Patents Represented by Attorney Carver C. Joyner

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  • Broad spectrum antibiotic complex produced by a novel micromonospora
    Patent number: 4440751
    Abstract: The novel antibiotic complex designated hazymicin consisting of eight components, is produced by a novel strain of Micromonospora herein designated Micromonospora echinospora var. challisensis SCC 1411. Also disclosed are the structures of the two components namely, Component 5 and Component 6.
    Type: Grant
    Filed: October 6, 1980
    Date of Patent: April 3, 1984
    Assignee: Schering Corporation
    Inventors: Jay A. Waitz, Joseph A. Marquez, Mahesh G. Patel, Ann C. Horan
  • (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
    Patent number: 4411906
    Abstract: Disclosed herein are (5R,6S,8R)-6-(1-hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylic acid and the metabolisable esters thereof and alkali metal salts thereof, which are potent antibacterial agents.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: October 25, 1983
    Assignee: Schering Corporation
    Inventors: Viyyoor M. Girijavallabhan, Stuart W. McCombie, Ashit K. Ganguly
  • Macrolide antibacterial AR-5 components
    Patent number: 4373095
    Abstract: Desmycinosyl derivatives of 12,13-desepoxy-12,13-dehydro antibiotic AR-5 component 1 and 12,13-desepoxy-12,13-dehydro antibiotic AR-5 component 2 are useful antibacterial agents and may be converted to other such agents by processes analogous to those generally known in the art.
    Type: Grant
    Filed: March 17, 1981
    Date of Patent: February 8, 1983
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Olga Sarre, Yi-Tsung Liu
  • 5 Phenyl-1,3-alkano-1,2,3,4,4a,9b-hexahydropyrido [4,3-b]indoles
    Patent number: 4360673
    Abstract: This invention relates to 5-phenyl-1,3-alkano-1,2,3,4,4a,9b-hexahydropyrido [4,3-b]indoles which are antidepressants useful in the treatment of mental depression.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: November 23, 1982
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Pirouz Tahbaz
  • Antibiotic 67-121, a new polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4359462
    Abstract: A microorganism of the genus Acetinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: May 14, 1980
    Date of Patent: November 16, 1982
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • (S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine
    Patent number: 4349472
    Abstract: This invention relates to esters of 7 halo-substituted 8-hydroxy-3 methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, processes for the preparation thereof, and pharmaceutical compositions containing them. The novel compounds of this invention show neuroleptic, antidepressive and antiaggressive activity.
    Type: Grant
    Filed: February 5, 1980
    Date of Patent: September 14, 1982
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei K. Chang
  • Macrolide antibiotic complex
    Patent number: 4349665
    Abstract: The AR-5-3 Complex consisting of four macrolide antibiotics is elaborated by a mutant strain of Micromonospora polytrota. The antibiotics exhibit substantial activity against gram positive bacteria in vitro and in vivo.
    Type: Grant
    Filed: June 27, 1980
    Date of Patent: September 14, 1982
    Assignee: Schering Corporation
    Inventors: Bong K. Lee, Joseph A. Marquez, J. Allan Waitz
  • Microbiological methylation of aminoglycosyl-aminoglycosides
    Patent number: 4348516
    Abstract: The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.
    Type: Grant
    Filed: June 12, 1980
    Date of Patent: September 7, 1982
    Assignee: Schering Corporation
    Inventors: Bong K. Lee, Gerald H. Wagman, Dinanath F. Rane, Joseph A. Marquez, Peter J. L. Daniels
  • Antibiotic AR-5 complex, antibiotics coproduced therewith and derivatives thereof
    Patent number: 4307085
    Abstract: The Antibiotic AR-5 complex is elaborated by a novel species of the Micromonospora; namely, Micromonospora polytrota. The microorganism also elaborates a number of minor components including the gentamicin complex and a complex of gentamicin antibiotics.
    Type: Grant
    Filed: November 9, 1979
    Date of Patent: December 22, 1981
    Assignee: Schering Corporation
    Inventors: J. Allan Waitz, Walter Reiblein, Imbi Truumees
  • Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof
    Patent number: 4292323
    Abstract: This application relates to phenyl-substituted 1,2,3,4-tetrahydrocarbazoles and to their use as anti-depressant agents useful in the treatment of mental depression of either endogenous or reactive nature.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: September 29, 1981
    Assignee: Schering Corporation
    Inventor: Pirouz Tahbaz
  • 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4284555
    Abstract: This invention relates to substituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. The compounds of this invention show neuroleptic, antidepressive and antiagressive activity.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: August 18, 1981
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei K. Chang
  • 1-N-aminohydroxyacyl derivatives of gentamicin B
    Patent number: 4283528
    Abstract: 1-N-(R-.beta.-amino-.alpha.-hydroxypropionyl) gentamicin B, 1-N-(R-.gamma.-amino-.alpha.-hydroxybutyryl) gentamicin B, 1-N-(R-.delta.-amino-.alpha.-hydroxyvaleryl) gentamicin B and the corresponding diastereoisomers derived from the respective S-aminohydroxy acids and the acid addition salts thereof exhibit substantial antibacterial activity, especially against strains of bacteria which are resistant to gentamicin B and acid addition salts thereof.
    Type: Grant
    Filed: April 24, 1979
    Date of Patent: August 11, 1981
    Assignee: Schering Corporation
    Inventors: Peter J. L. Daniels, Tattanahalli L. Nagabhushan
  • Novel 20-imino macrolide antibacterial agents
    Patent number: 4279896
    Abstract: Rosaramicin and 12,13-desepoxy-12,13-dehydrorosaramicin form novel 20-imino-20-deoxy derivatives having substantial antibacterial activity. Methods for preparing such compounds are also disclosed.
    Type: Grant
    Filed: June 23, 1980
    Date of Patent: July 21, 1981
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Yi-Tsung Liu
  • Process for preparing 1-aminonaphthyridines
    Patent number: 4260759
    Abstract: This invention relates to 1-amino naphthyridines prepared by a base-catalyzed condensation while in an aprotic solvent. In this condensation an o-alkyl aryl nitrile may be reacted either with the same or different o-alkyl aryl nitrile or with another nitrile. The 1-amino naphthyridines are useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: April 7, 1981
    Assignee: Schering-Corporation
    Inventors: Joseph Mayer, Margaret H. Sherlock
  • Method for producing rosaramicin (rosamicin)
    Patent number: 4234690
    Abstract: Rosaramicin, (also known as rosaramicin) a new broad spectrum antibiotic is described together with methods for its production via the cultivation under controlled conditions of Micromonospora rosaria, a new species of Micromonospora, and to methods for purifying and using the same. Its 2'-monoesters and its 3,2'-diesters and their acid addition salts also possess antibiotic activity.
    Type: Grant
    Filed: July 16, 1979
    Date of Patent: November 18, 1980
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Microbiological methylation of aminoglycosyl-aminoglycosides
    Patent number: 4234685
    Abstract: The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.
    Type: Grant
    Filed: June 25, 1979
    Date of Patent: November 18, 1980
    Assignee: Schering Corporation
    Inventors: Bong K. Lee, Gerald H. Wagman, Dinanath F. Rane, Joseph A. Marquez, Peter J. L. Daniels
  • Antibiotic W-10 complex, antibiotic 20561 and antibiotic 20562 as antifungal agents
    Patent number: 4232006
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotic W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: November 4, 1980
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom
    Patent number: 4230799
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotoc W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: October 28, 1980
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Antibiotic 67-121, a polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4223130
    Abstract: A microorganism of the genus Actinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: September 16, 1980
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • 1-Peptidyl derivatives of di-O-aminoglycosyl-1,3-diaminocyclitol antibacterial agents
    Patent number: 4169141
    Abstract: Disclosed herein are di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents having on the 1-N-position of the 1,3-diaminocyclitol moiety a dipeptidyl or a tripeptidyl substituent. The compounds are useful antibacterial agents, as are their non-toxic pharmaceutically acceptable acid addition salts. Also disclosed are methods for preparing such agents from di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents which are unsubstituted at the 1-N-position.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: September 25, 1979
    Assignee: Shering Corporation
    Inventors: John G. Topliss, Adriano Afonso