Patents Represented by Attorney Dara L. Dinner

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  • Cycloalkenyl substituted compounds
    Patent number: 6362193
    Abstract: Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ravi Garigipati
  • Pharmaceutical formulation
    Patent number: 6358528
    Abstract: A tablet formulation which comprises a core containing a pharmaceutically active material containing amoxycillin and clavulanate, coated with a release retarding coating, surrounded by a casing layer which includes a second pharmaceutically active material containing amoxycillin and clavulanate.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: March 19, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Francis Walter Grimmett, Nigel Philip McCreath Davidson
  • Pharmaceutical formulations comprised of compacted amoxicillin granulates
    Patent number: 6352720
    Abstract: The present invention discloses tablet formulations, produced by dry roller compaction comprising compacted granulates of a mixture of a medicament and an intra-granular disintegrant. The granulates are compacted together into a tablet with an extra-granular disintegrant, an optional extragranular lubricant and excipients.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: March 5, 2002
    Assignee: Laboratorios Beecham SA
    Inventors: Luis Carvajal Martín, Juan Dedios Romero
  • Rapidly disintegrating methylcellulose tablets
    Patent number: 6350469
    Abstract: The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP standards in 0.1N hydrochloric acid as well as water.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Bruce Daggy, Naresh I Mehta, Priyashri Nayak
  • Reinforced blister pack
    Patent number: 6345717
    Abstract: A blister pack wherein the material between the blisters is reinforced to confer rigidity relative to flexing deformation of the blister pack. The reinforcement may take the form of a reinforcing slab or sheet, or ribs in the blister pack material. The invention facilitates handling by users with weak or deformed hands.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: February 12, 2002
    Assignee: SmithKline Beecham plc
    Inventor: Harry Flewitt
  • Compositions and method for reducing gastro-intestinal distress due to alpha-d-galactoside-linked/containing sugars
    Patent number: 6344196
    Abstract: A composition is provided for ingestion by mammals for in vivo conversion of alpha-D-galactoside comprising an amount of alpha-galactosidase effective to hydrolyze alpha-D-galactoside to D-galactose, and non-toxic, ingestible excipient(s) for said alpha-galactosidase. Gastric distress in mammals due to ingestion of foods containing alpha-D-galactoside may be reduced by ingesting the foregoing composition of alpha-galactosidase and non-toxic, ingestible excipient contemporaneously with the ingestion of said food in an amount effective to hydrolyze the alpha-D-galactoside to D-galactose.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: February 5, 2002
    Assignee: Block Drug Company, Inc.
    Inventor: Alan E. Kligerman
  • compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
    Patent number: 6335340
    Abstract: Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: January 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Timothy Francis Gallagher, Jeffrey Charles Boehm, Jerry Leroy Adams
  • IL-8 receptor antagonists
    Patent number: 6335352
    Abstract: Novel compounds useful in the treatment of Interleukin-8 mediated diseases, and methods of using them are disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: January 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Deborah Lynn Bryan, John Gerald Gleason, Katherine L. Widdowson
  • Cycloalkyl substituted imidazoles
    Patent number: 6329526
    Abstract: 1,4,5-substituted imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: December 11, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ravi S. Garigipati, Margaret E. Sorenson
  • Liquid oral compositions comprising a calcium compound and an acidulant
    Patent number: 6319490
    Abstract: Acidic oral compositions having reduced tooth erosion characteristics, especially acid beverages such as fruit juice drink concentrates, or oral healthcare products such as mouthwashes, are prepared by adding a calcium compound to the acid composition so that the mol ratio of calcium to acid ranges from 0.3 to 0.8, and the pH of the composition, if necessary after adjustment with an alkali, is from 3.5 to 4.5.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: November 20, 2001
    Assignee: SmithKline Beecham plc
    Inventor: David Myatt Parker
  • Swallow tablet comprising paracetamol
    Patent number: 6316025
    Abstract: The present invention relates to a swallow tablet or capsule formulation comprising paracetamol, sodium bicarbonate, and at least one pharmaceutically acceptable excipient.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham plc
    Inventor: Timothy James Grattan
  • IL-8 receptor antagonists
    Patent number: 6316478
    Abstract: This invention relates to novel spiro compound derivatives of benzoisothiazolyl-urea and -thiourea and compositions thereof. These compounds are useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine L. Widdowson, Hong Nie
  • Compounds
    Patent number: 6306883
    Abstract: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines by a compound of formula (I) and the treatment of cytokines mediated diseases, in mammals, by administration of said compound.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: October 23, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Ravi Shanker Garigipati, Susan Mary Thompson
  • Delayed release pharmaceutical formulation containing a &bgr;-lactam antibiotic
    Patent number: 6299903
    Abstract: Pharmaceutical formulations for oral administration, comprising a matrix which comprises a &bgr;-lactam antibiotic, a &bgr;-lactamase inhibitor, and granules in a delayed release form dispersed within the matrix which comprise a &bgr;-lactam antibiotic and a &bgr;-lactamase inhibitor.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Ernest Lionel Gilbert Rivett, Francis Walter Grimmett, Michael William Hartnell
  • Process for the preparation of a metal salt of clavulanic acid
    Patent number: 6300495
    Abstract: A process for the preparation of a metal salt of clavulanic acid which comprises the reaction between an organic amine salt of clavulanic acid and a metal salt precursor compound, the reaction taking place in a liquid medium which comprises a liquid florinated and/or chlorinated hydrocarbon.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Michael Allen Cook, Mazin Nicola
  • IL-8 receptor antagonists
    Patent number: 6300325
    Abstract: This invention relates to novel benzo-2-triazole substituted compounds, pharmaceutical compositions, processes for their preparation, and use thereof in treating IL-8, GRO&agr;, GRO&bgr;, GRO&ggr; and NAP-2 mediated diseases.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine L. Widdowson, Melvin C. Rutledge
  • Benzoisothiazole-substituted compounds useful as IL-8 receptor antagonists
    Patent number: 6297265
    Abstract: This invention relates to novel benzoisothiazole substituted compounds, pharmaceutical compositions, processes for their preparation, and use thereof in treating IL-8, GRO&agr;, GRO&bgr;, GRO&ggr;, ENA-78 and NAP-2 mediated diseases.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine L. Widdowson, Hong Nie
  • Method of treating a bacterial infection comprising administering amoxycillin
    Patent number: 6294199
    Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: September 25, 2001
    Assignee: Beecham Pharmaceuticals (Pte) Limited
    Inventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
  • Oxazoles for treating cytokine mediated diseases
    Patent number: 6288062
    Abstract: This invention relates to the novel oxazole compounds of Formula (I) and novel pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines and the treatment of cytokine mediated diseases, in mammals, thereby by administration of an effective amount of a compound according to Formula (I).
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: September 11, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Jeffrey Charles Boehm, Susan Mary Thompson
  • Pharmaceutical tablet
    Patent number: D448075
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: September 18, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Cynthia Marie Klaja-McLaughlin