Patents Represented by Attorney Charles W. Ashbrook

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  • Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-Quinolones and naphthyridones as antibacterial agents
    Patent number: 5633264
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: May 27, 1997
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5620981
    Abstract: 6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, Diane H. Boschelli, Annette M. Doherty, James M. Hamby, Sylvester Klutchko, Robert L. Panek
  • Isothiazolones
    Patent number: 5620997
    Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, John M. Domagala, Edward F. Elslager, Rocco D. Gogliotti, Terri S. Purchase, Joseph P. Sanchez, Bharat K. Trivedi
  • Methods for inhibiting and controlling viral growth
    Patent number: 5612330
    Abstract: Benzothiophene, benzofuran and indolethiazepinones, oxazepinones, and diazepinones are effective therapeutic agents for treating viral diseases, including those caused by herpesvirus and HIV.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: March 18, 1997
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Stephen J. Gracheck
  • Combination chemotherapy
    Patent number: 5597830
    Abstract: Suramin in combination with a vinca alkaloid or estramustine is synergistic for treating cancer.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: January 28, 1997
    Assignee: Warner-Lambert Company
    Inventors: Wayne D. Klohs, Charles D. Kowal
  • PLA.sub.2 inhibitors and their use for inhibition of intestinal cholesterol absorption
    Patent number: 5578639
    Abstract: Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: November 26, 1996
    Assignee: Warner-Lambert Company
    Inventor: Reynold Homan
  • Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
    Patent number: 5571792
    Abstract: Novel inhibitors of protein farnesyltransferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: November 5, 1996
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, John C. Hodges, Michael W. Wilson
  • Treatment of prostate cancer
    Patent number: 5569667
    Abstract: Prostate cancer is treated with 5-[(2-aminoethyl)amino]-2-[2-(diethylamino)ethyl]-2H-[1]benzothiopyrano-[4 ,3,2-cd]indazol-8-ol or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: October 29, 1996
    Assignee: Warner-Lambert Company
    Inventors: William R. Grove, Wilbur R. Leopold
  • Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of HIV
    Patent number: 5565446
    Abstract: Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compounds also inhibit the activation of human immunodeficiency virus (HIV).
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 15, 1996
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
  • Individual stereosiomers of 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
    Patent number: 5563155
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: October 8, 1996
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Process for preparing an ultra-pure thrombin preparation
    Patent number: 5525498
    Abstract: An ultra-pure, clear thrombin solution having a high specific activity is described as well as a method of manufacture.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: June 11, 1996
    Assignee: Warner-Lambert Company
    Inventors: Amal Boctor, Surendra Mehta, Galen Radebaugh
  • 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
    Patent number: 5525625
    Abstract: 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran inhibits MEK and, as such, is effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: June 11, 1996
    Assignee: Warner-Lambert Company
    Inventors: Alexander J. Bridges, Alan R. Saltiel
  • Method for treating vascular proliferative disorders following balloon angioplasty
    Patent number: 5516807
    Abstract: Polyamines inhibit vascular smooth muscle proliferation and thus are useful in treating and preventing vascular proliferative disorders such as restenosis following balloon angioplasty.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: May 14, 1996
    Assignee: Warner-Lambert Company
    Inventors: Donald Hupe, Joan A. Keiser
  • Sulfonate ACAT inhibitors
    Patent number: 5510379
    Abstract: .beta.-Carboxy sulfonates of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is -O-, -S-, or -NR.sub.2 -, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: April 23, 1996
    Assignee: Warner-Lambert Company
    Inventors: Helen T. Lee, Joseph A. Picard, Drago R. Sliskovic
  • PLA.sub.2 inhibitors and their use for inhibition of intestinal cholesterol absorption
    Patent number: 5504073
    Abstract: Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: April 2, 1996
    Assignee: Warner-Lambert Company
    Inventor: Reynold Homan
  • 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
    Patent number: 5494927
    Abstract: The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: February 27, 1996
    Assignee: Warner-Lambert Company
    Inventors: Wiaczeslaw A. Cetenko, David T. Connor, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst
  • .beta.-carboxy sulfonamide ACAT inhibitors
    Patent number: 5491170
    Abstract: .beta.-Carboxy sulfonyl compounds of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 is hydrogen or alkyl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is --O--, --S--, or --NR.sub.2 --, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: February 13, 1996
    Assignee: Warner-Lambert Company
    Inventors: Helen T. Lee, Joseph A. Picard, Drago R. Sliskovic
  • Method for treating inflammatory disease in humans
    Patent number: 5489586
    Abstract: Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: February 6, 1996
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
  • Method for lowering plasma levels of lipoprotein (a)
    Patent number: 5489611
    Abstract: Retinoids are effective to lower plasma levels of Lp (a) in mammals.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: February 6, 1996
    Assignee: Warner-Lambert Company
    Inventors: Helen T. Lee, Joseph A. Picard, Randy R. Ramharack, Bruce D. Roth, Drago R. Sliskovic
  • Cytoprotection utilizing aryltriazol-3-thiones
    Patent number: 5489598
    Abstract: 5-Aryltriazol-3-thiones are useful for inhibiting adhesion of Mac-1 and thereby providing cytoprotection for diseases mediated by Mac-1 adhesion.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: February 6, 1996
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Janet S. Plummer