Abstract: ELP fusion proteins, multimeric ELP spider complexes formed of ELP fusion proteins, and methods of using the same. The construct may be in the form of an ELP spider structure complex including multi-leg moieties comprising ELP fusion proteins capable of forming covalent disulfide bonds. The multimeric fusion constructs may be employed in peptide production and purification and/or to enhance protelytic resistance of a protein or peptide moiety in a fusion construct, by provision of the fusion protein in an ELP spider complex.

Abstract: A system includes a graphics processing unit with a processor responsive to a debug instruction that initiates the storage of execution state information. A memory stores the execution state information. A central processing unit executes a debugging program to analyze the execution state information.

Abstract: A computer implemented method includes forming column range-bands, generating row range-bands, and establishing global range-bands in conjunction with the column range-bands and the row range-bands.

Abstract: Apparatus, system, and method for clipping graphics primitives are described. In one embodiment, a graphics processing apparatus includes a clipping engine and an output unit connected to the clipping engine. The clipping engine is configured to clip an input graphics primitive with respect to a set of clipping planes to derive spatial attributes of new vertices. The output unit is configured to identify a subset of the new vertices that defines an output graphics primitive, and the output unit is configured to derive non-spatial attributes of the subset of the new vertices to produce the output graphics primitive.

Abstract: The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

Abstract: A method of tracing processor data includes receiving a first trace stream from a first processor operating in response to a first clock and a second trace stream from a second processor operating in response to a second clock. The first trace stream is routed to a first dual-port synchronous memory in accordance with the first clock and the second trace stream is routed to a second dual-port synchronous memory in accordance with the second clock. The first trace stream and the second trace stream are delivered to a memory in accordance with a third clock.

Abstract: A semiconductor device package includes a semiconductor device mounted and electrically coupled to a substrate, a package body encapsulating the semiconductor device against a portion of an upper surface of the substrate; and an electromagnetic interference shielding layer formed over the package body and substantially enclosing the semiconductor device. The present invention further provides methods for manufacturing the semiconductor device package.

Abstract: Provided are processes for preparing a 3?-deoxypentopyranosyl oligomers with linkers for linking biomolecules. The processes can the steps of: bonding a 4?-protected-3?-deoxypentopyranosyl nucleoside to a solid support by coupling the 2?-OH group with a CPG support or other similar support with an amide linkage; deprotecting the 4?-protected-3?-deoxypentopyranosyl nucleoside at the 4? position; deprotecting the 4?-protected-3?-deoxypentopyranosyl nucleoside at the 4? position; and conjugating a linker to the free 4? position. The resulting product can be conjugated via the linker to a biomolecule. The method can include, prior to addition of the linker, reacting the 4?-OH group of the 4?-protected-3?-deoxypentopyranosyl nucleoside that is linked to the solid support with a 4?-protected-3?-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product. This step can be repeated one or more times to produce an oligomer of desired length.

Abstract: The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.

Abstract: A graphics system has parallel processing units that do not share vertex information. The graphics system constructs independent batches of work for the parallel processing units in which each batch of work has a list of vertices for a set of primitives.

Abstract: Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted risk for developing rheumatoid arthritis by correlating the parameter values with predefined risk values associated with ranges of parameter values. Parameters values that are decisive for the risk for developing rheumatoid arthritis may include serum levels of C-reactive protein, Rheumatoid factors, anti-CCP antibodies, as well as age, gender, localization of the joint complaints, length of morning stiffness, and number of tender and/or swollen joints. The method may be performed by a computer. The invention further relates to a computer, a sample analyser and a computer program product for performing the method and a data carrier with the computer program product.

Abstract: Systems and methods that determine a position value of a first object and a position value of a second object, and compare the position value of the first object with the position value of the second object to determine if the second object is in a queue with the first object are provided.

Abstract: An apparatus to manage a set of switches in a computer network is described. In particular, a computer-readable medium to direct a computer network to function in a specified manner is provided. The computer-readable medium comprises instructions to configure a first switch of a set of switches as a first master switch and instructions to identify a first plurality of switches of the set of switches that are connected to the first master switch. The first plurality of switches includes a second switch and a third switch, and the second switch can be configured as a second master switch. The computer-readable medium also comprises instructions to modify an operational parameter associated with the third switch using the first master switch.

Abstract: An authorization and authentication system utilizing a mobile communication device. The authentication and authorization system enables a trusted server, in conjunction with a user controlled mobile communication device (which has been registered with the trusted site), to authorize a transaction carried out at a transaction management system. An identity of the user is authenticated by a verification that the user is in possession of the mobile communication device. In this way, the transaction management system is able to effectuate an authorized transaction with confidence that the authorization was from the user and not a third party. In variations, the authentication is a multi-factor authentication, i.e., the user must both possess the mobile communication device and information, e.g., a password.

Abstract: The present invention pertains to modified xylanase enzymes that exhibit increased thermostability and alkalophilicity, when compared with their native counterparts. Several modified xylanases exhibiting these properties are disclosed including xylanases with at least one modification at amino acid position 10, 27, 29, 75, 104, 105, 125, 129, 132, 135, 144, 157, 161, 162 or 165, or a combination thereof. Also included within the present invention is a modified xylanase that comprises at least one substituted amino acid residue and that may be characterized as having a maximum effective temperature (MET) between about 69° C. and about 78° C., wherein the modified xylanase is a Family 11 xylanase obtained from a Trichoderma sp. The present invention also includes a modified Family 11 xylanase obtained from a Trichoderma sp. characterized as having a maximum effective pH (MEP) between 5.8 and about 7.6. Modified xylanases characterized as having a MET between about 69° C. and about 78° C.

Abstract: A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or set random pattern so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic permeable hydrogel coating. The collection region is formed as a cavity in a body molded from PDMS, which flexible body is sandwiched between a glass slide or comparable flat plate and a rigid top cap plate, both of which are pressed into abutting relation with the PDMS body by a heat-shrunk polymeric sleeve. Following cell separation and washing, cells can be released from the sequestering agents and the device centrifuged to force said cells to collect adjacent the hydrogel-coated slide or plate.

Abstract: An apparatus comprises a matrix of thermoelectric devices for applying thermal gradients across an electronic component mounted in a PCB substrate within an enclosed housing. A matrix of thermosensitive devices are placed around the perimeter of the electronic component to measure thermal gradients associated with the component. A controller controls the matrix of thermoelectric devices based on the thermal gradients measured by the matrix of thermosensitive devices with a matrix of thermocouple coefficients.

Abstract: A computer readable medium stores executable instructions to receive a Multidimensional Expressions (MDX) query. The MDX query is recursively rationalized to form a rationalized query. The rationalized query is applied to a multidimensional data source to produce query results. The query results are returned.

Abstract: The present invention provides methods for determining a level of methotrexate polyglutamates (MTXPGs) in an individual undergoing methotrexate (MTX) therapy and for optimizing dose efficacy of MTX therapy in an individual by genotyping the individual at a polymorphic site in at least one folate pathway gene (e.g., a reduced folate carrier (RFC-1) gene, a gamma glutamyl hydrolase (GGH) gene, etc.). Methods are also provided for determining a level of MTXPGs in an individual undergoing MTX therapy and for optimizing dose efficacy of MTX therapy in an individual by generating a pharmacogenetic index based upon the genotype of the individual at a polymorphic site in an RFC-1 gene and/or a GGH gene.

Abstract: A method and device for securing a removable Attached Computer Module (“ACM”) 10. ACM 10 inserts into a Computer Module Bay (“CMB”) 40 within a peripheral console to form a functional computer such as a desktop computer or portable computer. The present ACM 10 includes a locking system, which includes hardware and software 600, 700, to prevent accidental removal or theft of the ACM from the peripheral console. While ACM is in transit, further security is necessary against illegal or unauthorized use. If ACM contains confidential data, a high security method is needed to safeguard against theft.