Patents Represented by Attorney Carver C. Joyner

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  • Process for the preparation of antibiotic W-10 complex and for the isolation of antibiotic 20561 and antibiotic 20562 therefrom
    Patent number: 4137224
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotic W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: February 9, 1977
    Date of Patent: January 30, 1979
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Trityl picolinic acid derivatives and their use as anti-acne agents
    Patent number: 4133887
    Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: January 9, 1979
    Assignee: Schering Corporation
    Inventor: Margaret H. Sherlock
  • Aminoeverninomicin and derivatives thereof
    Patent number: 4129720
    Abstract: Everninomicin B, C or D may be converted to amino derivatives by reductive means. The amino derivatives may, subsequently, be converted to novel N-acyl, N-alkyl or N,N-dialkyl derivatives. Alternatively, everninomicins B, C or D may be converted to N-acyl-N-hydroxylamino derivatives also by reductive means. The derivatives so-produced and the non-toxic pharmaceutically acceptable cationic salts thereof are novel and are antibacterial agents.
    Type: Grant
    Filed: September 16, 1977
    Date of Patent: December 12, 1978
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Viyyoor M. Girijavallabhan, Olga Sarre, Hans Reimann
  • Cyanoalkyl-5-(substituted triphenylmethyl)picolinate
    Patent number: 4127662
    Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: November 28, 1978
    Assignee: Schering Corporation
    Inventor: Margaret H. Sherlock
  • 2-Cyano-5-(substituted triphenylmethyl) pyridines
    Patent number: 4123433
    Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: October 31, 1978
    Assignee: Schering Corporation
    Inventor: Margaret H. Sherlock
  • Aminoacyl derivatives of aminoglycoside antibiotics
    Patent number: 4117221
    Abstract: Disclosed herein are novel 1-N-X-aminoglycoside anti-bacterial agents produced from antibiotics elaborated by species of the genus Micromonospora wherein X is a member selected from the group consisting of S-3-amino-2-hydroxypropionyl and S-4-amino-2-hydroxybutyryl and S-5-amino-2-hydroxypentanoyl. Also disclosed are novel intermediates in the production of the foregoing.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: September 26, 1978
    Assignee: Schering Corporation
    Inventor: Peter J. L. Daniels
  • Amino glycoside antibiotics having antiprotozoal activity
    Patent number: 4110439
    Abstract: In the fermentation production of gentamicin C a plurality of additional antibiotic compounds are obtained. Four of these compounds, gentamicin A, gentamicin B, gentamicin B.sub.1 and gentamicin X exhibit significant anti-protozoal and anthelmintic activity while gentamicin B and B.sub.1 have significant antibacterial properties with markedly reduced side effects.
    Type: Grant
    Filed: December 20, 1976
    Date of Patent: August 29, 1978
    Assignee: Schering Corporation
    Inventors: David J. Cooper, Jay A. Waitz, Mae Counelis, Jay Weinstein
  • Process for the preparation of 2,5-dideoxystreptamine and of a novel intermediate therefor
    Patent number: 4092359
    Abstract: The aminocyclitol 2,5-dideoxystreptamine may be prepared by a novel two-step synthesis from cis-4,8-dioxatricyclo [5.1.0.0.sup.3,5 ]octane. The aminocyclitol and a novel intermediate in the synthesis thereof are utilized by a Micromonospora inyoensis (M. inoyensis strain 155OF-1G NRRL 5742) for the elaboration of a novel antibacterial agent designated Mutamicin 2.
    Type: Grant
    Filed: February 15, 1974
    Date of Patent: May 30, 1978
    Assignee: Schering Corporation
    Inventors: Peter J. L. Daniels, Mohammad Mehdi Nafissi Varchei
  • Antibiotic complex from micromonospora arborensis
    Patent number: 4078056
    Abstract: Micromonospora arborensis produces a plurality of antibiotics named herein antibiotic 68-1147 complex, when cultivated under controlled aerobic conditions. Two of the antibiotics, antibiotic 68-1147 I and antibiotic 68-1147 II are described and shown to be effective antibacterial agents, especially against gram positive bacteria.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Raymond T. Testa
  • Process for the production of dihydroxyacetone
    Patent number: 4076589
    Abstract: Glycerol is efficiently converted to dihydroxyacetone by Acetobacter suboxydans at an acid pH under aerobic conditions in a medium consisting of yeast hydrolysate or fish hydrolysate, glycerol and water.
    Type: Grant
    Filed: July 17, 1975
    Date of Patent: February 28, 1978
    Assignee: Schering Corporation
    Inventor: William Charney
  • Monoesters of rosamicin for eliciting an antibacterial response
    Patent number: 4075331
    Abstract: Described herein are novel monoesters of rosamicin, also known as Antibiotic 67-694. Also described is a process for the preparation of such esters by the selective solvolysis of diester precursors. The monoesters are broad spectrum antibacterial agents but are generally more effective against gram-positive bacteria.
    Type: Grant
    Filed: January 13, 1977
    Date of Patent: February 21, 1978
    Assignee: Schering Corporation
    Inventor: Hans Reimann
  • Rosamicin derivatives and method of using same
    Patent number: 4056616
    Abstract: Rosamicin is an antibiotic elaborated by Micromonospora rosaria. The compounds described herein are antibacterial derivatives of rosamicin. Also described are processes for the preparation of these antibacterial derivatives from rosamicin.
    Type: Grant
    Filed: March 5, 1976
    Date of Patent: November 1, 1977
    Assignee: Schering Corporation
    Inventors: Hans Reimann, Robert S. Jaret, Mohammad Mehdi Nafissi-Varchei
  • Substituted aryl and aralkyl amides
    Patent number: 4053509
    Abstract: Amides having aromatic substituents of the formula: ##STR1## wherein R is an acyl radical derived from a carboxylic acid having from 3 to 20 carbon atoms, X and Y are members selected from the group consisting of hydrogen, fluoro, trifluoromethyl and hydroxy, and n is an integer selected from the group consisting of 0, 1 and 2, exhibit an effect upon the central nervous system.
    Type: Grant
    Filed: March 15, 1973
    Date of Patent: October 11, 1977
    Assignee: Schering Corporation
    Inventors: Hans-Peter Faro, Samson Symchowicz
  • Methods for the preparation of semi-synthetic aminocyclitol aminoglycoside antibiotics
    Patent number: 4049498
    Abstract: Micromonospora inyoensis strain 155OF-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, antibiotics are produced, said antibiotics being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: December 15, 1976
    Date of Patent: September 20, 1977
    Assignee: Schering Corporation
    Inventors: Marvin Joseph Weinstein, Peter John Lovell Daniels, Gerald Howard Wagman, Raymond Thomas Testa
  • Amino glycoside antibiotics having antibacterial activity
    Patent number: 4049796
    Abstract: In the fermentation production of gentamicin C a plurality of additional antibiotic compounds are obtained. Four of these compounds, gentamicin A, gentamicin B, gentamicin B.sub.1 and gentamicin X exhibit significant anti-protozoal and anthelmintic activity while gentamicin B and B.sub.1 have significant antibacterial properties with markedly reduced side effects.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: September 20, 1977
    Assignee: Schering Corporation
    Inventors: David J. Cooper, Jay Allan Waitz, Mae Counelis, Jay Weinstein
  • Trityl picolinic acid derivatives and their use as anti-acne agents
    Patent number: 4044140
    Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
    Type: Grant
    Filed: November 28, 1975
    Date of Patent: August 23, 1977
    Assignee: Schering Corporation
    Inventor: Margaret H. Sherlock
  • Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
    Patent number: 4011390
    Abstract: Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: June 5, 1974
    Date of Patent: March 8, 1977
    Assignee: Schering-Plough Corporation
    Inventors: Marvin J. Weinstein, Peter J. L. Daniels, Gerald H. Wagman, Raymond Testa
  • Antibiotic compositions and methods from micromonospora purpurea JI-20
    Patent number: 4009269
    Abstract: A mutant strain of Micromonospora purpurea herein designated M. purpurea JI-20 elaborates an antibiotic complex comprising gentamicin and at least two novel antibiotic substances namely Antibiotic JI-20A and Antibiotic JI-20B. The so-produced antibiotics have an adverse effect upon the growth of gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: February 22, 1977
    Assignee: Schering Corporation
    Inventors: Jan Ilavsky, Aris P. Bayan, William Charney, Hans Reimann
  • Antibiotic G-418 and the production thereof
    Patent number: 3997403
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: October 10, 1975
    Date of Patent: December 14, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antibiotics sisomicin and verdamicin I and complex containing same
    Patent number: 3988316
    Abstract: A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of which Verdamicin I is a novel basic antibiotic possessing a broad antibacterial spectrum. The other components have been produced previously.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: October 26, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez