Abstract: Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

Abstract: Novel polycyclic gamma-pyrone derivatives having a carboxaldehyde group on the 3-position and optionally substituted on the 5, 6, 7, 8, 9 or 10 positions with a hydroxy, lower alkyl or lower alkoxy group are disclosed, as well as the corresponding N-substituted, formyl imine derivatives thereof. These compounds, and pharmaceutical compositions containing these compounds, are useful for the treatment of allergic conditions and for the treatment of hyperacidity.

Abstract: The invention relates to 1-phenyl-4-amino-cyclohex-2-ene-1-carboxylic-acid-esters of the general formula I ##SPC1##wherein R.sub.1 and R.sub.2 may be the same or different and may be H, alkyl, hydroxyalkyl, alkenyl, preferably with 1 to 4 C-atoms, aralkyl which may be bonded to each other, in which connection the heterocyclic system formed may be substituted further by the OH-- group and where attachment takes place by an oxygen or a nitrogen atom, if desired, which in its turn carries an H, alkyl with 1 to 4 C-atoms, aryl which may be substituted by chlorine, preferably in 3 or 4-position, and by methoxy, preferably in 2 or 4-position, acyl, preferably alkanoyl with 1 to 4 C-atoms, and aroyl, or aralkyl, and R.sub.3 represents an alkyl radical with 1 to 4 C-atoms, the salts thereof and quarternary ammonium compounds, and a process for their preparation. These compounds have analgesic and neuroleptic properties.

Abstract: This invention relates to a system for the identification of bacteria which comprises a series of punched cards, each card representing a different biochemical test.

Abstract: A novel process for preparing 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (I), starting with 3-amino-5-methylisoxazole (II) is disclosed. Compound I exhibits anti-inflammatory properties and is useful for treating inflammation. In the process of the invention an intermediate obtained, 2,3-dihydro-N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzisothiazole-2-acetamid e 1,1-dioxide (IV) undergoes rearrangement to provide 1-{[5-(4-hydroxy-2H-1,2-benzothiazin-3-yl)-1,2,4-oxadiazol-3-yl]methyl}eth anone S,S-dioxide (V), which is methylated, according to conventional procedures. The methylated intermediate VI, upon further treatment, undergoes a second rearrangement to obtain the desired anti-inflammatory compound I.

Abstract: A diagnostic test system for detecting .beta.-galactosidase producing micro-organisms is prepared by impregnating one zone of a bibulous material with an aqueous acetone solution of an o-nitrophenyl-.beta.-D-galactopyranoside substrate and evaporating to dryness; and impregnating a contiguous and separate zone of the bibulous material with a solution of a microbiologically inert buffer system which will maintain a pH of from about 6.5 to 8.5 and evaporating to dryness. Preferably, the bibulous material contains 1.5 mg of dry o-nitrophenyl-.beta.-D-galactopyranoside and 0.02 millimoles of a buffer which will maintain a pH of 7.4. Optionally, a waterproof barrier zone and an identifying dye zone may be present. In use, the impregnated bibulous material is inserted into a test tube of a saline suspension of unknown organism and incubated for 4 hours. The development of a yellow coloration indicates that .beta.-galactosidase is produced by the organism being tested.

Abstract: The specific disclosure provides an automatic dispenser for periodically actuating a replaceable aerosol container to discharge a quantity of the contents of the container. The aerosol container includes a valve, means for biasing the valve to a closed position, an outwardly extending valve stem having an internal passage in fluid communication with the valve and a discharge outlet in fluid communication with the stem passage. The container discharges a quantity of the contents therein through the valve, the passage and the discharge outlet upon relative movement between the valve stem and the container against the biasing means.

Abstract: The specific disclosure provides a shaving unit having two flexible double edge razor blades with the cutting edges of the top blade being set back a slight distance from the cutting edges of the bottom blade. Each one of the blades has a pair of transversely spaced end tabs. The blades are vertically separated by a spacer, and a transversely elongated aperture extends through the blades and the spacer between the end tabs for locating the shaving unit in a double edge safety razor. First means are provided between the aperture and the cutting edges to each side of the aperture for permanently connecting the top blade to the spacer, and second means are provided outwardly in the direction of each bottom blade end tab from the first connecting means and between the aperture and the cutting edges to each side of the aperture for permanently connecting the bottom blade to the spacer.

Abstract: Prostaglandin analogues of the formula:- ##SPC1##Wherein A represents a PGF or PGE grouping, X represents ethylene or cis-vinylene, Y represents ethylene or transvinylene, R.sup.1 represents hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 represents alkyl of 1 to 10 carbon atoms, or alkyl of 1 to 4 carbon atoms substituted by phenyl or cycloalkyl containing from 5 to 7 carbon atoms, or R.sup.2 represents a grouping of the formula:- ##SPC2##Wherein R.sup.3 represents alkylene of 1 to 4 carbon atoms, R.sup.4 represents oxygen or sulphur or sulphinyl, and R.sup.5 and R.sup.6 represent hydrogen, halogen, trifluoromethyl, alkyl of 1 to 3 carbon atoms are new compounds possessing pharmacological properties.

Abstract: The present invention is concerned with new cyclic sulphoximide derivatives with valuable pharmacological properties and with the preparation thereof.

Abstract: The present invention relates to 16-methylene prostaglandins. These compounds are useful as anti-ulcer agents, bronchodilators and so on.

Abstract: The present invention is concerned with novel cyclic sulphoximides and their preparation. These novel compounds are intermediates for a series of novel cyclic sulphoximides which show pharmaceutical activity.

Abstract: The present invention relates to novel 1-(aryl)-2-(arylalkyl)-3-(or-4-)-[4'-(substituted alkyl-)-piperazino-1']-butanols-2, and butenes-1 showing antimicrobial action, to their pharmaceutically acceptable salts, and to the process of manufacture thereof.

Abstract: The present invention relates to an improved process for the production of a deficient citrated plasma useful in the clinical laboratory as a control plasma for the testing of clotting function, and particularly, in patients who are on oral anticoagulant thereapy.

Abstract: Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

Abstract: 3-substituted cinnolinones having the following structural formula are disclosed: ##SPC1##Wherein R.sub.1 is hydrogen, lower alkyl, aralkyl or acyl and R.sub.2 and R.sub.3 are hydrogen, halogen, lower alkoxy or lower alkyl, and X is ##EQU1## CH.sub.3 COOCH.sub.2 S-, or ##SPC2##These compounds are useful as immunosuppressants.

Abstract: Novel pyrano[3,2-c][1,2]benzothiazine 6,6-dioxides are disclosed, substituted on the 3 position by a lower alkyl, carboxaldehyde, or hydroxymethyl group and, optionally substituted on the 5 position by a lower alkyl group. The corresponding aldehyde thiosemicarbazone derivatives of these compounds are also disclosed. Pharmaceutical compositions containing the substituted pyrano[3,2-c][1,2]benzothiazine 6,6-dioxides of this invention are useful in the treatment of hyperacidity; certain of these compounds also demonstrate anti-allergy activity.

Abstract: Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids having the structural formula: ##SPC1##Wherein R.sub.1 represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, or acyloxy; R.sub.2 represents hydrogen, lower alkyl, fluorinated lower alkyl, alkoxycarbonyl, carboxy, or lower alkyl carboxylic acid; Z represents cyano, carboxy, alkoxycarbonyl, or ##EQU1## wherein X represents amino, N-lower-alkylamino, hydroxylamino, N-lower-alkylhydroxylamino, ureido, piperidino, or anilino, with the proviso that when R.sub.2 represents hydrogen, Z represents cyano or ##EQU2## wherein X has the same meaning as given above; and wherein R.sub.2 and Z together may form a substituted pyrrole ring; and the corresponding non-toxic, pharmaceutically acceptable salts.

Abstract: Novel (hydroxymethylene) chromone derivatives of the general formula I: ##SPC1##wherein n represents 1 or 2, are prepared by reacting a cycloalkanone II with a boron trifluoride compound and acetic anhydride to obtain novel boron complex intermediates of the formula III: ##SPC2##wherein n represents 1 or 2, and reacting III with a Vilsmeier reagent prepared from phosphorus oxychloride and dimethylformamide. The final product I and pharmaceutical compositions containing I are useful in the treatment of allergic conditions and in the treatment of hyperacidity.

Abstract: A process for the production of partially saturated gamma-pyrones of the general formula I: ##SPC1##wherein R represents hydrogen, hydroxy, lower alkyl, or lower alkoxy and n represents 1 or 2, by reacting a suitably substituted tetralone (IIa) or indanone (IIb) with a boron trifluoride compound and acetic anhydride to obtain intermediate boron complexes III, which are reacted with a Vilsmeier reagent prepared from phosphorus oxychloride and dimethylformamide to obtain the partially saturated gamma-pyrones of formula I. The gamma-pyrones I have anti-allergy and anti-secretory activity.