Patents Represented by Attorney, Agent or Law Firm Cushman Darby & Cushman IP Group of Pillsbury Madison & Sutro
  • Diagnosis and treatment of infections due to Streptococci and Enterococci
    Patent number: 5861157
    Abstract: The present invention provides a purified bacterial protein expressed during infection due to streptococci or enterococci and isolated from human sera, together with immunogenic fragments, analogs, inhibitors, antibodies and antigenic fragments specific thereto. Also provided is a DNA sequence coding for a bacterial protein or an immunogenic fragment or an analogue thereof expressed during infection due to Streptococci or Enterococci, together with homologues thereof, together with vectors, probes and inhibitors therefor. Also provided is fibronectin or an immunogenic fragment thereof or an analogue thereof or an antibody thereto or an anigen binding fragment thereof when used in a method of treatment or diagnosis of the human or animal body for infection due to Streptococci or Enterococci.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: January 19, 1999
    Assignee: NeuTec Pharma plc
    Inventors: James Peter Burnie, Ruth Christine Matthews
  • Serine protease inhibitors-keto and di-keto containing ring systems
    Patent number: 5861380
    Abstract: The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: January 19, 1999
    Assignee: Cortech, Inc.
    Inventors: Albert Gyorkos, Lyle W. Spruce
  • Scintillation camera using a photomultiplier having a plurality of anodes
    Patent number: 5862061
    Abstract: A high resolution scintillation camera includes a scintillator which generates scintillation light having a light amount proportional to the energy value of incident radiation at the radiation incident position. The generated scintillation light is supplied to several of a plurality of photodetectors forming a detector array. These photodetectors output electrical signals proportional to the supplied light amounts, respectively. The output electrical signals are supplied to a selector to select a photodetector arranged at the radiation incident position and a plurality of photodetectors adjacent to this photodetector. A detection unit detects the radiation incident position on the scintillator on the basis of output signals from a plurality of segments of each photodetector selected by the selector.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: January 19, 1999
    Assignee: Hamamatsu Photonics K.K.
    Inventors: Takaji Yamashita, Tomohide Omura
  • Method and apparatus for detecting denaturation of nucleic acid
    Patent number: 5861124
    Abstract: An apparatus for detecting denaturation of a nucleic acid, including: denaturation condition controlling means for controlling condition of denaturation under which a double-stranded nucleic acid is separated into a first single-stranded nucleic acid and a second single-stranded nucleic acid; excitation light irradiation means for irradiating the double-stranded nucleic acid before denaturation, and the first single-stranded nucleic acid and second single-stranded nucleic acid after the denaturation; fluorescence detection means for detecting fluorescence emission based on the excitation light irradiation; and processing means for receiving, storing and processing a signal supplied from the fluorescence detection means.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: January 19, 1999
    Assignee: Hamamatsu Photonics KK
    Inventors: Shigeru Hosoi, Tadashi Fukami, Akihiko Tsuji, Makiko Hiyoshi
  • Aqueous .beta.2'-glycoprotein I composition
    Patent number: 5859213
    Abstract: A method for preparing an aqueous protein composition from human blood plasma, wherein the plasma undergoes a series of treatments by heating and precipitating agent to give albumin solutions containing the precipitating agent, and said precipitating agent is separated from the resulting solutions to give a crude aqueous albumin solution which is subjected to at least one liquid phase chromatography step to retain at least part of the secondary proteins other than albumin. The chromatography comprises affinity chromatography on a particulate support consisting of neutral particles loaded with at least one compound comprising sulphate groups, whereby, after the albumin solution has been fed through, the particulate affinity chromatography support is eluted by feeding through an aqueous saline solution, preferably by increasing the ionic strength, and the desired protein composition is collected by elution.
    Type: Grant
    Filed: October 23, 1995
    Date of Patent: January 12, 1999
    Inventors: Elie Stefas, Marcel Rucheton, Hubert Graafland
  • Method of manufacturing optical waveguide
    Patent number: 5858051
    Abstract: A method of manufacturing an optical waveguide comprises a first step of laminating, on one major surface of a first glass material, a second glass material to a desired thickness, the second glass material having optical characteristics different from those of the first glass material, a second step of forming the second glass material to have a desired circuit pattern, and a third step of laminating a third glass material having optical characteristics similar to those of the first glass material on an entire surface of the first glass material on which the circuit pattern is formed by the second glass material. In at least one of the first and third steps, the glass material to be laminated is laminated by coupling.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: January 12, 1999
    Assignee: Toshiba Machine Co., Ltd.
    Inventors: Yoshizo Komiyama, Isao Matsuzuki, Kazunori Urushibata, Toshihisa Kamano, Tetsuya Tanioka, Hirotaka Masaki
  • Salts of azelastine having improved solubility
    Patent number: 5859003
    Abstract: The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid or malic acid. A pharmaceutical composition may be prepared containing an azelastine salt and a pharmaceutically-acceptable carrier or diluent therefor. The pharmaceutical composition is useful in the treatment of allergies, asthma, inflammatory and psoriasis disorders and provides a cytoprotective effect.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: January 12, 1999
    Assignee: Asta Pharma Aktiengesellschaft
    Inventors: Helmut Hettche, Reinhard Muckenschnabel, Gerhard Scheffler, Ilona Fleischhauer, Wolfgang Morick
  • Plants and processes for obtaining them
    Patent number: 5859333
    Abstract: Plants with an altered starch synthesizing ability are produced by incorporating into the genome of the plant at least one donor gene encoding a starch primer. The starch primer is an enzyme capable of initiating starch synthesis, such as an amylogenin and/or glycogenin. DNA constructs encoding a starch primer are provided, particularly constructs encoding amylogenin from maize.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: January 12, 1999
    Assignees: Zeneca Limited, The University of Miami
    Inventors: Peter Lewis Keeling, Joseph Lomako, Dave Gieowar-Singh, George William Singletary, William Joseph Whelan
  • Soft-milling wheats which produce dough with low elasticity
    Patent number: 5859315
    Abstract: A soft-milling wheat which produces dough having exceptionally low visco-elasticity is provided by breeding from a variety having Glu-D1 double null trait, such as the landrace "Nap Hal". The wheat can be used in the manufacture of biscuits and wafers without the need to treat the flour with agents such as sodium metabisulphite.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: January 12, 1999
    Assignee: Unilever Patent Holdings BV
    Inventor: Peter Ivor Payne
  • Process for preparing alkanones and alkanols
    Patent number: 5859301
    Abstract: An improved process for preparing alkanones and alkanols by oxidizing an alkane and/or alkene having from 3 to 30 carbon atoms to form an oxidation mixture containing alkylhydroperoxide. A basic, aqueous solution is added to the oxidation mixture so that a separate basic water phase with a pH higher than 8.5 is formed. The alkylhydroperoxide is then decomposed in the presence of a heterogeneous catalyst which contains a metal compound immobilized on a carrier material. The metal of the catalyst is selected from the group consisting of Mn, Fe, Co, Ni, and Cu. The carrier material is stable in the presence of the separate basic water phase.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: January 12, 1999
    Assignee: DSM N.V.
    Inventors: Ubaldus F. Kragten, Henricus A. C. Baur
  • Process for the production of a .beta.-amino alcohol
    Patent number: 5859248
    Abstract: A process for producing 2-?3(S)-amino-2-(R)-hydroxyl-4-phenyl butyl!-N-tert,butyl decahydro-(4aS,8aS)-isoquinoline-e(S)-carboxamide of the formula (I) via 3(S)-?lower alkoxy carbonyl amino, phenoxy carbonyl amino or benzyl oxycarbonyl amino!-2-hydroxy-4-phenyl butyric acid and process for producing said acid.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: January 12, 1999
    Assignees: F. Hoffman-La Roche AG, Degussa Aktiengesellschaft
    Inventors: Matthias Kottenhahn, Karlheinz Drauz, Hans Hilpert
  • Homing process
    Patent number: 5857644
    Abstract: The invention describes a target approach procedure for a guided, mobile missile for use against ground targets, particularly bridges, roads, rail junctions, hangars, shelters, command posts, harbor installations as well as ships, in which the missile is released at a great distance from the target and flies automatically to the target, with guidance by parallel lines that characterize ground structures, and hits it from the most favorable approach direction.
    Type: Grant
    Filed: May 13, 1988
    Date of Patent: January 12, 1999
    Inventor: Manfred Kusters
  • Process for the preparation of triazolinone herbicides
    Patent number: 5856495
    Abstract: A process for the preparation of substituted 1,2,4-triazoline-3(2H)-ones of general formula (I) ##STR1## by reacting an amide of general formula (IV) ##STR2## with phosgen or thiophosgen or a phosgen substitute or thiophosgen substitute to a compound of general formula V ##STR3## and subsequent reaction of (V) with a compound of general formula (VI) or of an acid addition salt of (VI)Q--NH--NH--CO--R.sup.26 (VI)to compounds of general formula (I).Compounds of general formula (I) can be used as herbicides.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: January 5, 1999
    Assignee: Degussa Aktiengesellschaft
    Inventors: Christoph Weckbecker, Karlboing Drauz
  • Inhibition of farnesyltransferase
    Patent number: 5856310
    Abstract: Peptidomimetics of the formula C-AMBA-X where C is cysteine, X is, for example, methionine or phenylalanine and AMBA is a hydrophobic spacer, notably 3-aminomethylbenzoic acid. These compounds are effective inhibitors of p21ras farnesyltransferase. Other modifications including alternative spacers for AMBA, and replacement of the A.sub.1 A.sub.2 X component of known CA.sub.1 A.sub.2 X tetrapeptides by a non-peptide aryl or heterocyclic component are also disclosed as are various phosphorylated and arylated derivatives of peptides and peptidomimetics. Pro-drugs made by functionalizing terminal amino and carboxylic acid groups of peptides and peptidomimetics are also disclosed. Such functionalized derivatives demonstrate increased cell uptake. Other structural modifications are also referred to.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 5, 1999
    Assignee: University of Pittsburgh
    Inventors: Said Sebti, Andrew Hamilton, Churl Min Seong
  • Motor vehicle frame assembly and method of forming the same
    Patent number: 5855394
    Abstract: A frame assembly for a motor vehicle and method of manufacturing the same. The method includes the steps of: forming a rearward frame module, forming a forward frame module, and forming a central frame module including a pair of longitudinal central frame siderails.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: January 5, 1999
    Assignee: Cosma International Inc.
    Inventors: Frank A. Horton, Kenneth B. Jacobs, Jason D. Jacobs, Howard A. Mayo, III
  • Anellated (oxa)hydantoins and their use as herbicides
    Patent number: 5856478
    Abstract: The invention relates to new anellated (oxa) hydantoins, and herbicidal compositions containing same. The invention also relates to methods for controlling noxious plants using the anellated (oxa) hydantoins of the invention.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: January 5, 1999
    Assignee: Degussa Aktiengesellschaft
    Inventors: Matthias Schafer, Helmut Baier, Karlheinz Drauz, Hans-Peter Krimmer, Sabine Landmann
  • Liquid crystal display and manufacturing method therefor
    Patent number: 5853822
    Abstract: A liquid crystal display and a manufacturing method thereof are provided. The liquid crystal display includes upper and lower substrates, electrodes on each of the upper and lower substrates such that the electrodes are facing each other, a first alignment layer formed on the upper and lower substrates and formed of a material which aligns perpendicular to a rubbing direction, and a second alignment layer pattern formed on the first alignment layer and formed of a material which aligns parallel to the rubbing direction. The method for manufacturing the liquid crystal display involves a process where pixels are divided into two halves or in single units, and then each pixel having different aligning directions can be performed through one rubbing step, so that the process is simplified and damage to the surfaces of alignment layers is reduced. Thus, the angle of visibility and display quality are enhanced.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: December 29, 1998
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Jae-jin Lyu
  • Method of manufacturing double-chambered infusion bags by folding
    Patent number: 5852917
    Abstract: A tubular blank of filter paper containing measured and separate quantities of tea, or a similar infusionable substance, is pleated and folded so as to obtain a bag with two envelopes by a method that includes the steps of advancing blanks singly and in succession along a feed direction tangential to an indexing wheel with radial grippers, taking up each blank in a position above three bearing elements ordered along the feed direction, forming a pleat in an intermediate portion of the blank, then pinching the two ends of the blank by use of movable pressure elements interacting with two of the bearing elements so as to prevent the escape of the contents from the envelopes while at the same time drawing the tubular blank toward the wheel to bring the two envelopes together and give the filter bag its final shape.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: December 29, 1998
    Assignee: I.M.A. Industria Machine Automatiche S.p.A.
    Inventor: Andrea Romagnoli
  • Process for making lithographic printing plate
    Patent number: 5853950
    Abstract: Disclosed is a process for making a lithographic printing plate by subjecting a lithographic printing material having physical development nuclei between an aluminum support and a silver halide emulsion layer to exposure and then processing the lithographic printing material at least with a developing solution and a water washing solution in this order, which comprises performing the processing(s) with the developing solution and/or the water washing solution by using the developing solution and/or the water washing solution containing an organic compound which coagulates gelatin.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: December 29, 1998
    Assignee: Mitsubishi Paper Mills Limited
    Inventors: Toshiro Kondo, Makiko Oko, Yutaka Araki, Hajime Fujioka
  • Maize acetyl CoA carboxylase encoding DNA clones
    Patent number: 5854420
    Abstract: Clones are disclosed comprising at least part of a DNA sequence of a gene encoding maize acetyl CoA carboxylase, or a sequence showing substantial homology therewith, flanked by heterologous DNA. DNA from such clones may be used to isolate similar sequences in other plants. Such sequences may be used to transform plants to give a variety of useful effects, including resistance to herbicides such as fluazifop, and modified oil-bearing properties.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: December 29, 1998
    Assignees: Zeneca Limited, ICI Australia Operations Proprietary Limited
    Inventors: Anthony Richard Ashton, Colin Leslie Dow Jenkins, Paul Raymond Whitfeld