavefront interactive refraction display and more particularly to systems and methods for capturing and displaying eye wavefront interactive refraction data based on the desired refractive state of the patient's eye.

Abstract: A photodisruptive laser delivery system and method for use in eye surgery. The photo disruptive laser delivered in pulses in the range of <10000 femtoseconds, used to create incisions in eye tissue is delivered by novel means to minimize optical aberrations without the use of a complex system of multiply precisely arranged lenses. This novel means include a scanning design that allows the focusing lens to always remain under normal incidence to the photodisruptive laser beam, negating the need for overly complex aberration correction set up. The focusing lens is configured to move within a surrounding beam to facilitate two dimensional controls over the treatment space. Controlling beam divergence prior to focusing allows for 3D incisions. The system and methods of use accomplish precise treatment without the need to contact the patient and can be integrated into standard surgical microscopes to improve operational efficiency and hospital workflow.

Abstract: To protect tissue in the treatment of an eye (3) with a focused pulsed laser beam (21) generated by a laser system (2), e.g. a femtolaser system, operating data which define an operating area operated on by the focus (F) of the laser beam (21) during the treatment are acquired in a device (1). The device (1) comprises a processing module (14) for providing control data for the laser system (2) on the basis of the operating data and taking into consideration the light propagation in the eye. The control data limit the time of the treatment by the focus (F) at positions within the operating area in each case in such a manner that tissue damage resulting from the treatment by the laser beam (21) is essentially prevented in eye structures located outside the operating area.

Abstract: Proposed is an apparatus for assistance in the implantation of a corneal prosthesis in a human eye. The apparatus comprises a laser device for providing focussed, pulsed laser radiation, and a control program for the laser device. The control program is designed, to create an incision figure in the tissue of the eye by means of the laser radiation, this incision figure allowing the corneal prosthesis to be inserted. The incision figure in this case comprises a bed incision located entirely in the depth of the corneal material and an annular incision, which, within the circumferential line of the bed incision, extends from the latter, along its entire annular circumference, as far as the corneal anterior surface. The incision figure further may comprise an auxiliary incision, which extends from a location of the eye surface outside the circumferential line of the bed incision as far the bed incision.

Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.

Abstract: An ultrashort pulsed laser instrument is used to perform refractive surgery. The invention operates in ablative and incisional modalities. In the ablative mode, spiral ablation disks (10) consisting of individual laser pulses (40) are produced at high scanning speeds. Ablation profile (11) may be produced in cornea (22) by stacking and arranging multiple ablation disks (10) to produce a specified shape change. Placement of ablation disks (10) is assisted by an optical tracking and control system that compensates for eye motion. A preferred embodiment allows for ablative corrections to be performed on non-planar posterior surface (112) of a laser cut flap affixed to registration platen (120), thereby avoiding exposing the eye interior to high radiant power. Laser cut and contrast agent dyed fiduciary marks (30) may serve as reference features for the optical tracking system. Incisional procedures, such as corneal flaps for LASIK, may also be performed.

Abstract: Described herein are apparatus and associated methods for the generation of at least one user adjustable, accurate, real-time, virtual surgical reference indicium. The apparatus includes one or more real-time, multidimensional visualization modules, one or more processors configured to produce real-time, virtual surgical reference indicia, and at least one user control input for adjusting the at least one real-time virtual surgical reference indicium. The associated methods generally involve the steps of providing one or more real-time multidimensional visualizations of a target surgical field, identifying at least one visual feature in a pre-operative dataset, aligning the visual features with the multidimensional visualization, and incorporating one or more real-time, virtual surgical reference indicium into the real-time visualization. In exemplary embodiments, the apparatus and methods are described in relation to ocular surgery, more specifically capsulorrhexis.

Abstract: A system for refractive ophthalmological surgery, in particular LASIK, has—in addition to the ablation laser and, where appropriate, further optical guidance means (18, 30)—a device (34) for optical coherence tomography as an integrated component, in order to make available results of measurement acquired with this device either for the purpose of representation on a display device and/or for the purpose of control of the ablation.

Abstract: An apparatus and method for selecting a lens that accounts for Decentration and/or Rotation Errors. The method includes obtaining results of a first wavefront exam on a patient, including a wavefront map and Zernike polynomials, selecting a first lens that improves vision, obtaining the results of a second wavefront exam including a wavefront map and Zernike polynomials, calculating the Decentration and/or Rotation Errors of the selected lens by calculating a difference between the Zernike polynomails, and selecting a second lens that better corrects accounts for the calculated Decentration and/or Rotation Errors.

Abstract: A new and novel method for performing refractive correction on a patient's eyes is introduced. In one embodiment the method includes (1) performing a surface ablation corrective procedure on a corneal surface of the patient's non-dominant eye; and (2) reshaping a corneal stroma of the patient's dominant eye, where the reshaping includes the making of a lamillar cut in the surface of the dominant eye to create a flap; folding the flap back to reveal the corneal stroma and ablating a portion of the corneal stroma, after which the flap is replaced.

Abstract: A method for using a laser to create a pocket in a patient's cornea is provided. The pocket is created using a femtosecond or a nanosecond laser. The laser ablates tissue within the cornea in a specific shape. The shape of the pocket can be determined by software to custom program a three-dimensional path of the laser. A variety of corneal pocket configurations or computer programmed shapes can be used accommodate various corneal lens shapes and sizes. An intracorneal lens can then be inserted into the pocket, in order to correct the patient's vision.

Abstract: Treatments to improve ocular conditions such as presbyopia are provided. Structural (mechanical) weakening of the sclera is accomplished through the formation of a 3-D pattern of laser foci in the sclera resulting in an increase in the range of ocular accommodation.

Abstract: The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.

Abstract: Methods and systems for correcting presbyopia using a surgical excimer laser include activating the laser once and transmitting a pre-defined three dimensional ablation profile to treat presbyopia based on the single activating step.

Abstract: An ophthalmic surgical system includes a display device and a user interface. The display device generates a display on an image of a patient's eye comprising a plurality of non-overlapping display sectors. Each display sector displays one of a plurality of user-selectable surgical parameters. A user interface receives a user selection of one or more of the user-selectable surgical parameters to be displayed.

Abstract: A laser device, in particular for ophthalmological laser surgery, comprising a laser source (14) for providing laser radiation, controllable scan components (20) for setting a focus position of the laser radiation, measuring components (30) for registering information that is representative of an actual position of the radiation focus, and also a control arrangement (22) controlling the laser source and the scan components.

Abstract: A multi-spectral imaging system includes a first light source that emits a first wavelength and a second light source that emits a second wavelength different than the first wavelength. The system further includes a camera having a lens, a beam splitter downstream of the lens and a pair of sensors downstream of the beam splitter. The lens is configured to focus the first and second wavelengths onto separate ones of the sensors, and the beam splitter allows one of the first wavelength or the second wavelength to pass through the beam splitter, and the other of the first wavelength or the second wavelength to be reflected off the beam splitter. One of the pair of sensors is configured to receive the first wavelength to produce a first image and the other of the sensors is configured to receive the second wavelength to produce a second image different from the first image.

Abstract: A method for performing a corneal ablation procedure on an eye of a patient including determining a refractive correction for the eye and determining a first parameter corresponding to the refractive correction or a condition of the patient. An ablation profile is selected that includes a refractive correction component and a pre-compensating component that is selected based on the first parameter. The ablation profile is configured to promote a controlled induction of a higher order aberration, where the pre-compensating component limits the induction of the higher order aberration to be within a predefined range. The cornea is ablated using the selected ablation profile.

Abstract: System and method of photoaltering a region of a material using a pulsed laser beam. The method includes scanning the pulsed laser beam in a first portion of the region with a first pattern, scanning the pulsed laser beam in a second portion of the region with a second pattern, and separating a flap of the material at the region. The system includes a laser, a controller selecting at least first and second patterns, and a scanner operable in response to the controller. The first pattern has a first maximum acceleration associated with the second portion, and the second pattern has a second maximum acceleration associated with the second portion. The second maximum acceleration is less than the first maximum acceleration. The scanner scans the pulsed laser beam from the laser in the first portion with the first pattern and in the second portion with the second pattern.

Abstract: Systems and methods of photoaltering a region of a material using a pulsed laser beam. The method includes scanning the pulsed laser beam in a first portion of the region with a first pattern, scanning the pulsed laser beam in a second portion of the region with a second pattern, and separating a flap of the material at the region. The system includes a laser, a controller selecting at least first and second patterns, and a scanner operable in response to the controller. The first pattern has a first maximum acceleration associated with the second portion, and the second pattern has a second maximum acceleration associated with the second portion. The second maximum acceleration is less than the first maximum acceleration. The scanner scans the pulsed laser beam from the laser in the first portion with the first pattern and in the second portion with the second pattern.

Abstract: An adjusting ophthalmic docking system is described that includes a curved contact element, disposed on a procedure eye, a conformation platform at a distal tip of an optical system to support an adjustment of the curved contact element, and a connector to accommodate the adjustment of the contact element. The curved contact element can be a meniscus-shaped contact lens, with a proximal surface radius larger than a distal surface radius. The contact lens can be made of an approximately refractive index-matching material, such as a fluoro-polymer.

Abstract: A treatment device for the surgical correction of hyperopia in the eye comprising a laser device controlled by a control device. The laser device separating corneal tissue by applying laser radiation. The control device controls the laser device for emitting the laser radiation into the cornea such that a lenticule-shaped volume is isolated. Removal thereof effects the desired correction. The control device (12) predefines the volume such that a posterior surface and an anterior surface are connected via an edge surface that has a width in projection along the visual axis that is wider than the one which a straight line in the same projection, that is perpendicular at the edge of the posterior or the anterior surface would have relative to the associated surface and connects the anterior surface to the posterior surface or to the perceived extension thereof.

Abstract: A device for producing control data for a laser device for the surgical correction of defective vision. The device produces the control data such that the laser emits the laser radiation such that a volume in the cornea is isolated. The device calculates a radius of curvature RCV* to determine the control data, the cornea reduced by the volume having the radius of curvature RCV* and the radius of curvature being site-specific and satisfying the following equation: RCV*(r,?)=1/((1/RCV(r,?))+BCOR(r,?)/(nc?1))+F, wherein RCV(r,?) is the local radius of curvature of the cornea before the volume is removed, nc is the refractive index of the material of the cornea, F is a coefficient, and BCOR(r,?) is the local change in refractive force required for the desired correction of defective vision in a plane lying in the vertex of the cornea, and at least two radii r1 and r2 satisfy the equation BCOR(r=r1,?)?BCOR(r=r2,?).

Abstract: One embodiment is directed to a patient interface system for ophthalmic intervention on an eye of a patient, comprising: a housing; an optical lens coupled to the housing and having a focal axis; a eye surface engagement assembly coupled to the housing and comprising an inner seal having an inner seal diameter and being configured to circumferentially engage the eye, an outer seal having an outer seal diameter and being configured to circumferentially engage the eye, and a tissue migration bolster structure configured to be positioned circumferentially between the inner and outer circumferential seals and to prevent migration of tissue of the eye toward the eye surface engagement assembly when a vacuum load is applied within the assembly to cause vacuum engagement of the inner and outer seals against the eye.

Abstract: Systems and methods include a cutting instrument that creates incisions in selected areas of the cornea; an eye therapy system that applies reshaping forces to the cornea; and a controller that determines the selected areas of the cornea for the incisions and the reshaping forces from the eye therapy system, such that the reshaping forces and the incisions combine to achieve corrective reshaping of the cornea. Other systems and methods include measuring an eye to determine a required amount of reshaping of a cornea; determining one or more doses of cross-linking agent and one or more corresponding doses of photoactivating light according to the required amount of reshaping; applying the cross-linking agent to the cornea; and delivering, from a light source, the photoactivating light to the area of the eye, the photoactivating light combining with the cross-linking agent to induce the corrective reshaping of the cornea.