Abstract: A contact lens composition, having improved dimensional stability, suitable for use in the preparation of a corrective hydrated lens or an eye bandage, comprises polymerized random graft copolymers containing (in the dry state) from 67.2 to 79.3% HEMA; from 14.25 to 35% PVP; from 0.1 to 4.04% EDMA; from 0.1 to 2.5% MA; from 0.1 to 5.0% water; from 0 to 4 ppm HQ inhibitor; and from 50 to 250 ppm MEHQ inhibitor. The contact lens composition contains from 45 to 65% water after hydration. An improved method for shaping, polymerizing, and cutting and hydrating the contact lens composition is provided. The polymerization is conducted using only a low temperature initiator, by de-gassing prior to polymerization to remove substantially all oxygen, and by conducting the initial polymerization reaction at from 23.degree. to 30.degree.C for 16 to 30 hours, during which the heat of the reaction is continuously absorbed to control the reaction exotherm.

Abstract: The present invention relates to a process for 3r-N-Monomethylamino-4 cis-phenyl-4 trans-ethoxycarbonyl-cyclohexene and its N-substitution products which are generally useful as analgesics.

Abstract: The present invention relates to a method for reducing blood pressue in a hypertensive mammal by the administration of a novel hydroxypyrimidine of the formula: ##SPC1##Wherein R.sub.1 is -CH.sub.3 or -NH.sub.2 ; and R.sub.

Abstract: 3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides of the formula I: ##SPC1##wherein R is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity.

Abstract: Deodorant compositions containing from 0.01% to 0.1% by weight of trans-1,4-diphenyl-2-butene-1,4-dione by weight of the total composition are disclosed. For oral use, any suitable, non-toxic, orally acceptable formulation such as breath sprays, toothpaste, tooth powder, liquid dentifrices, liquid mouthwash, powdered mouthwash, candy products, chewing gums and the like may be used as the carrier portion of the deodorant compositions of this invention. The preferred composition is a breath spray containing about 0.05% by weight of trans-1,4-diphenyl-2-butene-1,4-dione. The trans-1,4-diphenyl-2-butene-1,4-dione deodorant ingredient may also be used directly or in a suitable formulation to eliminate various objectionable odors such as household odors caused by the presence of hydrogen sulfide and organic sulfides.

Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##SPC1##Wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 R.sup.3, wherein R' is an alkyl radical of 1 to 5 carbons which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.

Abstract: This invention relates to novel indolothiopyrones having the formula: ##SPC1##Wherein R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen or halogen; and R.sub.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, nitro-substituted-aryl, or .omega.-substituted lower alkyl wherein the substituent is: ##EQU1## --COOH, or ##EQU2## wherein R.sub.4 and R.sub.5 each represent hydrogen, lower alkyl, or together with the nitrogen atom, form a heterocyclic ring; and R.sub.6 is lower alkoxy or amino, and novel intermediates used in their preparation. The indolothiopyrones are prepared by reacting a 3-mercaptoindole with sodium propiolate or a substituted sodium propiolate followed by acidification to obtain an intermediate acid; the intermediate acid cyclizes in the presence of an acid catalyst to obtain the indolothiopyrone structure which may be additionally subjected to halogenation, alkylation or hydrolysis to obtain derivatives having the various substituent groups disclosed.

Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.

Abstract: An apparatus and method for sequentially cleaning and coating articles. The apparatus is in the form of a multi-chamber device, with each chamber being partially defined by valve units which permit passage of articles to be coated therethrough. Each chamber has associated therewith means for drawing a vacuum therein, several chambers include means for leaking a minute quantity of an inert but ionizable gas therein, and at least one chamber further includes at least one electrode, which may be placed in electrical communication with the articles so as to establish, in one of several ways, a direct current bias on the article with respect to another point within the chamber. Coating material to be transferred to the article is placed on one electrode, preferably in the form of a flat plate, in those chambers in which coating is to take place, whereas target material is not present in the cleaning or other non-coating chambers.

Abstract: The present invention relates to an improved intravaginal catamenial tampon which is comprised of a plurality of individual small absorbent masses attached at intervals along a string.

Abstract: New prostaglandin analogues having therapeutic utility of the formula: ##SPC1##(wherein B is a grouping of the formula: ##SPC2##X is --CH.sub.2 CH.sub.2 -- or cis --CH=CH--, Y is trans --CH=CH-- or, when X is --CH.sub.2 CH.sub.2 --, Y is additionally --CH.sub.2 CH.sub.2 --, A is alkyl of 1 through 3 carbon atoms, n is 4 or 5, and indicates attachment of the hydroxy radical to the carbon atom in alpha or beta configuration), and alkyl esters thereof, and cyclodextrin clathrates of such acids and esters, and non-toxic salts of such acids.

Abstract: Process for the production of substituted pyrano[3,2-c] [1,2]benzothiazine 6,6-dioxides and novel intermediates produced thereby of the general formula I: ##SPC1##wherein R represents hydrogen and lower alkyl; R' represents lower alkyl and formyl; by reacting, as the first step, the corresponding 2-substituted-2H-1,2-benzothiazin-4(3H)-one 1,1-dioxide (II) with a boron trifluoride compound and an acid anhydride IV; alternately, the starting material may be a 3-acetyl-2-substituted-2H-1,2-benzothiazin-4-[3H]-one 1,1-dioxide (III) which is reacted with the boron trifluoride compound, without the necessity for the acid anhydride (IV). Starting materials II and III subjected to step one of the process yield novel boron complex intermediates V (2,2-difluoro-4,5-disubstituted-2H-1,3,2-dioxaborino[5,4-c]-1,2-benzothiaz ine 6,6-dioxide).

Abstract: .beta.-Ketoacyl derivatives of 6-aminopenicillanic acid of the formula: ##SPC1##Are disclosed. In the above structure R.sup.1 is hydrogen, alkyl, halogen, alkoxy, cyano, trifluoromethyl and the like; Z is CHR.sup.2 or NR.sup.2 ; R.sup.2 is hydrogen, alkyl, aralkyl; M is an alkali or alkaline earth metal such as sodium, potassium, or calcium. These compounds are useful as anti-bacterials.

Abstract: The present invention relates to a process for the preparation of 1-(m- and p- hydroxyphenyl)-2-aminoethanol which consists of converting an m- or p- hydroxyacetophenone to an isonitrosoketone followed by hydrogenation of the isonitrosoketone. These compounds are sympathomimetics which produce vasoconstricting and cardiotonic effects.

Abstract: The present invention relates to new thymol derivatives with strong sympatholytic effect and low toxicity and to a process for their preparation.These novel thymol derivatives have the following general formula: ##SPC1##Wherein R is an alkyl group of 4 to 11 carbon atoms or an alkoxy group R'--O-- wherein R' is an alkyl group of 3 to 10 carbon atoms, and their pharmaceutically acceptable salts.

Abstract: A specific embodiment provides an adjustable safety razor comprising a guard structure hinged to a blade seat, and a manually operable slide. A recess and a rail slidably interconnect the slide member and the blade seat for guiding the slide member in a direction parallel to an axis defined by the hinging structure. Another recess and rail slidably interconnect the slide member and the guard structure in an angular direction with respect to the axis of the hinging structure for moving the guard structure about the axis of the hinging structure upon manual operation of the slide member.

Abstract: Prostaglandin compounds of the formula: ##SPC1##Wherein A represents a grouping of formula II, III or IV indicated below and (i)R.sub.1 represents an unsubstituted n-butyl, n-pentyl, n-hexyl or n-heptyl radical, or such a radical carrying one, two or three alkyl substituents of 1 to 4 carbon atoms, or R.sub.1 represents a methyl, ethyl, propyl or butyl radical carrying a phenyl, cyclohexyl or cyclopentyl substituent, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, and R.sub.3 represents a hydrogen atom, or (ii) R.sub.1 represents n-butyl, or n-butyl or n-pentyl carrying one, two or three alkyl substituents of 1 to 4 carbon atoms, or R.sub.1 represents a methyl, ethyl, propyl or butyl radical carrying a phenyl, cyclohexyl or cyclopentyl substituent, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, and R.sub.3 represents an alkyl radical of 1 to 4 carbon atoms are disclosed. These compounds exhibit characteristic prostaglandin-like activity.

Abstract: Compounds of the formula: ##SPC1##Are disclosed. In the above formula, R.sub.1 is aryl such as benzene or a heterocycle such as pyridine, isoxazole, or thiazole. The aryl or heterocyclic group R.sub.1 is substituted or unsubstituted. R.sub.2 is hydrogen, lower alkyl, halogen, lower alkoxy, trifluoromethyl and the like.These compounds are useful as anti-inflammatory agents indicated in conditions such as rheumatoid arthritis.

Abstract: Disclosed is a novel substituted benzopyranopyridine which is active as a bronchodilator agent.

Abstract: An improved process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (I), a known anti-inflammatory agent, requires the use of specific proportions of reactants and carefully controlled reaction conditions. An alkali metal alkoxide, suspended in dimethylformamide is combined, with stirring, as rapidly as possible with a solution of alkyl 2,3-dihydro-3-oxo-1,2-benzisothiazole-2-acetate 1,1-dioxide (II) in dimethylformamide, while maining the internal reaction temperature within 15.degree.-30.degree.C. More than two but less than six moles of the alkoxide are used per mole of the alkyl 2,3-dihydro-3-oxo-1,2-benzisothiazole-2-acetate 1,1-dioxide (II). After all reactants have been combined, stirring is continued for a specific period of time and then the reaction mixture is acidified. Total elapsed time from initial combination of reactants to acidification is from 30 to 50 minutes.