Material Characteristic Of Lens Patents (Class 623/6.56)
-
Patent number: 8088314Abstract: Provided are a process for producing an intraocular lens capable of inhibiting secondary cataract that may occur after the insertion of an intraocular lens and a secondary-cataract-inhibiting intraocular lens obtained by the above process, and the process is for producing a surface-treated intraocular lens, which comprises irradiating the surface of an intraocular lens with active light that works to decompose oxygen molecules to generate ozone and that also works to decompose the ozone to generate active oxygen, in the presence of oxygen, and the lens is a secondary-cataract-inhibiting intraocular lens obtained by the above process.Type: GrantFiled: November 8, 2005Date of Patent: January 3, 2012Assignee: Hoya CorporationInventors: Hiroyuki Matsushima, Hidetoshi Iwamoto
-
Prepolymerizable surface active monomers with both fluorine-containing groups and hydrophilic groups
Patent number: 8071704Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.Type: GrantFiled: September 30, 2008Date of Patent: December 6, 2011Assignee: Bausch & Lomb IncorporatedInventors: Weihong Lang, Yu-Chin Lai -
Publication number: 20110295367Abstract: Generally, an intraocular implant and methods for treating an ocular condition. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.Type: ApplicationFiled: August 2, 2011Publication date: December 1, 2011Inventor: Kevin H. Cuevas
-
Publication number: 20110270389Abstract: A device and method for forming an adaptive optic in the capsule of a human eye is disclosed, comprising a capsular interface enclosing an optically acceptable medium. The device establishes a physiologic range of optical power in response to a range of ciliary contractile states. The preferred bi-phasic medium of the device is comprised of a solid three dimensional polymeric network suspended in a liquid aqueous phase and bonded to a capsular interface. The polymeric network provides shape to the capsular interface, optical power, and a physiologic response to the suspensory ligament. The three dimensional network of the bi-phasic medium mimics the stacked fiber configuration and elasticity of a natural lens. An alternative embodiment utilizing a single phase medium is also disclosed with associated structural features provided in the capsular interface.Type: ApplicationFiled: April 28, 2011Publication date: November 3, 2011Inventors: Liane Clamen Glazer, Paul Glazer, Michael T. Milbocker
-
Patent number: 8048445Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.Type: GrantFiled: July 15, 2008Date of Patent: November 1, 2011Assignee: Allergan, Inc.Inventors: Jane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
-
Patent number: 8043369Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer comprising one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming monomers are disclosed.Type: GrantFiled: June 16, 2009Date of Patent: October 25, 2011Assignee: Bausch & Lomb IncorporatedInventors: Jeffrey G. Linhardt, Ivan M. Nunez, Joseph A. McGee, Jennifer Hunt, Michele Alton, Drazen Pavlovic, Devon A. Shipp
-
Publication number: 20110251685Abstract: Intraocular lenses with high contrast haptics, materials and methods for making optical blanks and lenses, and methods of use are disclosed and claimed. Such lenses may provide easily recognizable visual cues that may be used to detect and correct misorientation of lenses prior to and during use.Type: ApplicationFiled: April 9, 2010Publication date: October 13, 2011Inventor: Milton W. Chu
-
Patent number: 8026326Abstract: A composition comprising a polymer backbone and at least one side group, wherein the side group comprises a benzene ring-based chromophore comprising a ketone at the 1-position, a substituted or unsubstituted amino group at the 2-position, and an oxygen atom at the 3-position of the benzene ring. The chromophore is a kynurenine-based compound. Methods of making and using the composition are also provided. The composition can be used in an ophthalmic lens or device for protecting the retina by blocking UV rays and filtering violet rays.Type: GrantFiled: March 4, 2008Date of Patent: September 27, 2011Assignee: Benz Research and Development Corp.Inventors: Patrick H. Benz, Jose A. Ors
-
Publication number: 20110230963Abstract: Generally, an intraocular implant and methods for treating an ocular condition. As to certain embodiments, an intraocular biocompatible biodegradable implant (11) which can provide a biocompatible biodegradable material in the form of a flexible membrane (12) containing an active agent (24) which implanted between an intraocular lens (8) and the surface of the posterior capsule (5) of the eye (1)(4) inhibits migration of residual lens epithelial cells after cataract surgery by providing structural or pharmaceutical barriers to reduce posterior capsule (5) opacification of the eye (1)(4).Type: ApplicationFiled: November 19, 2009Publication date: September 22, 2011Inventor: Kevin H. Cuevas
-
Publication number: 20110153015Abstract: An accommodating intraocular lens (AIOL) construction having optics (2) and haptic (1) connected with the optics for positioning the optics within the eye, wherein the introcular lens construction is made of a single material having spatially-distributed different elasto-mechanical properties, and the elasto-mechanical properties of the haptic differ from the elasto-mechanical properties of the optics. The haptic and the optics made from the same polymer material, i.e., having the same molecular constituency. The optical power of the lens construction can change along with change in the shape of the haptic and intraocular lens construction. The haptic is shaped such that compression along the circumference of the haptic increases the optical strength of the optics.Type: ApplicationFiled: June 18, 2009Publication date: June 23, 2011Applicant: AKKOLENS INTERNATIONAL B.V.Inventors: Aleksey Nikolaevich Simonov, Michiel Christiaan Rombach
-
Patent number: 7923520Abstract: The present invention relates to high refractive index monomers according to formula (I) and (co)polymers comprising such high refractive index monomers. The 5 (co)polymers are highly suitable for the manufacture of optical articles, in particular flexible optical articles, more in particular intraocular lenses.Type: GrantFiled: February 14, 2007Date of Patent: April 12, 2011Assignee: Procornea Holding B.V.Inventors: Bernardus Franciscus Maria Wanders, Henk Haitjema
-
Publication number: 20110071629Abstract: Opthalmic devices, particularly intraocular lenses (IOL), with improved contrast sensitivity and methods of making same. In one aspect, blue light blocking chromophores (BLBC) are diffused into, e.g. an IOL lens body to create a BLBC gradient in the lens. Orange dyes are preferred BLBCs.Type: ApplicationFiled: November 29, 2010Publication date: March 24, 2011Applicant: KEY MEDICAL TECHNOLOGIES, INC.Inventor: Khalid Mentak
-
Patent number: 7909458Abstract: 1,4-disubstituted-1,2,3-triazole UV absorbing monomers are disclosed. The UV absorbers are particularly suitable for use in intraocular lens materials.Type: GrantFiled: April 29, 2008Date of Patent: March 22, 2011Assignee: Alcon, Inc.Inventor: Douglas C. Schlueter
-
Patent number: 7909867Abstract: The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.Type: GrantFiled: December 13, 2006Date of Patent: March 22, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David Myung, Christopher Ta, Curtis W. Frank, Won-Gun Koh, Jaan Noolandi
-
Patent number: 7875661Abstract: An intraocular lens with an ordered polymer system contained within a lens capsule or a membrane in the lens capsule. The ordered polymer system includes at least one negatively charged copolymer comprising hydrophilic groups, anionic groups and hydrophobic groups, and at least one positively charged copolymer comprising hydrophilic groups, cationic groups and hydrophobic groups. The at least one negatively charged copolymer and the at least one positively charged copolymer are associatively arranged through non-covalent interactions in the lens capsule or the membrane.Type: GrantFiled: December 11, 2007Date of Patent: January 25, 2011Assignee: Bausch & Lomb IncorporatedInventor: Joseph C. Salamone
-
Patent number: 7857447Abstract: The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.Type: GrantFiled: December 7, 2006Date of Patent: December 28, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David Myung, Jaan Noolandl, Christopher Ta, Curtis W. Frank
-
Patent number: 7857849Abstract: A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.Type: GrantFiled: October 4, 2005Date of Patent: December 28, 2010Assignees: The Board of Trustees of the Leland Stanford Junior Iniversity, Santa Clara UniversityInventors: David Myung, Jaan Noolandi, Alan J. Smith, Curtis W. Frank, Christopher Ta, Yin Hu, Won-Gun Koh, Michael R. Carrasco
-
Publication number: 20100324671Abstract: An intraocular lens (IOL) that provides for optical power adjustment following its implantation, for example, for use in treating cataract patients. The lens body has first and second surface portions that bound at least one interior chamber or space that extends from the central optic portion to the lens periphery. The interior chamber or space has a microporous body that is intermediate inner and outer portions of the space. In one embodiment, the microporous body is capable of cooperating with an external Rf or light source to expose a charge to a charge-carrying fluid within the interior chamber. By this system, fluid flows are induced to alter the optical parameters of the lens.Type: ApplicationFiled: August 9, 2010Publication date: December 23, 2010Applicant: PowerVision, Inc.Inventor: John H. Shadduck
-
Publication number: 20100318185Abstract: Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a multi-armed macromonomer comprising multiple side chains attached to a nucleus, wherein each side chain comprises a thio carbonyl thio fragment of the same or different reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.Type: ApplicationFiled: June 16, 2009Publication date: December 16, 2010Applicant: Bausch & Lomb IncorporatedInventors: Ivan M. Nunez, Jay F. Kunzler, Jeffrey G. Linhardt, Jennifer Hunt
-
Patent number: 7847025Abstract: The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.Type: GrantFiled: December 20, 2005Date of Patent: December 7, 2010Assignee: AMO Groningen B.V.Inventors: Yan Liu, Jöns Gunnar Hilborn, Hendrick Jan Haitjema, Sverker Norrby, Thom Terwee
-
Patent number: 7842367Abstract: Opthalmic devices, particularity intraocular lenses (IOL), with improved contrast sensitivity and methods of making same. In one aspect, blue light blocking chromophores (BLBC) are diffused into, e.g. an IOL lens body to create a BLBC gradient in the lens. Orange dyes are preferred BLBCs.Type: GrantFiled: February 8, 2006Date of Patent: November 30, 2010Assignee: Key Medical Technologies, Inc.Inventor: Khalid Mentak
-
Patent number: 7841716Abstract: A method of providing a polymerized ophthalmic lens in which a polymerized ophthalmic lens is heated with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent after its polymerization, and the ophthalmic lens formulation not having the wetting agent prior to its polymerization.Type: GrantFiled: February 10, 2006Date of Patent: November 30, 2010Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Kevin P. McCabe, Robert B. Steffen, Helene Aguilar, W. Anthony Martin, Susan W. Neadle, Ann-Marie W. Meyers, Douglas G. Vanderlaan, Dominic P. Gourd, Kristy L. Canavan, Gregory A. Hill
-
Publication number: 20100298933Abstract: The invention is directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.Type: ApplicationFiled: July 30, 2010Publication date: November 25, 2010Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani, Candido D. Pinto
-
Patent number: 7799845Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing a hydrophilic block in the polymer backbone. The materials have improved glistening resistance.Type: GrantFiled: October 3, 2008Date of Patent: September 21, 2010Assignee: Alcon, Inc.Inventor: Douglas C. Schlueter
-
Patent number: 7794498Abstract: An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.Type: GrantFiled: December 3, 2004Date of Patent: September 14, 2010Assignee: Innolene LLCInventor: Leonard Pinchuk
-
Patent number: 7789507Abstract: This invention includes methods and systems for processing hydrogel biomedical devices, such as ophthalmic lenses using polyethylene glycol to facilitate release of the devices from a mold part.Type: GrantFiled: February 7, 2007Date of Patent: September 7, 2010Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Diana Zanini, Douglas G. Vanderlaan, James D. Ford, Vincent H. Barre, Rachel E. Hauser
-
Patent number: 7789910Abstract: A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye.Type: GrantFiled: November 30, 2007Date of Patent: September 7, 2010Assignees: Bausch & Lomb Incorporated, University of RochesterInventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani, Candido D. Pinto
-
Publication number: 20100215720Abstract: The present invention refers to an implantable optical system comprising a central optical part and an annular anchoring part, where said annular part comprises animals cells, including human cells, that encourage the integration of the implant into the ocular tissue of the patient, as well as a system for dosing chemical compounds directed at a particular function, creating a stabilising microenvironment for the presence of the implant in the tissue. A method for obtaining said system by polymerisation and its applications in various types of ocular disorders is also described.Type: ApplicationFiled: August 8, 2006Publication date: August 26, 2010Applicant: FUNDACION INASMETInventors: Nerea Garagorri Ganchegui, Iratxe Madarieta Pardo, Beatriz Olalde Graells
-
Patent number: 7781536Abstract: It is an object of the present invention to provide an ocular lens superior in the wettability of the surface thereof, hydrating properties, oxygen permeability, flexibility, elasticity, transparency and shape recoverability though it has a composition using a silicone-containing monomer. The present invention relates to a highly oxygen-permeable hydrated ocular lens obtained by saponifying a copolymer prepared from a specific both-terminal (meth)acryl polydimethylsiloxane, a vinyl carboxylate, a (meth)acrylamide type monomer, a vinyl type crosslinking agent, one or both of a (meth)acrylate having a tertiary structure and a (meth)acrylate having a cyclic structure as (meth)acrylates each having a bulky structure at its side chain and a monomer copolymerizable with these compounds.Type: GrantFiled: September 15, 2005Date of Patent: August 24, 2010Assignee: Seed Co., Ltd.Inventors: Takehisa Kamiya, Kazunori Kobayashi, Kenji Uno
-
Publication number: 20100211170Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.Type: ApplicationFiled: October 6, 2009Publication date: August 19, 2010Applicant: VISIOGEN, INC.Inventor: Xiugao Liao
-
Patent number: 7763682Abstract: Intraocular lenses comprised of an acrylic-silicone hybrid polymer are disclosed. The intraocular lenses described herein are suitable for insertion through incisions of 2 mm or less.Type: GrantFiled: March 27, 2006Date of Patent: July 27, 2010Assignee: Abbott Medical Optics Inc.Inventors: Michael D. Lowery, Harish C. Makker
-
Patent number: 7662180Abstract: An accommodating IOL comprises an optic adapted to focus light toward a retina of an eye, and a movement assembly coupled to the eye to provide effective accommodating movement, preferably axial movement, of the optic. At least a portion of the movement assembly is made from a material that is less stiff and/or more resilient than the material used to make the optic. Optionally, an outer ring or support portion made at least partially from either a relatively stiff material such as the material used in the optic or a relatively resilient material such as the material used in the movement assembly is also provided.Type: GrantFiled: December 5, 2002Date of Patent: February 16, 2010Assignee: Abbott Medical Optics Inc.Inventors: Marlene L. Paul, Michael D. Lowery, Daniel Brady, Arlene Gwon
-
Publication number: 20090326651Abstract: An ophthalmic device is formed by additive fabrication, the optical device having an optical surface with a surface roughness on the order of less than 10 microns. A method is provided for making an ophthalmic device including an optical surface having a surface roughness of less than 10 microns by depositing on a stage in a first relative position a first lamina of particulates having a size less than 10 microns and in select configurations less than two microns and certain configurations less than one micron, and, synergistically stimulating the first lamina of particulates to form a first solidified layer.Type: ApplicationFiled: December 22, 2008Publication date: December 31, 2009Inventors: Ronald Spoor, Sanjay M. Rastogi, Charles P. Henning
-
Publication number: 20090312836Abstract: An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.Type: ApplicationFiled: June 11, 2009Publication date: December 17, 2009Inventors: Leonard Pinchuk, Jean-Marie Parel
-
Publication number: 20090292357Abstract: A material comprising at least one polymer and at least one sensitizer wherein the sensitizer is localised at a surface of the material wherein the sensitizer is an agent or compound able to provide improved anti-bacterial and/or anti-viral activity following exposure of the sensitizer to a particular wavelength or range of wavelengths of electromagnetic radiation.Type: ApplicationFiled: February 5, 2007Publication date: November 26, 2009Applicant: THE QUEEN'S UNIVERSITY OF BELFASTInventors: Colin P. McCoy, Sean P. Gorman, David S. Jones, Steven E.J. Bell
-
Publication number: 20090276042Abstract: The present invention relates to a macromonomer having a polydimethylsiloxane backbone that has a mol % dimethyl siloxanes, b mol % siloxanes substituted with -K-RIM, c mol % siloxanes substituted with -K-RIM-Z and d mol % siloxanes substituted with -L-Z, and in which the terminal siloxane groups are tri-substituted with R, wherein RIM is a refractive index modifying group; Z is a free radically polymerisable group; K is a spacer group; L is optional and is a spacer group; each R is independently selected from an RIM, a lower alkyl group, hydrogen or Z; and a is a molar percentage of the macromonomer which is in the range of from 0 to 95 mol %; b is a molar percentage of the macromonomer which is in the range of from 5 to 99 mol %; c is a molar percentage of the macromonomer which is in the range of from 0 to 2 mol %; and d is a molar percentage of the macromonomer which is in the range of from 0 to 2 mol %; with the proviso that c and d are not both 0 mol %.Type: ApplicationFiled: May 3, 2007Publication date: November 5, 2009Applicant: Vision CRC LimitedInventors: Timothy Charles Hughes, John Stuart Wilkie, Justine Leigh Jeffery, Xuan Thi Thanh Nguyen, Xiaojuan Hao
-
Publication number: 20090198327Abstract: Disclosed are soft, high refractive index device materials having improved strength. The materials contain a polystyrene macromer.Type: ApplicationFiled: April 2, 2009Publication date: August 6, 2009Inventor: Douglas C. Schlueter
-
Patent number: 7559949Abstract: Polymeric materials and methods that realize a gel-type intraocular lens that is formed in situ within the lens capsule of the eye. The polymeric material of the intraocular lens includes reactive end groups that effectively bond with lens capsule walls, thus eliminating space between the intraocular lens and the lens capsule walls and significantly reducing the proliferation of lens epithelial cells which can cause unwanted posterior capsule opacification.Type: GrantFiled: April 27, 2007Date of Patent: July 14, 2009Inventor: Leonard Pinchuk
-
Publication number: 20090171459Abstract: This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.Type: ApplicationFiled: December 15, 2008Publication date: July 2, 2009Inventors: Jeffrey G. Linhardt, Devon A. Shipp, Jay F. Kunzler
-
Publication number: 20090163602Abstract: A polymeric material with a variable modulus of elasticity is described herein. The polymeric material described herein is useful for forming implantable medical devices (e.g. ophthalmic lenses, breast implants, and body augmentation devices). In addition, medical devices formed from the polymer material can be used to controllably release a therapeutic agent. Also, the polymeric material may be used to prepare topical compositions or other applications or devices where control of a mechanical property such as material modulus is important.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Applicant: Advanced Medical Optics, Inc.Inventors: Can B. Hu, Thuy B. Mai
-
Publication number: 20090164009Abstract: Described herein are silicone fluids and silicone materials that posses high glass transition temperatures (Tgs) when compared to conventional silicone materials. In one embodiment, an increased Tg allows the formation of objects and materials by cryogenic lathing. The fluids and materials can be formed by curing silicone fluid with a cross-linker mixture comprising a cross-linker and a monofunctional hydride compound. Upon formation, the silicone materials can be extracted over long periods of time without loss of optical quality. The silicone materials can be sufficiently soft allowing folding and insertion through small incisions in the eye. Additionally, methods of forming optical silicone materials, lenses and silicone materials in general are also disclosed. In one embodiment, the method of forming a silicone based lens using cryogenic lathing techniques is described.Type: ApplicationFiled: September 5, 2008Publication date: June 25, 2009Applicant: Advanced Medical OpticsInventors: Can Hu, Derek D. Pham, Michael D. Lowery
-
Publication number: 20090157178Abstract: The invention relates to an artificial intraocular lens consisting of a polymer material which permits a change of the optical properties of the artificial intraocular lens when exposed to light. This enables the lens to be exactly adjusted to the required visual acuity upon implantation thereof.Type: ApplicationFiled: September 22, 2006Publication date: June 18, 2009Inventor: Norbert Hampp
-
Publication number: 20090143858Abstract: A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye.Type: ApplicationFiled: November 30, 2007Publication date: June 4, 2009Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani, Candido D. Pinto
-
Publication number: 20090138081Abstract: Implants and methods for treating ocular disorders are disclosed. One implant has an inlet portion configured to extend through a portion of a tissue of an eye and an outlet portion configured to extend into and along a physiologic outflow pathway of the eye. The implant provides a flow path between an anterior chamber of the eye and the physiologic outflow pathway. One implant includes a body having adjacent regions of differing cross-sectional dimensions configured to anchor the implant and/or stabilize at least a portion of the flow path through the implant. One method involves inserting a fiber optic in an eye, locating a distal end of the fiber optic at a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of the eye, and delivering a material comprising a therapeutic agent along the fiber optic and into the physiologic outflow pathway.Type: ApplicationFiled: February 5, 2009Publication date: May 28, 2009Applicant: GLAUKOS COPPORATIONInventors: Olav B. Bergheim, Morteza Gharib
-
Patent number: 7534262Abstract: The invention concerns an implant forming an intraocular lens comprising a central optical part, a globally circular outline, at least partly made of a flexible material and a haptic part, at said optical part periphery, made at least partially of a rigid material. Said implant has a single-piece structure. The implant rigid material is a shape modified by at least one process selected among chemical reactions and polymerisation reactions of the starting flexible material, for example based on PMMA-PHMA, cross-linked by adding a multifunctional agent such as diethyleneglycol dimethacrylate.Type: GrantFiled: June 21, 1999Date of Patent: May 19, 2009Assignee: Ioltechnologie-ProductionInventors: Marc Dolatkhani, Alain Deffieux
-
Publication number: 20090092655Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.Type: ApplicationFiled: September 30, 2008Publication date: April 9, 2009Inventors: Weihong Lang, Yu-Chin Lai
-
Publication number: 20090054978Abstract: The present invention relates a method for manufacturing an intraocular lens in a closed mould, wherein an acrylic monomer composition containing a single high refractive index monomer according to formula (I): is polymerized by employing an initiator that is activated by light having a wavelength of 390 nm or more.Type: ApplicationFiled: February 14, 2007Publication date: February 26, 2009Inventors: Bernardus Franciscus Maria Wanders, Henk Haitjema
-
Publication number: 20090005866Abstract: An accommodating lens where the optic is moveable relative to the ends of the extended haptic portions. The lens comprises an optic made from a flexible material combined with haptics capable of multiple flexions without breaking. The haptics having in longitudinal cross section wide and deep hinges adjacent the optic to better allow the elastic hinges to “stretch” when the optic is subjected to posterior pressure thus allowing the optic to move forward relative to both the outer and inner ends of the haptics. When this movement is combined with the movement of the optic relative to the outer ends of the haptics and the anterior movement of the whole lens, the refractive power of the eye is further enhanced.Type: ApplicationFiled: October 29, 2007Publication date: January 1, 2009Inventor: J. Stuart Cumming
-
Publication number: 20080288066Abstract: There is disclosed herein a “piggyback” cylindrical (toric) intraocular lens for placement in front of an accommodating or standard intraocular lens that is already in the capsular bag of the eye. This additional lens is placed in the sulcus, which leaves a significant space between the two lenses, particularly if the lens in the capsular bag is vaulted backwards.Type: ApplicationFiled: October 31, 2007Publication date: November 20, 2008Inventor: J. Stuart Cumming
-
Publication number: 20080286336Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.Type: ApplicationFiled: July 15, 2008Publication date: November 20, 2008Applicant: ALLERGAN, INC.Inventors: Jane-Guo SHIAH, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber