Abstract: 2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R.sub.4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; the pharmaceutically acceptable, acid addition salts thereof; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.

Abstract: The present invention is concerned with new pharmacologically effective 5-phenyl-thiazolidin-4-one derivatives and with the preparation thereof. These compounds are useful for treating liver dysfunctions.

Abstract: Compounds of the formula: ##STR1## are disclosed, wherein R.sub.1 and R.sub.2 are hydrogen; or where R.sub.1 is methyl, R.sub.2 is hydrogen, phenyl, or phenyl substituted in the para-position by hydroxy, alkoxy, chloro, phenyl or alkyl having 1-6 carbon atoms. The compounds of this invention are useful in the treatment of bronchial asthma. These compounds exhibit unique biological properties in that they provide the desired bronchial dilation effect without accompanying cardiac stimulation.

Abstract: The present invention relates to substituted [4-oxo-4H-1-benzopyran-2-yl]cyclopropane carboxylic acids and esters having the following structural formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkyl, lower alkoxy, phenyl or when R.sub.1 and R.sub.2 are hydrogen, R.sub.3 and R.sub.4 taken together form an additional aromatic ring and A is hydrogen or ethyl. The compounds of this invention exhibit anti-allergy properties and are indicated in the management of allergic manifestations such as bronchial asthma.

Abstract: Disclosed are novel substituted benzopyranopyridines which are active as bronchodilators.

Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##STR1## wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 N.sup.3, wherein R' is an alkyl radical of 1 to 5 carbons which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.

Abstract: A compound of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## , R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms, R.sup.2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, X represents trans-vinylene or ethylene, and the wavy line indicates attachment of the hydroxy radical in .alpha.- or .beta.-configuration and cyclodextrin clathrates thereof and, when R.sup.2 represents a hydrogen atom, non-toxic salts thereof. These compounds exhibit characteristic prostaglandin activity.

Abstract: A contact lens composition, having improved dimensional stability, suitable for use in the preparation of a corrective hydrated lens or an eye bandage, comprises polymerized random graft copolymers containing (in the dry state) from 67.2% to 79.3% HEMA; from 14.25% to 35% PVP; from 0.1% to 4.04% EDMA; from 0.1% to 2.5% MA; from 0.1% to 5.0% water; from 0 to 4 ppm HQ inhibitor; and from 50 to 250 ppm MEHQ inhibitor. The contact lens composition contains from 45% to 65% water after hydration. An improved method for shaping, polymerizing, and cutting and hydrating the contact lens composition is provided. The polymerization is conducted using only a low temperature initiator, by de-gassing prior to polymerization to remove substantially all oxygen, and by conducting the initial polymerization reaction at from 23.degree. to 30.degree. C for 16 to 30 hours, during which the heat of the reaction is continuously absorbed to control the reaction exotherm.

Abstract: A thermographic strip chart recorder for the recording of medical data includes a thermo printout head for the digital recording of additional medical data. Thermo sensitive paper is transported from a supply spool over a knife edge member and across a platen. Both a galvanometrically controlled thermo stylus for recording analog data and the thermo printout head are aligned to produce their respective indicia on that portion of the paper in contact with the apex of the knife edge. The thermo printout head permits the recording of digitally coded or alphanumeric data relative to the patient in real time registration with the analog information. Physical location of the thermo printout head along the knife edge permits viewing of the paper as it crosses the platen without obstruction.

Abstract: A safety razor comprises a blade seat member having a transversely elongated guard surface, and a first plurality of upwardly extending support posts. A first razor blade is situated on the blade seat member with a cutting edge spaced upwardly and rearwardly of the guard surface. A plurality of perforations are formed in the first blade and the first plurality of support posts extend upwardly through the perforations. A second razor blade is positioned above the first blade in abutting engagement with the top surfaces of the first plurality of support posts. The second blade includes a cutting edge spaced upwardly and rearwardly of the cutting edge of the first blade, and a plurality of perforations formed therethrough. A cap member is positioned above the second blade, and includes a second plurality of support posts extending downwardly through the perforations in the second blade and in abutting engagement with the top surface of the first blade.

Abstract: The present invention relates to cyclic and acyclic amide derivatives of the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATTC No. 25532), to the acetates thereof and to processes for the production of the amides and their corresponding diacetates. The amide derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: A specific embodiment provides a valve structure for an oral evacuator system adapted to be connected to a source of negative pressure. The valve structure includes an elongated housing having a longitudinal bore extending through the housing, a valve seat formed by a reduced diameter portion of the bore, and a slot extending through the housing to the bore and longitudinally of the housing. A valve member is situated in the bore for abutting engagement with the valve seat to prevent passage of flowable materials therebetween. A spring is provided for biasing the valve member into abutting engagement with the valve seat, and the spring includes an offset portion extending outwardly through the slot. A manually operable member is connected to the offset spring portion for moving the offset spring portion to compress the spring and thereby move the valve member out of engagement with the valve seat to permit passage of flowable materials therebetween.

Abstract: The present invention relates to a method for reducing blood pressure in a hypertensive mammal by the administration of a novel hydroxypyrimidine of the formula: ##STR1##

Abstract: A clear gel composition containing a topically active anti-inflammatory steroid and a neomycin salt is disclosed. The clear gel composition is prepared by dissolving the steroid in a polyhydroxy alcohol/lower alcohol solvent, a major proportion of the polyhydroxy alcohol solvent being propylene glycol, and adding a hydroxycellulose ingredient; an aqueous solution of the neomycin salt is then added to the steroid formulation and, upon the addition of an alkali metal chloride salt, such as sodium chloride, a clear gel is obtained. The pH may be adjusted to 4-5. The resulting composition is indicated for the relief of corticosteroid-responsive dermatoses.

Abstract: Processes for the production of the compounds of the formula: ##STR1## are disclosed. In the above formula, R.sub.1 is aryl which may be substituted or unsubstituted; R.sub.2 is hydrogen, alkyl, aryl, aralkyl, alkoxy, halogen, cyano, nitro, trifluoromethyl and the like.These compounds are prepared by the following reaction schemes: ##STR2## These compounds are useful as anti-inflammatory agents.

Abstract: This invention relates to substituted indolobenzoxazepines which show neuroleptic activity.

Abstract: Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##STR1## In the above formula, R.sub.1 R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c] pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

Abstract: This invention relates to substituted 2-aminothiochromones of the general structure I: ##STR1## wherein R.sub.1 and R.sub.2 may be hydrogen; lower alkyl or lower alkoxy of 1 to 6 carbon atoms; or halogen such as chloro or bromo; and X may be cyano or carboxamido. The compounds are prepared using a thiosalicylic acid or a substituted thiosalicylic acid as starting material.The compounds of this invention are active in the prevention of allergic and asthmatic reactions in mammals.

Abstract: There is disclosed 2,3-dihydro-3-(2-pyridinyl)-4H-1-benzopyran-4-one N-oxides of the formula: ##STR1## in which R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy or amino; R.sub.2 is hydrogen or --CH.sub.2 OH. These compounds are indicated in the treatment of gastric ulcers.

Abstract: An apparatus comprising a sterilizing capsule for the sterilizing of soft contact lenses in an aqueous hydrogen peroxide solution is disclosed.