Patents Represented by Attorney Charles W. Ashbrook

Find this attorney in the Justia Lawyer Directory

  • Arylthio compounds
    Patent number: 5929114
    Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N,R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
    Type: Grant
    Filed: May 15, 1997
    Date of Patent: July 27, 1999
    Assignee: Warner-Lambert Company
    Inventors: John Michael Domagala, Edward Faith Elslager, Rocco Dean Gogliotti
  • Method for treating and preventing neurodegenerative disorders by administering a thiazolidinone
    Patent number: 5912259
    Abstract: Neurodegenerative disorders, i.e., Alzheimer's disease, stroke, multiple sclerosis and head trauma are treated with 5-??{3,5-bis(1,1,-dimethylethyl)-4-hydroxyphenyl!methylene!-2-imino-4-thia zolidinone or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: June 15, 1999
    Assignee: Warner-Lambert Company
    Inventors: Richard Thomas Carroll, Jr., Richard Dennis Dyer, Lillian Jane Robichaud, Brenda DeRae Shivers
  • Isothiazolones
    Patent number: 5889034
    Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: March 30, 1999
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, John Michael Domagala, Edward Faith Elslager, Rocco Dean Gogliotti, Terri Stoeber Purchase, Joseph Peter Sanchez, Bharat Kalidas Trivedi
  • Sulfonylurea-glitazone combinations for diabetes
    Patent number: 5859037
    Abstract: Combinations of a sulfonylurea antidiabetic agent and a glitazone antidiabetic agent are useful for treating diabetes mellitus and improving glycemic control.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: January 12, 1999
    Assignee: Warner-Lambert Company
    Inventor: Randall Wayne Whitcomb
  • Sulfhydryl containing peptides for treating vascular disease
    Patent number: 5786335
    Abstract: Sulfhydryl containing peptides having the formulaX--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --Yinhibit the formation of Lp(a) and thus are useful for treating vascular diseases such as coronary heart disease, myocardial infarction, ischemic stroke, cervical atherosclerosis, cerebral infarction, and restenosis.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: July 28, 1998
    Assignee: Warner-Lambert Company
    Inventors: Wayne Livingston Cody, Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Tomi Sawyer, Drago Robert Sliskovic
  • Carboxyalkylethers, formulations, and treatment of vascular diseases
    Patent number: 5783600
    Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: July 21, 1998
    Assignee: Warner-Lambert Company
    Inventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
  • Combination chemotherapy
    Patent number: 5767110
    Abstract: Suramin in combination with a vinca alkaloid or estramustine is synergistic for treating cancer.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: June 16, 1998
    Assignee: Warner-Lambert Company
    Inventors: Wayne Daniel Klohs, Charles Dale Kowal
  • Antipsychotic method utilizing certain tetrahydrochromeno?3,4-c!pyridin-5-ones
    Patent number: 5760050
    Abstract: 1,2,3,4-Tetrahydro-chromeno?3,4-c!pyridin-5-ones of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.5 include hydrogen, alkyl, alkoxy, hydroxy, halo, nitro, amino, and trifluoromethyl; R.sub.4 is unsubstituted or substituted phenyl, pyridyl, or quinolinyl; and n is 0 to 4, are useful to treat psychosis in mammals, particularly schizophrenia.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: June 2, 1998
    Assignee: Warner-Lambert Company
    Inventors: David Thomas Connor, Steven Robert Miller, Paul Charles Unangst, Lawrence David Wise
  • Carboxyalkylethers, formulations, and treatment of vascular diseases
    Patent number: 5756544
    Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: May 26, 1998
    Assignee: Warner-Lambert Company
    Inventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
  • Biphenysulfonamide matrix metal alloproteinase inhibitors
    Patent number: 5756545
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 includes alkyl, halo, nitro, amino, cyano, alkoxy, and alkoxycarbonyl; R.sup.2 is alkyl and substituted alkyl; and R.sup.3 is OH or NHOH are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: May 26, 1998
    Assignee: Warner-Lambert Company
    Inventors: Patrick Michael O'Brien, Drago Robert Sliskovic
  • Carboxyalkylethers, formulations, and treatment of vascular diseases
    Patent number: 5750569
    Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: May 12, 1998
    Assignee: Warner-Lambert Company
    Inventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
  • Isothiazolone compounds
    Patent number: 5733921
    Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: March 31, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, John Michael Domagala, Edward Faith Elslager, Rocco Dean Gogliotti, Terri Stoeber Purchase, Joseph Peter Sanchez, Bharat Kalidas Trivedi
  • Pyrido?2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5733914
    Abstract: 6-Aryl pyrido?2,3-d!pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: March 31, 1998
    Assignee: Warner-Lambert Company
    Inventors: Clifton John Blankley, Diane Harris Boschelli, Annette Marian Doherty, James Marino Hamby, Sylvester Klutchko, Robert Lee Panek
  • 6-Aryl pyrido?2,3-d! pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5733913
    Abstract: 6-Aryl pyrido?2,3-d!pyrimidines and naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: March 31, 1998
    Inventors: Clifton John Blankley, Annette Marian Doherty, James Marino Hamby, Robert Lee Panek, Mel Conrad Schroeder, Howard Daniel Hollis Showalter, Cleo Connolly
  • Arylthio compounds
    Patent number: 5734081
    Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N,R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 31, 1998
    Assignee: Warner-Lambert Company
    Inventors: John Michael Domagala, Edward Faith Elslager, Rocco Dean Gogliotti
  • Method for inhibiting and controlling viral growth
    Patent number: 5703069
    Abstract: Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones, and diazepinones are effective therapeutic agents for treating viral diseases, including those caused by herpesvirus and HIV.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: December 30, 1997
    Assignee: Warner-Lambert Company
    Inventors: David Thomas Connor, Stephen Joseph Gracheck
  • Isothiazolones lower plasma levels of lipoprotein(a)
    Patent number: 5668162
    Abstract: Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: September 16, 1997
    Inventors: John Michael Domagala, Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Tomi Sawyer, Drago Robert Sliskovic
  • Arylthio compounds
    Patent number: 5668291
    Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N, R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 16, 1997
    Assignee: Warner-Lambert Company
    Inventors: John Michael Domagala, Edward Faith Elslager, Rocco Dean Gogliotti
  • Arylthio compounds
    Patent number: 5668178
    Abstract: Phenylthiols and dithiobisbenzamides are potent antibacterial and antiviral agents.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: September 16, 1997
    Assignee: Warner-Lambert Company
    Inventors: Edward Faith Elslager, Rocco Dean Gogliotti
  • Carboxyalkylethers, formulations, and treatment of vascular diseases
    Patent number: 5648387
    Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri