Patents Represented by Attorney Dara L. Dinner

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  • Substituted imidazoles having anti-cancer and cytokine inhibitory activity
    Patent number: 6548520
    Abstract: The present invention is related to novel 2-alkyl substituted imidazoles of formula (I) useful for the treatment of CSBP kinase mediated diseases.
    Type: Grant
    Filed: March 3, 2001
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Susan B. Dillon, Sandra D. Griego, Dennis Lee
  • Pharmaceutical formulations comprised of amoxicillin in combination with clavulanic acid
    Patent number: 6544558
    Abstract: Syrup formulations comprising water and compacted granulates which are mixture of amoxycillin and clavulanic acid, together with an intra-granular disintegrant.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: April 8, 2003
    Assignee: Labratorios Beecham SA
    Inventors: Luis Carvajal Martin, Juan Dedios Romero
  • Treatment and compounds
    Patent number: 6531600
    Abstract: A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): or if appropriate a pharmaceutically acceptable salt thereof, wherein R1 and R2 each independently represent alkyl or a moiety of formula (a): —(CH2)m−A   (a) wherein m represents zero or an integer 1, 2 or 3; A represents a substituted or unsubstituted cyclic hydrocarbon radical; and R3 represents a halogen atom, a nitro group, or a group −NR4R5 wherein R4 and R5 each independently represents hydrogen, alkyl or alkylcarbonyl or R4 and R5 together with the nitrogen to which they are attached forming an optionally substituted, heterocyclic group; certain novel compounds falling within formula (I) and compositions comprising such compounds.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: March 11, 2003
    Assignee: Beecham Group p.l.c.
    Inventors: Barbara Ann Spicer, Harry Smith, Harald Maschler
  • Pyrimidine compounds useful in treating cytokine mediated diseases
    Patent number: 6528512
    Abstract: This invention relates to the novel amino substituted pyrimidine compounds of Formulas (I), (II) and (III), and pharmaceutical compositions comprising a compound of these Formulas and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting CSBP kinase and cytokines mediated by this kinase, for the treatment of cytokine mediated diseases, in mammals, by administration of a compound of Formula (I), (II) or (III).
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: March 4, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Timothy F. Gallagher, Susan M. Thompson
  • Formulation
    Patent number: 6515008
    Abstract: The present invention is directed to a novel pharmaceutical composition of polymorph B which has been found to be stable and palatable for long term commercial usage.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: February 4, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Antonio S. Tiongson, Chungbin Kim
  • Stable, optically clear compositions
    Patent number: 6509044
    Abstract: A process for preparing an aqueous composition for the preparation of optically clear products, especially beverages, having enhanced stability in syrup and bioavailability for human or animal healthcare. The compositions include an oil soluble ingredient and a primary and a secondary surfactant which match the fatty acid profile of the oil soluble ingredient and follow specific ratios of oil soluble ingredient to emulsifier and specific ratios of primary to cosurfactant.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: January 21, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Maarten Van Den Braak, Andrew Symonds, Michael Anthony Ford
  • Substituted imidazole compounds
    Patent number: 6489325
    Abstract: The present invention relates to novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as CSBP/p38 inhibitors.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: December 3, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ralph F. Hall
  • Process for manufacturing bite-dispersion tablets
    Patent number: 6475510
    Abstract: This invention relates to a method for the manufacture of Bite-dispersion tablets which disperse easily and quickly in the oral cavity, after a gentle bite, without the aid of water, and if necessary includes masking the bitter taste of medicaments. The process comprises preparing a dry granulation of one or more of medicaments blended with suitable excipients, flavors and a combination of a waxy material and phospholipid (BMI-60) or an intense sweetener derived from fruit flavonoids (Neohesperidine) for taste-masking and compressing into tablets which can be packaged in bottles or blisters using conventional equipment.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: November 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Gopadi M. Venkatesh, Nageswara R. Palepu
  • Beta lactams as antiproliferative agents
    Patent number: 6451785
    Abstract: A method of inhibiting or reducing cell proliferation in a human or mammal is disclosed. This method involves administering to a human or mammal an effective amount of CoA-independent transacylase inhibiting amount of a compound of the formula disclosed in the specification.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: September 17, 2002
    Assignees: SmithKline Beecham Corporation, Wake Forest University
    Inventors: James David Winkler, Floyd Harold Chilton, III
  • Effervescent laxatives
    Patent number: 6444198
    Abstract: The present invention is directed to a novel osmotic/effervescent system for the treatment of constipation and fecal impaction in a human or mammal in need thereof.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: September 3, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Bruce P. Daggy, Kenneth G. Mandel
  • IL-8 receptor antagonists
    Patent number: 6440993
    Abstract: A compound of the formula: wherein R1 and R1 and m are as defined in the specification.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: August 27, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 6436927
    Abstract: The present invention involves certain 8-ureido and 8-thioureido, 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: August 20, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Hong Nie, Katherine L. Widdowson
  • 4,5-disubstituted imidazole compounds
    Patent number: 6414150
    Abstract: The present invention is directed to novel 4,5-disubstituted imidazole compounds, and compositions for use in therapy as an anti-inflammatory agent, and as an inhibitor of cytokine p38/MAP kinase mediated diseases.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: July 2, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Jeffrey C. Boehm
  • Sulfonyl isatin compounds and methods of blocking apoptosis therewith
    Patent number: 6403792
    Abstract: The present invention is to novel sulfonyl isatin compounds of Formula (I), their pharmaceutical compositions, and the novel inhibition of caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: June 11, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis Lee, Scott Allen Long
  • Treatment for CNS injuries
    Patent number: 6387898
    Abstract: This invention relates to a novel use of imidazole compounds in the treatment of CNS injuries.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: May 14, 2002
    Assignee: Smithkline Beecham Corporation
    Inventor: Giora Z. Feuerstein
  • Solid composition for reducing tooth erosion
    Patent number: 6383473
    Abstract: Acidic oral compositions having reduced tooth erosion characteristics, especially acid beverages such as fruit juice drink concentrates, or oral healthcare products such as mouthwashes, are prepared by adding a calcium compound to the acid composition so that the mol ratio of calcium to acid ranges from 0.3 to 0.8, and the pH of the composition, if necessary after adjustment with an alkali, is from 3.5 to 4.5.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: May 7, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventor: David Myatt Parker
  • Rapidly disintegrating methylcellulose tablets
    Patent number: 6372253
    Abstract: The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP disintegration standards in 0.1N hydrochloric acid as well as water.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: April 16, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Bruce Daggy, Naresh I Mehta, Priyashri Nayak
  • Use of CSAID™ compounds as inhibitors of angiogenesis
    Patent number: 6372741
    Abstract: The present invention is to the novel use of a cytokine inhibitor, which cytokine is inhibited by the inhibition of the kinase CSBP/p38/RK, for the treatment of chronic diseases which are caused by excessive, undesired or inappropriate angiogenesis.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: April 16, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jeffrey R. Jackson, James D. Winkler
  • Process of making an aqueous calcium carbonate suspension
    Patent number: 6368638
    Abstract: The present invention relates to a high dosage calcium carbonate aqueous antacid pharmaceutical suspension for oral use, and methods of preparation.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: April 9, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Antonio Tiongson
  • Amino substituted pyrimidine containing compounds
    Patent number: 6369068
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: April 9, 2002
    Assignee: Smithkline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Irennegbe Kelly Osifo, Jeffrey Charles Boehm