Patents Represented by Attorney Alan D. Lourie

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  • Tetrahydroquinolinylalkyl amino pyridones and ring homologues thereof, useful as histamine-H.sub.1 -receptor antagonists
    Patent number: 4727076
    Abstract: The invention provides tetrahydroquinolinylalkylamino pyrimidones, and ring homologues thereof, of the general formula (1): ##STR1## wherein R.sup.1 is hydrogen or an alkyl, alkoxy, halogen or amino-substituent, m and n are each 2, 3 or 4 and R.sup.2 is hydrogen, alkyl or variously substituted benzyl.The compounds are useful as histamine-H.sub.1 -receptor antagonists.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: February 23, 1988
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: David G. Cooper, George S. Sach
  • Inactivated rabies vaccine for veterinary use
    Patent number: 4726946
    Abstract: The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabies virus is disclosed.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: February 23, 1988
    Assignee: Norden Laboratories, Inc.
    Inventors: Edmund P. Bass, Richard L. Sharpee
  • Tamper evident container seal
    Patent number: 4724973
    Abstract: A tamper evident seal for containers having a plastic shrink sleeve placed around the cap and neck and extending over the shoulder. A paper label is placed over a portion of the sleeve to prevent the sleeve from being removed intact. The sleeve has zigzag, saw-tooth perforations above and below a median line. The perforations are between the shoulder and cap of the container. When the cap is twisted and removed the plastic sleeve is randomly fragmented making it difficult, if not impossible to match in any attempt to reseal the container.
    Type: Grant
    Filed: April 7, 1987
    Date of Patent: February 16, 1988
    Assignee: SmithKline Beckman Corporation
    Inventor: Hemant D. Shah
  • Arg-arg-arg-vasopressin antagonists
    Patent number: 4724229
    Abstract: Vasopressin antagonists which have a tripeptide side chain comprised of three basic amino acids, such as arginine, lysine or ornithine, demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-arginine]-va sopression.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: February 9, 1988
    Assignee: Smithkline Beckman Corporation
    Inventor: Fadia E. Ali
  • Imidazolethiol dopamine-beta-hydroxylase inhibitors
    Patent number: 4719223
    Abstract: Potent dopamine-.beta.-hydroxylase inhibitors having the Formula: ##STR1## which are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: January 12, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Carl Kaiser, Lawrence I. Kruse, Stephen T. Ross
  • Pharmacologically active 5-oxo-1-imidazolidine acetamide compounds
    Patent number: 4719222
    Abstract: The invention relates to 5-oxo-1-imidazolidineacetamide derivatives which help restore learning and memory difficulties associated with ageing. A compound of the invention is 2,2-dimethyl-5-oxo-1-imidazolidineacetamide.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: January 12, 1988
    Assignee: Societe I.S.F. S.p.A.
    Inventors: Mario Pinza, Carlo Farina, Silvano Banfi, Ugo Pfeiffer
  • Diuretic compositions and methods of producing diuresis
    Patent number: 4719199
    Abstract: 2- or 3-.beta.-Indolylalanyl and .beta.-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: January 12, 1988
    Assignee: Smithkline Beckman Corporation
    Inventor: Nelson C. Yim
  • Cloned streptomycete lividans excretable .beta.-galactosidase gene
    Patent number: 4717666
    Abstract: A DNA fragment from Streptomyces sp. which contains a gene which can code for an excretable protein is isolated, inserted into a plamid vector and used to transform other Streptomycetes.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: January 5, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Mary E. Brawner, Thomas G. Eckhardt, Louis R. Fare
  • ARG.sup.7 -ARG.sup.8 -vasopressin antagonists
    Patent number: 4717715
    Abstract: Vasopressin antagonists which have a dipeptide side chain comprised of two basic amino acids demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-desglycine]- vasopressin.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: January 5, 1988
    Assignee: SmithKline Beckman Corporation
    Inventor: Fadia E. Ali
  • Certain bis(di-2 or 4-pyridyl-phosphino) alkanes #10 having anti-tumor properties
    Patent number: 4716230
    Abstract: Heterocyclic phosphine compounds, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises administering a tumor cell growth-inhibiting amount of such a compound to an animal afflicted by said tumor cells.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: December 29, 1987
    Assignee: Smithkline Beckman Corporation
    Inventor: David T. Hill
  • Temperature sensitive strain of bovine viral diarrhoea virus
    Patent number: 4714678
    Abstract: Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: December 22, 1987
    Assignee: SmithKline-RIT
    Inventors: Jean-Claude Delgoffe, Michele Lobmann, Nathan Zygraich
  • Animal feed methods and compositions using cysteamine
    Patent number: 4711897
    Abstract: Cysteamine is used as an active ingredient in animal feed compositions and in methods for increasing the feed efficiency of immature, monogastric, meat-producing animals. A particularly useful active ingredient of this invention is cysteamine hydrochloride in a quantity selected from the range of 15-1200 ppm.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: December 8, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Thomas O. Lindsey, Michael T. Zavy
  • 6-pen-vasopressin compounds
    Patent number: 4711877
    Abstract: Vasopressin derivatives having unexpected VSP site binding activity whose structures are characterized by a Mpr unit at position 1 and a Pen unit at position 6 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a linear peptide dimercaptan. A representative species is [1-.beta.-mercaptopropionic acid-2-(O-ethyl)-D-tyrosine-4-valine-6-penicillamine-8-arginine]vasopressi n.
    Type: Grant
    Filed: September 18, 1985
    Date of Patent: December 8, 1987
    Assignee: SmithKline Beckman Corporation
    Inventor: Michael L. Moore
  • Inactivated rabies vaccine for veterinary use
    Patent number: 4711778
    Abstract: The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabies virus is disclosed.
    Type: Grant
    Filed: May 22, 1985
    Date of Patent: December 8, 1987
    Assignee: Norden Laboratories, Inc.
    Inventors: Edmund P. Bass, Richard L. Sharpee
  • 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
    Patent number: 4707483
    Abstract: 1-Phenyl-3-benzazepine compounds are useful in treating gastrointestinal motility disorders. A particular compound of this invention is 8-hydroxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepi ne.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: November 17, 1987
    Assignee: Smithkline Beckman Corporation
    Inventors: William E. Bondinell, Thomas Wen-Fu Ku, Herbert S. Ormsbee, III
  • Substituted te[1]trahydroisoquinoline derivatives having .beta.-adrenergic receptor activity
    Patent number: 4707485
    Abstract: Compounds having the formula ##STR1## are .beta.-adrenergic receptor antagonists. Also disclosed are pharmaceutical compositions and methods for producing .beta.-adrenergic receptor antagonistic activity in animals including man.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: November 17, 1987
    Assignee: Smithkline Beckman Corporation
    Inventors: Carl Kaiser, Lawrence I. Kruse
  • Dopamine-.beta.-hydroxylase inhibitors and use thereof
    Patent number: 4707488
    Abstract: The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: November 17, 1987
    Assignee: Smithkline Beckman Corporation
    Inventors: Carl Kaiser, Lawrence I. Kruse
  • Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines
    Patent number: 4705862
    Abstract: New intermediates, namely 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines, are prepared by a synthetic sequence which uses a Darzen's reaction in a homogeneous solvent system.
    Type: Grant
    Filed: September 19, 1986
    Date of Patent: November 10, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Clifford S. Labaw, Alan W. Tremper
  • Nootropic imidazolidinones
    Patent number: 4703054
    Abstract: The invention relates to 4-imidazolidinone derivatives which help restore learning and memory difficulties associated with ageing.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: October 27, 1987
    Assignee: ISF, S.p.A.
    Inventors: Mario Pinza, Carlo Farina, Silvano Banfi, Ugo Pfeiffer
  • Monoclonal antibody to activated macrophages
    Patent number: 4701408
    Abstract: A monoclonal antibody which is preferentially reactive with activated macrophages and a hybridoma which produces the antibody.
    Type: Grant
    Filed: January 30, 1984
    Date of Patent: October 20, 1987
    Assignee: SmithKline Beckman Corporation
    Inventor: Thomas P. Koestler