Abstract: The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula —R1R2SiO— and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.

Abstract: 1,4-disubstituted-1,2,3-triazole UV absorbing monomers are disclosed. The UV absorbers are particularly suitable for use in intraocular lens materials.

Abstract: The invention relates to an intraocular lens comprising at least one pharmaceutically-acceptable photochromic polymer that enables all or part of the intraocular lens to change colour reversibly when exposed to light.

Abstract: High refractive index and optically clear copoly(carbosilane and siloxane) elastomers and ophthalmic lenses made therefrom are provided. The elastomers are comprised of copolymers having carbosilane repeat units and siloxane repeat units. The copolymers and ophthalmic lenses of the present invention have a high refractive index and excellent folding recoverability.

Abstract: This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.

Abstract: Provided is an intraocular lens that inhibits secondary cataract which occurs after insertion of an intraocular lens and that is free from the adherence and deposition of a protein, etc., to/on the front surface of the lens, and the intraocular lens has an optic portion with a front surface and a back surface, said front surface and said back surface being different from each other in the property of adhering to a protein and satisfying the relationship of the expression (x), PAF<PAB ??(x) wherein PAF is the property of adherence of said front surface to fibronectin and PAB is the property of adherence of said back surface to fibronectin in a fibronectin adherence test.

Abstract: In one aspect, the present invention provides an intraocular lens that includes a posterior optic and anterior optic. The optics have different chromatic dispersions adapted to cooperatively provide compensation for natural chromatic aberrations of the eye over a wavelength range of interest, e.g., over a wavelength range of about 400 nm to about 700 nm.

Abstract: An intraocular lens with an ordered polymer system contained within a lens capsule or a membrane in the lens capsule. The ordered polymer system includes at least one negatively charged copolymer comprising hydrophilic groups, anionic groups and hydrophobic groups, and at least one positively charged copolymer comprising hydrophilic groups, cationic groups and hydrophobic groups. The at least one negatively charged copolymer and the at least one positively charged copolymer are associatively arranged through non-covalent interactions in the lens capsule or the membrane.

Abstract: Hydrophilic, arylsiloxy-containing macromonomers have at least a terminal hydrophilic group attached to an arylsiloxy group. The aryl groups attached to siloxy groups can be substituted with other hydrophilic groups. Polymers comprising such hydrophilic, arylsiloxy-containing macromonomers avoid or reduce the risk of forming vacuoles of absorbed water. Furthermore, such polymers have high refractive index, and, thus, are advantageously used for making ophthalmic devices, such as intraocular lenses, contact lenses, corneal rings, corneal inlays, and keratoprostheses.

Abstract: The invention includes a method for the passivation of the surface of an intraocular lens, wherein the surface includes Brönsted sites. The intraocular lens is dipped into a solution of a fluoroalkyl silane having the general formula: Rf—(CH2)n—Si—(O—R)3. The residue R is selected from the group of H, CH3, C2H5 and C3H7 and the fluoroalkyl residue Rf is selected from the series CF3(CF2)m, with m=3 to 11 and n=0 to 4. The Brönsted sites on the surface are thereby deactivated by formation of Si—Q—bonds.

Abstract: A colorant for ocular lenses represented by the formula (I) defined herein or a colorant for ocular lenses represented by the formula (II) defined herein.

Abstract: A method for prevention of migration of epithelial cells in a capsular bag of an eye of a mammal is provided. The method comprises removing the natural lens of the eye from the capsular bag; introducing an object with at least one sharp edge into the capsular bag, in such a way that said sharp edge contacts the inside of the capsular bag to form a barrier preventing migration of epithelial cells across said barrier; and injecting a lens-forming composition into the capsular bag.

Abstract: A method of restoring the vision of an eye having an impaired lens with an artificial lens implant includes replacing the lens by a polymerizable material injected into the emptied lens capsule and thereby providing a new lens implant with a predetermined refractive value, while admitting the possibility of controlling and adjusting the refractive value of the eye during the surgical process.

Abstract: There is disclosed an accommodating intraocular lens for implantation in an eye having an optical axis. The lens comprises an anterior portion which in turn comprises an anterior viewing element and an anterior biasing element. The lens further comprises a posterior portion which in turn comprises a posterior viewing element in spaced relationship to the anterior viewing element and a posterior biasing element. The anterior portion and posterior portion meet at first and second apices of the intraocular lens. The anterior portion and the posterior portion and/or the apices are responsive to force thereon to cause the separation between the viewing elements to change. Additional embodiments and methods are also disclosed.

Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Abstract: High refractive index and optically clear copoly(carbosilane and siloxane) elastomers and ophthalmic lenses made therefrom are provided. The elastomers are comprised of copolymers having carbosilane repeat units and siloxane repeat units. The copolymers and ophthalmic lenses of the present invention have a high refractive index and excellent folding recoverability.

Abstract: An intraocular lens suitable for implantation into an eye has an optically clear, deformable lens body composed of a silicone polymer and a silica reinforcer that structurally reinforces the polymer. The silica reinforcer is chemically modified with aryl groups effective to increase the refractive index of the silica reinforcer, preferably so as to substantially match the refractive index of the silicone polymer.

Abstract: It is an object of the present invention to provide an ophthalmic lens characterized in that it is capable of developing a color at a position where a light is irradiated, and to provide a marking method of the ophthalmic lens. It is another object of the present invention to provide an ophthalmic lens, which can form a clear and easily readable mark, without causing problems such as discoloration of the mark, caused by cleaning of the lens by rubbing, or deterioration of the mechanical strength of the lens, and to provide a marking method of the ophthalmic lens. The ophthalmic lens of the present invention is obtained by a polymerization of a polymerizable composition of monomers, which contains an alkyl (meth)acrylate as an essential polymerizable component, and this polymerization is carried out while the rhodamine derivative is present in the composition.

Abstract: The invention relates to a method of performing ocular surgery, after an anterior capsulotomy has been made, by forming a sealed expanded capsular bag. The method includes sealing the capsular bag with a viscoelastic material to provide a gas tight seal to prevent leakage into the anterior chamber of the eye during the surgical process; expanding the capsular bag by introducing a gas capable of exerting a pressure on the inner surface of the capsular bag wall; inspecting and/or treating the capsular bag with one or several devices and/or agents suitable for performing inspection and/or treatment. The inspection and/or treatment can comprise any of visual inspection, estimation of capsular bag volume; labeling any residual epithelial cells to detect the presence thereof; removing residual epithelial cells, implanting one or more intracapsular implants; injecting a lens forming material for molding a lens in situ; drying the lens capsule; alone or in any combination.

Abstract: An ophthalmologic implant for the prophylaxis or treatment of capsule opacification after implantation and completion of wound healing of a synthetic lens is described. This treatment can be repeated if necessary.

Abstract: A method for prevention of capsular opacification is provided.

Abstract: Diamond-like carbon films are deposited on devices for implantation in tissues of a living body, preferably, retinal implants. Openings may be formed in the diamond-like carbon film, preferably in alignment with portions of the device intended for electrical contact with surrounding tissues, i.e., electrodes. Alternatively, the diamond-like carbon film may be rendered electrically conductive. Furthermore, the diamond-like carbon films may be created in such a manner that they are substantially transparent to various wavelengths of electromagnetic radiation, including visible and/or infrared light. In a presently preferred embodiment, the diamond-like carbon film is deposited using a magnetically-filtered, cathodic arc physical vapor deposition process. Implantable devices, particularly retinal implants, comprising a diamond-like carbon film may exhibit excellent biocompatibility and biodurability properties in comparison with prior art devices and passivation coatings.

Abstract: A process for removing contaminants and/or leachables from polymeric materials useful in the manufacture of biocompatible medical devices such as intraocular lenses, corneal inlays and contact lenses using continuous soxhlet extraction.

Abstract: A system and method of processing an item at least partially formed of a hydrophilic material to reduce or increase the item's protein affinity. In one example, the system and method prevent or greatly reduce the formation of insoluble ionic materials in or on the item during processing, thereby reducing its affinity for binding with pertinacious materials. An example application involves reducing the protein affinity of an ocular item such as an intra ocular lens or a contact lens, thereby reducing the potential for in-eye or on-eye ossification of the item.

Abstract: An intraocular lens includes an optic adapted to focus light toward a retina of an eye, and at least one fixation member configured to at least assist in supporting the optic in the eye. The fixation member includes a proximal portion coupled to the optic and a distal portion configured to be in contact with eye tissue when the intraocular lens is in use in the eye. The proximal portion of the fixation member includes at least one first area formed of a first, substantially rigid material, and at least one second area formed of a second material which is more flexible than the first material.

Abstract: The present invention relates to methods of implementing an optical element having a refraction modulating composition. The methods include using a wavefront sensor to provide an optical measurement of the optical element. The present invention also relates to systems comprising an optical element having a refraction modulating composition and a wavefront sensor.

Abstract: Intraocular lenses, for example intraocular implants, contact lenses and the like. The optical system is made of a material whereof the refractive index varies along at least one given direction, this material being a homogeneous material with variable index according to its chemical composition or by the action of mechanical effects, or a heterogeneous material with different molecular orientations. The invention is useful for making lenses with accommodative sighting.

Abstract: Ophthalmic lenses, such as intraocular lenses, include cross-linked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of acrylates, methacrylates and mixtures thereof, and a second constituent derived from a second component in an amount effective as a cross linker in the cross-linked polymeric material. The cross-linked polymeric material has branched chain alkyl groups, preferably included with at least a portion of the first monomeric component, in an amount effective to reduce the tackiness of the cross-linked polymeric material relative to a substantially identical cross-linked polymeric material without the branched chain alkyl groups.

Abstract: Phakic refractive lens (PRL) for correcting myopia or hyperopia are disclosed. The lens is implanted in the posterior chamber of the eye, with no permanent point of fixation, such that it floats between the patient's iris and natural lens. The lens corrects refractive errors in the eye, while maintaining the fluid dynamics of the eye and not causing stress or damage to eye structures. The lenses are made from a flexible material (such as those having a hardness of from about 20 to about 50 Shore A), having a specific gravity of from about 0.9 to about 1.2 g/cm3, and have a mass per unit area of from about 0.03 to about 0.30 mg/mm2. The method for using those lenses and surgical kits including those lenses are also disclosed.

Abstract: Foldable intraocular lenses having a reduced risk of posterior capsule opacification are disclosed. The foldable intraocular lenses have optics that are prepared such that their surface is glassy and their bulk is rubbery.

Abstract: An intraocular lens for implantation in an eye comprising an optic configured so that the optic can be deformed to permit the intraocular lens to be passed through an incision into the eye. A peripheral zone circumscribes the optical zone of the optic and one or more fixation members coupled to the peripheral zone and extending outwardly from the peripheral zone to retain the optic in the eye are provided. In one embodiment the fixation member or members are located so that the optical zone is free of such member or members. The peripheral zone preferably has a maximum axial thickness which is larger than the maximum axial thickness of the periphery of the optical zone.

Abstract: Disclosed are soft, high refractive index, acrylic device materials having improved strength. The materials contain cross-linked acrylate or methacrylate microspheres.

Abstract: Ophthalmic devices suitable for implantation into the eye through small incisions are disclosed. These devices are made from a composition comprising crystalline or semi-crystalline polymeric materials which have a glass transition temperature (Tg) of from about −100° C. to about 20° C., a melting point temperature (Tm) of from about 0° C. to about 37° C., and wherein Tg for the material is lower than Tm for the composition. Disclosed devices include intraocular lenses, corneal inlays, ocular drug delivery devices and implants for reducing intraocular pressure in glaucoma patients; intraocular lenses are preferred.

Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Abstract: An hydratable porous polymer comprising a polymerized polyorganosiloxane macromonomer of formula I Q—[M—L]c—M—Q  (I) wherein c is in the range of from 0 to 5, preferably in the range of from 0 to 3; M may be the same or different and is a difunctional block of molecular weight in the range of from 100 to 8000 and wherein at least one M comprises a residue from a difunctional polymer or copolymer comprising siloxane repeat units of formula II where R1 and R2 may be the same or different and are selected from the group consisting of hydrogen, optionally substituted alkyl, alkenyl, alkynyl, aryl, haloalkyl, haloalkenyl, haloalkynyl, haloaryl, heterocyclyl, and haloheterocyclyl; L is a difunctional group; and Q may be the same or different and is a polymerizable group.

Abstract: A method for prevention of migration of epithelial cells in a capsular bag of an eye of a mammal is provided. The method comprises removing the natural lens of the eye from the capsular bag; introducing an object with at least one sharp edge into the capsular bag, in such a way that said sharp edge contacts the inside of the capsular bag to form a barrier preventing migration of epithelial cells across said barrier; and injecting a lens-forming composition into the capsular bag.

Abstract: Methods of producing an intraocular lens in vivo comprise preparing a composition of discrete water soluble macromolecular particles, mixing the composition with a water soluble photoinitiator and forming an opthalmically acceptable aqueous solution having a refractive index of at least 1.39, injecting the resulting aqueous solution into the capsular bag of an eye, and initiating crosslinking between the macromolecular particles by irradiation of a wavelength in the range of about 380 to 700 nm to create a lens in the capsular bag.

Abstract: A method of preparing phakic intraocular lenses from hydrophobic materials is described. In this process, the lens is tested to determine whether it can float submerged in an aqueous medium. If it cannot (e.g., if it remains on top of the aqueous medium), the lens is surface treated (for example, by vacuum UV or corona discharge processes) to increase its wetting ability (e.g., to reduce its hydrophobicity). The lenses prepared by this process are also described.

Abstract: Prosthetic implants designed to be implanted in the cornea for modifying the cornea curvature and altering the corneal refractive power for correcting myopia, hyperopia, astigmatism, and presbyopia, and, in addition, such implants formed of a micro-porous hydrogel material.

Abstract: The vision of an eye having an impaired lens is stored with an artificial lens implant. The method involves replacing the lens by a polymerizable material injected into the emptied lens capsule and thereby providing a new lens implant with a predetermined refractive value, while admitting the possibility of controlling and adjusting the refractive value of the eye during the surgical process.

Abstract: A one-piece intraocular lens having an optic portion and a haptic portion, the optic portion being formed of a copolymer obtained by copolymerization of predetermined amounts of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate, 2-phenylethyl (meth)acrylate, alkyl (meth)acrylate and a crosslinking monomer, the haptic portion being formed of polymethyl methacrylate, a process for the production thereof, and a soft intraocular lens having an optic portion and a haptic portion formed of a soft material, the haptic portion having a bendable portion having specific functions, the one-piece intraocular lens being insertable into an eye through a small incision with the optic portion being bent, the soft intraocular lens permitting the prevention of the deformation of the soft optic portion caused by the shrink of a capsule when the soft intraocular lens is inserted into an eye.

Abstract: The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.

Abstract: Disclosed is a two-step method of making soft, high refractive index, acrylic ophthalmic device materials. In the first step, a copolymer containing pendant oxirane groups is formed by copolymerizing one or more aryl acrylic hydrophobic monomers with one or more compounds of the formula wherein X is H or CH3; and n is 1-4. In the second step, the copolymer containing pendant oxirane groups formed in the first step is reacted with a compound of the formula W—T—H wherein W is H, CH3(CH2)a, or Z(OCH2CH2)b; a is 0-3; b is 1-5; Z is H, or CH3(CH2)p; p is 0-3; and T is O, NH, S; provided that if T≠O, then W≠H.

Abstract: An intraocular lens (IOL) that provides means for optical power adjustable following its implantation, for example for use in treating cataract patients. The lens body has first and second surface portion that bound at least one interior chamber or space that extends from the central optic portion to the lens periphery. The interior chamber or space has a microporous body that is intermediate inner and outer portions of the space. In one embodiment, the microporous body is capable of cooperating with an external Rf or light source to expose a charge to a charge-carrying fluid within the interior chamber. By this means, fluid flows are induced to alter the optical parameters of the lens.

Abstract: A method for treatment of residual lens epithelial cells is disclosed. The method provides increased safety during local treatment in ocular surgery by improved administration of active agents. The method is particularly useful in treatment of proliferative events in ocular surgery, such as posterior capsular opacification.

Abstract: The current invention discloses an ophthalmic lens composed of a transparent organic polymer material with a high refractive index and a high Abbe number by copolymerization of a mixture of monomers comprising at least one polythiol monomer and at least one monomer with a high Abbe number comprising two to four bridged cyclic end groups comprising an intracyclic ethylenic double bond or a linear or branched aliphatic residue comprising an ethylenic unsaturation, preferably a vinyl or ethylidene group bonded directly to a carbon of the ring.

Abstract: A one-piece intraocular lens having an optic portion and a haptic portion, the optic portion being formed of a copolymer obtained by copolymerization of predetermined amounts of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate, 2-phenylethyl (meth)acrylate, alkyl (meth)acrylate and a crosslinking monomer, the haptic portion being formed of polymethyl methacrylate, a process for the production thereof, and a soft intraocular lens having an optic portion and a haptic portion formed of a soft material, the haptic portion having a bendable portion having specific functions, the one-piece intraocular lens being insertable into an eye through a small incision with the optic portion being bent, the soft intraocular lens permitting the prevention of the deformation of the soft optic portion caused by the shrink of a capsule when the soft intraocular lens is inserted into an eye.

Abstract: A method of selecting an intraocular lens material for toric lenses is disclosed. The method comprises determining the tack of the material.

Abstract: An aspheric soft intraocular lens, having an optical power surface, which may have multiple radii portions or aspherical portions, as well as spherical portions, intended to replace the crystalline lens of a patient's eye, in particular after a cataract extraction. Such an aspheric soft lens is molded in a coined mold. A pair of core pins, positioned within the mold cavity during the lens forming process, will produce a pair of haptic-mounting holes within the lens. As the lenses are subsequently tumbled to remove flash, indentations will form adjacent to the haptic-mounting holes. These indentations allow for tangential attachment of the haptic to the lens which, in turn, enables maximum flexibility without exceeding the width of the optic.

Abstract: Ophthalmic lenses, such as intraocular lenses, include crosslinked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of 2-phenylpropyl acrylate or methacrylate and mixtures thereof, and a second constituent derived from a second component in an amount effective as a crosslinker in the crosslinked polymeric material. The crosslinked polymeric material has branched chain alkyl groups, in an amount effective to reduce the tackiness of the crosslinked polymeric material relative to a substantially identical crosslinked polymeric material without branched chain alkyl groups.