Patents Represented by Attorney, Agent or Law Firm Bozicevic, Field, & Francis
  • Production of isoprenoids and isoprenoid precursors
    Patent number: 8257957
    Abstract: The present invention provides genetically modified host cells and use of same for producing isoprenoid compounds.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: September 4, 2012
    Assignees: The Regents of the University of California, Amyris Biotechnologies, Inc.
    Inventors: Jay D. Keasling, Farnaz Nowroozi, Douglas J. Pitera, Jennifer Anthony, Jack D. Newman, Larry Anthony
  • Multi-mode communication ingestible event markers and systems, and methods of using the same
    Patent number: 8258962
    Abstract: Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: September 4, 2012
    Assignee: Proteus Biomedical, Inc.
    Inventors: Timothy Robertson, Mark J. Zdeblick
  • Proteomic analysis of active multiple sclerosis lesions
    Patent number: 8257700
    Abstract: The invention provides methods for treating demyelinating inflammatory diseases by administering to the subject an effective amount of an agent that provides activated protein C activity, where the dose is effective to reduce the adverse clinical indicia of the disease. In some embodiments, the patient being treating is of the chronic active plaque type.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: September 4, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lawrence M. Steinman, May H. Han
  • Method and composition for crystallizing G protein-coupled receptors
    Patent number: 8260596
    Abstract: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: September 4, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Kobilka, Daniel Rosenbaum
  • LED lamp for producing biologically-corrected light
    Patent number: 8253336
    Abstract: A light-emitting diode (LED) lamp for producing a biologically-corrected light. In one embodiment, the LED lamp includes a color filter, which modifies the light produced by the lamp's LED chips, to increase spectral opponency and minimize melatonin suppression. In doing so, the lamp minimizes the biological effects that the lamp may have on a user. The LED lamp is appropriately designed to produce such biologically-correct light, while still maintaining a commercially acceptable color temperature and commercially acceptable color rending properties. Methods of manufacturing such a lamp are provided, as well as equivalent lamps and equivalent methods of manufacture.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: August 28, 2012
    Assignee: Biological Illumination, LLC
    Inventors: Fredric S. Maxik, Robert R. Soler, David E. Bartine
  • Method and apparatus for rapidly counting and identifying biological particles in a flow stream
    Patent number: 8253938
    Abstract: A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, by utilizing the technique of laser rastering. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flow cell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: August 28, 2012
    Assignee: Abbott Laboratories
    Inventors: Giacomo Vacca, Norman R. Goldblatt, Michael W. Yee
  • Method of treating multiple sclerosis with phosphocholine containing lipids
    Patent number: 8252775
    Abstract: To perform large-scale multiplex analysis of lipid-specific binding, lipid microarrays were developed. Lipids identified as disease associated, or analogs there, can be tolerogenic to patients suffering from autoimmune disease. Lipid array analysis has revealed anti-lipid antibodies in patients with immune disorders, and may contribute to the pathogenesis of disease.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: August 28, 2012
    Assignees: The Board of Trustees of the Leland Stanford Junior University, U.S. Department of Veteran Affairs
    Inventors: Jennifer L. Kanter, William H. Robinson, Lawrence Steinman
  • Microbial blend compositions and methods for their use
    Patent number: 8250806
    Abstract: Microbial blend compositions and method for their use are provided. The subject compositions comprise a plurality of distinct microbial species that all share the following characteristics: (i) are antagonistic against a plurality of microbial pathogens; (ii) are non-pathogenic towards plants and animals; (iii) are tolerant of high temperatures; (iv) grow rapidly; and (v) proliferate on a complex substrate. In many embodiments, the compositions further include a carrier, e.g., a liquid or solid carrier medium. In practicing the subject methods, the compositions are applied to at least one of soil and plant tissue, and in certain embodiments are applied in conjunction with a complex substrate. Also provided are methods of preparing the subject compositions.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: August 28, 2012
    Inventor: Thomas T. Yamashita
  • Lyotropic liquid crystal coated analyte monitoring device and methods of use
    Patent number: 8255034
    Abstract: The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: August 28, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Pawel Rowinski, Benjamin J. Feldman
  • Digital image and content display systems and methods
    Patent number: 8255495
    Abstract: Disclosed herein are systems and methods for displaying images and contextually relevant content on a digital content platform, such as a web page. In one embodiment, for example, the systems and methods include: (1) providing a publisher of the image with a reference script for publication with the image, wherein the reference script is a computer-readable instruction that causes an end-user device to call to a content server; and (2) configuring the content server to (a) receive a request for content from the end-user device, (b) identify content that is contextually relevant to the image, (c) deliver the content to the end-user device, and (d) deliver a computer-readable instruction that causes the end-user device to perform an animation that modifies the image and displays the content in a spatial relationship with respect to the image as originally published.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: August 28, 2012
    Assignee: Luminate, Inc.
    Inventor: Amy Lee
  • Tricalcium phosphate coarse particle compositions and methods for making the same
    Patent number: 8246736
    Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: August 21, 2012
    Assignee: Skeletal Kinetics, LLC
    Inventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
  • Linoleic acid active agents for enhancing probability of becoming pregnant
    Patent number: 8247450
    Abstract: The present invention is directed to a methods and compositions for enhancing the probability that a subject will become pregnant. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a linoleic acid active agent, e.g., linoleic acid, a polyunsaturated fatty acid analog thereof, etc. Also provided are kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications, including but not limited to the treatment of infertility conditions.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: August 21, 2012
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee, Albert Cha
  • Role of miRNA in T cell leukemia
    Patent number: 8247388
    Abstract: The ability of miR-181a to support active signaling between Notch and pre-TCR pathways by coordinately dampening negative regulators of these pathways allows the use of miR-181a as a therapeutic target for T-ALL.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: August 21, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chang-Zheng Chen, Tin Mao
  • Neoplasia targeting peptides and methods of using the same
    Patent number: 8247529
    Abstract: The present invention provides compositions including neoplasia targeting peptides as well as methods of using the neoplasia targeting peptides in diagnosing, detecting, treating, monitoring treatment, and analyzing cancer or cancer cells in vivo and in vitro.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: August 21, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas D. Wang, Shaoying Lu
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 8241485
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: August 14, 2012
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
  • Needleless injector drug capsule and a method for filling thereof
    Patent number: 8241243
    Abstract: A method for filling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 14, 2012
    Assignee: Zogenix, Inc.
    Inventors: Henry William, Lewis Andrew
  • Biological fuel cell and methods
    Patent number: 8241797
    Abstract: A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: August 14, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Adam Heller
  • Regenerative dot cells
    Patent number: 8241898
    Abstract: Methods and compositions are provided for the isolation, culture and use of highly regenerative somatic mammalian cells. The cells are very small, and have an undefined nuclear structure. The cells may be isolated from fetal or adult tissues, and are found in tissue including, without limitation, fetal dermal tissue, blood, and bone marrow. The cells are characterized as expressing one or more markers selected from E-cadherin, integrin ?1, CXCR4, CD90 and CD34, and may be selected on the basis of such expression patterns.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: August 14, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Wuyi Kong, Shaowei Li, Peter Lorenz
  • Needleless injector drug capsule and a method for filling thereof
    Patent number: 8241244
    Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: August 14, 2012
    Assignee: Zogenix, Inc.
    Inventors: William Henry, Andrew Lewis
  • Stereoisomers propofol therapeutic compounds
    Patent number: 8242315
    Abstract: A (+)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: August 14, 2012
    Assignee: Singature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins