Patents Represented by Attorney Alan D. Lourie

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  • Intermediate to dopamine-.beta.-hydroxylase inhibitors
    Patent number: 4912226
    Abstract: Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
    Type: Grant
    Filed: September 15, 1989
    Date of Patent: March 27, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: Lawrence I. Kruse, Stephen T. Ross, Eliot H. Ohlstein
  • Producing anxiolytic activity and treating depression with 3(H)-indolones
    Patent number: 4912126
    Abstract: The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: March 27, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: David A. A. Owen
  • Steroid 5-alpha-reductase inhibitors
    Patent number: 4910226
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 1, 1987
    Date of Patent: March 20, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Pyridyl and pyridazinyl substituted thyronine compounds
    Patent number: 4910305
    Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.
    Type: Grant
    Filed: March 16, 1988
    Date of Patent: March 20, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4908475
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 13, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • N-phenylpyridone type III phosphodiesterases
    Patent number: 4906628
    Abstract: Phosphodiesterase (type III) inhibitors having the formula: ##STR1## which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: March 6, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Benzene compounds having two pyridazinone substituents
    Patent number: 4904664
    Abstract: The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): ##STR1## wherein: R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or methyl; and represent double or single bonds; and the benzene ring is para- or meta-substituted; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 1, 1986
    Date of Patent: February 27, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Hunter D. Prain, Brian H. Warrington
  • Canine coronavirus vaccine
    Patent number: 4904468
    Abstract: A vaccine for protecting canine animals from disease caused by infection with canine corona virus (CCV) which comprises an effective amount of the cell-associated CCV peplomer protein. A polyvalent vaccine comprising an effective amount of cell-associated CCV peplomer protein and an effective amount of an antigenic component which is protective against one or more additional pathogenic organisms or viruses are also disclosed.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: February 27, 1990
    Assignee: Norden Laboratories, Inc.
    Inventors: Michael A. Gill, Stephen W. May
  • "2-pyridyl and 4-pyridyl phosphine gold (I) anti tumor complexes"
    Patent number: 4902675
    Abstract: 2-pyridyl and 4-pyridyl phosphine gold compounds of the formula: ##STR1## and 2-pyridyl phosphine gold compounds of the formula: ##STR2## and pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: February 20, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: David T. Hill, Randall K. Johnson
  • Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub. 2
    Patent number: 4902698
    Abstract: The invention provides a class of alkanoic acids substituted with a benzenesulphonamidopyridyl group. The compounds have activity as thromboxane A.sub.2 -antagonists.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: February 20, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: David G. Cooper
  • Pyridine compounds which have useful histamine-H.sub.2 antagonist activity
    Patent number: 4894372
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylalkyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: January 16, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Steroid 5-alpha-reductase inhibitors
    Patent number: 4888336
    Abstract: Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: December 19, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Bordetella Bronchiseptica vaccine
    Patent number: 4888169
    Abstract: A vaccine for protecting canines against infection by Bordetella bronchiseptica is prepared by inactivating whole cells with glutaraldehyde.
    Type: Grant
    Filed: November 9, 1988
    Date of Patent: December 19, 1989
    Assignee: Norden Laboratories, Inc.
    Inventors: Albert L. Brown, Joseph C. Frantz, Richard H. Peetz
  • Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities
    Patent number: 4885301
    Abstract: This invention relates to purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)-6-purinone.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: December 5, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • 2-(aminoalkylthio)imidazoles as dopamine-.beta.-hydroxylase inhibitors
    Patent number: 4882348
    Abstract: Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mannals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
    Type: Grant
    Filed: December 29, 1987
    Date of Patent: November 21, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Lawrence I. Kruse, Stephen T. Ross, Eliot H. Ohlstein
  • Carboxamide derivatives of glycopeptides
    Patent number: 4882313
    Abstract: Carboxamide derivatives of glcopeptide antibiotics and their salts are useful for treating or preventing infection in an animal by gram-positive bacteria and also increase feed-utilization efficiency, promote growth in domestic animals and increase propionate production in lactating ruminants.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: November 21, 1989
    Assignee: SmithKline Beckman Corporation
    Inventor: Robert D. Sitrin
  • Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-.alpha.-reductase
    Patent number: 4882319
    Abstract: Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: November 21, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • 1-aralkyl-2-mercaptoimidazolines as DBH inhibitors
    Patent number: 4876266
    Abstract: Disclosed are novel substituted 3-aralkylimidazolines of the structure. ##STR1## processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy in particular as dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: December 31, 1987
    Date of Patent: October 24, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Lawrence I. Kruse, Thomas B. Leonard, Stephen T. Ross
  • Vasopressin compounds
    Patent number: 4876243
    Abstract: Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities.
    Type: Grant
    Filed: August 27, 1987
    Date of Patent: October 24, 1989
    Assignee: Smithkline Beckman Corporation
    Inventors: Garland R. Marshall, Michael L. Moore
  • Delayed action dosage unit for releasing medicaments or the like in ruminants
    Patent number: D306347
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: February 27, 1990
    Assignee: SmithKline Beckman Corporation
    Inventor: Robert J. Gyurik