Patents Represented by Attorney Charles W. Ashbrook

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  • 7-substituted quinolones and naphthyridones as antibacterial agents
    Patent number: 5342844
    Abstract: 7-Substituted quinolones and naphthyridones are described as antibacterial agents as well as a process for their manufacture, compositions therefor, wherein the 7-substituent is a pyrrolidine ring substituted at the 3-position by a substituted aromatic hydrocarbon or a heteroaromatic group.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: August 30, 1994
    Assignee: Warner-Lambert Company
    Inventors: Edgardo Laborde, Mel Schroeder
  • Process for preparing chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds
    Patent number: 5342959
    Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.
    Type: Grant
    Filed: August 5, 1993
    Date of Patent: August 30, 1994
    Assignees: Warner-Lambert Company, British Tech. Group
    Inventors: Vladimir Genukh Beylin, Anthony D. Sercel, Howard D. H. Showalter, Gerald E. Adams, Edward M. Fielden, Matthew A. Naylor, Ian J. Stratford
  • 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
    Patent number: 5340815
    Abstract: The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: August 23, 1994
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Catherine R. Kostlan
  • Biphenyl oxadiazoles and thiadiazoles as angiotensin II antagonists
    Patent number: 5338737
    Abstract: Novel heterocyclic methyl derivatives of biphenyl oxadiazoles and thiadiazoles are described, as well as methods for the preparation of said derivatives and pharmaceutical compositions of the same, which are useful as antagonists of the angiotensin II enzyme and thus useful in treating hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: August 16, 1994
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Catherine R. Kostlan
  • Angiotensin II antagonists used to treat reproductive functions associated with AT.sub.2 receptors
    Patent number: 5338744
    Abstract: The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors.
    Type: Grant
    Filed: August 19, 1992
    Date of Patent: August 16, 1994
    Assignee: Warner-Lambert Company
    Inventors: David T. Dudley, John C. Hodges, Thomas A. Pugsley, Michael D. Taylor
  • Aminosulfonyl carbamates composition and method of use to treat hypercholesterolemia and atherosclerosis
    Patent number: 5336690
    Abstract: A compound of the following general formula which is useful in treating hypercholesterolemia and atherosclerosis: ##STR1## wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a heterocyclic group, or a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds and each of R.sub.2 and R.sub.3 is selected from hydrogen, provided both are not hydrogen, an aralkyl group, a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds, an w-substituted alkylC.sub.1-6, a heterocyclic group, phenyl, substituted phenyl or NR.sub.2 R.sub.3 taken together form a monocyclic heterocyclic group.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: August 9, 1994
    Assignee: Warner-Lambert Company
    Inventors: Joseph A. Picard, Drago R. Sliskovic
  • Tetrahydropyridine isoxazoline derivatives
    Patent number: 5330994
    Abstract: A novel compound of the following formulas useful in treating immune-related diseases, inflammation, stoke, epilepsy, dystonias, psychoses, anxiety, and depression: ##STR1##
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: July 19, 1994
    Assignee: Warner-Lambert Company
    Inventors: Yazhong Pei, Haile Tecle
  • R-cefuroxime axetil
    Patent number: 5063224
    Abstract: R-Cefuroxime axetil which is substantially free of the S-isomer is readily absorbed from the stomach and gastro-intestinal track of animals, and is therefore ideally suited to oral therapy of bacterial infections.
    Type: Grant
    Filed: July 9, 1990
    Date of Patent: November 5, 1991
    Assignee: Eli Lilly and Company
    Inventors: Gerold L. Mosher, Michael V. Mullen
  • N-heterocyclic benzamides
    Patent number: 4943634
    Abstract: N-Aryl benzaimides wherein the aryl group is a nitrogen containing heterocycle are useful as selective herbicidal agents. Compositions containing the novel benzamides and a herbicidal method of selective weed control are disclosed.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: July 24, 1990
    Assignee: Eli Lilly and Company
    Inventor: Kenneth W. Burow, Jr.
  • Phenethanolamines, compositions containing the same and method for effecting weight control
    Patent number: 4845127
    Abstract: Optically active N-3-(4-substituted phenyl)propyl-.beta.-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese animals utilizing optically active phenethanolamine is disclosed. Novel intermediates useful in the preparation of optically active .beta.-phenethanolamines are provided.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: July 4, 1989
    Assignee: Eli Lilly and Company
    Inventors: Jack Mills, Klaus K. Schmiegel, Walter N. Shaw
  • 6 oxo-decahydroquinolines
    Patent number: 4778894
    Abstract: Tautomeric mixtures of trans-(.+-.)-3,5-dialkyloctahydropyrazolo[3,4-g]quinoline, of trans-(.+-.)-6-alkyloctahydropyrazolo[4,3-f]quinoline, and of trans-(.+-.)-1,6-dialkyloctahydropyrazolo[4,3-f]quinoline, individual enantiomer thereof, pharmaceutically-acceptable acid addition salts thereof, and intermediates useful in the preparation thereof, useful as hypotensive agents.
    Type: Grant
    Filed: April 23, 1986
    Date of Patent: October 18, 1988
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Diane L. Huser, Richard N. Booher
  • Synthesis of nizatidine intermediate
    Patent number: 4777260
    Abstract: The present invention provides a process for preparing a novel intermediate for nizatidine.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: October 11, 1988
    Assignee: Eli Lilly and Company
    Inventors: Charles W. Ryan, Bruce A. Slomski
  • Substituted hexahydro-4H-indolo[6,5,4-cd]indoles
    Patent number: 4742075
    Abstract: There are disclosed pharmaceutical compounds of the formula ##STR1## in which R.sup.1 is an aliphatic or aromatic function, and R.sup.2 and R.sup.3 are each hydrogen, C.sub.1-4 alkyl or a protecting group; and salts thereof.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: May 3, 1988
    Assignee: Lilly Industries Limited
    Inventor: William H. Hunter
  • Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
    Patent number: 4740599
    Abstract: The present invention provides a process for preparing alkylsulfinyl 2-phenylimidazo[4,5-c]pyridines comprising reacting an N-(3-amino-4-pyridinyl)alkylthiobenzamide with an oxidizing agent in a lower alkanoic acid solvent.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: April 26, 1988
    Assignee: Eli Lilly and Company
    Inventors: Jane A. Goedde, James M. Greene
  • Growth promotion
    Patent number: 4734437
    Abstract: .beta.-Phenethanolamines are effective in promoting growth and improving feed efficiency and leanness in animals.
    Type: Grant
    Filed: May 7, 1986
    Date of Patent: March 29, 1988
    Assignee: Eli Lilly and Company
    Inventors: David B. Anderson, Klaus K. Schmiegel, Edward L. Veenhuizen
  • Soluble dobutamine salts
    Patent number: 4704407
    Abstract: Hydroxyalkanoic or alkandioic acid salts of dobutamine having desirable water solubility, useful in preparing intravenous solution for treatment of cardiogenic shock.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: November 3, 1987
    Assignee: Eli Lilly and Company
    Inventor: Eddie H. Massey
  • Octahydro-oxazolo[4,5-g]quinolines derivatives and decahydro quinoline intermediates and their use as dopamine D-2 agonists
    Patent number: 4698347
    Abstract: Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.
    Type: Grant
    Filed: December 11, 1986
    Date of Patent: October 6, 1987
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Growth promotion
    Patent number: 4690951
    Abstract: .beta.-Phenethanolamines are effective in promoting growth and improving feed efficiency and leanness in animals.
    Type: Grant
    Filed: December 19, 1985
    Date of Patent: September 1, 1987
    Assignee: Eli Lilly and Company
    Inventors: David B. Anderson, Klaus K. Schmiegel, Edward L. Veenhuizen
  • Process for the preparation of octahydro-oxazolo [4,5-G]quinolines
    Patent number: 4659832
    Abstract: Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: April 21, 1987
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • 9-aminoalkylfluorenes
    Patent number: 4658061
    Abstract: Fluorenes bearing a 9-aminoalkyl substituent are useful antiarrhythmic agents. Pharmaceutical formulations containing such compounds are provided, as well as a method of treatment.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: April 14, 1987
    Assignee: Eli Lilly and Company
    Inventors: William B. Lacefield, Richard L. Simon