Patents Represented by Attorney Alan D. Lourie

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  • Quinate salts of antimalarial phenanthrenemethanol compounds
    Patent number: 4818767
    Abstract: The compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical containing one to six carbon atoms and R.sub.2 is an alkyl radical containing one to six carbon atoms possess markedly increased activity against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.
    Type: Grant
    Filed: November 2, 1983
    Date of Patent: April 4, 1989
    Assignee: SmithKline Beckman Corporation
    Inventor: Jean F. Rossignol
  • Pharmaceutically active compounds
    Patent number: 4812573
    Abstract: The invention relates to a class of tetrahydroisoquinolinylalkanoic acids containing an aryl sulphonamide group which have activity as thromboxane A.sub.2 antagonists.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: March 14, 1989
    Assignee: SmithKline & French Laboratories, Ltd.
    Inventors: Graham J. Durant, Andrew D. Gribble, Robert A. Slater
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4810778
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • Dopamine-beta-hydroxylase inhibitors
    Patent number: 4810811
    Abstract: The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: August 24, 1987
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Carl Kaiser, Lawrence I. Kruse
  • Pyrimidone derivatives
    Patent number: 4808589
    Abstract: This invention provides 5-substituted-4-pyrimidones having in the 2-position a heterocyclic (or substituted phenyl) alkyl group. These compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: February 9, 1983
    Date of Patent: February 28, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Thomas H. Brown
  • 4-amino-3-carbonyl substituted quinolines
    Patent number: 4806549
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: February 21, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • 4-Amino-3-carbonyl substituted quinolines as inhibitors of gastric acid secretion
    Patent number: 4806550
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: February 21, 1989
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Vaccine formulation
    Patent number: 4806350
    Abstract: A highly immunogenic aqueous vaccine formulation adjuvanted with a saponin and an oil.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: February 21, 1989
    Assignee: Norden Laboratories, Inc.
    Inventor: Jay D. Gerber
  • Immunomodulation
    Patent number: 4803072
    Abstract: An immunomodulating pharmaceutical composition comprising an effective, leukocyte interferon production inducing amount of NS1 and a pharmaceutically acceptable carrier or diluent; and a method of modulating the immune response in a human or other animal in need thereof by inducing the production of leukocyte IFN which comprises administering an effective amount of NS1 to such human or animal.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: February 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Barbara J. Dalton, Robert C. Rees
  • 2-mercaproimidazole dopamine-.beta.-hydroxylase inhibitors
    Patent number: 4798843
    Abstract: Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutial compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: January 17, 1989
    Assignee: SmithKline Beckman Corporation
    Inventor: Lawrence I. Kruse
  • Antibiotics produced by Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323
    Patent number: 4797280
    Abstract: A novel antibiotic complex of "vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.
    Type: Grant
    Filed: June 10, 1986
    Date of Patent: January 10, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Betty A. Bowie, Richard D. Hedde, Thomas O. Lindsey, David J. Newman, Marcia C. Shearer, Robert D. Sitrin, Joseph R. Valenta
  • Process for the preparation of pyrrolidone derivatives
    Patent number: 4797496
    Abstract: Process for preparing pyrrolidinone derivatives of (1) ##STR1## in which R is hydrogen, alkyl or acyl characterized in that a compound of (2) ##STR2## wherein R.sup.1 is hydrogen and R.sup.2 is benzyl or substituted benzyl, or R.sup.1 and R.sup.2 can together form a group ##STR3## where R.sup.4 and R.sup.5 are independently hydrogen, alkyl, phenyl or optionally substituted aryl or together are 1,4-butylene or 1,5-pentylene; R.sup.3 is hydrogen or straight or branched alkyl of 1 to 4 carbon atoms; and X is alkyl subjected to N-deprotection and the deprotected intermediate is cyclized intramolecularly.The deprotected intermediates can be isolated as acid-addition salts.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: January 10, 1989
    Assignee: I.S.F. Societa Per Azioni
    Inventors: Mario Pinza, Ugo C. Pfeiffer
  • Inhibition of interleukin-1 production by monocytes and/or macrophages
    Patent number: 4794114
    Abstract: A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl-substituted imidazole fused to a thiazole pyrrolidine, thiazide or piperidine ring to such animal.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: December 27, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Don E. Griswold, Nabil Hanna, John C. Lee
  • Plasmids from nocardia
    Patent number: 4791064
    Abstract: A plasmid naturally present in N. orientalis can be used as a vector for cloning or expression in Actinomycetales and to derive other vectors.
    Type: Grant
    Filed: June 12, 1985
    Date of Patent: December 13, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Louis R. Fare, Yong K. Oh, Dean P. Taylor, Jenifer B. Widger
  • Method and device for collecting and testing for fecal occult blood
    Patent number: 4789629
    Abstract: A method and slide for collecting and testing fecal occult blood which permits multiple analyses of a single fecal sample. The slide contains a pocket-like member on a portion of the inside front cover of the slide. An absorbent insert is disposed in the pocket. When the cover is in a closed position the pocket overlies the fecal smear on the specimen viewing sheet and the insert can be removed from the pocket. This design permits an analysis to be done on the specimen receiving sheet of the slide together with a second confirmatory test on the insert.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: December 6, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Josefina T. Baker, Joseph F. Pagano, Ronald J. Schoengold
  • Substituted butanamido acetate compounds for the preparation of pyrrolidone derivatives
    Patent number: 4788300
    Abstract: A process for preparing compounds (1) ##STR1## where Y is NR.sup.1 R.sup.2 or OR, R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 alkyl, and R is C.sub.1-3 alkyl, which comprises protecting the hydroxy group of a compound (2) ##STR2## cyclizing the product under basic conditions and removing the protecting group.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: November 29, 1988
    Assignee: I.S.F. Societa per Azioni
    Inventors: Mario Pinza, Ugo C. Pfeiffer
  • Process for preparing cimetidine polymorph B
    Patent number: 4786735
    Abstract: A novel process for preparing cimetidine polymorph "B" comprises precipitating cimetidine from an aqueous-alcoholic solution of an acid addition salt. The precipitation is conducted at a temperature of above 15.degree. C.
    Type: Grant
    Filed: July 27, 1987
    Date of Patent: November 22, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: Harold Graboyes, David S. Kirkpatrick
  • N-(1-carboxy-2-hydroxy-5-phenyl)-2-(6-methoxy-2-naphthyl)propionamide and anti-inflammatory use thereof
    Patent number: 4783487
    Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: November 8, 1988
    Assignee: Smith Kline Dauelsberg GmbH
    Inventor: Kay Brune
  • Viable cell labelling
    Patent number: 4783401
    Abstract: Methods for reproducibly labelling viable cells with cyanine dyes that do not significantly affect cell viability. Applications for labelled cells include using labelled red blood cells to distinguish post-transfusional bleeding from immunologic reaction and using dilution to measure growth rate of cultured cells.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: November 8, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul K. Horan, Bruce D. Jensen, Sue E. Slezak
  • 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines
    Patent number: 4782163
    Abstract: New intermediates, namely 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines, are prepared by a synthetic sequence which uses a Darzen's reaction in a homogeneous solvent system.
    Type: Grant
    Filed: August 17, 1987
    Date of Patent: November 1, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Clifford S. Labaw, Alan W. Tremper