Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.

Abstract: Watch movement having a display mechanism with: several rotating indicators (12, 15), for displaying a two-digit number in an aperture, cams (5, 6) arranged to control the angular position of the rotating indicator or indicators (12), selection means actuated by the crown (34) for selecting the cam acting on each indicator (12, 15).

Abstract: There is provided a method of manufacturing a heat exchanger, including a first step of mounting an end part of flat tube to a header, assembling the flat tube and fins, and sealing a part where the header and the end part is attached, and a second step of increasing an internal pressure of the flat tube to expand other part of flat tubes aside from the end parts with respect to the end part of the tube in order to make the fins and the other part of the flat tube in contact each other. According to this method of manufacturing, in the second step, the other part of the flat tube that passes through the fins is expanded, so that it is possible to mechanically join the flat tube and the fins, and a plate fin-type heat exchanger with high strength and heat exchange efficiency can be easily provided.

Abstract: A combined system and method synchronizes optical coherence tomography and acoustic radiation force for simultaneously imaging and mechanically displacing tissue in a patient as a detection and analytic tool. An endoscope is provided which has a piezoelectric element and an OCT scanner. The piezoelectric element generates the acoustic force to displace the tissue. The OCT scanner images the tissue and the system determines the mechanical displacement of the tissue. Cancer and arterial plaques can be recognized from the mechanical displacement of the tissue.

Abstract: A path-conversion valve assembly for a vacuum cleaner comprises a valve member rotatably mounted in an air path formed in a cleaner of a vacuum cleaner which includes a socket for receiving a hose nozzle, and a resilient member mounted in the air path to resiliently press the rotating valve member in an opposite direction to the rotating direction of the valve member.

Abstract: An electrical signal connection, an electrical signaling system, and a method of connecting printed circuit boards. The electrical signal connection having a first conductive via and a second conductive via disposed in a first printed circuit board. A first conductive trace with a first end and a second end has the first end electrically coupled to the first conductive via at a first distance from the top surface of the first printed circuit board. The second end of the first conductive via is electrically coupled to the second printed circuit board. A second conductive trace with a first end and a second end has the first end being electrically coupled to the second conductive via at a second distance from the top surface of the first printed circuit board. The second end being is electrically coupled to the second printed circuit board.

Abstract: A target is sensed by an antenna array having a transmitter antenna and a receiver antenna, both of which are caused to be electromagnetically coupled to the target. The antenna array is rotated, and as the array rotates, a change in at least one of the coupling between the transmitter antenna and the target and the coupling between the receiver antenna and the target is detected at multiple rotational orientations of the antenna array.

Abstract: There is provided a modular walking support system separable into two independently functioning walking supports, typically cane-like structures. Fastening elements hold the two walking supports together in a unitary walking support until two independent supports may be required by a user. The two sections may be manually separated or, optionally, a force augmenting mechanism may also be provided to facilitate separation by users having very little hand strength. The tip of the walking support remains in firm contact with the ground during both separation and reunification operation thereby providing continuous support to a user of the device. A variety of interchangeable handles, shaft portions, and tips are provided. In addition, many accessories may be provided, either within the structure or as add-on devices. The modular walking support is provided in colors, with decorations, etc. to help overcome the stigma perceived by some users arising from usage of such a device.

Abstract: A pharmaceutical composition comprising tacrolimus (FK-506) dissolved and/or dispersed in a hydrophilic or water-miscible vehicle to form a solid dispersion or solid solution at ambient temperature have improved bioavailability.

Abstract: A system and method for broadband communications over power lines has a low-voltage transformer for the house connection unit and/or the electricity distribution inside the house. The system method allow for several parallel asynchronous data communications in different sub-channels with individual transmit power in each sub-channel. Sub-channel separation uses pass-band filters with high stop-band attenuation. High data rate in each sub-channel is achieved through the use of discrete wavelet multi-tone modulation. Coarse synchronization in each sub-channel and the optimization of the coefficients of the time-domain equalizer are carried out using a training sequence.

Abstract: A method of making a multilumen catheter assembly to include a unitary portion and at least two distal end tubes extending distally from the unitary portion. The unitary portion includes an exterior having a generally circular or oval shape in cross section and includes at least two distal end tubes of generally semi-circular (or other) cross sectional shape extending longitudinally therethrough. The catheter assembly may be made by extruding a unitary tube having internal longitudinally extending lumens (of semi-circular or other shape), then splitting the tube on its distal end portion to form distal end tubes. The tubes are then ground and polished, the finished tubes retaining in combination the cross sectional shape of the unitary extrusion, or the finished tubes can each be finished to another cross sectional shape, or the finished tubes could include a combination of cross sectional shapes over their longitudinal lengths.

Abstract: A cable winding machine for winding together a multiple number of subconductors into a composite cable includes holding means for holding a first subconductor in the machine direction, and in a predetermined orientation of the first subconductor about its longitudinal axis as it moves through the machine; a first rotating member arranged and rotate the second subconductor around the first subconductor as the second subconductor moves through the machine and one or more further rotating members arranged to hold further subconductors aligned in the machine direction and in a predetermined orientation about their longitudinal axes and rotate the further subconductors around the subconductors wound with one another in the first winding stage of the machine.

Abstract: A junction for a conveyor belt that includes first and second half-junctions attachable to one end of the conveyor belt. Each of the half-junctions having substantially matching shapes that allow the half-junctions to be interlinked. The half-junctions include a flexible core, and being respectively equipped with cup inserts and bush inserts allowing the passage of an assembly mechanism. Each of the cores extend towards the inside of each half-junction forming a fold at a free edge of each of the half-junctions. The top level of the first half-junction contains the fold and in which a front edge of the bottom level has substantially the same shape as a front edge of the top level, but is shifted towards the rear at least by the distance that separates the front edge of the top level from the cup inserts that are the furthest from the front edge of the top level.

Abstract: An emergency pulmonary resuscitation device is described. The device of the present invention provides emergency breathing for use in techniques such as CPR, and is preferably capable of interaction with an automatic external defibrillator. The device is easy to operate and provides feedback so that it may be used by persons without medical training. The device also works through a simple action, making it possible for it to be inexpensively manufactured and widely disseminated.

Abstract: An active EMC filter for medical applications allows reducing the leakage current normally induced by large phase-to-ground capacitances. The filter may comprise an active shunt module or an impedance converter or a correction signal generator and is suitable both for three-phase and single-phase applications.

Abstract: Aircraft decoy arrangement and method for generating a decoy signal from an aircraft having an isolated decoy. An aircraft receiver detects a threat signal from a threat source targeting the aircraft. An aircraft signal processor produces a decoy relay signal based on the threat signal, where the decoy relay signal frequency is significantly lower than the threat signal frequency and is slowly attenuated through air, the signal processor calibrating the decoy relay signal in accordance with a received test signal to compensate for inaccuracies. An aircraft transmitter transmits the decoy relay signal and an optional reference signal to the decoy, where it is received by a decoy receiver, converted back to a decoy signal by a decoy frequency converter, and transmitted by a decoy transmitter, causing the threat source to detect the decoy signal and lock onto the decoy rather than the aircraft.

Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Abstract: The invention provides a method for molding three-dimensional products from a mass of foodstuff starting materials which are suitable for consumption, in particular a meat mass. The method comprises the steps of filling a mold cavity, which is open on one side, with the mass of foodstuff starting materials which are suitable for consumption, which mold cavity is defined by a boundary comprising walls and base, in order to mold a molded three-dimensional product, and the removal of the molded three-dimensional product from the mold cavity. In the method according to the invention, during removal the adhesion forces between the molded product and the boundary are eliminated virtually simultaneously along all the interfaces.

Abstract: An electronic assembly for housing circuit cards of different types, which communicate with one another at high speed. Circuit cards of a first type plug into a backplane side-by-side. Circuit cards of a second type are arranged perpendicularly to the circuit cards of the first type. The arrangement allows cards of the first type to communicate with cards of the second type over short distances, thus improving system throughput. It also allows cards of different types to be cooled differently, thus promoting efficient cooling.

Abstract: Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance the immune system are described.