Patents Represented by Attorney, Agent or Law Firm Barbara V. Maurer
  • Galanthamine derivatives as acetylcholinesterase inhibitors
    Patent number: 5777108
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined within, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the compounds.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 7, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Raymond W. Kosley, Jr., Larry Davis, Veronica Taberna
  • (1H-indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
    Patent number: 5646300
    Abstract: There are disclosed neuroprotective compounds having the formula ##STR1## wherein the moieties are defined in the specification, and processes for making them.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 8, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Raymond W. Kosley, Jr., Denise M. Flanagan, Lawrence L. Martin, Peter A. Nemoto
  • Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals
    Patent number: 5620996
    Abstract: The invention relates to sulfonamidocarbonylpyridine-2-carboxesteramides and their pyridine-N-oxides according to the formula I ##STR1## Said compounds are used as pharmaceuticals against fibrotic disorders, as fibrosuppressants and as inhibitors of proline hydroxylase.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: April 15, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar G unzler-Pukall
  • Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals
    Patent number: 5610172
    Abstract: Sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation, and their use as pharmaceuticalsThe invention relates to sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides according to the formula I ##STR1## Said compounds are used as pharmaceuticals against fibrotic disorders, as fibrosuppressants and as inhibitors of proline hydroxylase and of collagen biosynthesis.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: March 11, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar G unzler-Pukall
  • Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals
    Patent number: 5607954
    Abstract: The invention relates to sulfonamido- and sulfonamido-carbonylpyridine-2-carboxa of the formula I ##STR1## and their use as pharmaceuticals, in particular against fibrotic diseases.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: March 4, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Weidmann, Martin Bickel, Volkmar G unzler-Pukall
  • (1H-indol-1-yl)-2-(amino)acetamide derivatives and preparation thereof
    Patent number: 5591866
    Abstract: There are disclosed compounds having the formula ##STR1## wherein the variables are defined in the specification, and pharmaceutically acceptable addition salts thereof, or where applicable, the optical or geometrical isomers or racemic mixtures thereof, intermediates in the process for making the compounds, a process for making the compounds and pharmaceutical compositions and method of use as neuroprotective agents.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 7, 1997
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Raymond W. Kosley, Jr., Denise M. Flanagan, Lawrence L. Martin, Peter A. Nemoto
  • Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
    Patent number: 5580982
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 3, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors
    Patent number: 5567718
    Abstract: 2,3-dihydro-1H-isoindole derivatives of the formula ##STR1## where R.sub.1 -R.sub.5 and X are defined herein which are useful as serotonin reuptake inhibitors are disclosed. As such, these compounds may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
    Type: Grant
    Filed: August 11, 1994
    Date of Patent: October 22, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gregory M. Shutske, Kevin J. Kapples
  • (1H-indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides
    Patent number: 5565579
    Abstract: There are disclosed compounds having the formula ##STR1## wherein X, Y, Z and R.sub.1 -R.sub.6 are defined in the specification and pharmaceutically acceptable addition salts thereof, or where applicable, the optical or geometrical isomers or racemic mixtures thereof, intermediates in the process for making the compounds, a process for making the compounds and pharmaceutical compositions and method of use as neuroprotective agents.
    Type: Grant
    Filed: March 25, 1994
    Date of Patent: October 15, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Raymond W. Kosley, Jr., Denise M. Flanagan, Lawrence L. Martin, Peter A. Nemoto
  • Fenbendazole formulations
    Patent number: 5538989
    Abstract: This application relates to an aqueous formulation of fenbendazole which is stable and efficacious, does not agglomerate upon standing and wherein the fenbendazole remains in suspension after standing for twenty-four hours.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: July 23, 1996
    Assignee: Hoechst-Roussel Agri-Vet Company
    Inventor: Leslie E. Kyle
  • 7-[4-(substituted amino)-2-butynl]benzo[B]pyrrolo[3,2,1-JK]-[1,4]benzodiazepin-6-ones
    Patent number: 5536717
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where the parameters X, Y, R.sub.1 and R.sub.2 are as defined in the specification which are useful as antidepressant and analgesic agents.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: July 16, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Edward J. Glamkowski, Yulin Chiang
  • Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
    Patent number: 5521320
    Abstract: This invention relates to a process of obtaining optically pure enantiomers of an alkylated oxindole selected from ##STR1## where R is methyl, ethyl or benzyl.
    Type: Grant
    Filed: May 27, 1993
    Date of Patent: May 28, 1996
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Thomas B. K. Lee, George S. K. Wong
  • Synthesis of pyridooxazinyl-indoles
    Patent number: 5519131
    Abstract: This application relates to a process for the preparation of indolylpyridooxazines of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification which comprises cyclizing compound of the formula ##STR2## in the presence of a strong base such as sodium hydride or potassium t-butoxide.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: May 21, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Richard C. Effland, Larry Davis, Gordon E. Olsen
  • Substituted aminothienopyridines, pharmaceutical composition and use
    Patent number: 5519032
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: May 21, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Richard C. Effland, Joseph T. Klein, Lawrence L. Martin
  • Substituted 1,2,3,4-tetrahydrocyclopent b!indoles, compositions and use
    Patent number: 5514700
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 7, 1996
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Helen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
  • Preparation of physostigmine carbamate derivatives from physostigmine
    Patent number: 5498726
    Abstract: This application relates to a new process for the preparation of a product of the formula ##STR1## wherein R, R.sup.1, R.sup.2, X and m are as defined within, which process comprises preparing treating a compound such as physostigmine to form eseroline which is then treated with an appropriate compound or its equivalent. Acetic acid is added to the reaction mixture after the formation of eseroline.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: March 12, 1996
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: George E. Lee, Thomas B. K. Lee, Donna M. Borek
  • Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
    Patent number: 5494908
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: February 27, 1996
    Assignee: Hoechst-Roussel Pharmaceutical Incorporated
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines
    Patent number: 5475107
    Abstract: Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines3,7-Dialkylxanthines are obtained from the corresponding 3-alkylxanthines using an alkylating agent in the presence of quaternary ammonium and/or phosphonium compounds and, where appropriate, of additional polyethers in a two-phase mixture.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: December 12, 1995
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Gerhard Korb, Hans-Wolfram Flemming
  • Process for obtaining proinsulin possessing correctly linked cystine bridges
    Patent number: 5473049
    Abstract: A process is described for obtaining proinsulin possessing correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan and chaotropic auxiliary agents and at a pH of 10 to 11, as well as its direct isolation from the reaction mixture using hydrophobic adsorber resins.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: December 5, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Obermeier, Martin Gerl, Jurgen Ludwig, Walter Sabel
  • Compounds 31668P and 31668U, a process for their production and their use
    Patent number: 5459141
    Abstract: Compounds 31668P and 31668U, a process for their production and their use.Compound 31668P and compound 31668U with the formulae ##STR1## have an antibiotic and an antitumor action.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: October 17, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laslo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Matthias Helsberg, Herbert Kogler, Michael Limbert, Dieter-Andreas Sukatsch, Ramaiyer R. Chandran, Bimal N. Ganguli