Patents Represented by Attorney Charles W. Ashbrook

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  • 2-alkoxy-1-((2-trialkylaminoethoxy)phosphinyloxy)-alkenes and alkynes, hydroxy inner salts
    Patent number: 4647685
    Abstract: 2-Alkoxy C.sub.12-26 straight chain ethylenic or acetylenic hydrocarbyl hydroxy phosphonyl cholenic, useful as platelet aggregation modifiers and antitumor agents.
    Type: Grant
    Filed: April 25, 1985
    Date of Patent: March 3, 1987
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Michael L. Phillips
  • Method for improving memory
    Patent number: 4647591
    Abstract: Fluoxetine can be employed to improve memory in mammals and to treat amnesia.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: March 3, 1987
    Assignee: Eli Lilly and Company
    Inventors: Arthur Cherkin, James F. Flood, David T. Wong
  • Octa- and deca-hydroquinoline intermediates
    Patent number: 4647667
    Abstract: A 1-substituted-3-permissibly-substituted-6 (or 7)-oxodecahydroquinoline is converted to the corresponding 7 (or 6)-formyl derivative. The 6-oxo-7-formyl compound, upon treatment with hydrazine, is cyclized to a tautomeric mixture of 5-substituted-7-permissibly-substituted-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: March 3, 1987
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • 3-sulfonylamino-4-amino phenyl acyl derivatives
    Patent number: 4645861
    Abstract: A 4-acyl-o-phenylenediamine is selectively sulfonated on the amino group meta to the acyl group to provide an important intermediate for benzimidazole pharmaceuticals. Some of the intermediates are new to organic chemistry.
    Type: Grant
    Filed: April 25, 1986
    Date of Patent: February 24, 1987
    Assignee: Eli Lilly and Company
    Inventors: Charles W. Ryan, Bruce A. Slomski
  • Intermediates for anticonvulsant agents
    Patent number: 4642379
    Abstract: This invention provides certain 4-acylamino benzamide derivatives, their pharmaceutical formulations, and their use as anticonvulsant agents.
    Type: Grant
    Filed: August 30, 1985
    Date of Patent: February 10, 1987
    Assignee: Eli Lilly and Company
    Inventors: Edward E. Beedle, David W. Robertson
  • Benzamides, compositions and agricultural method
    Patent number: 4636243
    Abstract: N-Aryl benzamides wherein the aryl group is a nitrogen containing heterocycle are useful as selective herbicidal agents. Compositions containing the novel benzamides and a herbicidal method of selective weed control are disclosed.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: January 13, 1987
    Assignee: Eli Lilly and Company
    Inventor: Kenneth W. Burow, Jr.
  • 3-sulfonylamino-4-aminobenzophenone derivatives
    Patent number: 4629811
    Abstract: A process is provided which produces 3-sulfonylamino-4-aminobenzophenone intermediates useful in the regiospecific synthesis of benzimidazole antiviral agents.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: December 16, 1986
    Assignee: Eli Lilly and Company
    Inventor: Samuel J. Dominianni
  • Treatment of obesity with aryloxyphenylpropylamines
    Patent number: 4626549
    Abstract: 3-Aryloxy-3-phenylpropylamines and acid addition salts thereof are useful in blocking uptake of monoamines by brain neurons, and are thus effective in treating disorders of sleep, sexual performance, appetite, muscular function, and pituitary function.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: December 2, 1986
    Assignee: Eli Lilly and Company
    Inventors: Bryan B. Molloy, Klaus K. Schmiegel
  • Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines
    Patent number: 4626591
    Abstract: A process for preparing 1-alkyl-6-oxodecahydroquinolines in 5 steps--a quaternization, hydrogenation, two organometallic reductions and hydrolysis of the thus formed enol ether--from 6-alkyloxyquinoline and intermediates useful therein.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: December 2, 1986
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Polyhydroxybenzoic acid derivatives
    Patent number: 4623659
    Abstract: Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.
    Type: Grant
    Filed: May 23, 1983
    Date of Patent: November 18, 1986
    Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
  • Dialkylaminotetrahydroquinazoline
    Patent number: 4622398
    Abstract: 2-Permissibly-substituted-6-dialkylaminotetrahydroquinazolines, receptor agonists.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: November 11, 1986
    Assignee: Eli Lilly and Company
    Inventor: Bennett C. Laguzza
  • Novel oxiodinium and thiaiodinium compounds
    Patent number: 4613620
    Abstract: Novel oxiodinium and thiaiodinium compounds having a superior inhibitory effect against micro-organisms coupled with outstanding stability and low toxicity are described.
    Type: Grant
    Filed: February 13, 1981
    Date of Patent: September 23, 1986
    Assignee: Eli Lilly and Company
    Inventor: William N. Cannon
  • Method of treatment of estrogen deficiency disease
    Patent number: 4605649
    Abstract: 2,4-Difluoro-.beta.-estradiol, 2-fluoro-.beta.-estradiol, and related fluoro estrogens used to treat estrogen-deficiency states in human females with genetic predisposition to cancer of estrogen-sensitive tissues.
    Type: Grant
    Filed: March 28, 1984
    Date of Patent: August 12, 1986
    Inventor: Joachim G. Liehr
  • .beta.-phenethanolamine antiobesity agents
    Patent number: 4602044
    Abstract: .beta.-Phenethanolamines are useful as antiobesity agents.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: July 22, 1986
    Assignee: Eli Lilly and Company
    Inventors: Klaus K. Schmiegel, Walter N. Shaw
  • Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(.+-.) and tran(.+-.)isomers so prepared
    Patent number: 4600777
    Abstract: 1-C.sub.1-3 straight chain alkyl 7-oxodecahydroquinoline, chemical intermediates.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus, Robert D. Titus, Leland O. Weigel
  • Crystalline cephalexin hydrochloride monohydrate
    Patent number: 4600773
    Abstract: Crystalline cephalexin hydrochloride ethanol solvate converts to crystalline cephalexin hydrochloride monohydrate upon being exposed to moisture.
    Type: Grant
    Filed: December 1, 1983
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Gary L. Engel, Joseph M. Indelicato, Harry A. Rose
  • Benzonitrile and benzothiocyano intermediates
    Patent number: 4595540
    Abstract: There are described compounds of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen, C.sub.1-6 alkyl or C.sub.3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z is 1H-tetrazol-5-yl, 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation.
    Type: Grant
    Filed: October 19, 1983
    Date of Patent: June 17, 1986
    Assignee: Lilly Industries Limited
    Inventors: John Goldsworthy, Winston S. Marshall, John P. Verge
  • Pyridazinone derivatives as inotropic agents
    Patent number: 4591591
    Abstract: This invention provides for the use of certain pyridazinones as positive inotropic agents.
    Type: Grant
    Filed: March 8, 1984
    Date of Patent: May 27, 1986
    Assignee: Eli Lilly and Company
    Inventor: David W. Robertson
  • Preparation of oxazolines
    Patent number: 4587053
    Abstract: Oxazolino-azetidinones are prepared by reaction of a phosphorus compound with a 3-exomethylenecepham sulfoxide.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: May 6, 1986
    Assignee: Eli Lilly and Company
    Inventors: Robin D. G. Cooper, John M. Morin, Jr., Lynn R. Peters
  • Aurone derivatives
    Patent number: RE32196
    Abstract: Substituted aurones of formula (I): ##STR1## wherein R.sup.1, R.sup.2 R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and can each represent hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.3-8 cycloalkyl, optionally substituted phenyl, C.sub.1-6 haloalkyl, amido, amino, cyano, hydroxy, nitro, C.sub.2-4 alkenyl, carboxyl, tetrazol-5-yl and --CH.dbd.CHCOOH; orwherein R.sup.1 and R.sup.2 taken together can represent a group of formula --CH.dbd.CH--CH.dbd.CH-- provided that at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is carboxyl, tetrazol-5-yl or --CH.dbd.CHCOOH;or a pharmaceutically-acceptable salt or ester thereof, are effective in the prophylactic chemotherapy of allergic conditions such as bronchial asthma.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: July 1, 1986
    Assignee: Lilly Industries Limited
    Inventors: Stephen R. Baker, William B. Jamieson, William J. Ross