Abstract: The present invention is concerned with improved dental semi-solid or paste-like elastomeric materials which have the capability of precise surface detail reproduction at ambient and body temperature. Such materials are prepared by treating liquid polysulfide with a synergistic accelerator system comprising a metallic peroxide, e.g., zinc peroxide, 2,2' dithiobisbenzothiazole and 2-mercaptobenzothiazole.

Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##STR1## wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 R.sup.3, wherein R' is an alkyl radical of 1 to 5 carbon atoms which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.

Abstract: A specific embodiment provides a valve structure for an evacuator system adapted to be connected to a source of negative pressure. The valve structure includes an elongated housing having a longitudinal bore extending through the housing, and a valve seat formed by a reduced diameter portion of the bore. A valve member is situated in the bore for abutting engagement with the valve seat to prevent passage of flowable materials therebetween. Biasing means is provided for urging the valve member into abutting engagement with the valve seat. A manually operable member is operatively associated with the biasing means for moving the valve member out of engagement with the valve seat to permit passage of flowable materials therebetween.

Abstract: The specific disclosure provides a device and method of making an incision of precise dimensions in a patient, preferably in the forearm, and determining exact bleeding from initial puncture of the skin until the flow of blood has ceased, i.e. hemostatis is complete. The device comprises a housing including a blade aperture at one end thereof adapted to be positioned in abutting engagement with the skin of the subject. A spring member and a blade member having at least one cutting edge are located in the housing. Means are also provided in the housing and is connected to the blade member for retracting the blade member inwardly from the blade aperture and against the bias of the spring member. Manually operable means are provided for releasably engaging the retracting means to maintain the blade member in a retracted position against the bias of the spring member until the device is ready for use.

Abstract: Substituted 3-(2-pyridinyl)-4(1H)-quinolinone N-oxides having the formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or --CH.sub.2 OH; the dotted line indicates the possible presence of a double bond at the 2,3-position of the quinoline ring; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity and for the prevention of allergic and asthmatic reactions.

Abstract: The present invention relates to compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy or lower alkyl, R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl.These compounds, including their corresponding pharmaceutically acceptable salts, are useful in the management of allergic conditions such as hay fever and as a prophylactic in the treatment of bronchial asthma.

Abstract: Disclosed are novel benzo[g]Pyrido[2,1-b]-quinazolinones which are active as anti-allergy agents and thus have utility in the treatment of allergic reactions such as bronchial asthma.

Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC NO. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.

Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.

Abstract: The present invention is concerned with new dibenzylglycolic acid derivatives and with the preparation thereof. These derivatives show an extraordinary anti-hypertensive and antisecretory profile.

Abstract: This invention relates to a process for the preparation of 1-{[5-(4-hydroxy-2H-1,2-benzothiazin-3-yl)-1,2,4-oxadiazol-3-yl]methyl}eth anone S,S-dioxide (III), a novel intermediate useful in the preparation of the known anti-inflammatory agent, 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (IV). According to the process of this invention, the saccharin compound, 2,3-dihydro-N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzisothiazole-2-acetamid e 1,1-dioxide (I) is reacted with an alkali metal alkoxide of a lower alcohol in an inert solvent at temperatures below 30.degree. C. to form the benzenesulfonylglycineamide, alkyl 2-{[({[(5-methyl-3-isoxazolyl)amino]carbonyl}methyl)amino]sulfonyl}benzoat e (II), which is ring closed and rearranged by reaction with an alkali metal alkoxide of a lower alcohol in an inert solvent at temperatures of from 60.degree. to 70.degree. C. to form the desired oxadiazole compound III.

Abstract: A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to give II, ##STR1## wherein R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl, aryl or a heterocyclic ring selected from the group consisting of pyridyl, substituted-pyridyl, and thiazolyl. Compounds of the formula II have useful anti-inflammatory properties. In addition, they can be used as intermediate in the preparation of known anti-inflammatory agents.

Abstract: This invention relates to substituted indolobenzoxazepines which show neuroleptic activity.

Abstract: The present invention relates to 17-oxo-17-phenyl-prostaglandins having the following structural formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 and R.sup.3, which may be the same or different, each represent a hydrogen or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and R.sup.4 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms and cyclodextrin clathrates of such acids and esters, and when R.sup.4 represents a hydrogen atom, non-toxic salts thereof.These compounds exhibit characteristic prostaglandin activity, e.g., abortifacient activity, stimulation activity on uterine contraction, and so on.

Abstract: A razor blade assembly which is flexible in at least one bending mode. A seat member of substantially planar shape has an integrally formed guard located transversely along its forward margin. The guard and seat members are formed of a flexible material. A flexible blade having a sharpened edge along a transverse margin is disposed on a surface of the seat member having its edge parallel to and rearwardly located of the guard bar. A cap member of flexible material has a planar surface in contact with the blade and a front margin located rearwardly of the cutting edge. The seat, blade and cap are yieldingly bonded together and freely flexible about an axis parallel to the plane of the blade and perpendicular to the cutting edge.

Abstract: The present invention relates to compounds of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## B represents a single bond or a straight- or branched-chain alkylene group containing from 1 to 9 carbon atoms, W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydroxymethyl group or a grouping of the formula --COOR.sup.4, in which R.sup.4 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a hydrogen atom or a methyl or ethyl group and R.sup.3 represents a hydrogen or chlorine atom or a hydroxy group and cyclodextrin clathrates of such alcohols, acids and esters and, when R.sup.4 in the formula --COOR.sup.4 represents a hydrogen atom, non-toxic salts thereof, and intermediates therefor. These compounds exhibit characteristic prostaglandin-like activity.

Abstract: Prostaglandin analogues of the formula: ##STR1## wherein X represents oxygen or sulphur, R.sup.1 and R.sup.2 each represent hydrogen or alkyl of from 1 to 3 carbon atoms, alkenyl of from 2 to 4 carbon atoms or trifluoromethyl, and the double bonds depicted in positions C.sub.5 -C.sub.6 and C.sub.13 -C.sub.14 are cis and trans respectively. These compounds are indicated in the treatment of impaired fertility, induction of labor or termination of pregnancy in females.

Abstract: The specific disclosure provides a dispensing system for razor blade cartridges comprising a dispenser, a plurality of cartridges in the dispenser, and a holder having a plurality of transverse supporting surfaces on top of a frame member for sliding engagement with surfaces extending transversely of each cartridge. The dispenser has a used cartridge storage end comprising a transverse opening between a used cartridge entrance port in one side wall and a holder exit port in the other side wall. A used cartridge is positioned in the used cartridge storage end through the used cartridge entrance port by means of the holder. The frame member of the holder is moved through the transverse opening to abut a side of the used cartridge against wall surfaces forming the holder exit port. Continued movement of the holder disengages the transverse supporting surfaces of the holder from the used cartridge, and such holder surfaces are removed from the storage end through the holder exit port.