Abstract: The present invention relates to compounds of the formula: ##SPC1##Wherein R.sub.1 is alkyl, R.sub.2 and R.sub.3 are hydrogen, halogen, alkyl, alkoxy, hydroxy, or methylenedioxy, and R.sub.4 and R.sub.5 are hydrogen, halogen, alkyl, alkoxy, hydroxy, or methylenedioxy and pharmaceutically acceptable salts thereof.These compounds are useful as antianginal agents.

Abstract: Novel, substituted 9-Benzylacridines and the methods for their preparation are disclosed. These compounds are useful in the treatment of angina pectoris.

Abstract: Water-wettable anhydrous products, such as the powders and creams used in cosmetic and drug products, are admixed with 20 to 60% by weight, based on the weight of the total formulation, of a powdered polyethylene or powdered polypropylene polymer, to improve wettability characteristics. Denture adhesive powders prepared from an anionic/cationic adhesive combination, together with the powdered polyethylene or polypropylene polymer display particularly improved properties. The polyethylene or polypropylene polymer may also be admixed with other anhydrous products including dentifrices, vaginal powder sprays, and the like. Low molecular weight polyethylene powder, with an average molecular weight of from 1,000 to 3,500, is suitable for use in products of the invention. For the polypropylene, a molecular weight of from 120,000 to 350,000 is specified. The powdered polymers have a particle size of less than 422 microns.

Abstract: The present invention is concerned with new cardenolide acetals of the general formula: ##SPC1##Wherein R.sub.1 is an unsubstituted or substituted glycosyl radical and Ar is an unsubstituted or substituted aryl or heteroaryl radical and with the preparation thereof. These compounds exert a positive inotropic action on the cardiac muscle of mammals.

Abstract: The present invention relates to compounds having the following formula: ##SPC1##In which R.sub.2 is naphthyl alkyl of 1 to 3 carbons or phenyl alkyl of 1 to 3 carbons substituted in the aryl moiety by one or two alkoxy of 1 to 6 carbons, or one or two chloro. This compound is useful as an intermediate for the production of the compounds of the formula: ##SPC2##Which are useful as antianginal or bronchodilator agents.

Abstract: The specific disclosure provides a razor blade cartridge having a pair of single edge blades which are tandemly mounted and vertically separated by a spacer. The blades and spacer are permanently bonded between a cap member and a blade seal member. Each of the blades has its cutting edge in abutting engagement with a respective pair of spaced stops. Means are provided for abutting engagement with the rear edges of the blades to prevent rearward movement thereof.

Abstract: This invention relates to substituted 2-amino chromones of the general structure I: ##SPC1##wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 may be hydrogen, hydroxy, lower alkyl or lower alkoxy of 1-6 carbon atoms, halogen such as chloro or bromo, or aryl such as phenyl, and X may be cyano or carboxamido. Two novel procedures for preparing substituted 2-amino chromones having the Formula I, starting with salicylic acid or substituted salicylic acid, are described. The compounds of this invention are active in the prevention of allergic and asthmatic reactions in mammals.

Abstract: The present invention relates to triols derived from antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), to the acetates thereof and to processes for the production of the triols and corresponding acetates. These triols and acetates are potent antifungal agents inhibiting the growth of a variety of fungi, including H. capsulatum, T. mentagrophytes and M. fulvum.

Abstract: The present invention relates to keto and ketoxime derivatives of the novel antibiotic substance, acid S, produced by the microorganism Polyangium cellulosum var. fulvum (ATCC N0. 25532) and to processes for their preparation. The novel keto and ketoxime derivatives of acid S of this invention are useful antifungal agents.

Abstract: New process for the preparation of trans-.DELTA..sup.2 -prostaglandins of the formula ##SPC1##(wherein A represents a grouping of the PGE, PGF or PGA type, X represents --CH.sub.2 CH.sub.2 -- or trans --CH=CH--, R.sub.1 represents an alkyl radical of 1 to 10 carbon atoms or an alkyl radical of 1 to 6 carbon atoms carrying a phenyl substituent or a cycloalkyl substituent of 5 to 7 carbon atoms, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms) and alkyl esters thereof having 1 to 10 carbon atoms in the chain, which comprises reacting a cyclopentane derivative of the formula: ##SPC2##(where R.sub.3 represents a 2-tetrahydropyranyl group unsubstituted or substituted by at least one alkyl radical, or a 1-ethoxyethyl group) with an alkyl phosphonate of the general formula: ##EQU1## (wherein R.sub.4 represents a methyl or ethyl radical, and R.sub.5 represents an alkyl radical of 1 to 10 carbon atoms), optionally hydrolyzing the resulting trans-.DELTA..sup.

Abstract: 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles having the following structural formula are disclosed ##SPC1##In the above formula, R.sub.1, R.sub.2, and R.sub.3 are hydrogen or alkyl, R.sub.4 is alkyl, aryl, aralkyl, or a heterocyclic, R.sub.5 is hydrogen, alkyl, halogen, alkoxy, hydroxyl and the like.These compounds exhibit central nervous system depressing properties and are useful as anti-aggression agents.

Abstract: The present invention concerns compounds of Formula I ##SPC1##wherein R.sub.1 is hydrogen, lower alkyl, aralkyl; R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, cyano, nitro, and the like; R.sub.3 is lower alkyl; ##EQU1## (where R.sub.4 and R.sub.5 are lower alkyl), ##EQU2## (where R.sub.6 is hydrogen, lower alkyl, aryl, acetamido and R.sub.7 is lower alkyl), ##SPC2##(where R.sub.8 and R.sub.9 are hydrogen or lower alkyl), --CH(SO.sub.2 C.sub.6 H.sub.5).sub.2, ##SPC3## ##EQU3## (where R.sub.10 is hydrogen, CN, acyl), ##EQU4## (where R.sub.11 and R.sub.12 are lower alkyl), --SO.sub.2 C.sub.6 H.sub.5, --CONH.sub.2, --CO.sub.2 R.sub.13 (where R.sub.13 is lower alkyl), ##EQU5## (R.sub.14 and R.sub.15 are lower alkyl). These compounds are useful as sedatives and antiaggression agents.

Abstract: 2-Hydroxy-phenyl-1-oxa-4-azaspiroalkane derivatives, the preparation thereof, and pharmaceutical compositions containing these 2-hydroxyphenyl-1-oxa-4-azaspiroalkane derivatives are disclosed. These derivatives possess unexpectedly valuable therapeutic properties which make them outstandingly useful for the treatment of cardiovascular circulatory insufficiencies and hypotonic states.