Abstract: A method for improving mobility and/or the quality of synovial fluid of an affected articular joint, wherein the joint is associated with at least a first muscle group and at least a second muscle group each having an antagonistic relationship for effecting mobility of the joint through a range of motion when recruited by natural neural impulses. The method includes positioning at least two first electrodes proximate to the at least first muscle group, positioning at least two second electrodes proximate to the at least second muscle group, and applying motor-level electrical stimulation to the at least first and second muscle groups via the at least two first and second electrodes in a multiphasic pattern corresponding to a sequence of electromyographic outputs.

Abstract: We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2, but not TH1, cells. Here we measured cytokine expression in ex vivo TH2 cells and in a mouse model of asthma upon activation with antiCD3/28 and challenge with an NKG2A-specific agonist. We show that signaling through NKG2A modulates Th2 cell effector function. This new molecular pathway data provides a novel explanation and treatment for respiratory virus-associated asthma. RSV and hMPV suppress IFN-? and HLA-E expression and therefore decrease NKG2A signaling in activated TH2 cells. This results in a relatively robust Th2 response and an unfavorable shift in Th1/Th2 balance. The data presented here suggest that increasing signaling via the NKG2A receptor suppresses Th2 effector function and could positively impact Th1/Th2 balance in asthma.

Abstract: The present invention relates to chemical and bioanalytical sensors and sensor systems, particularly to systems incorporating a calibration device for sensors where the calibration device is comprised of an array of micromachined MEMS structures and materials for trapping and retaining calibrant or interferant materials until they are needed and released quantitatively using structure operatively associated with the array.

Abstract: A charged particle filter comprises a magnetic deflector and an outer shield. The magnetic deflector has a bore along an axis thereof passing through the deflector from a specimen end to a detector end of the deflector and through which charged particles pass when in use. The deflector is formed from one or more magnets positioned around the bore in a Halbach configuration thereby generating a relatively high magnetic field strength within the bore and a relatively low magnetic field strength outside of the deflector. The deflector has a geometry defining an outer surface and an inner surface, wherein each of the outer and inner surfaces of the deflector taper towards the axis as a respective function of distance in the specimen direction along the axis.

Abstract: An integrated system for the management of a healthcare provider is disclosed and has a scheduling module for supporting scheduling encounters with the patients, a registration component for registering the patients, an account management module for maintaining patient financial information, and a clinical module for maintaining electronic patient records. The integrated system is stored on a portable computer-readable resource and run on a processor connected to the portable computer-readable resource.

Abstract: A safety hypodermic needle and a method of using the same are disclosed. The safety needle comprises a hypodermic needle and a protective sheath molded of a flexible polymeric material. The protective sheath comprises a needle sleeve with an open central passage which houses the sharp needle point. The needle sleeve is supported on a plurality of inwardly bowed ribs in an unflexed “at rest” condition in which the needle point is retained inside the needle sleeve to prevent inadvertent needle sticks. Levers attached to the ribs are used to move the ribs from their inwardly bowed unflexed “at rest” condition to an outwardly bowed flexed condition to permit the needle to pass through the open central passage of the needle sleeve and into a patient's body. After the needle is removed from the patient's body, the ribs automatically return to the unflexed “at rest” condition without the assistance of any additional biasing or restoring means.

Abstract: Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. The process comprises of reacting 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.

Abstract: In the automation of project risk identification, various qualitative and quantitative measures are combined to report a project's risk level, areas, and mitigation in an automatic and objective manner. The software package includes a risk assessment and report framework and a risk engine, a portfolio analysis, a project plan validator, an integrated project management office toolkit and process asset library, and an integrated skills tracking, locating and availability module with a skills engine.

Abstract: The present invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wetted heparin. The inclusion of wetted heparin rather than un-wetted heparin in the solid pharmaceutical composition results in increased delivery of the heparin. Without being bound by any particular theory, applicants believe that because the polymer chain of the wetted heparin is already in an “open” form, while un-wetted heparin is not, less of the wetted heparin is broken down in the gastrointestinal tract and is more readily absorbed in the stomach.

Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

Abstract: The present invention provides pharmaceutical compositions for buccal delivery of human growth hormone (hGH) comprising a delivery agent and hGH. The compositions of the present invention provide improved delivery of hGH compared to comparable oral compositions, resulting in increased serum concentrations of hGH. The present invention further provides for methods of stimulating tissue growth in an animal by buccally co-administering hGH and a delivery agent.

Abstract: An automated small items dispensing apparatus is disclosed. In a preferred embodiment, the invention includes a networked, programmable, automatic medication items dispensing apparatus for use by individual patients who are enrolled in a medication protocol or medication therapy regimen. The device is located separate from the patient's health care provider's facility, such as in the patient's home.

Abstract: An illumination fiber optic ribbon includes optically-transmissive fibers which are adjacent to each other. At least two of the optically-transmissive fibers are twisted together to form a twisted segment. Where the two optically-transmissive fibers are not twisted forms a non-twisted segment. The twisted segments and non-twisted segments alternate along the length of the ribbon. Bends are disposed along the twisted segment and are formed by twisting adjacent optically-transmissive fibers. A light source is connected to one or both ends of the optically-transmissive fibers. The light source emits a light flux into the ribbon so that light emits from the bends in the twisted segment.

Abstract: The present invention provides a membrane, kit, and method of making a hydrophilic-hydrophobic random copolymer membrane. The hydrophilic-hydrophobic random copolymer membrane includes a hydrophilic-hydrophobic random copolymer. The hydrophilic-hydrophobic random copolymer includes one or more hydrophilic monomers having a sulfonated polyarylsulfone monomer and a second monomer and one or more hydrophobic monomers having a non-sulfonated third monomer and a fourth monomer. The sulfonated polyarylsulfone monomer introduces a sulfonate into the hydrophilic-hydrophobic random copolymer prior to polymerization.