Patents Represented by Attorney Arthur E. Jackson

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  • Valyl tRNA synthetase from Staphylococcus aureus
    Patent number: 6090600
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: July 18, 2000
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • Topoisomerase III
    Patent number: 6025156
    Abstract: Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: February 15, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Michael N. Gwynn, Howard Kallendar, Leslie M. Palmer
  • Leucyl tRNA synthetase from staphylococcus aureus
    Patent number: 5994111
    Abstract: The invention provides novel tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: November 30, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • Polynucleotides encoding gluS polypeptides of streptococcal pneumoniae
    Patent number: 5976840
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: November 2, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Vectors carrying coding sequence for the SpsB protein of Staphylococcus aureus
    Patent number: 5977085
    Abstract: spsB polypeptides and DNA (RNA) encoding such spsB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsB for the treatment of infection, particularly bacterial infections. Antagonists against such spsB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spsB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding spsB and for detecting the polypeptide in a host.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: November 2, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Michael T. Black, Karen M. O'Dwyer
  • Arginyl tRNA synthetase from staphyloccus aureus
    Patent number: 5965416
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: October 12, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • Topoisomerase III
    Patent number: 5962303
    Abstract: Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Streptococcal Topoisomerase III and for detecting the polypeptide in a host.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: October 5, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael N. Gwynn, Howard Kallendar
  • Response regulator polynucleotides
    Patent number: 5962259
    Abstract: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: October 5, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Nicola Gail Wallis
  • Polynucleotides encoding gluS polypeptides of streptococcus pneumoniae
    Patent number: 5958734
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: September 28, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventor: Elizabeth Jane Lawlor
  • DivIB
    Patent number: 5955304
    Abstract: The invention provides DivIB polypeptides and DNA (RNA) encoding such DivIB, particularly those of S. aureus, and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such DivIB for the treatment of infection, to screen for antagonists against such DivIB, diagnostic assays for detecting disease.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: September 21, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: John Edward Hodgson, David John Payne, Stewart Campbell Pearson
  • Prolyl tRNA synthetase polynucleotides
    Patent number: 5952196
    Abstract: The invention provides proS polypeptides and DNA (RNA) encoding proS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing proS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: September 14, 1999
    Assignee: SmithKline Beecham plc
    Inventor: Elizabeth Jane Lawlor
  • Phenylalanyl-tRNA synthetase from Staphylococcus aureus
    Patent number: 5948657
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly baterial infections.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: September 7, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • DNA encoding phenylalanyl tRNA synthetase alpha sub-unit from chlamydi a trachomatis
    Patent number: 5939298
    Abstract: The invention provides pheS polypeptides and DNA (RNA) encoding pheS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pheS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: August 17, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: James R Brown, Elizabeth J Lawlor, Raymond W Reichard
  • Chlamydia trachomatis lysS polynucleotides
    Patent number: 5935816
    Abstract: The invention provides lysS polypeptides and DNA (RNA) encoding lysS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lysS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: August 10, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: James R. Brown, Elizabeth J Lawlor, Raymond W Reichard
  • Seryl tRNA synthetase from Staphylococcus aureus
    Patent number: 5932461
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: August 3, 1999
    Assignee: SmithKline Beecham, plc
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • ribA
    Patent number: 5932701
    Abstract: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: August 3, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Michael Terence Black, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Anna Lisa Kosmatka, Richard Oakley Nicholas, Leslie Marie Palmer, Lisa Kathleen Shilling, Robert King Stodola, Richard Lloyd Warren
  • IgA Fc binding protein
    Patent number: 5928895
    Abstract: The invention provides IgA Fc binding protein polypeptides and DNA (RNA) encoding IgA Fc binding protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing IgA Fc binding protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Martin Karl Russel Burnham
  • Threonyl tRNA synthetase from Staphylococcus aureus
    Patent number: 5928920
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham plc
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae
    Patent number: 5929045
    Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Gail Wallis, Joanna Lynn Fueyo, Michael Arthur Lonetto
  • Peptide release factor, prfC (RF-3), a GTP-Binding protein
    Patent number: 5919664
    Abstract: The invention provides prfC polypeptides and DNA (RNA) encoding prfC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing prfC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: July 6, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Stewart C Pearson