Patents Represented by Attorney, Agent or Law Firm Bernard F. Plantz
  • Patent number: 6471991
    Abstract: The present invention relates to a compressed, chewable tablet containing at least one active ingredient, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into convex-shaped tablet having a hardness of about 2 to about 11 kp/cm2 and friability less than 1%.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: October 29, 2002
    Assignee: McNeil-PPC, Inc.
    Inventors: Ronni L. Robinson, James R. Damon, James R. Mossop, Michael D. Palmer
  • Patent number: 6270790
    Abstract: The present invention relates to a compressed, chewable tablet containing at least one active ingredient, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into convex-shaped tablet having a hardness of about 2 to about 11 kp/cm2 and friability less than 1%.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: August 7, 2001
    Assignee: MxNeil-PPC, Inc.
    Inventors: Ronni L. Robinson, James R. Damon, James R. Mossop, Michael D. Palmer
  • Patent number: 6160020
    Abstract: Isolated salts of acetaminophen are disclosed. Alkali metal and alkaline-earth metal salts of acetaminophen were formed by reacting the free acid of acetaminophen with the corresponding metal hydroxide and then immediately isolating the resulting salt. These salts have been found to be more water soluble and less bitter in taste than the free acid form of acetaminophen. The isolated salts may also be combined with other active ingredients.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: December 12, 2000
    Assignee: McNeill-PPC, Inc.
    Inventors: Lena A. Ohannesian, David Nadig, John D. Higgins, III, Max Rey, Stephen A. Martellucci
  • Patent number: 5980944
    Abstract: A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of granules of diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier coat on the granules which is substantially impermeable to simethicone.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: November 9, 1999
    Assignee: McNeil-PPC, Inc.
    Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
  • Patent number: 5919481
    Abstract: The present invention relates to a substantially translucent, semi-solid fill material for a soft gelatin capsule containing a therapeutically effective amount of a pharmaceutical dissolved or suspended in the semi-solid. The semi-solid is sufficiently viscous so that it cannot be readily expelled at room temperature from the capsule with a syringe.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: July 6, 1999
    Assignee: NcNeil-PPC, Inc.
    Inventors: Sharon L. Cody, Brid T. Devlin, John Dubek, Michael R. Hoy
  • Patent number: 5916592
    Abstract: A simulated capsule-like medicament comprising a subcoating of a mixture of a water-soluble, film-forming polymer, e.g. hydroxypropylmethyl cellulose and a hydrophobic plasticizer e.g. castor oil, which promotes a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; capsule-like medicaments which are slightly bowed in shape; and a process of making such medicaments.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: June 29, 1999
    Assignee: McNeil-PPC, Inc.
    Inventors: Kishor B. Parekh, Dennis C. Wieand, Jean B. Leasure
  • Patent number: 5916590
    Abstract: The present invention relates to a substantially translucent, gel fill material for a soft gelatin capsule containing a therapeutically effective amount of a pharmaceutical dissolved or suspended in the gel. The gel is sufficiently viscous so that it cannot be expelled at room temperature from the capsule with a syringe.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: June 29, 1999
    Assignee: McNeil-PPC, Inc.
    Inventors: Sharon L. Cody, Michael R. Hoy, Edward J. Roche, Eric J. Walter
  • Patent number: 5908636
    Abstract: The present invention relates to a semi-solid fill material for a soft gelatin capsule containing a therapeutically effective amount of an antiflatulent. The semi-solid is sufficiently viscous so that it cannot be expelled readily at room temperature from the capsule with a syringe.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: June 1, 1999
    Assignee: McNeil-PPC, Inc.
    Inventors: Brid T. Devlin, Michael R. Hoy
  • Patent number: 5876759
    Abstract: The present invention relates to a compressed pharmaceutical dosage form containing pharmaceutical particles coated with a taste-masking composition, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into a dosage form, such as a tablet, having a hardness sufficient to cause the carbohydrate to disintegrate within 30 seconds after oral administration, thereby allowing the coated particles to be swallowed.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: March 2, 1999
    Assignee: McNeil-PPC, Inc.
    Inventor: Walter G. Gowan, Jr.
  • Patent number: 5840337
    Abstract: The present invention relates to gelling liquid polyethylene glycol at room temperature with calcium acetate.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: November 24, 1998
    Assignee: McNeil-PPC, Inc.
    Inventors: Sharon L. Cody, Michael R. Hoy, Eric J. Walter
  • Patent number: 5807568
    Abstract: The present invention is directed to flurbiprofen-containing compositions for topical administration comprising about 0.5 to 10% flurbiprofen; about 10 to 80% of a lower alcohol; about 0 to 25% of a glycol; about 0 to 5% of a gelling agent; an amount of a pH adjusting agent sufficient to adjust the pH of the composition to a range of from about 2 to less than 4.5; and water in an amount sufficient to make up the balance of the composition, and methods for delivering flurbiprofen-containing compositions through the skin.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: September 15, 1998
    Assignee: McNeil-PPC, Inc.
    Inventors: Sharon L. Cody, Richard D. Fegley, Michael R. Hoy
  • Patent number: 5770225
    Abstract: A simulated capsule-like medicament comprising a subcoating of a mixture of a water-soluble, film-forming polymer, e.g. hydroxypropylmethyl cellulose and a hydrophobic plasticizer, e.g. castor oil, which promotes a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; capsule-like medicaments which are slightly bowed in shape; and a process of making such medicaments.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 23, 1998
    Assignee: McNeil-PPC, Inc.
    Inventors: Kishor B. Parekh, Dennis C. Wieand, Jean B. Leasure
  • Patent number: 5716641
    Abstract: A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: February 10, 1998
    Assignee: McNeil-PPC, Inc.
    Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
  • Patent number: 5679376
    Abstract: A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 21, 1997
    Assignee: McNeil-PPC, Inc.
    Inventors: Charles A. Stevens, Michael R. Hoy, Edward J. Roche
  • Patent number: 5674522
    Abstract: The present invention relates to a beverage concentrate suitable for delivering orally administrable pharmaceutical actives. The beverage concentrate contains an instant food, the pharmaceutical active, and sweetening and flavoring agents. The concentrate produces a pleasant tasting beverage when dissolved in hot water.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: October 7, 1997
    Assignee: McNeil-PPC, Inc.
    Inventors: Manoj N. Shah, Warren L. Sunshine
  • Patent number: 5660859
    Abstract: The present invention relates to gelling liquid polyethylene glycol at room temperature with calcium acetate.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: August 26, 1997
    Assignee: McNeil-PPC, Inc.
    Inventors: Sharon L. Cody, Michael R. Hoy, Eric J. Walter
  • Patent number: 5658589
    Abstract: A simulated capsule-like medicament comprising a subcoating of a mixture of a water-soluble, film-forming polymer, e.g. hydroxypropylmethylcellulose and a hydrophobic plasticizer, e.g. castor oil, which promotes a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; capsule-like medicaments which are slightly bowed in shape; and a process of making such medicaments.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: August 19, 1997
    Assignee: McNeil-PPC, Inc.
    Inventors: Kishor B. Parekh, Dennis C. Wieand, Jean Berger Eble
  • Patent number: 5658919
    Abstract: The present invention relates to an aqueous pharmaceutical suspension composition containing suspended acetaminophen and at least one additional pharmaceutical active, a suspension system containing xanthan gum, a mixture of microcrystalline cellulose and sodium carboxymethylcellulose and an auxiliary suspending agent selected from the group consisting of hydroxyethylcellulose and a pharmaceutically acceptable salt of carboxymethylcellulose, an effective amount of a taste-masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: August 19, 1997
    Assignee: McNeil-PPC, Inc.
    Inventors: Sheila M. Ratnaraj, Warren L. Sunshine
  • Patent number: 5631026
    Abstract: The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 20, 1997
    Assignee: McNeil-PPC, Inc.
    Inventors: Douglas S. Beyerle, Gerard P. McNally
  • Patent number: 5628847
    Abstract: An improved system for applying labels to pharmaceutical vials or the like includes a heating tunnel assembly having an insulated heating chamber defined by a first stationary portion and a second removable portion, with a heater positioned within the insulated heating chamber. The assembly includes movable mounting structure for mounting the second removable portion of the insulated heating chamber for movement between a first position engaged with the first stationary portion, and a second retracted position remote from said first portion. An actuator is provided for moving the second portion of the insulated heating chamber into its engaged position, while a biasing spring resiliently biases the second removable portion of the chamber toward the retracted position. As a result, the heating tunnel assembly will automatically be opened to prevent products from overheating or burning in the event of an emergency that disables the actuator.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: May 13, 1997
    Assignee: McNeil-PPC, Inc.
    Inventor: Harry Sowden