Patents Represented by Attorney Dale Lovercheck

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  • Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
    Patent number: 4252802
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## or ##STR3## R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or methyl;R.sub.3 is hydrogen, lower alkyl or lower alkylphenyl;R.sub.4 is hydrogen, --OCONH.sub.2, ##STR4## R.sub.7 is hydrogen or lower alkyl; R.sub.8 is hydrogen or --CONH.sub.2 ;R.sub.9 is hydrogen, lower alkyl, ##STR5## or --(CH.sub.2).sub.p --N--(lower alkyl).sub.2 ; R.sub.10 is hydrogen or lower alkyl;R.sub.11 is hydrogen, sodium or potassium;n is 1, 2, 3 or 4;m is 0, 1 or 2;p is 1, 2, 3 or 4.
    Type: Grant
    Filed: March 13, 1980
    Date of Patent: February 24, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hermann Breuer
  • Process for chemically removing the acyl sidechain from cephalosporins and penicillins
    Patent number: 4252973
    Abstract: A process for removing the acyl sidechain from penicillins and cephalosporins which comprises chlorinating the acyl compound and treating the resulting iminochloride with an o-aminothiophenol to obtain the corresponding 6.beta.-aminopenicillin or 7.beta.-aminocephalosporin.
    Type: Grant
    Filed: July 6, 1979
    Date of Patent: February 24, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Christopher M. Cimarusti
  • 8H-Pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine
    Patent number: 4233300
    Abstract: New derivatives of 8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: November 11, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Phthalidyl esters of the acetone adduct of epicillin
    Patent number: 4206218
    Abstract: Penicillin esters and their acid addition salts of the formula ##STR1## wherein X is hydrogen, methyl, methoxy, chloro, or bromo and n is an integer from 1 to 3 provided that n is 2 or 3 only when X is hydrogen or methoxy; are disclosed. Upon oral administration, these esters provide improved absorption and result in high concentrations of the antibacterially active parent penicillin in the blood, tissues and urine.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William E. Brown, Christopher M. Cimarusti
  • 6.alpha.-Bromopenicillanic acid sulfone
    Patent number: 4203993
    Abstract: (2S,5R,6S)-6.alpha.-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept ane-2-carboxylic acid, S,S-dioxide, physiologically acceptable salts thereof and readily hydrolyzable ester thereof inhibit the action of the .beta.-lactamase enzyme RTEM.
    Type: Grant
    Filed: December 11, 1978
    Date of Patent: May 20, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Eric M. Gordon
  • .beta.-Bromopenicillanic acid sulfone
    Patent number: 4203992
    Abstract: (2S,5R,6S)-6.beta.-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hepta ne-2-carboxylic acid, S,S-dioxide, physiologically acceptable salts thereof and readily hydrolyzable ester thereof inhibit the action of the .beta.-lactamase enzyme RTEM.
    Type: Grant
    Filed: December 11, 1978
    Date of Patent: May 20, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, William H. Koster
  • 8H-Pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine
    Patent number: 4202899
    Abstract: New derivatives of 8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]-pyrido[3,4-e]pyrimidine have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: May 13, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Imidazolylethoxy derivatives of pyridin-5-methanols
    Patent number: 4191831
    Abstract: Imidazolylethoxy derivatives of pyridin-5-methanols having the general formula ##STR1## and their acid addition salts are useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: October 25, 1978
    Date of Patent: March 4, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Hans Hoehn