Abstract: A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50.degree.-100.degree. C.) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.
Abstract: A system for applying a heat-shrinkable sleeve or label to a container such as a vial for pharmaceuticals includes a novel heat tunnel assembly. The heat tunnel assembly, in a preferred embodiment, includes a conveyor for moving the sleeved containers past a heat source. The conveyor has a plurality of rollers upon which the sleeved containers are supported and rotated. The rollers turn at a first rate during initial shrinkage of the sleeve, and at a second, slower, rate after the initial shrinkage has occurred to reduce distortion and unwanted displacement of the label during its application. The heat tunnel assembly also includes a system for withdrawing the heat source from the vicinity of the conveyor should unexpected circumstances arise.
Abstract: Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. ibuprofen, polyvinylpyrrolidone, sodium starch glycolate and sodium lauryl sulfate and the rotogranules are coated with hydroxyethyl cellulose or a mixture of hydroxyethyl cellulose and hydroxypropyl methylcellulose and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules in a tablet.
Abstract: The reaction products of the alpha-halogenated half esters or amides of succinic acid and thiadiazole dimercaptides as new compositions of matter and their use as lubricant additives possessing multifunctional properties such as extreme pressure, antiwear, antioxidant and anticorrosion.
Abstract: Polyolefins are stabilized against the harmful effects of U.V.-light by incorporating therein certain organosulfides. The organosulfides may be used alone or in synergistic combination with two classes of known light stabilizers, namely the benzophenones and the esters of aromatic acids.
Abstract: A penetration sensor is disclosed which contains first and second transducers sandwiched around a layer which capacitively isolates the individual transducers. This sensing arrangement allows for the operational state of the sensor to be tested by applying an interrogation signal to each of the transducers.
Abstract: Tetrahalophthalate esters are disclosed herein as flame retardant processing aids for ABS (acrylonitrile-butadienestyrene terpolymer) resins.
Abstract: An amusement device is disclosed which contains a signal generator attached to a flexible member. When the flexible member is repeatedly waved, an oscillatory electrical signal is produced by the signal generator and supplied to a sound generator which produces sound which synchronously varies with the repeated flexure of the member caused by the waving action. The sound generator produces a first tone with respect to the oscillatory electrical signal and a second tone when the frequency of the oscillatory electrical signal exceeds a predetermined value.
Abstract: A hail sensor is disclosed which contains a piezoelectric transducer positioned to produce an output signal when it is vibrated by a hailstone. In one embodiment, the transducer is mounted on a perforated member which is exposed to falling precipitation. In an alternative embodiment, the hailstone impacts a rebound surface and is deflected toward the transducer where an electrical output is produced.
Type:
Grant
Filed:
January 24, 1989
Date of Patent:
February 27, 1990
Assignee:
Pennwalt Corporation
Inventors:
John C. Henry, Kyung Tae Park, Edward Tom
Abstract: Compositions of poly(fluoroacetylene) useful for providing electrically conductive properties to plastics by a method of dehydrofluorination of saturated fluoroethylene polymers.
Abstract: The reaction products of the alpha-halogenated half esters or amides of succinic acid and thiadiazole dimercaptides as new compositions of matter and their use as lubricant additives possessing multifunctional properties such as extreme pressure, antiwear, antioxidant and anticorrosion.
Abstract: Oil soluble lubricant additives produced by the reaction of dimercapto thiadiazoles or cyanodithioimidocarbonate polymers with a polyalkenylenesuccinimide, an aliphatic carboxylic acid and a mercaptan are disclosed.
Abstract: A sensing device is disclosed which produces a response when the point of impact between an object and a member occurs at a preselected location on the member. When the member vibrates after being impacted by the object, an oscillatory electrical signal is produced by a piezoelectric sensor. Appropriate circuitry is provided for analyzing the oscillatory electrical signal and for producing a response if the object impacted the member at the preselected location. The sensing apparatus is particularly useful in athletics for determining whether a game object contacted the athletic instrument at its "sweet spot".
Abstract: The present invention discloses the use of propanone 1,3-disulfonic acid as an esterification catalyst. This catalyst has a significantly higher reaction rate when compared to conventional esterification catalysts, such as methanesulfonic acid and sulfuric acid.
Abstract: Piezoelectric polymer film, when conformably adhered to inner or outer surfaces of an inflated balloon, functions as a microphone when the pressure of sound waves causes the film to vibrate and generate an electrical signal. The film may be in the form of an helical strip, individual strips electrically serially connected, or may itself form the inflatable material. A receiving device is electrically coupled with the electrodes formed on the piezoelectric film for processing the electrical signals generated by the vibrating piezoelectric polymer film.
Abstract: A silicon-on-insulator (SOI) device is fabricated by forming at least one island of semiconductor material on a surface of an insulating material. Silicon is then formed on the areas which surround the at least one island. The silicon is oxidized to form silicon dioxide regions which surround the at least one island.