Patents Represented by Attorney Dara L. Dinner

Find this attorney in the Justia Lawyer Directory

  • Therapeutic effervescent compositions
    Patent number: 6274172
    Abstract: Granulates comprising an effervescent couple of anhydrous powdered monosodium citrate and powdered sodium bicarbonate and prepared using a roller compactor are formulated into pharmaceutical compositions.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: August 14, 2001
    Assignee: SmithKline Beecham Laboratoires Pharmaceutiques
    Inventor: Jacky Andre Gustave Mention
  • IL-8 receptor antagonists
    Patent number: 6271261
    Abstract: Novel IL-8 receptor antagonists and methods of using them are provided.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: August 7, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Katherine L Widdowson
  • Compounds
    Patent number: 6268370
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Cancer treatments
    Patent number: 6268156
    Abstract: The present invention is to a method of treating cancer in patients in need thereof with an effective amount of cimetidine. Cimetidine has been found to inhibit the expression of E-selectin, the ligands of sialyl Lewis X and sialyl Lewis A antigen-bearing cancer cells are incapable of attaching to a vascular wall. The present invention has found that cimetidine inhibits metastasis in patients whose specimens stained strongly for sialyl Lewis X and sialyl Lewis A antigens.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Seiyaku K.K.
    Inventors: Sumio Matsumoto, Kenichi Kobayashi, Takashi Okamoto
  • IL-8 receptor antagonists
    Patent number: 6262113
    Abstract: The present invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease states mediated by the chemokine Interleukin-8 (IL-8).
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine Louisa Widdowson, Daniel Frank Veber, Anthony Joseph Jurewicz, Robert Philip Hertzberg, Melvin Clarence Rutledge, Jr.
  • Synthesis of intermediate compounds for 4-adyl-5-pyrimidine imidazole substituted derivatives
    Patent number: 6255491
    Abstract: The present invention relates to a method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a cycloaddition reaction.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Cycloalkyl substituted imidazoles
    Patent number: 6251914
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Jeffrey Charles Boehm, Ravi Shanker Garigipati, Margaret Sorenson
  • Stable, optically clear compositions
    Patent number: 6251441
    Abstract: Stable aqueous compositions of biologically active oils for the preparation of optically clear products for use in human or animal healthcare, for example beverages, are prepared.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Maarten Van Den Braak, Andrew Symonds, Michael Anthony Ford
  • Desiccant-containing stopper
    Patent number: 6247604
    Abstract: A container having a closure comprising a closure wall having a puncturable region in communication with the interior of the vessel, and having on an inwardly facing region of the closure wall a desiccant material separated from the interior of the vessel by a semi-permeable membrane which permits transmission of water vapor therethrough but is substantially impermeable to liquid water.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Charles Bernard Taskis, Paul John Whatmore
  • Spherical pharmaceutical granules comprising microcrystalline cellulose and a process for their production
    Patent number: 6242008
    Abstract: A high speed agitation granulator method of preparing a substantially spherical granule for pharmaceutical use comprising a medicament for pharmaceutical use, wherein the medicament has an aqueous solubility of 0.01 to 0.30 g/ml, which method comprises introducing a mixture of medicament and excipients comprising at least 5% crystalline cellulose into the granulator and spraying on water or a mixture of ethanol and water as binder solution; a substantially spherical granule for pharmaceutical use comprising famciclovir and 5% or more crystalline cellulose, together with an optional coating; and a sachet containing a unit dose of famciclovir in the form of such granules.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham Seiyaku K.K.
    Inventors: Hidero Akiyama, Zene Matsumoto, Takashi Ueno
  • Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
    Patent number: 6239279
    Abstract: The present invention relates to a novel method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a novel cycloaddition reaction.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Treatment for CNS injuries
    Patent number: 6235760
    Abstract: The present invention is directed to the use of 2,4,5-trisubstituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Giora Z. Feuerstein
  • Nozzle
    Patent number: 6235008
    Abstract: The invention relates to a novel douche nozzle suitable for vaginally administering a douche fluid.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Bert D. Heinzelman, Theresa C. Desantis, Susan M. Clement, Robert W. Pritchard, Joseph A. Matthias, Jeffrey A. Karg
  • CD23 processing enzyme preparation
    Patent number: 6232089
    Abstract: The present invention is to the discovery of a novel CD23 processing enzyme which is of importance in the human immune response and regulation of IgE production, and is a protein expressed on the surface of a variety of cells.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derek Richard Buckle, Gary Christie, Ariane Elizabeth Marolewski, Ruth Judik Mayer, David Glynn Smith
  • Multi-reactor synthesizer and method for combinatorial chemistry
    Patent number: 6224832
    Abstract: Solid phase combinatorial synthesis is carried out in a multi-reactor synthesizer comprising an array of separate reactor cells (1-9) containing a solid reaction support medium (26). Subsets of the reactor cells (1-9) are interconnected with one another in a desired pattern, and, in a first reaction step, reagents (A, B, C) are circulated through the subsets. After the first reaction step is completed, the reactor cells (1-9) are rearranged into a new configuration of the subsets, and the same, or other, reagents (A, B, C) are circulated through the new subsets. The process can be repeated to produce large numbers of compounds differing from one another.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Lee Moore, Dennis Shinji Yamashita
  • Process of preparing 2-thiopyrimidine aldehyde
    Patent number: 6222036
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Zhi-Qiang Peng
  • Beta-lactam inhibitors of CoA-IT
    Patent number: 6221860
    Abstract: This invention relates to methods for treating diseases or disorders mediated by lipid inflammatory mediators, arachidonic acid, its metabolites and/or platelet activating factor (PAF), which method comprises administration to a mammal in need thereof of an effective Coenzyme A independent transacylase (CoA-IT) inhibiting amount of a triphenylmethylazetidinone. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a triphenylmethylazetidinone.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: William E. Bondinell, James David Winkler
  • Process for making pyridyl and pyrimidine substituted imidazole compounds
    Patent number: 6218537
    Abstract: 1,4,5,-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • IL-8 receptor antagonists
    Patent number: 6218539
    Abstract: The present invention relates to the use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Katherine L. Widdowson
  • Caspases and apoptosis
    Patent number: 6214858
    Abstract: A compound of formula wherein R1 is hydrogen, or C1-4 alkyl; R2 is C1-10 alkyl, optionally substituted arylC1-4alkyl, optionally substituted heteroaryl C1-4 alkyl optionally substituted C3-7 cycloalkyl, or R1 and R2 together with the nitrogen to which they are attached from a 3 to 10 membered ring which optionally contains an aditional heteroatom selected from oxygen, nitrogen or sulfur, R3 and R4 are C1-6alkyl, hydrogen, nitro, or halogen and R5 is C1-6alkyl, hydrogen, arylalkyl or heteroarylalkyl. The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of Caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: April 10, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis Lee, Scott Allen Long