Abstract: A confectionery composition comprising: (i) an effective amount of a natural plant extract selected from tea, gold thread, honeysuckle, magnolia extracts and mixtures thereof; (ii) an oral care active selected from the group consisting of anti-calculus agents; anti-plaque agents; fluoride ion source; desensitising agents; oral malodour control agents; H2 antagonists; and mixtures thereof; (iii) less than about 10% water; and (iv) a suitable confectionery carrier material.

Abstract: The present invention relates to a non-aqueous denture adhesive composition comprising a safe and effective adhesive amount of a denture adhesive; a safe and effective amount of an anticalculus agent; and a non-aqueous denture adhesive carrier; wherein the anticalculus agent is a material effective in reducing calcium phosphate mineral deposition related to calculus formation. The present invention further relates to a method of delivering an anticalculus agent to the oral cavity and teeth, by applying the above composition to dentures, directly to the oral cavity, or applying it to both, and thereafter securing the dentures to the oral cavity.

Abstract: Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice.

Abstract: Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers.

Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.

Abstract: The present invention relates to a denture adhesive composition comprising mixed salts of an alkyl vinyl ether-maleic acid or anhydride copolymer and/or terpolymer with isobutylene wherein the mixed salt contains a cationic salt function comprising at least about 22.5% calcium cations, from about 15% to about 25% of zinc cations, of the total initial carboxyl groups reacted, the mixed salt containing from about 36% to about 50% free acid component. In addition the present invention relates to denture adhesive compositions comprising the above composition and at least one non-adhesive self-supporting layer. The present invention further relates to a method of increasing the adhesion of dentures to the oral cavity by applying the above compositions to dentures, directly to the oral cavity, palate or ridge of the oral cavity, or applying it to both, and thereafter securing the denture to the ridge or palate of the oral cavity.

Abstract: The subject invention involves compounds having structure (I): wherein each R1 is independently alkyl, aryl, or heterocycle; each R2, R4, R7, and R8 is independently hydrogen or other substituent; A is aryl or heterocycle; and pharmaceutically acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases or disorders using such compounds.

Abstract: Disclosed is a composition for delivering an oral care substance to the oral cavity, comprising: (a) an organosiloxane resin; (b) a volatile carrier capable of solubilizing the organosiloxane resin; (c) a rheology modifier; and (d) at least one oral care substance. The present invention is also directed to such compositions comprising: (a) an organosiloxane resin; (b) a fluid diorganopolysiloxane polymer; (c) a volatile carrier capable of solubilizing the organosiloxane resin and the fluid diorganopolysiloxane polymer; (d) a rheology modifier; and (e) at least one oral care substance. Further disclosed is a method of using these compositions.

Abstract: Disclosed is a composition for delivering an oral care substance to the oral cavity, comprising: (a) an organosiloxane resin; (b) a volatile carrier capable of solubilizing the organosiloxane resin; (c) a rheology modifier; and (d) at least one oral care substance. The present invention is also directed to such compositions comprising: (a) an organosiloxane resin; (b) a fluid diorganopolysiloxane polymer; (c) a volatile carrier capable of solubilizing the organosiloxane resin and the fluid diorganopolysiloxane polymer; (d) a rheology modifier; and (e) at least one oral care substance.

Abstract: The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

Abstract: The present invention relates to dual phase oral compositions providing effective antimicobial activity for reducing plaque and gingivitis. One of the phases of the dual phase composition will contain stannous. The stannous phase comprises a stannous ion source, a fluoride ion source, and a gluconate salt. The stannous phase is essentially free of either an abrasive polishing material or chloride ions. The stannous phase containing phase inhibits the formation of a stannous chloro gluconate complex. The present invention also provides a method for effective delivery of stannous-containing compositions.

Abstract: According to the present invention there is provided a visually clear, dentrifice gel comprising; a) sufficient tetrasodium pyrophosphate to provide from 0.2% to 5% pyrophosphate anion; b) a silica dental abrasive having a refractive index of from 1.445 to 1.47; c) from 0.7% to 3% sodium alkyl sulphate; and d) an aqueous liquid carrier. The gel has excellent clarity, high anticalculus efficiency and good foaming. According to a further aspect of the invention there is provided a process for making a clear dentifrice gel comprising the step of adding anhydrous tetrasodium pyrophosphate to an aqueous carrier, the gel comprising: a) a silica dental abrasive having a refractive index of from 1.445 to 1.47; and b) an aqueous liquid carrier comprising less than 27% total water. The use of anhydrous tetrasodium pyrophosphate allows greater formulation flexibility at the processing stage by freeing up water for the dissolution and/or hydration of other dentrifice components.

Abstract: The present invention relates to a method of reducing, controlling, inhibiting, preventing, protecting against, or minimizing calculus, tartar, plaque, or stain, in the oral cavity, by applying a denture adhesive composition to the oral cavity, the denture adhesive composition comprising: (a) a safe and effective adhesive amount of a denture adhesive component; and (b) a safe and effective amount of a non-aqueous denture adhesive carrier.

Abstract: The subject invention involves compounds having the structure: wherein the C&agr;—N&bgr;, C5-C6, and C6-C7 bonds are each single or double bonds, except that both C5-C6, and C6-C7 are double bonds; R1 is selected from hydrogen, alkyl, aryl, and heterocycle; R2-R15 are independently selected from hydrogen and other substituents; and pharmaceutically-acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases and disorders using such compounds.

Abstract: The present invention relates to a non-aqueous denture adhesive composition comprising a safe and effective adhesive amount of a denture adhesive; a safe and effective amount of an anticalculus agent; and a non-aqueous denture adhesive carrier; wherein the anticalculus agent is a material effective in reducing calcium phosphate mineral deposition related to calculus formation. The present invention further relates to a method of delivering an anticalculus agent to the oral cavity and teeth, by applying the above composition to dentures, directly to the oral cavity, or applying it to both, and thereafter securing the dentures to the oral cavity.

Abstract: A throat drop comprises from 60% to 95% of an edible shell and from 5% to 40% of an aqueous filling, by weight of the drop. The filling contains a throat relief agent, from 8% to 95%, by weight, water and from 0.001% to 10%, by weight, of a vesicle-forming agent which encapsulates the throat relief agents with vesicles which are dispersed within the filling. The vesicles have a number average particle size of from about 1 to about 100 &mgr;m.

Abstract: The present invention relates to a denture adhesive composition comprising mixed salts of an alkyl vinyl ether-maleic acid copolymer wherein the mixed salt contains a cationic salt function comprising from about 5% to about 50% zinc cations; from 0% to about 2.5% of a cation selected from the group consisting of iron, boron, aluminum, vanadium, chromium, manganese, nickel, copper, yttrium, titanium, and mixtures thereof; from about 30% to about 60% free acid component; an effective adhesive amount of magnesium cations; and an effective adhesive amount of a cation selected from the group consisting of calcium, strontium, and mixtures thereof; wherein the total level of magnesium, calcium and strontium is from about 5% to about 65%. In addition the present invention relates to denture adhesive compositions comprising the above composition and at least one non-adhesive self-supporting layer.

Abstract: The present invention relates to topical oral compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, lozenges (including breath mints), dental implements (such as dental floss and tape), and pet care products comprising at least a minimally effective amount of chlorite ion, wherein the pH of the final composition is greater than 7 and the composition is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing diseases and conditions of the oral cavity such as gingivitis, plaque, periodontal disease, herpetic lesions, and infections that may develop following dental procedures such as osseous surgery, tooth extraction, periodontal flap surgery, dental implantation, and scaling and root planing, in humans and other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.